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Pharmacology & Pharmacy 2011年第4期2卷 282-288页

作者： Tan Nhut Doan dao thanh tran 不详

A new series of chalcones (4a-c) and allylicchalcones (11a-b) have been prepared by the Claisen-Schmidt condensation. A novel series of pyrazolicchalcones (5a-c) have been synthesized by the reaction of respective chalcones (4a-c) and hydrazine hydrate. The structures of the compounds were confirmed by spectral data (infrared spectroscopy and 1H nuclear magnetic resonance). All of the compounds (4/5a-c and 11a-b) have been tested for their antimicrobial activities (agar disc-diffusion method) and antioxidant activities (1,1-biphenyl-2-picrylhydrazyl free radical scavenging method). The test compounds failed to show antibacterial properties (4a-c, 5b, and 11a-b) or exhibited such properties poorly (5a and 5c). None of the test compounds displayed antifungal properties. Of the compounds tested, compounds 5a-c and 11a-b exhibited promising antioxidant activities.

关键词： AllylicChalcones Antioxidant Activity Antimicrobial Activity PyrazolicChalcones

Assessment of Livelihood Vulnerability to Drought: A Case Study in Dak Nong Province, Vietnam

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International Journal of Disaster Risk Science 2019年第4期10卷 604-615页

作者： Nguyen Thi thanh Thao dao Nguyen Khoi tran thanh Xuan Bernard Tychon Universite de Liege 6700 ArlonBelgium Institute for Environmental Science Engineeringand ManagementIndustrial University of Ho Chi Minh CityHo Chi Minh CityVietnam Institute of Research and Development Duy Tan UniversityDa NangVietnam Faculty of Environment University of ScienceVietnam National University Ho Chi Minh CityHo Chi Minh CityVietnam NTT Institute of Hi-Technology Nguyen Tat Thanh UniversityHo Chi Minh CityVietnam

In recent years,droughts have strongly affected the Central Highlands of Vietnam and have resulted in crop damage,yield decline,and serious water *** study investigated the livelihood vulnerability of five communities of farmers who are exposed to droughts in one of the more vulnerable regions of Vietnam—Dak Nong Province.A survey of 250 households was conducted in the five communities to collect data on the region’s sociodemographic profile,livelihood systems,social networks,health status,food and water security,drought conditions,and climate *** were aggregated using a livelihood vulnerability index and the IPCC vulnerability *** survey results indicate that Quang Phu community is the most vulnerable of the study’s communities,followed by Nam N’dir,Dak Nang,Duc Xuyen,and Dak D’ro in descending order of *** availability and livelihood strategies are the most important variables in determining the vulnerability of the five surveyed *** order to reduce vulnerability to droughts,water management practices and livelihood diversification in farming and nonfarming activities are recommended for the study area.

关键词： Agricultural drought Livelihood vulnerability Vietnam Vulnerability indicators

Microcystin accumulation and biochemical responses in the edible clam Corbicula leana P. exposed to cyanobacterial crude extract

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Journal of Environmental Sciences 2016年第6期28卷 120-130页

作者： thanh-Luu Pham Kazuya Shimizu Ayako Kanazawa Yu Gao thanh-Son dao Motoo Utsumi Graduate School of Life and Environmental Sciences University of Tsukuba 1-1-1 Tennodai Tsukuba Ibaraki 305-8572 Japan Faculty of Life Sciences Toyo University Ora-gun Gunma 374-0193 Japan College of Chemical and Environmental Engineering Shandong University of Science and Technology qingdao 266590 China Ho Chi Minh City University of Technology 268 Ly Thuon9 Kiet St. Dist. 10 Ho Chi Mirth City Viet Nam Vietnam Academy of Science and Technology （VAST) Institute of Tropical Biology 85 Tran Quoc Toan St. Dist. 3 Ho Chi Minh City Viet Nam

We investigated the accumulation and effects of cyanobacterial crude extract（CCE）containing microcystins（MCs） on the edible clam Corbicula leana P. Toxic effects were evaluated through the activity of antioxidant and detoxification enzymes： catalase（CAT）,superoxide dismutase（SOD）, and glutathione-S-transferases（GSTs） from gills, foot, mantle and remaining soft tissues. Clams were exposed to CCE containing 400 μg MC-LReq/L for10 days and were then kept in toxin-free water for 5 days. Clam accumulated MCs（up to 3.41 ± 0.63 μg/g dry weight（DW） of unbound MC and 0.31 ± 0.013 μg/g DW of covalently bound MC）. Detoxification and antioxidant enzymes in different organs responded differently to CCE during the experiment. The activity of SOD, CAT, and GST in the gills and mantle increased in MC-treated clams. In contrast, CAT and GST activity was significantly inhibited in the foot and mostly only slightly changed in the remaining tissues. The responses of biotransformation, antioxidant enzyme activity to CCE and the fast elimination of MCs during depuration help to explain how the clam can survive for long periods（over a week） during the decay of toxic cyanobacterial blooms in nature.

