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Foregut bypass *** bariatric procedures for nonalcoholic fatty liver disease:a meta-analysis of 3,355 individuals

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Hepatobiliary Surgery and Nutrition 2023年第5期12卷 658-670,I0001-I0003页

作者： Wen Hui Lim Snow Yunni Lin Cheng Han Ng darren Jun Hao Tan Jieling Xiao Jie Ning Yong Phoebe Wen Lin Tay Nicholas Syn Yip Han Chin Kai En Chan Chin Meng Khoo Nicholas Chew Roger S.Y.Foo Asim Shabbir Eunice X.Tan Daniel Q.Huang Mazen Noureddin Arun J.Sanyal Mohammad Shadab Siddiqui Mark D.Muthiah Yong Loo Lin School of Medicine National University of SingaporeSingaporeSingapore Division of Endocrinology Department of MedicineNational University HospitalSingaporeSingapore Department of Cardiology National University Heart CentreNational University HospitalSingaporeSingapore Division of General Surgery(Upper Gastrointestinal Surgery) Department of SurgeryNational University HospitalSingaporeSingapore Division of Gastroenterology and Hepatology Department of MedicineNational University HospitalSingaporeSingapore National University Centre for Organ Transplantation National University Health SystemSingaporeSingapore Cedars-Sinai Fatty Liver Program Division of Digestive and Liver DiseasesDepartment of MedicineComprehensive Transplant CenterCedars-Sinai Medical CentreLos AngelesCAUSA Division of Gastroenterology Hepatology and NutritionDepartment of Internal MedicineVirginia Commonwealth UniversityRichmondVAUSA

Background:Bariatric surgery represents an important treatment option for severely obese patients with nonalcoholic fatty liver disease(NAFLD).However,there remains inadequate data regarding the effects of different bariatric procedures on various NAFLD parameters,especially for histological ***,this meta-analysis aimed to compare the effects of restrictive bariatric procedures and foregut bypass on the metabolic,biochemical,and histological parameters for patients with ***:Medline and Embase were searched for articles relating to bariatric procedures and *** meta-analysis was conducted to compare efficacy of bariatric procedures ***-procedure with subgroup analysis to further compare restrictive against foregut bypass ***:Thirty-one articles involving 3,355 patients who underwent restrictive bariatric procedures(n=1,460)and foregut bypass(n=1,895)were *** foregut bypass(P<0.01)and restrictive procedures(P=0.03)significantly increased odds of fibrosis *** to restrictive procedures,foregut bypass resulted in a borderline non-significant decrease in fibrosis score(P=0.06)and significantly lower steatosis score(P<0.001).For metabolic parameters,foregut bypass significantly lowered body mass index(P=0.003)and low-density lipoprotein(P=0.008)compared to restrictive *** significant differences were observed between both procedures for aspartate aminotransferase(P=0.17)and alkaline phosphatase(P=0.61).However,foregut bypass resulted in significantly lower gamma-glutamyl transferase than restrictive procedures(P=0.01)while restrictive procedures resulted in significantly lower alanine transaminase than foregut bypass(P=0.02).Conclusions:The significant histological and metabolic advantages and comparable improvements in biochemical outcomes support the choice of foregut bypass over restrictive bariatric procedures in NAFLD management.

关键词： Bariatric surgery non-alcoholic fatty liver disease(NAFLD) obesity fibrosis endoscopy

干旱气候中的水质管理:十年干旱的经验与教训(英文)

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干旱气候中的水质管理:十年干旱的经验与教训(英文)

药学专业人员的参与是减少全科医生工作量的有效路径之一

北京论坛（2010）文明的和谐与共同繁荣——为了我们共同的家园：责任与行动

作者： darren S.Baldwin Sally Hladyz Susanne Watkins Kerry Whitworth Todd Wallace Murray Darling Freshwater Research Centre PO Box 991 Wodonga Vic 3689 Australia CSIRO Land and Water La Trobe University

"And it never failed that during the dry years the people forgot about the rich years,and during the wet years they lost all memory of the dry *** was always that way."John Steinbeck - East of Eden. ***: It is a given that water is essential for life and securing sufficient water supply is fundamental to a sustainable ***,while water quantity is paramount in our thinking about water resources,water quality is also *** of poor quality can be damaging to the

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英国医学杂志中文版 2021年第8期24卷 477-477页

作者： Steven Williams Lawrence Brad darren Jones Jamie Hayes 陈明敏(译) 任菁菁(校) Poole Bay and Bournemouth Primary Care Network Westboume Medical CentreBournemouth BH49HJUK Welsh Medicines Resource Centre Academic CentreUniversity Hospital LlandoughPenarthUK 浙江大学医学院附属第一医院全科医学科

相信许多全科医生与Salisbury一样,对目前全科医生的工作量感到痛苦1。不少全科医生发现,让药学专业团队(包括临床药师和药学技术人员)成为诊所、基层医疗机构或地方卫生部门的一员,不仅可以提升患者照护质量,还可以显著减少全科医生的... 详细信息

相信许多全科医生与Salisbury一样,对目前全科医生的工作量感到痛苦1。不少全科医生发现,让药学专业团队(包括临床药师和药学技术人员)成为诊所、基层医疗机构或地方卫生部门的一员,不仅可以提升患者照护质量,还可以显著减少全科医生的患者管理工作量(一位临床药剂师的参与可帮助每名全科医生每月节省80个小时)2,这也使得药学人员的参与成为“必需品,而非奢侈品”。虽然初始阶段的指导和监督很关键,但在跨学科照护的时代,我们应该发挥创造力,重新理解“共同价值”,并在医务人员的专业发展、评估或重新评价中认识到这一价值的存在。

