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Separate Least Mean Square Based Equalizer with Joint Optimization for Multi-CAP Visible Light Communication

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China Communications 2022年第1期19卷 264-273页

作者： Jianli Jin Jianping Wang Huimin Lu danyang chen School of Computer and Communication Engineering University of Science and Technology BeijingBeijing 100083China

Visible light communication(VLC) is expected to be a potential candidate of the key technologies in the sixth generation(6G) wireless communication system to support Internet of Things(IoT) applications. In this work, a separate least mean square(S-LMS) equalizer is proposed to compensate lowpass frequency response in VLC system. Joint optimization is employed to realize the proposed S-LMS equalizer with pre-part and post-part by introducing Lagrangian. For verification, the performance of VLC system based on multi-band carrier-less amplitude and phase(m-CAP) modulation with S-LMS equalizer is investigated and compared with that without equalizer,with LMS equalizer and with recursive least squares(RLS)-Volterra equalizer. Results indicate the proposed equalizer shows significant improved bit error ratio(BER) performance under the same conditions. Compared to the RLS-Volterra equalizer, SLMS equalizer achieves better performance under low data rate or high signal noise ratio(SNR) conditions with obviously lower computational complexity.

关键词： visible light communication Internet of Things equalization least mean square

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Up-regulation of HCN2 channels in a thalamocortical circuit mediates allodynia in mice

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National Science Review 2023年第2期10卷 107-122页

作者： Jun-Ma Yu Rui Hu Yu Mao Yingju Tai Sen Qun Zhi Zhang danyang chen Yan Jin Department of Anesthesiology The Third Affiliated Hospital of Anhui Medical University (The First People's Hospital of Hefei) Department of Anesthesiology The First Affiliated Hospital of Anhui Medical University Department of Biophysics and Neurobiology Division of Life Sciences and Medicine University of Science and Technology of China Stroke Center and Department of Neurology The First Affiliated Hospital of USTC Division of Life Sciences and Medicine University of Science and Technology of China

Chronic pain is a significant problem that afflicts individuals and society,and for which the current clinical treatment is inadequate.In addition,the neural circuit and molecular mechanisms subserving chronic pain remain largely uncharacterized.Herein we identified enhanced activity of a glutamatergic neuronal circuit that encompasses projections from the ventral posterolateral nucleus(VPLGlu) to the glutamatergic neurons of the hindlimb primary somatosensory cortex(S1HLGlu),driving allodynia in mouse models of chronic pain.Optogenetic inhibition of this VPLGlu→S1HLGlucircuit reversed allodynia,whereas the enhancement of its activity provoked hyperalgesia in control mice.In addition,we found that the expression and function of the HCN2(hyperpolarization-activated cyclic nucleotide-gated channel 2) were increased in VPLGluneurons under conditions of chronic pain.Using in vivo calcium imaging,we demonstrated that downregulation of HCN2 channels in the VPLGluneurons abrogated the rise in S1HLGluneuronal activity while alleviating allodynia in mice with chronic pain.With these data,we propose that dysfunction in HCN2 channels in the VPLGlu→S1HLGluthalamocortical circuit and their upregulation occupy essential roles in the development of chronic pain.

关键词： chronic pain HCN2 channels neural circuit in vivo recordings

A nanoconcrete welding strategy for constructing high-performance wound dressing

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Bioactive Materials 2022年第8期7卷 31-41页

作者： Yingshuai Wang Yanxia Zhu Penghe Zhao Bin Wei Mingjian Fan danyang chen Zhaokui Jin Qianjun He School of Life Science and Technology Weifang Medical UniversityWeifangShandongChina Central Laboratory Longgang District People’s Hospital of Shenzhen&the Third Affiliated Hospital(Provisional)of the Chinese University of Hong KongShenzhenGuangdongChina School of Biomedical Engineering Health Science CenterShenzhen UniversityNo.1066 Xueyuan RoadShenzhen518060GuangdongChina Department of Quantum and Energy Materials International Iberian Nanotechnology Laboratory(INL)Braga4715-330Portugal Center of Hydrogen Science Shanghai Jiao Tong UniversityShanghai200240China