关键词： Bioaccumulation Cyanotoxins Covalently bound microcystins Aqueous extracts

Occurrence of microcystins in water,sediment,and aquatic animals in Dau Tieng Reservoir,Vietnam

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Journal of Oceanology and Limnology 2024年第6期42卷 1751-1763页

作者： thanh Luu PHAM Manh Ha BUI Tan Duc NGUYEN thanh Son dao Faculty of Environment and Labour Safety Ton Duc Thang UniversityHo Chi Minh City 700000Vietnam Faculty of Environment Saigon UniversityHo Chi Minh City 700000Vietnam Guangdong Provincial Key Laboratory of Marine Disaster Prediction and Prevention and Guangdong Provincial Key Laboratory of Marine BiotechnologyShantou UniversityShantou 515063China Faculty of Environment and Natural Resources Ho Chi Minh City University of Technology(HCMUT)Ho Chi Minh City 700000Vietnam Asian Center for Water Research(Centre Asiatique de Recherchesur l’Eau CARE)Ho Chi Minh City University of Technology(HCMUT)Vietnam National UniversityHo Chi Minh City 700000Vietnam

This study investigates the variations of microcystins(MCs)in water,cyanobacterial blooms,sediment,and aquatic organisms collected from the Dau Tieng Reservoir(DTR).*** liquid chromatography(HPLC)was employed to measure MC concentrations in various target *** indicate that Microcystis *** as the primary MC producer in the *** average concentrations of analyzed MCs in surface water ranged from 1.10 to 5.54μg/L,temporally and *** sediment,average concentrations varied from 0.15 to 1.13μg/g wet weight(WW)temporally and from 0.41 to 0.72μg/g WW *** were detected in different organs of fish species(Oreochromis *** Labiobarbus sp.)and in the entire soft tissues of bivalve(Corbicula sp.)and gastropod(Assiminea sp.).The highest observed MC concentration in July was 0.83±0.22μg/g WW in the intestines of fish Oreochromis *** presence of MCs in grass shrimp Palaemonetes *** observed solely in June,reaching a concentration of 0.28±0.19μg/g *** is the first report of MC accumulation in the grass shrimp Palaemonetes *** field *** the bivalve Corbicula sp.,the presence of analyzed MCs was consistent throughout the study period,except for March and September,with the highest concentrations in July at 0.77±0.1μg/g *** correlation analysis revealed significant positive correlations between MCs in water and sediment with MC concentrations in aquatic animals,indicating the potential transfer of MCs across different trophic *** estimated daily intake values for analyzed MCs indicate that fish collected from the DTR are considered safe for consumption,as long as only the edible organs,such as the muscle,are ***,bivalves or gastropods collected from the DTR are not safe for human *** study underscored the importance of monitoring MC accumulation in aquatic animals used as food to mitigate adverse effects on human health.

关键词： aquatic animal bioaccumulation cyanotoxin health risk toxic cyanobacteria

Blockchain for Education:Verification and Management of Lifelong Learning Data

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Computer Systems Science & Engineering 2022年第11期43卷 591-604页

作者： Ba-Lam Do Van-thanh Nguyen Hoang-Nam Dinh thanh-Chung dao BinhMinh Nguyen School of Information and Communication Technology Hanoi University of Science and TechnologyHanoiVietnam

In recent years,blockchain technology has been applied in the educational domain because of its salient advantages,i.e.,transparency,decentralization,and *** systems typically use public blockchain networks such as Ethereum and Bitcoin to store learning ***,the cost of writing data on these networks is significant,making educational institutions limit data sent to the target network,typically containing only hash codes of the issued *** this paper,we present a system based on a private blockchain network for lifelong learning data authentication and management named B4E(Blockchain For Education).B4E stores not only certificates but also learners’training data such as transcripts and educational programs in order to create a complete record of the lifelong education of each user and verify certificates that they have *** a result,B4E can address two types of fake certificates,i.e.,certificates printed by unlawful organizations and certificates issued by educational institutions for learners who have not met the training *** addition,B4E is designed to allow all participants to easily deploy software packages to manage,share,and check stored information without depending on a single point of *** such,the system enhances the transparency and reliability of the stored *** experiments show that B4E meets expectations for deployment in reality.

