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Adult Intussusception in Patients with Peutz-Jeghers Syndrome: Case Series and Review of Literature

Surgical Science 2017年第2期8卷 118-132页

作者： Mohamed A. Mlees Tamer A. El-Bakary Magdy M. El-Gendy Ahmed A. darwish Department of General Surgery Tanta University Hospital Tanta Egypt

Background: Peutz-Jeghers syndrome (PJS) is a rare autosomal dominant disorder characterized by gastrointestinal hamartomatous polyps and mucocutaneous pigmentations in the mouth, facial skin, hands & feet. Small bowel obstruction, intussusception, bleeding, intestinal and extra-intestinal malignancies are the major complications of PJS. The aim of this study is to analyze the clinical characteristics, preoperative diagnosis, and surgical management of PJS associated-intussusception in adults. Patients and Methods: This study included 5 cases with intussusception in PJS patients presented to Surgical Oncology Unit, General Surgery Department, Tanta University Hospital, Egypt and Hamad General Hospital, Hamad Medical Corporation, Qatar, between October 2011 and March 2016. Patients’ demographics were collected. After thorough clinical examination, abdominal X-ray, US, & CT scan were done. All the patients were submitted to midline laparotomy with resection anastomosis of the affected bowel segment. Results: The mean age was 28.4 years. Female: male ratio was 3:2. Abdominal pain was the most common presenting complaint with or without intestinal obstruction manifestations. Palpable abdominal mass was found in 3 patients (60%). Intussusception was proved pre-operatively in all the cases by abdominal ultrasound and CT scan. The intussusception was found in the jejunum in 3 patients, ileum in 1 patient, & in 1 patient, there was double intussusception (one jejunal & one ileo-cecal). Histopathological examination revealed the presence of typical Peutz-Jeghers hamartomatous polyp. No morbidity or mortality was reported at a mean follow-up period of 32 months. Conclusion: Family history, physical examination, abdominal ultrasound and CT scan were important in the diagnosis of acute intussusception caused by PJS. Surgical management of PJS associated intussusception is the recommended treatment to relieve patient’s symptoms and to avoid missing underlying malignancy. Patient

关键词： Peutz-Jeghers Syndrome Intussusception Hamartomatous Polyp

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利水消臌膏联合肝病治疗仪治疗乙肝肝硬化顽固性腹水的临床疗效

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中国实验方剂学杂志 2022年第22期28卷 123-130页

作者：王岗朱琦陈新岳仁宋车德亚成都中医药大学附属医院成都610075 自贡市第一人民医院四川自贡643000

目的:观察利水消臌膏外敷联合肝病治疗仪治疗乙肝后肝硬化顽固性腹水的疗效。方法:按随机数字表法把120例乙肝后肝硬化顽固性腹水患者分为对照组、观察组,每组各60例。对照组予以DSG-Ⅲ肝病治疗仪和常规西医基础治疗,观察组在对照组基... 详细信息

目的:观察利水消臌膏外敷联合肝病治疗仪治疗乙肝后肝硬化顽固性腹水的疗效。方法:按随机数字表法把120例乙肝后肝硬化顽固性腹水患者分为对照组、观察组,每组各60例。对照组予以DSG-Ⅲ肝病治疗仪和常规西医基础治疗,观察组在对照组基础上加利水消臌膏肝区及腹部外敷。连续治疗4周,对比分析两组患者治疗前后体质量、腹围、24 h尿量、临床症状量化积分、肝功能、内皮素-1(ET-1)、一氧化氮(NO)、γ干扰素(IFN-γ)的变化情况,并用彩色多普勒超声评估治疗前后门静脉血流动力学变化情况。结果:两组患者经治疗4周后,观察组治疗总有效率为87.72%(50/57),高于对照组的67.9%(38/56),差异具有统计学意义(χ^(2)=6.411,P<0.05)。两组患者腹围、体质量和24 h尿量均优于本组治疗前(P<0.05);治疗后,上述指标观察组优于对照组(P<0.05)。中医临床症状积分方面,对照组食欲、乏力、睡眠、身目发黄与治疗前差异无统计学意义,其余各项指标两组患者均优于本组治疗前(P<0.05);治疗后,观察组在腹胀、胁痛、食欲、乏力、下肢水肿等症状改善方面均优于对照组(P<0.05),但在改善睡眠和身目发黄方面两组之间差异无统计学意义。实验室检查方面,两组患者总胆红素(TBIL)、丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、白蛋白/球蛋白(AGR)、ET-1、NO、IFN-γ各指标组内比较标均优于本组治疗前(P<0.05);治疗后,两组患者TBIL差异无统计学意义,其余指标观察组均优于对照组(P<0.05)。在门静脉血流动力学方面,与本组治疗前比较,两组患者门静脉主干内径(D_(pv))、最大血流速度(V_(max)),门脉血流量(Q)均有明显改善(P<0.05);治疗后,观察组D_(pv)、V_(max)、Q改善程度优于对照组(P<0.05)。结论:利水消臌膏外敷联合肝病治疗仪可显著提高乙肝后肝硬化顽固性腹水的有效率,作用机制可能与减少NO、ET-1水平,增加IFN-γ水平和改善门静脉血流动力学有关。

