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Indomethacin but not a selective cyclooxygenase-2 inhibitor inhibits esophageal adenocarcinogenesis in rats

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World Journal of Gastroenterology 2012年第35期18卷 4866-4874页

作者： Paula Esquivias Antonio Morandeira Alfredo Escartín Carmelo Cebrián Sonia santander Francisco Esteva María Asunción García-González Javier Ortego Angel Lanas Elena Piazuelo CIBEr Digestive and Hepatic Deseases Service of Surgery University Hospital "Lozano Blesa" Service of Pathology University Hospital "Lozano Blesa" Department of Medicine University of Zaragoza Service of Clinical Biochemistry University Hospital "Lozano Blesa" Aragon Health Science Institute Service of Gastroenterology University Hospital "Lozano Blesa"

AIM： To evaluate the effects of indomethacin [dual cyclooxygenase （COX）-I/COX-2 inhibitor] and 3-（3,4-difluorophenyl）-4-（4-（methylsulfonyl） phenyl）- 2-（5H）-furanone （MF-tricyclic）（COX-2 selective inhibi- tor） in a rat experimental model of Barrett＇s esophagus and esophageal ***： A total of 112 surviving post-surgery rats were randomly divided into three groups： the control group （n = 48）, which did not receive any treatment; the indomethacin group （n = 32）, which were given 2 mg/kg per day of the COX-I/COX-2 inhibitor; and the MF-tricyclic group （n = 32）, which received 10 mg/kg per day of the selective COX-2 inhibitor. randomly se- lected rats were killed either 8 wk or 16 wk after sur- gery. The timing of the deaths was in accordance with a previous study performed in our group. Only rats that were killed at the times designated by the protocol were included in the study. We then assessed the histology and prostaglandin E2 （PGE2） expression levels in the rat esophagi. An additional group of eight animals that did not undergo esophagojejunostomy were included in order to obtain normal esophageal tissue as a control. rESULTS： Compared to a control group with no treat- ment （vehicle-treated rats）, indomethacin treatment was associated with decreases in ulcerated esophageal mucosa （16% vs 35% and 14% vs 17%, 2 mo and 4 mo after surgery, respectively; P = 0.021）, length of intestinal metaplasia in continuity with anastomosis （2 4- 1.17 mm vs 2.29 ＋ 0.75 mm and 1.25 4- 0.42 mm vs 3.5 4- 1.54 mm, 2 mo and 4 mo after surgery, respec- tively; P = 0.007）, presence of intestinal metaplasia beyond anastomosis （20% vs 71.4% and 0% vs 60%, 2 mo and 4 mo after surgery, respectively; P = 0.009）, severity of dysplasia （0% vs 71.4% and 20% vs 85.7% high-grade dysplasia, 2 mo and 4 mo after surgery, re- spectively; P = 0.002）, and adenocarcinoma incidence （0% vs 57.1% and 0% vs 60%, 2 mo and 4 mo after surgery, respectively; P 〈 0.0001）. Treatment with the select

关键词： Intestinal metaplasia Esophageal adeno-carcinoma Indomethacin MF-tricyclic

Free vibration and transient response of double curved beams connected by intermediate straight beams

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 37-62页

作者： r.A.JAFArI-TALOOKOLAEI H.GHANDVAr E.JUMAEV S.KHATIr T.CUONG-LE School of Mechanical Engineering Babol Noshirvani University of Technology Department of Mechanical Engineering Faculty of Engineering New Uzbekistan University University of Business and Science Center for Engineering Application and Technology Solutions Ho Chi Minh City Open University

This paper investigates the free vibration and transient response of interconnected structures including double curved beams and intermediate straight beams,which are all constructed from functionally graded porous(FGP) materials. The strain potential and kinetic energies of each beam along with the work done by the external force are calculated. Additionally, a higher-order beam element is introduced to derive stiffness and mass matrices, along with the force vector. The curved and straight beams are discretized, and their assembled stiffness, mass matrices, and force vectors, are *** conditions at the joints are used to derive the total matrices of the entire structure. Subsequently, the natural frequencies and transient response of the system are determined. The accuracy of the mathematical model and the self-developed computer program is validated through the comparison of the obtained results with those of the existing literature and commercial software ANSYS, demonstrating excellent ***, a comprehensive study is conducted to investigate the effects of various parameters on the free vibration and transient response of the considered structure.