关键词： Training data certificate verification and management private blockchain

The Effect of Hydraulic Retention Times and Loading Rates on the Removal of Pollutants from Fish Processing Wastewater by Anaerobic Process

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Journal of Food Science and Engineering 2018年第6期8卷 237-240页

作者： dao Khanh Chau tran thanh Dai Faculty of Health and Applied Sciences Dong Nai Technology UniversityNguyen Khuyen StreetTrang Dai ward 810000Bien Hoa cityDong Nai provinceVietnam

Anaerobic treatment model treats fish processing wastewater to be necessary for a small and medium factory that is very popular in Vietnam and other *** techniques have been ***,they are quite expensive and hard to operate,especially in remote *** this study,the hydraulic retention times(HRT)including 3,5,and 7 hours with a various organic loading rate of 1.5 to 6.5 kg COD/m3/day were *** concentration as mix-liquor volatile suspended solid(MLVSS)in the model is at 6,000 to 9,000 mg/*** the basis of the result the optimal HRT with a 4.0 kg COD/m3/day organic loading rate was 8 hours which BOD5,COD removal efficiency were 92.18,87.36 percent *** the end of the optimal hydraulic retention times,the total methane gas volume as a by-product was collected with 2.6 liters.

关键词： Wastewater treatment anaerobic process hydraulic retention time organic loading rate

Spatiotemporal Trend Analysis of Precipitation Extremes in Ho Chi Minh City, Vietnam During 1980–2017

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International Journal of Disaster Risk Science 2021年第1期12卷 131-146页

作者： Nguyen Trong Quan dao Nguyen Khoi Nguyen Xuan Hoan Nguyen Ky Phung thanh Duc Dang Faculty of Environmental and Food Engineering Nguyen Tat Thanh UniversityHo Chi Minh City 700000Vietnam Faculty of Environment University of ScienceHo Chi Minh City 700000Vietnam Vietnam National University Ho Chi Minh City 700000Vietnam Ho Chi Minh City University of Food Industry Ho Chi Minh City 700000Vietnam Institute for Computational Science and Technology Ho Chi Minh City 700000Vietnam Engineering Systems and Design Pillar Singapore University of Technology and DesignTampines 487372Singapore

In this study,the spatiotemporal variability of trends in extreme precipitation events in Ho Chi Minh City during the period 1980–2017 was analyzed based on several core extreme precipitation indices(Rx1 day,Rx5 day,CDD,CWD,R20 mm,R25 mm,R95 p,and SDII).The nonparametric Mann–Kendall and Sen’s slope methods were used to compute the statistical strength,stability,and magnitude of trends in annual rainfall,as well as the extreme precipitation *** found that 64%of the stations had statistically significant upward trends in yearly rainfall,with high magnitudes frequently observed in the northern and southern regions of the *** the extreme precipitation indices,only SDII and R25 mm showed dominantly significant ***,there were increasing trends in the frequency and duration at the southern and central regions of the city during the study ***,El Ni?o-Southern Oscillation and Pacific Decadal Oscillation positively correlated with the duration and negatively correlated with the intensity and frequency of extreme ***,water management plans should be adjusted appropriately to reduce the severe impacts of precipitation extremes on communities and ecosystems.

关键词： Spatiotemporal trend Extreme precipitation Extreme precipitation indices Ho Chi Minh City

Anti-inflammatory effects of alkaloid enriched extract from roots of Eurycoma longifolia Jack

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Asian Pacific Journal of Tropical Biomedicine 2019年第1期9卷 18-23页

作者： dao Thi thanh Hien tran Phi Long tran Phuong Thao Jeong-Hyung Lee Duong Thu trang Nguyen Thi Thu Minh Pham Van Cuong Do Thi Ngoc Lan Nguyen Hai Dang Nguyen Tien Dat Deparment of Traditional Pharmacy Hanoi University of Pharmacy Department of Biochemistry College of Natural Sciences Kangwon National University Advanced Center for Bio-organic Chemistry Institute of Marine Biochemistry Vietnam Academy of Science and Technology National Institute of Drug Quality Control Center for Research and Technology transfers