关键词：乙肝后肝硬化顽固性腹水利水消臌膏中药外敷肝病治疗仪

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Salvia ceratophylla L. from South of Jordan: new insights on chemical composition and biological activities

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Natural Products and Bioprospecting 2020年第5期10卷 307-316页

作者： Mohammad Sanad Abu-darwish Célia Cabral Zulfigar Ali Mei Wang Shabana IKhan Melissa RJacob Surendra KJain Babu LTekwani Fazila Zulfiqar Ikhlas AKhan Hatem Taifour Lígia Salgueiro Thomas Efferth Department of Basic and Applied Sciences Al-Balqa Applied UniversityAl-Salt 19117Jordan National Center for Natural Products Research School of PharmacyUniversity of MississippiUniversityMS 38677USA Coimbra Institute for Clinical and Biomedical Research(iCBR) Faculty of MedicineUniversity of Coimbra3000-548 CoimbraPortugal Center for Innovative Biomedicine and Biotechnology(CIBB) University of Coimbra3000-548 CoimbraPortugal Centre for Functional Ecology Department of Life SciencesUniversity of CoimbraCalçada Martim de Freitas3000-456 CoimbraPortugal School of Geosciences University of Edinburgh219 Crew BuildingKing’s BuildingsEdinburgh EH93FFUK CIEPQPF/Faculty of Pharmacy University of CoimbraHealth Sciences CampusAzinhaga de S.Comba3000-548 CoimbraPortugal Department of Pharmaceutical Biology Institute of Pharmaceutical and Biocmedical SciencesJohannes Gutenberg UniversityStaudinger Weg 555128 MainzGermany

In Jordan,Salvia ceratophylla *** traditionally used in the treatment of cancer,microbial infections,and urinary *** study aimed:(1)to chemically characterize *** essential oil(EO)from South Jordan,by gas chromatography(GC)and gas chromatography-mass spectrometry(GC-MS);and(2)to evaluate in vitro the cytotoxic,anti-inflammatory,and antiprotozoal activities of the EO,it’s predominant components,and the hexane(A),ethyl acetate(B),methanol(C)and crude-methanol extracts(D).The analysis revealed that the EO has 71 compounds,with linalool(54.8%)as main *** the hexane extract(A)showed some cytotoxic activity against SK-MEL,KB,BT-549,SK-OV-3,LLC-PK1 and VERO cells lines with IC50 between 60 and>100μg/*** EO inhibited NO production(IC5090μg/mL)and NF-κB activity(IC5038μg/mL).The extracts A,B,and D inhibited NO production and NF-κB activity with IC50 between 32 and 150μg/*** considerably inhibited NO production(IC5018μg/mL).The extracts tested did not exhibit antileish-manial *** antitrypanosomal activity,the EO exhibited significant results with IC502.65μg/*** conclu-sion,Jordan *** EO represents a rich source of linalool and bears a promising therapeutic potential for further antitrypanosomal drug development.

关键词： Lamiaceae Essential oil Chemical composition Cytotoxicity Anti-inflammatory activity Neglected diseases

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炭黑含量对丁腈橡胶与尼龙帘布之间粘合的影响

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橡胶参考资料 1999年第11期29卷 42-48页

作者： N.A.darwish 王韶晖

橡胶和织物的复合制品(如轮胎、胶管和胶带)是所有橡胶制品的重要组成部分。改善弹性体和织物之间粘合的技术既涉及用适当的粘合体系对织物帘布进行处理,又包括在橡胶胶料中加入粘合剂,或者两种方法结合使用。间苯二酚甲醛树脂被用作含... 详细信息