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Technosols Made of Wastes to Improve Physico-Chemical Characteristics of a Copper Mine Soil

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Pedosphere 2013年第1期23卷 1-9页

作者： V.ASENSIO F.A.vega M.L.ANDrADE E.F.COVELO Department de Bioloxía Vexetal e Ciencia do Solo Facultade de Bioloxia Universidade de VigoLagoas Marcosende 36310 Vigo Pontevedra (Spain)

Mine tailing soils created from the copper extraction in Touro Mine （Northwest Spain） are very degraded both physically and chemically. Three plots in this mine tailing were amended with Technosols in different proportions in each one to know if this mixture improved the physico-chemical characteristics of the mine soil and contaminated it with heavy metals. The Technosols were made of organic wastes, including mussel residues, wood fragments, sewage sludges and paper mill ashes. An unamended area was used as a control soil. Pseudototal and diethylenetriaminepentaacetic acid （DTPA）-extractable contents of A1, Cr, Cu, Fe, Mn, Ni, Pb and Zn were determined in soil samples. The untreated soil had significant limitations for vegetation growth. All the Technosols improved the properties of the mine soil by increasing organic carbon and pH value, but they added Ni, Pb or Zn to the soil. It is advisable to check whether the heavy metal concentrations of the wastes are hazardous or not before adding to soils. It is also necessary to study the effect of these wastes over time and in more areas to conclude if they are actually favourable to restore degraded mine soils.

关键词： heavy metals mine tailing vegetation growth waste amendment

Modeling gut neuro-epithelial connections in a novel microfluidic device

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Microsystems & Nanoengineering 2023年第6期9卷 235-246页

作者： Jose M.de Hoyos-vega Xi Yu Alan M.Gonzalez-Suarez Sisi Chen Arnaldo Mercado-Perez Eugene Krueger Jeric Hernandez Yaroslav Fedyshyn Brooke r.Druliner David r.Linden Arthur Beyder Alexander revzin Department of Physiology and Biomedical Engineering Mayo ClinicRochesterMNUSA Enteric Neuroscience Program(ENSP) Mayo ClinicRochesterMNUSA Division of Gastroenterology and Hepatology Department of MedicineMayo ClinicRochesterMNUSA

The intestinal lumen is filled with diverse chemical and physical *** epithelial cells sense these stimuli and signal to enteric neurons which coordinate a range of physiologic processes required for normal digestive tract ***,the neuro-epithelial connections remain poorly resolved,in part because the tools for orchestrating interactions between these cellular compartments are *** describe the development of a two-compartment microfluidic device for co-culturing enteric neurons with intestinal epithelial *** device contains epithelial and neuronal compartments connected by *** epithelial compartment was designed for cell seeding via injection and confinement of intestinal epithelial cells derived from human intestinal *** demonstrated that organoids planarized effectively and retained epithelial phenotype for over a *** the second chamber we dissociated and cultured intestinal myenteric neurons including intrinsic primary afferent neurons(IPANs)from transgenic mice that expressed the fluorescent protein *** extended projections into microgrooves,surrounded and frequently made contacts with epithelial *** density and directionality of neuronal projections were enhanced by the presence of epithelial cells in the adjacent *** microfluidic device represents a platform that may,in the future,be used to dissect structure and function of neuro-epithelial connections in the gut and other organs(skin,lung,bladder,and others)in health and disease.

