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Psychological, social, and sexual challenges affecting men receiving male infertility treatment: a systematic review and implications for clinical care

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Asian journal of Andrology 2023年第4期25卷 448-453页

作者： Winston Wu justin La Kathryn M Schubach Daniel Lantsberg darren j katz Department of Urology Western HealthSt AlbansVIC 3021Australia Department of Urology Kaiser Permanente San Rafael Medical CenterSan RafaelCA 94903USA Men’s Health Melbourne MelbourneVIC 3000Australia Reproductive Services Unit The Royal Women’s HospitalParkvilleVIC 3052Australia Melbourne IVF East MelbourneVIC 3002Australia Department of Surgery Western PrecinctUniversity of MelbourneParkvilleVIC 3010Australia

In recent years, social research surrounding the consequences of infertility has increasingly focused on the male perspective;however, a gap exists in the understanding of men’s experiences of male infertility treatment. This review aims to synthesize theexisting evidence concerning the psychological, social, and sexual burden of male infertility treatment on men, as well as patientneeds during clinical care. A systematic search identified 12 studies that are diverse in design, setting, and methods. Psychologicalevaluations have found that urological surgery may have a lasting impact on infertility-specific stress, and treatment failure canlead to feelings of depression, grief, and inadequacy. Men tended to have an avoidant coping mechanism throughout fertilitytreatment, and their self-esteem, relationship quality, and sexual functions can be tied to outcomes of treatment. Partner bonds canbe strengthened by mutual support and enhanced communication;couple separation, however, has been noted as a predominantreason for discontinuing male infertility treatment and may be associated with difficult circumstances surrounding severe maleinfertility. Surgical treatments can affect the sexual functioning of infertile men;however, the impact of testicular sperm extractionoutcomes appears to be psychologically driven whereas the improvements after microsurgical varicocelectomy are only evident inhypogonadal men. Clinically, there is a need for better inclusion, communication, education, and resource provision, to addressreported issues of marginalization and uncertainty in men. Routine psychosocial screening in cases of severe male infertility andfollow-up in cases of surgical treatment failure are likely beneficial.

关键词： male infertility male infertility treatment patient experience patient-centered care psychosocial sexual

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The role of organic electron donors in the initiation of BHAS base-induced coupling reactions between haloarenes and arenes

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Science China Chemistry 2019年第11期62卷 1425-1438页

作者： Andrew j.Smith darren L.Poole john A.Murphy Department of Pure and Applied Chemistry University of StrathclydeStrathclydeGlasgow G11XLUnited Kingdom Flexible Discovery Unit GlaxoSmithKline Medicines Research CentreStevenageSG12NYUnited Kingdom

Coupling reactions between haloarenes and arenes(including heteroarenes)that are conducted without added transition metals but in the presence of KOtBu or NaOtBu,have been a topic of great interest since their discovery in *** organic structures act as additives that assist these *** additives are converted into organic electron donors by the butoxide base and this leads to initiation of the coupling reactions,which proceed by radical chain *** review provides an overview of the initiation stages of these reactions.

关键词： organic electron donor potassium tert-butoxide electron transfer base-promoted homolytic aromatic substitution(BHAS) coupling benzyne

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Experimentally unsupervised deconvolution for light-sheet microscopy with propagation-invariant beams

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Light(Science & Applications) 2022年第11期11卷 2790-2804页

作者： Philip Wijesinghe Stella Corsetti darren j.X.Chow Shuzo Sakata Kylie R.Dunning Kishan Dholakia SUPA School of Physics and AstronomyUniversity of St AndrewsNorth HaughSt AndrewsFife KY169SSUK Robinson Research Institute Adelaide Medical SchoolThe University of AdelaideAdelaideSAAustralia Australian Research Council Centre of Excellence for Nanoscale BioPhotonics The University of AdelaideAdelaideSAAustralia Institute for Photonics and Advanced Sensing The University of AdelaideAdelaideSAAustralia Strathclyde Institute of Pharmacy and Biomedical Sciences University of StrathclydeGlasgow G4 OREUK School of Biological Sciences The University of AdelaideAdelaideSAAustralia Department of Physics College of ScienceYonsei UniversitySeoul 03722South Korea

Deconvolution is a challenging inverse problem,particularly in techniques that employ complex engineered pointspread functions,such as microscopy with propagation-invariant ***,we present a deep-learning method for deconvolution that,in lieu of end-to-end training with ground truths,is trained using known physics of the imaging ***,we train a generative adversarial network with images generated with the known point-spread function of the system,and combine this with unpaired experimental data that preserve perceptual *** method rapidly and robustly deconvolves and super-resolves microscopy images,demonstrating a two-fold improvement in image contrast to conventional deconvolution *** contrast to common end-to-end networks that often require 1000-10,000s paired images,our method is experimentally unsupervised and can be trained solely on a few hundred regions of *** demonstrate its performance on light-sheet microscopy with propagation-invariant Airy beams in oocytes,preimplantation embryos and excised brain tissue,as well as illustrate its utility for Bessel-beam *** method aims to democratise learned methods for deconvolution,as it does not require data acquisition outwith the conventional imaging protocol.