橡胶和织物的复合制品(如轮胎、胶管和胶带)是所有橡胶制品的重要组成部分。改善弹性体和织物之间粘合的技术既涉及用适当的粘合体系对织物帘布进行处理,又包括在橡胶胶料中加入粘合剂,或者两种方法结合使用。间苯二酚甲醛树脂被用作含水的胶粘剂加入胶乳中。

关键词：丁腈橡胶尼龙帘布炭黑含量粘合

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用于高效DC/DC变换器的沟槽MOSFET

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电子产品世界 2003年第20期 44-45+3-4页

作者： Jess Brown ,Mohamed darwish Vishay Siliconix公司 Vishay Siliconix公司

面对市场对高效率电源的需求,工程师们无不急切期盼快速开关、低rDS(on)的功率MOSFET能有新进展。如今,一种新颖的厚底层氧化物工艺可以让Crss减小为栅极结构器件相应参数的一半,从而大大减少了器件导通所需的栅电荷,缩短了功率MOSFET... 详细信息

面对市场对高效率电源的需求,工程师们无不急切期盼快速开关、低rDS(on)的功率MOSFET能有新进展。如今,一种新颖的厚底层氧化物工艺可以让Crss减小为栅极结构器件相应参数的一半,从而大大减少了器件导通所需的栅电荷,缩短了功率MOSFET的开关瞬态过程,同时让导通电阻保持在一个极低的水平上。这一技术对DC/DC变换器来说,意味着电路工作效率将得以提高。

关键词： MOSFET 瞬态过程栅极电极 DC/DC 转换器变换器

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Natural Radioactivity Assessment and Radiological Hazards in Soils from Qarun Lake and Wadi El Rayan in Faiyum, Egypt

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Open Journal of Soil Science 2013年第7期3卷 289-296页

作者： Saher M. darwish Samia M. El-Bahi Amany T. Sroor Najat F. Arhoma Nuclear Physics Laboratory Ain Shams University Fac- ulty of Girls Heliopolis Cairo Egypt. Physics Department Faculty of Science Cairo University Giza Egypt Physics Department Faculty of Science Cairo University Giza Egypt

The activity concentrations of naturally occurring 238U, 232Th and 40K in surface soils along Qarun Lake and Wadi El Rayan located in Faiyum, Egypt were determined. The measurements were carried out through gamma-ray spectrometry using a coaxial HPGe detector. The results were compared with those reported in the literature. The radiological hazard radium-equivalent activity index, external and internal indices, radioactivity level index, absorbed dose rate, annual effective dose rate and total absorbed dose rate associated with radioactivity in all samples were evaluated and compared with recommended values. Correlation studies between pairs of radionuclides were performed and discussed.

关键词： Natural Radioactivity Radiological Hazards HPGe Detector Gamma-Ray Spectrometry

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Analytic Study of Spinal Infections: Clinical Picture, Treatment, and Outcomes in King Fahad Military Medical Complex in Dhahran, Saudi Arabia

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Open Journal of Medical Microbiology 2020年第3期10卷 103-113页

作者： Salma Albahrani Amal Shilash Ayat Albasri Sharifah Almuthen Sama Tawfiq Khalid Alzahrani Amjad darwish Muneera Albassam Jamil Barhoun King Fahad Military Complex Dhahran KSA Infectious Disease Consultant King Fahad Military Complex Dhahran KSA Epidemiologist Infection Control Department King Fahad Military Complex Dhahran KSA Internal Medicine Department King Fahad Military Complex Dhahran KSA Neurosurgeon Consultant King Fahad Military Complex Dhahran KSA Radiology Department King Fahad Military Complex Dhahran KSA

Objective: To evaluate the prevalence of spinal infection in a hospital located in the eastern region of Saudi Arabia through a retrospective review and to identify the associated etiological agents in terms of clinical picture, treatment, and outcomes. Design: Retrospective cross-sectional study. Setting: Single hospital in Dhahran, Saudi Arabia. Patients: Patients with any type of spinal infection and/or who had undergone neurosurgical intervention for spinal infection between January 2006 and December 2018. Methods: We collected data on all patients with an established diagnosis of spinal infection from January 2006 to December 2018 in the King Fahad Military Medical Complex in Dhahran, Saudi Arabia. A validated and structured checklist was used for data collection. Spinal infection diagnosis was based on the clinical manifestation, microbiological evidence, radiological findings, and antimicrobial therapy response. Results: Seventeen patients were included in this study, and their mean age was 54.93 years. Twelve of the patients were male and four were female. The approximate time from symptom onset to diagnosis was 2 - 6 months. Most of the patients experienced back pain, with lumbosacral spondylitis being the most commonly cited type (61.11%