关键词： fluid bladder organs

Lid scrubbing with a gel combining natural extracts for dry eye treatment

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International Journal of Ophthalmology(English edition) 2023年第7期16卷 1053-1059页

作者： Blanca Diaz-vega Carlos rodriguez-Fabuel Sofia Vitores-Mate Carlos Carpena-Torres Gran Visión Oftalmología Madrid 28026Spain e-Health Vision Department of OphthalmologyMadrid 28232Spain Gran Óptica Madrid Department of Dry EyeMadrid 28026Spain Ocupharm research Group Department of Optometry and VisionFaculty of Optics and OptometryComplutense University of MadridMadrid 28037Spain

AIM:To evaluate the effect of lid scrubbing using a gel combining different natural extracts on ocular signs and symptoms of dry eye ***:A retrospective study was performed on 19 dry eye patients(51.1±16.0y).Non-invasive tear break-up time,tear meniscus height,meibomian gland loss,lipid layer thickness,conjunctival redness,corneal staining,ocular surface disease index(OSDI),and ocular pain intensity were measured before(baseline),1wk,and 2mo after lid scrubbing with a gel containing different natural extracts(okra extract,aloe vera leaf juice,hydrolysed soy protein,caffeine,citrus unshiu peel extract,and raspberry seed oil).rESULTS:Compared with the baseline,there was a statistically significant improvement in both first(P=0.048)and average(P=0.026)non-invasive tear break-up time 2mo after treatment,as well as in corneal staining(P=0.043,0.012),OSDI(Pr pain intensity(Pr 1wk and *** addition,there was no correlation between ocular signs and ***:The lid scrubbing with a gel combining different natural extracts show beneficial effects on tear film stability,corneal damage,and ocular symptoms,which is the reason why this therapeutic procedure is proposed as an alternative for dry eye ***,it is not possible to attribute this beneficial effect solely to the presence of the natural extracts in the gel,primarily due to the absence of a negative control group.

关键词： lid hygiene natural extracts okra aloe vera soy dry eye

retention and Mobility of Copper and Lead in Soils as Influenced by Soil Horizon Properties

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Pedosphere 2011年第5期21卷 603-614页

作者： B.CErQUEIrA E.F.COVELO M.L.ANDrADE F.A.vega Department of Plant Biology and Soil Science University of Vigo

The mobility and bioavailability of heavy metals in soils is largely governed by sorption and desorption ***2+ and Pb2+ are among the most potentially toxic heavy metals and they are present,often concomitantly,in many polluting spills and in *** objective was to assess and compare the competitive sorption and desorption capacities and sorption hysteresis of Cu2+ and Pb2+,as well as their migration through the profiles of four natural soils:a Humic Umbrisol,an Umbric Cambisol,an Endoleptic Luvisol and a Humic *** all horizons Pb2+ was invariably sorbed and retained to a greater extent than Cu2+.The sorption and retention of Cu2+ were most in?uenced by pH,e?ective cation exchange capacity(CECe) and Mn oxide *** the other hand,the fixation capacity of Pb2+ was most in?uenced by pH,CECe,and Mn oxide and organic matter *** and CECe were the individual soil properties most markedly in?uencing Cu2+ and Pb2+ sorption and *** all the horizons Pb2+ exhibited greater hysteresis than Cu2+.In each soil the hysteresis in the A horizon was greater than that in the B horizon,except in the Bt horizon of the Endoleptic Luvisol,due to its high pH and vermiculite *** on migration indices,Pb2+ was less mobile than Cu2+ in the studied soils.

关键词： desorption heavy metal hysteresis migration sorption

Hadronic spectra from deformed AdS backgrounds

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Chinese Physics C 2020年第6期44卷 109-122页

作者： Eduardo Folco Capossoli Miguel Angel Martín Contreras Danning Li Alfredo vega Henrique Boschi-Filho Instituto de Física Universidade Federal do Rio de Janeiro21.941-972-Rio de Janeiro-RJ-Brazil Departamento de Física/Mestrado Profissional em Práticas da Educação Básica(MPPEB) Colégio Pedro II20.921-903-Rio de Janeiro-RJ-Brazil Instituto de Física y Astronomía Universidad de ValparaísoA.Gran Bretaña 1111ValparaísoChile Department of Physics and Siyuan Laboratory Jinan UniversityGuangzhou 510632China

Because of the presence of modified warp factors in metric tensors,we use deformed AdS5 spaces to apply the AdS/CFT correspondence to calculate the spectra for even and odd glueballs,scalar and vector mesons,and baryons with different *** the glueball cases,we derive their regge trajectories and compare them with those related to the pomeron and the *** the scalar and vector mesons,as well as baryons,the determined masses are compatible with the *** particular,for these hadrons we found regge trajectories compatible with another holographic approach as well as with the hadronic spectroscopy,which present an universal regge slope of approximately 1.1 GeV^2.