关键词： invariant propagation implantation

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Large-diameter trees, snags, and deadwood in southern Utah, USA

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Ecological Processes 2021年第1期10卷 130-141页

作者： james A.Lutz Soren Struckman Tucker j.Furniss joseph D.Birch Larissa *** darren j.McAvoy Department of Wildland Resources S.J.and Jessie E.Quinney College of Natural ResourcesUtah State University5230 Old Main HillLoganUT 84322-5230USA. Department of Renewable Resources University of AlbertaEdmontonAlbertaCanada.

Background:The epidemic Dendroctonus rufipennis(spruce beetle)outbreak in the subalpine forests of the Colorado Plateau in the 1990s killed most larger Picea engelmannii(Engelmann spruce)*** quarter century later,the larger snags are beginning to fall,transitioning to deadwood(down woody debris)where they may influence fire behavior,regeneration,and habitat ***:We tracked all fallen trees≥1 cm in diameter at breast height(1.37-m high)and mapped all pieces of deadwood≥10-cm diameter and≥1 m in length within 13.64 ha of a high-elevation mixed-species forest in the Picea–Abies zone annually for 5 years from 2015 through *** examined the relative contribution of Picea engelmannii to snag and deadwood pools relative to other species and the relative contributions of large-diameter trees(≥33.2 cm at this subalpine site).We compared spatially explicit mapping of deadwood to traditional measures of surface fuels and introduce a new method for approximating vertical distribution of ***:In this mixed-species forest,there was relatively high density and basal area of live Picea engelmannii 20 years after the beetle outbreak(36 trees ha^(−1) and 1.94 m^(2) ha^(−1)≥10-cm diameter)contrasting with the near total mortality of mature Picea in forests *** from tree boles≥10-cm diameter on the ground had biomass of 42 Mg ha^(−1),7 Mg ha^(−1) of Picea engelmannii,and 35 Mg ha^(−1) of other *** live aboveground biomass was 119 Mg ha^(−1),while snag biomass was 36 Mg ha^(−1).Mean total fuel loading measured with planar transects was 63 Mg ha^(−1) but varied more than three orders of magnitude(0.1 to 257 Mg ha^(−1)).Planar transects recorded 32 Mg ha^(−1) of wood≥7.62-cm diameter compared to the 42 Mg ha^(−1) of wood≥10-cm diameter recorded by explicit *** pieces of deadwood were often stacked,forming a vertical structure likely to contribute to active fire ***:Bark beetle mortality in the 1990s has made

关键词： Cedar Breaks National Monument Dendroctonus rufipennis Utah Forest Dynamics Plot Vertical fuel structure

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In vitro mineralisation of grafted ePTFE membranes carrying carboxylate groups

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Bioactive Materials 2017年第1期2卷 27-34页

作者： Norsyahidah Mohd Hidzir David j.T.Hill darren Martin Lisbeth Grøndahl School of Chemistry and Molecular Biosciences University of QueenslandSt LuciaQLD4072Australia Australian Institute for Bioengineering and Nanotechnology University of QueenslandSt LuciaQLD4072Australia School of Applied Physics Faculty of Science&TechnologyUniversiti Kebangsaan MalaysiaUKM BangiSelangor43600Malaysia

In vitro mineralisation in simulated body fluid(SBF)of synthetic polymers continues to be an important area of research as the outcomes cannot be *** study evaluates a series of ePTFE membranes grafted with carboxylate-containing copolymers,specifically using acrylic acid and itaconic acid for *** samples differ with regards to graft density,carboxylate density and polymer *** type and amount of mineral produced in 1.5×SBF was dependent on the sample characteristics as evident from XPS,SEM/EDX,and FTIR *** was found that the graft density affects the mineral phases that form and that low graft density appear to cause co-precipitation of calcium carbonate and calcium *** and branched graft copolymer topology led to hydroxyapatite mineralisation whereas crosslinked graft copolymers resulted in formation of a mixture of calcium-phosphate *** study demonstrates that in vitro mineralisation outcomes for carboxylate-containing graft copolymers are *** findings of this study have implications for the design of bioactive coatings and are important for understanding the bone-biomaterial interface.