Engineering biomaterials to meet specific biomedical applications raises high requirements of mechanical performances,and simultaneous strengthening and toughening of polymer are frequently necessary but very challenging in many cases.In this work,we propose a new concept of nanoconcrete welding polymer chains,where mesoporous CaCO3(mCaCO_(3))nanoconcretes which are composed of amorphous and nanocrystalline phases are developed to powerfully weld polymer chains through siphoning-induced occlusion,hydration-driven crystallization and dehydration-driven compression of nanoconcretes.The mCaCO_(3) nanoconcrete welding technology is verified to be able to remarkably augment strength,toughness and anti-fatigue performances of a model polymer poly(3-hydroxybutyrate-co-3-hydroxyvalerate)-based porous membrane.Mechanistically,we have revealed polymer-occluded nanocrystal structure and welding-derived microstress which is much stronger than interfacial Van der Waals force,thus efficiently preventing the generation of microcracks and repairing initial microcracks by microcracks-induced hydration,crystallization and polymer welding of mCaCO_(3) nanoconcretes.Constructed porous membrane is used as wound dressing,exhibiting a special nanoplates-constructed surface topography as well as a porous structure with plentiful oriented,aligned and opened pore channels,improved hydrophilicity,water vapor permeability,anti-bacterial and cell adherence,in support of wound healing and skin structural/functional repairing.The proposed nanoconcrete-welding-polymer strategy breaks a new pathway for improving the mechanical performances of polymers.

关键词： Tissue engineering Mechanical performances Calcium carbonate Mesoporous materials Organic/inorganic nanocomposite Wound dressing

L-Selenocystine induce HepG2 cells apoptosis through ROS-mediated signaling pathways

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BIOCELL 2022年第10期46卷 2267-2273页

作者： HAIYANG chen JINGYAO SU danyang chen YUYE DU RUILIN ZHENG QINGLIN DENG QIANQIAN DU BING ZHU YINGHUA LI Center Laboratory Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhouChina Nanfang Hospital Southern Medical UniversityGuangzhouChina Department of Laboratory Medicine The First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouChina

At present,Hepatocarcinoma is one of the main causes of tumor related death all over the world.However,there are still many clinical restrictions on the treatment of liver cancer.Recently,L-Selenocystine has been shown to be a novel treatment for tumors,especially human glioma cells.But,the mechanism of L-Selenocystine against hepatocellular carcinoma remains unclear.Therefore,the main objective of this study was to investigate the effects of L-Selenocystine on HepG2 cell proliferation and activation of reactive oxygen species(ROS)mediated signaling pathway.L-Selenocystine can significantly inhibit HepG2 cell proliferation by activating caspase-3 and cleaving PARP to induce apoptosis.Moreover,the excessive production of ROS and the influence of Bax signaling pathway which can promote cell apoptosis are key factors for L-Selenocystine to induce HepG2 cell apoptosis.Therefore,the date of this study suggest that ROS mediated signal transduction mechanism may provide certain reference significance for L-Selenocystine induced HepG2 cell apoptosis.

关键词： Selenium Apoptosis L-Selenocystine Anticancer activity ROS

Light-triggered nitric oxide release and structure transformation of peptide for enhanced intratumoral retention and sensitized photodynamic therapy

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Bioactive Materials 2022年第6期7卷 303-313页

作者： Lingdong Jiang danyang chen Zhaokui Jin Chao Xia Qingqing Xu Mingjian Fan Yunlu Dai Jia Liu Yuanpei Li Qianjun He Marshall Laboratory of Biomedical Engineering School of Biomedical EngineeringHealth Science CenterShenzhen UniversityNo.1066 Xueyuan AvenueShenzhen518060GuangdongChina Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Optoelectronic EngineeringShenzhen UniversityShenzhen518060GuangdongChina Central Laboratory Longgang District People’s Hospital of Shenzhen&The Third Affiliated Hospital(Provisional)of The Chinese University of Hong KongShenzhen518172GuangdongChina Department of Biochemistry and Molecular Medicine UC Davis Comprehensive Cancer CenterUniversity of California DavisSacramentoCA95817USA Cancer Centre and Institute of Translational Medicine Faculty of Health SciencesUniversity of MacaoMacao SAR999078China