关键词： hadronic spectra AdS/QCD model regge trajectories

Molecular analysis of pancreatic cystic neoplasm in routine clinical practice

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World Journal of Gastrointestinal Endoscopy 2021年第2期13卷 56-71页

作者： raquel Herranz Pérez Felipe de la Morena López Pedro L Majano rodríguez Francisca Molina Jiménez Lorena vega Piris Cecilio santander Vaquero Department of Gastroenterology and Hepatology Hospital Universitario de La PrincesaInstituto de Investigación Sanitaria PrincesaCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y DigestivasMadrid 28006Spain Molecular Biology Laboratory Department of Gastroenterology and HepatologyHospital Universitario de La PrincesaInstituto de Investigación Sanitaria PrincesaCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y DigestivasMadrid 28006Spain Methodological Support Unit Department of Statistical AnalysisHospital Universitario de La PrincesaInstituto de Investigación Sanitaria PrincesaCP MadridMadrid 28006Spain Department of Gastroenterology and Hepatology Hospital Universitario de La PrincesaInstituto de Investigación Sanitaria PrincesaMadrid 28006Spain

BACKGrOUND Cystic pancreatic lesions consist of a wide variety of lesions that are becoming increasingly diagnosed with the growing use of imaging *** these,mucinous cysts are especially relevant due to their risk of ***,morphological findings are often suboptimal for their *** ultrasound fine-needle aspiration(EUS-FNA)with molecular analysis has been suggested to improve the diagnosis of pancreatic *** To determine the impact of molecular analysis on the detection of mucinous cysts and *** An 18-month prospective observational study of consecutive patients with pancreatic cystic lesions and an indication for EUS-FNA following European clinical practice guidelines was *** cysts included those>15 mm with unclear diagnosis,and a change in follow-up or with concerning features in which results might change clinical ***-FNA with cytological,biochemical and glucose and molecular analyses with next-generation sequencing were performed in 36 pancreatic *** cysts were classified as mucinous and non-mucinous by the combination of morphological,cytological and biochemical analyses when surgery was not *** was defined as cytology positive for malignancy,high-grade dysplasia or invasive carcinoma on surgical specimen,clinical or morphological progression,metastasis or death related to neoplastic complications during the 6-mo follow-up ***-generation sequencing results were compared for cyst type and *** Of the 36 lesions included,28(82.4%)were classified as mucinous and 6(17.6%)as ***,5(13.9%)lesions were classified as *** amount of deoxyribonucleic acid obtained was sufficient for molecular analysis in 25(69.4%)pancreatic *** amount of intracystic deoxyribonucleic acid was not statistically related to the cyst fluid volume obtained from the *** of KrAS and/or GNAS showed 83.33%[95%confidence

关键词： Pancreatic cysts Molecular analysis Next-generation sequencing Mucinous cyst Pancreatic cyst fluid Pancreatic cancer

Biodegradable stents in gastrointestinal endoscopy

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World Journal of Gastroenterology 2014年第9期20卷 2212-2217页

作者： Vicente Lorenzo-Zú?iga Vicente Moreno-de-vega Ingrid Marín Jaume Boix Endoscopy Unit Department of Gastroenterology Hospital Universitari Germans Trias i Pujol 08916 Badalona Spain Centro de Investigación Biomédica en red de Enfermedades Hepáticas y Digestivas (CIBErEHD) 08916 Badalona Spain

Biodegradable stents(BDSs)are an attractive option to avoid ongoing dilation or surgery in patients with benign stenoses of the small and large *** experience with the currently the only BDS for endoscopic placement,made of Poly-dioxanone,have shown promising *** some aspects should be improved as are the fact that BDSs lose their radial force over time due to the degradable material,and that can cause stent-induced mucosal or parenchymal *** complication rate and modest clinical efficacy has to be carefully considered in individual patients prior to placement of ***,the price of these stents therefore it is nowadays an important limitation.

关键词： Biodegradable stents Strictures Endoscopy Endoscopic placement Stenoses