关键词： Simulated body fluid Expanded poly(tetrafluoroethylene) Graft copolymerisation Carboxylate groups

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A mixed acid methodology to produce thermally stable cellulose nanocrystal at high yield using phosphoric acid

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journal of Bioresources and Bioproducts 2022年第2期7卷 17-26页

作者： Khairatun Najwa Mohd Amin Alireza Hosseinmardi darren j.Martin Pratheep K.Annamalai Australian Institute for Bioengineering and Nanotechnology(AIBN) the University of QueenslandBrisbaneQLD 4072 Australia Faculty of Chemical and Process Engineering Technology College of Engineering TechnologyUniversiti Malaysia PahangLebuhraya Tun Razak26300 Gambang KuantanPahang D.M.Malaysia

Cellulose nanocrystal(CNC)with distinctive shape-morphology,enhanced thermal stability and dispersibility is essential for overcoming the challenges in processing polymer/CNC nanocom-posites through melt compounding at elevated *** study shows a mixed acid hy-drolysis method to produce CNC with improved thermal stability and high *** use of phosphoric acid(H_(3)PO_(4)),as a mild acid,in combination with a strong acid either sulphuric acid(H_(2)SO_(4))or hydrochloric acid(HCl)leads to reduced use of strong acids and low impact on our *** influences of acid combination and sequence of addition on the production yield were investigated by retaining the proportion of H_(3)PO_(4)to corrosive acid(H_(2)SO_(4)and HCl)4 to 1,and solid to liquid ratio 1꞉*** methodology has enabled to isolate CNC with higher thermal stability,dispersibility and productivity in terms of amount acid used 1 g of CNC,as compared with single acid *** CNC produced using the combination of H_(3)PO_(4)and HCl exhibits high thermal stability,dispersibility and rod-like shape morphology with length and width of(424±86)and(22±3)nm,***,this approach has reduced H_(3)PO_(4)consumption by 54%as compared with single acid hydrolysis method for the production of same amount of CNC.

关键词： Cellulose nanocrystal(CNC) Acid hydrolysis Thermal stability Mixed acid Crystallinity Production yield

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A near infrared spectroscopy calibration for the prediction of fresh grass quality on Irish pastures

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Information Processing in Agriculture 2022年第2期9卷 243-253页

作者： darren j.Murphy Bernadette O’Brien Michael O’Donovan Tomas Condon Michael D.Murphy Teagasc Animal&Grassland Research and Innovation CentreMooreparkFermoyCo.CorkIreland Department of Process Energy and Transport EngineeringMunster Technological UniversityCorkIreland

The aim of this study was to develop near infrared spectroscopy(NIRS)calibrations to predict quality parameters,dry matter(DM,g kg1)and crude protein(CP,g kg1 DM),in fresh un-dried *** of these parameters would enable more precise allocation of quality herbage to grazing *** ryegrass samples(n=1615)were collected over the 2017 and 2018 grazing seasons at Teagasc Moorepark to develop a NIRS calibration *** samples were collected for an independent validation dataset(n=197)during the 2019 grazing *** were scanned using a FOSS 6500 spectrometer at 2 nm intervals in the range of 1100~2500 nm and absorption was recorded as log 1/Reflec*** wet chemistry analysis was carried out for both parameters and the resultant data were calibrated against spectral data by means of modified partial least squares regression.A range of mathematical spectral treatments were examined for each calibration,which were ranked in order of standard error of prediction(SEP)and ratio of percent deviation(RPD).Best performing calibrations achieved high predictive precision for DM(R2=0.86 SEP=9.46 g kg1,RPD=2.60)and moderate precision for CP(R2=0.84 SEP=20.38 g kg1 DM,RPD=2.37).These calibrations will aid the optimisation of grassland management and the development of precision agricultural technologies.

关键词： Near infrared spectroscopy Fresh grass analysis Grassland management Grass quality Precision agriculture

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Effect of solution heat treatment and hot isostatic pressing on the microstructure and mechanical properties of Hastelloy X manufactured by electron beam powder bed fusion

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journal of Materials Science & Technology 2022年第3期98卷 99-117页

作者： Amal Shaji Karapuzha darren Fraser Yuman Zhu Xinhua Wu Aijun Huang Department of Materials Science and Engineering Monash UniversityVictoria 3800Australia Monash Centre for Additive Manufacturing 15-17 Normanby RdNotting HillVIC 3168Australia Manufacturing Unit CSIROClaytonVictoria 3168Australia

Prior to the application of AM components for critical applications,it is necessary to have a better understanding of the effect of different post-fabrication treatments on the microstructure and mechanical properties of such *** this study,efforts were made to achieve an in-depth understanding of the effect of post-fabrication Solution Heat Treatment(SHT)and Hot Isostatic Pressing(HIP)on the microstructure and mechanical properties of Hastelloy X parts built by electron beam powder bed fusion(PBF-EB)*** effects of SHT and HIP on porosity,microstructure,texture and mechanical properties have been investigated and compared with that of as-built PBF-EB Hastelloy ***-fabrication HIP treatment led to a significant reduction in the porosity content,whereas no notable difference in porosity was observed between SHT and as-built *** was no evidence of any recrystallization occurring following the post-fabrication treatments as elongated columnar grain structures observed within as-built part were found to be maintained even after SHT and HIP process alongside the strongcrystallographic *** was laid upon understanding the influence of SHT and HIP on mechanical properties through stress-strain curves and work-hardening behaviour.