关键词：全科医生基层医疗机构药学人员药学技术人员奢侈品药学专业临床药师管理工作量

Making cardiomyocytes with your chemistry set:Small molecule-induced cardiogenesis in somatic cells

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World Journal of Cardiology 2015年第3期7卷 125-133页

作者： Woong-Hee Kim Da-Woon Jung darren Reece Williams New Drug Targets Laboratory School of Life SciencesGwangju Institute of Science and Technology

Cell transplantation is an attractive potential therapy for heart diseases. For example, myocardial infarction(MI) is a leading cause of mortality in many countries. Numerous medical interventions have been developed to stabilize patients with MI and, although this has increased survival rates, there is currently no clinically approved method to reverse the loss of cardiac muscle cells(cardiomyocytes) that accompanies this disease. Cell transplantation has been proposed as a method to replace cardiomyocytes, but a safe and reliable source of cardiogenic cells is required. An ideal source would be the patients' own somatic tissue cells, which could be converted into cardiogenic cells and transplanted into the site of MI. However, these are difficult to produce in large quantities and standardized protocols to produce cardiac cells would be advantageous for the research community. To achieve these research goals, small molecules represent attractive tools to control cell behavior. In this editorial, we introduce the use of small molecules in stem cell research and summarize their application to the induction of cardiogenesis in noncardiac cells. Exciting new developments in this field are discussed, which we hope will encourage cardiac stem cell biologists to further consider employing small molecules in their culture protocols.

关键词： Cardiogenesis Cell reprogramming Somatic cells Small molecules Cardiovascular disease

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别挂我电话,并且爱上我(英文)

中学生百科（阅读写作） 2008年第23期 64-64页

作者： darren

如果你听过这首歌曲, 那么你看darren的这篇文章一定很亲切。Jason Cox was quarreling with his girlfriend on the phone when I was droppinga visit on his apartment last week.

关键词：电话歌曲文章

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钯金打造你的艳丽圣诞

大视野 2007年第12期 65-65页

作者： darren

节日存在的理由,或许只是给都市丽人们一个犒赏自己的理由,圣诞节也应如是!渐起的寒风挡不住女性骨子里对美好事物的追求,于是,款式大气、颇具质感、打磨精致的钯金07秋冬新款"艳"系列饰品撩拨着她们的心弦,触动着她们心底深处的渴望!

关键词：都市丽人几何图案感观首席设计师首饰设计师愉悦感绵延不绝冬风成功喜悦 Barbara

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填补领导力空白:培养有力追随者

项目管理评论 2019年第2期 12-15页

作者：达伦·达尔彻尉艳娟(译) 英国国家项目管理中心不详

领导力越来越被视为一种基本的生活技能,一种指导个人、团队、组织甚至国家走向更美好未来,以及提高地位或改善结果的实际能力。但是,根据罗柏特·凯利的研究,组织成功的原因只有20%与领导者有关,在实践中80%的功劳应该归于追随者。凯... 详细信息

领导力越来越被视为一种基本的生活技能,一种指导个人、团队、组织甚至国家走向更美好未来,以及提高地位或改善结果的实际能力。但是,根据罗柏特·凯利的研究,组织成功的原因只有20%与领导者有关,在实践中80%的功劳应该归于追随者。凯斯·格林特(KeithGrint)综合分析了多位成功的领导者,他的研究表明,令成功领导者脱颖而出的是支持并为他们'挡箭'的追随者。

关键词：领导力领导者追随力

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六月，用什么温暖我们的父亲

大视野 2008年第6期 41-41页

作者： darren

父亲,是我们心目中永远高大伟岸的人,用一双结实而温暖的手保护着我们走过了无数的人生阶段,度过了些许的艰难时刻。父亲的深沉,并不把对儿女的爱表现出来,并没有过多展示他内心的丰富感情,深藏在心里。但这不能说他不喜欢你送的礼物。... 详细信息

父亲,是我们心目中永远高大伟岸的人,用一双结实而温暖的手保护着我们走过了无数的人生阶段,度过了些许的艰难时刻。父亲的深沉,并不把对儿女的爱表现出来,并没有过多展示他内心的丰富感情,深藏在心里。但这不能说他不喜欢你送的礼物。虽然今日一般人对于父亲节的庆祝活动,不像对母亲节一般的重视与热闹。

关键词：父亲节人生阶段庆祝活动扶郎花

米老鼠回来了：迪斯尼将在日本推出手机移动业务

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消费电子 2007年第22期 16-16页

作者： darren Murph

有这样一种说法：下一件东西总是好过上一件。很显然，迪斯尼就像被附上了这么一道“魔咒”。据报道，就在迪斯尼大失颜面地在美国关闭其移动业务七周后，迪斯尼的日本分公司就宣布将在日本开展类似的业务。显然，公司已经与软银“达成... 详细信息

有这样一种说法：下一件东西总是好过上一件。很显然，迪斯尼就像被附上了这么一道“魔咒”。据报道，就在迪斯尼大失颜面地在美国关闭其移动业务七周后，迪斯尼的日本分公司就宣布将在日本开展类似的业务。显然，公司已经与软银“达成基本协议”，租用电信网络，并开始向日本全国范围内有兴趣的用户提供服务。此外，迪斯尼还将与软银合作“开发手机，并通过其他公司销售其手机产品”。

关键词：移动业务迪斯尼日本手机电信网络