关键词： Spinal Infection Mycobacterium tuberculosis Quambalaria cyanescens Tuberculosis Spondylodiscitis

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Effects of Adding Nanosilica on Performance of Ethylsilicat （TEOS） as Consolidation and Protection Materials for Highly Porous Artistic Stone

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材料科学与工程（中英文A版） 2016年第4期6卷 192-204页

作者： Mohammad A. Al-Dosari Sawsan darwish Mahmoud Abd El-Hafez Nagib Elmarzugi Nadia Al-Mouallimi Sayed Mansour Department of Conservation Faculty of Archaeology Cairo University Giza P. O. Box 12613 Egypt Faculty of Pharmacy Tripoli University & National Nanotechnology Project Biotechnology Research Center LARST P. O. Box13100 Tripoli Libya National Nanotechnology Research Center King Abdulalziz City for Science and Technology (KACST) P. O. Box 6086 RiyadhSaudi Arabia Saudi Nano Information Center Jeddah P. O. Box 20718 Saudi Arabia The Grand Egyptian Museum Ministry of Antiquities Cairo P. O. Box 12561 Egypt

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An eFP browser for visualizing strawberry fruit and flower transcriptomes

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Horticulture Research 2017年第1期4卷 227-234页

作者： Charles Hawkins Julie Caruana Jiaming Li Chris Zawora Omar darwish Jun Wu Nadim Alkharouf Zhongchi Liu Department of Cell Biology and Molecular Genetics University of MarylandCollege Park20742MDUSA Centre of Pear Engineering Technology Research Nanjing Agricultural UniversityNanjing210095China Department of Computer and Information Sciences Towson UniversityTowson21252MDUSA Irrigated Agriculture Research and Extension Center Washington State UniversityProsserWA 99350USA

Wild strawberry Fragaria vesca is emerging as an important model system for the cultivated strawberry due to its diploid genome and availability of extensive transcriptome data and a range of molecular genetic *** able to better utilize these tools,especially the transcriptome data,will greatly facilitate research progress in strawberry and other Rosaceae fruit *** electronic fluorescent pictograph(eFP)software is a useful and popular tool to display transcriptome data visually,and is widely used in other model organisms including Arabidopsis and *** we applied eFP to display wild strawberry RNA sequencing(RNA-seq)data from 42 different tissues and stages,including various flower and fruit developmental *** addition,we generated eight additional RNA-seq data sets to represent tissues from ripening-stage receptacle fruit from yellow-colored and red-colored wild strawberry *** gene expression analysis between these eight data sets provides additional information for understanding fruit-quality ***,this work greatly facilitates the utility of the extensive transcriptome data for investigating strawberry flower and fruit development as well as fruit-quality traits.

关键词： straw cultivated colored

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Spectroscopic Investigations of <i>β</i>-Amyloid Interactions with Propofol and L-Arginine

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Open Journal of Biophysics 2015年第2期5卷 50-67页

作者： Saqer M. darwish Shurook Y. Aiaidah Imtiaz M. Khalid Musa M. Abuteir Lena Qawasmi Physics Department Al-Quds University al-Bireh Palestine University College for Educational Sciences Nano - Technology Center

Beta amyloid (Aβ) aggregation has been characterized to be responsible for several amyloid diseases. Fourier transform infrared (FTIR) spectroscopy, fluorescence, and atomic force microscopy (AFM) are used to investigate induced changes in the secondary structure of Aβ upon thermal denaturation and interaction with propofol and L-arginine. Spectral analysis has revealed an effective static quenching for the intrinsic fluorescence of Aβ by propofol and l-arginine with binding constants of 2.81 × 102 M-1 for Aβ-propofol and 0.37 × 102 M-1 for Aβ-L-arginine. Fourier self-deconvolution (FSD) technique has been used to evaluate the relative intensity changes in the spectra of the component bands in the amide I and amide II regions at different ligand’s concentration in the protein complex. The analysis showed a decrease in the intensities of the parallel beta bands of propofol and L-arginine interactions with Aβ, accompanied with an increase in the antiparallel bands for the Aβ-propofol interaction and a decrease for the Aβ-l-arginine interaction. The relative increase in peaks’ intensities at 1694 cm-1 and 1531 cm-1 for the propofol interaction is linked to the formation of oligomers in the protein.

关键词： FTIR Spectroscopy Oligomeric Aβ Alzheimer’s Disease Amyloid β-Peptide Antiparallel β-Sheet

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