Objective: To examine the in vitro and in vivo anti-inflammatory effects of the alkaloid enriched extract(ELA) from the roots of Eurycoma longifolia. Methods: The in vitro antiinflammatory effects of ELA were evaluated by examining its inhibitory activities against nitric oxide(NO) production and inducible nitric oxide synthase(iN OS) and cyclooxygenase2(COX-2) expressions in lipopolysaccharide(LPS)-stimulated RAW264.7 cells. The level of NO produced in the culture media was determined by Griess method. The i NOS and COX-2 protein expressions were analyzed by Western blot. The in vivo effect of ELA was evaluated on LPS-induced septic shock in mice model. Mice mortality was monitored for5 days after injection of LPS. The chemical contents of the ELA were determined by using various chromatographic and spectroscopic techniques. Results: The ELA was found to exhibit a significant anti-inflammatory effect in both in vitro and in vivo models. The results demonstrated that ELA dose-dependently inhibited LPS-induced NO production as well as the protein iN OS and COX-2 expressions. In the septic shock model, ELA dose-dependently protected mice from LPS-induced mortality. Further study on the isolated components of ELA indicated that 9,10-dimethoxycanthin-6-one may contribute significantly to the antiinflammatory effects of the extract. Conclusions: These results suggest that ELA exhibits the anti-inflammatory activity via suppression of pro-inflammatory mediators such as NO, iN OS,and COX-2 and protects mice from LPS-induced mortality in septic shock model.

关键词： Eurycoma longifolia Anti-inflammation Alkaloid 9,10-dimethoxycanthin-6-one

Factors Affecting the Profitability of Cement ManufacturingEnterprises in Tuyen Quang Province

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Macro Management & Public Policies 2022年第2期4卷 20-28页

作者： Hoang Anh dao Pham thanh Tra tran Thao Nguyen Tantrao University Yenson DistrictTuyenquang ProvinceVietnam

This study focuses on analyzing the factors affecting the production and business efficiency of cement manufacturing enterprises in Tuyen Quang province. Production and business efficiency is measured by profitability ratios including return on assets (ROA), return on equity (ROE) and return on sales (ROS). Using a quantitative research method through estimating a linear regression model based on data of two cement manufacturing companies in the period 2019-2021, the research results show that the factors affecting business efficiency of cement manufacturing enterprises in Tuyen Quang province include size of enterprise, cost ratio, average collection period, inventory turnover, fixed assets turnover and debt ratio.

关键词： Business efficiency Profitability Cement manufacturing enterprises Tuyen Quang

In vivo anticancer activity of maesopsin 4—O— β—glucoside isolated from leaves of Artocarpus tonkinensis *** Gagnep

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Asian Pacific Journal of Tropical Medicine 2016年第4期9卷 343-348页

作者： Trinh Thi Thuy dao Duc Thien tran Quang Hung Nguyen thanh Tam Nguyen Thi Hoang Anh Nguyen Thi Nga Nguyen Thi Cuc Le Phuong Mai tran Van Sung Domenico V.Delfino Do Thi Thao Institute of Chemistry.Vietnam Academy of Science and Technology Institute of Biotechnology Vietnam Academy of Science and Technology National Research Council Canada Measurement Science and Standards1200 Montreal RoadBuilding M-12.Ottatca.Ontario KIA OR6 Department of Medicine University of PerugiaPiazzale Gambuli.S.Andrea delle Fratte

Objective:To investigate the antitumor effect of maesopsin 4-O-β-glucoside(TAT2) isolated from the leaves of Artocarpus tonkinensis(***) *** ***:The antitumor activity of TAT2 was evaluated in Lewis lung carcinoma(LLC) tumor-bearing ***/c mice had tumors induced by implantation with 2× 10~6 LLC cells into the subcutaneous right posterior ***-bearing mice were treated orally with a range of doses of TAT2 and a standard drug,*** were observed for tumor growth and mortality *** was collected to determine hematological and biochemical *** TAT2 was isolated from an ethanolic extract of *** *** structure was determined by MS and NMR spectroscopy,and identified as *** compound did not show acute toxicity at the highest dose tested(2 OIK) mg/kg body weight).TAT2 exhibited antitumor activity by decreasing tumor growth,increasing the survival rale,and ameliorating some hematological and biochemical parameters at doses of 100 and 200 mg/kg body weight(P<0.05).Conclusions:These results indicate that TAT2 possesses clear antitumor *** to its bioavailability and low toxicity,and the fact that it could be isolated in a large scale from *** leaves,the compound shows promise as a potential anticancer drug.

关键词： Artocarpus tonkinensis BALB/c Hematological parameters Lewis lung carcinoma Maesopsin 4-0-β-glucoside