关键词： Additive manufacturing Electron beam powder bed fusion Nickel-based superalloy Heat treatment Hot isostatic pressing

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McSNAC:A software to approximate first-order signaling networks from mass cytometry data

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Quantitative Biology 2023年第1期11卷 59-71页

作者： darren Wethington Sayak Mukherjee jayajit Das Steve and Cindy Rasmussen Institute for Genomic Medicine Abigail Wexner Research InstituteNationwide Children’s HospitalColumbusOhio 43205United States Biomedical Sciences Graduate Program College of MedicineThe Ohio State UniversityColumbusOhio 43210United States Department of Pediatrics College of MedicineThe Ohio State UniversityColumbusOhio 43210United States Pelotonia Institute for Immuno-Oncology College of MedicineThe Ohio State UniversityColumbusOhio 43210United States DepartmentofBiomedicalInformatics CollegeofMedicineTheOhioStateUniversityColumbusOhio43210United States Biophysics Graduate Program The Ohio State UniversityColumbusOhio 43210United States Battelle Memorial Institute ColumbusOhio 43201United States

Background:Mass cytometry(CyTOF)gives unprecedented opportunity to simultaneously measure up to 40 proteins in single cells,with a theoretical potential to reach 100 *** high-dimensional single-cell information can be very useful in dissecting mechanisms of cellular *** particular,measuring abundances of signaling proteins like phospho-proteins can provide detailed information on the dynamics of single-cell signaling ***,computational analysis is required to reconstruct such networks with a mechanistic ***:We propose our Mass cytometry Signaling Network Analysis Code(McSNAC),a new software capable of reconstructing signaling networks and estimating their kinetic parameters from CyTOF *** approximates signaling networks as a network of first-order reactions between *** assumption often breaks down as signaling reactions can involve binding and unbinding,enzymatic reactions,and other nonlinear ***,McSNAC may be limited to approximating indirect interactions between protein species,as cytometry experiments are only able to assay a small fraction of protein species involved in ***:We carry out a series of in silico experiments here to show(1)McSNAC is capable of accurately estimating the ground-truth model in a scalable manner when given data originating from a first-order system;(2)McSNAC is capable of qualitatively predicting outcomes to perturbations of species abundances in simple second-order reaction models and in a complex in silico nonlinear signaling network in which some proteins are ***:These findings demonstrate that McSNAC can be a valuable screening tool for generating models of signaling networks from time-stamped CyTOF data.

关键词： single-cell CyTOF data signaling network kinetics ODE McSNAC

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Diversity,endemism and conservation of the freshwater crabs of China(Brachyura:Potamidae and Gecarcinucidae)

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Integrative Zoology 2011年第1期6卷 45-55页

作者： Neil CUMBERLIDGE Peter K.L.NG darren C.j.YEO Tohru NARUSE Kirstin S.MEYER Lara j.ESSER Department of Biology Northern Michigan UniversityMarquetteMichiganUSA Department of Biological Sciences National University of SingaporeSingapore University of the Ryukyus NishiharaOkinawaJapan Imperial College University of LondonLondonUK

China lies at the heart of the global center of freshwater crab diversity in tropical Asia,where the 2 most diverse families occur:Potamidae(505 species,95 genera)and Gecarcinucidae(344 species,59 genera).China stands out as the country with the highest species richness of freshwater crabs *** fauna comprises 243 species in 37 genera and in 2 families,and species discovery is still progressing at a rapid *** vast majority of the species are distributed in southwest,south central and eastern China in the Oriental zoogeographical *** also stands out as having a highly endemic freshwater crab fauna at the species level(96%)and at the genus level(78%).Although the recent International Union for the Conservation of Nature(IUCN)red list conservation assessment found only 6 out of 228 species(2%)to be threatened(5 potamids and 1 gecarcinucid),the majority(more than 75%)of Chinese species are regarded as data deficient,so the number of threatened species is likely to be a serious *** from increasing habitat destruction and pollution are a major concern due to the rapidly growing economy and massive developments taking place in *** is therefore an urgent need for increased species exploration and for the development of a conservation strategy for China’s threatened(and potentially threatened)endemic freshwater crab species.

关键词： China conservation distribution endemism Potamoidea

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