Tumor-targeted delivery of nanomedicine is of great importance to improve therapeutic efficacy of cancer and minimize systemic side effects.Unfortunately,nowadays the targeting efficiency of nanomedicine toward tumor is still quite limited and far from clinical requirements.In this work,we develop an innovative peptide-based nanoparticle to realize light-triggered nitric oxide(NO)release and structural transformation for enhanced intratumoral retention and simultaneously sensitizing photodynamic therapy(PDT).The designed nanoparticle is self-assembled from a chimeric peptide monomer,TPP-RRRKLVFFK-Ce6,which contains a photosensitive moiety(chlorin e6,Ce6),aβ-sheet-forming peptide domain(Lys-Leu-Val-Phe-Phe,KLVFF),an oligoarginine domain(RRR)as NO donor and a triphenylphosphonium(TPP)moiety for targeting mitochondria.When irradiated by light,the constructed nanoparticles undergo rapid structural transformation from nanosphere to nanorod,enabling to achieve a significantly higher intratumoral accumulation by 3.26 times compared to that without light irradiation.More importantly,the conversion of generated NO and reactive oxygen species(ROS)in a light-responsive way to peroxynitrite anions(ONOO􀀀)with higher cytotoxicity enables NO to sensitize PDT in cancer treatment.Both in vitro and in vivo studies demonstrate that NO sensitized PDT based on the well-designed transformable nanoparticles enables to eradicate tumors efficiently.The light-triggered transformable nanoplatform developed in this work provides a new strategy for enhanced intratumoral retention and improved therapeutic outcome.

关键词： Nitric oxide Photodynamic therapy Structural transformation Peptide Enhanced intratumoral retention Nanomedicine

Inhibitory of EV-A71 virus-induced apoptosis by ZVAD through ROS mediated signaling pathways

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BIOCELL 2022年第4期46卷 1033-1039页

作者： TIANTIAN XU RUILIN ZHENG danyang chen HAIYANG chen MINGQI ZHAO MIN GUO YI chen CHANGBING WANG LU KUANG YINGHUA LI BING ZHU Center Laboratory Guangzhou Women and Children’s Medical CenterMedical UniversityGuangzhou510120China Nanfang Hospital Southern Medical UniversityGuangzhou510515China

Emerging evidence that Enterovirus A 71(EV-A71)infection closely related to apoptosis.The ZVAD is a caspase inhibitor that can prevent apoptosis.The aims of this project were to evaluate the mechanism of the ZVAD inhibited EV-A71 virus and to provide experiment basis for finding new antiviral drugs.In this study,after treated with ZVAD in EV-A71 infected Vero cells,the viral replication was reduced,and the cell viability was higher than EV-A71 group.Additionally,ZVAD decreased the cell apoptosis and the level of inflammatory cytokines induced by EV-A71 in the infected Vero cells.ZVAD inhibited cell apoptosis by regulating ROS mediated signaling pathway and inflammation cytokines to achieve antiviral.

关键词： ZVAD EV-A71 virus ROS Apoptosis

Quercetin induced HepG2 cells apoptosis through ATM/JNK/STAT3 signaling pathways

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BIOCELL 2023年第1期47卷 187-194页

作者： WANTONG LIU danyang chen JINGYAO SU RUILIN ZHENG RAN KONG BING ZHU HAO DONG YINGHUA LI Center Laboratory Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhou510120China College of Light Industry and Food Sciences Innovation Research Institute of Modern Agricultural EngineeringZhongkai University of Agriculture and EngineeringGuangzhou510225China

Liver cancer is the seventh most common malignant tumor in the world and is the second highest cause of death due to cancer.Quercetin,a flavonoid with low toxicity,widely exists in various fruits and vegetables.It has the potential to be a therapeutic agent against various cancers.This study aimed to demonstrate the anti-tumor effect of quercetin on HepG2 cells.Quercetin suppressed the HepG2 cell proliferation in a dose-dependent manner in cell viability assay.Induction of cell apoptosis was confirmed by apoptotic cells population(sub-G1 peak)detected by flow cytometer.A decrease in mitochondrial membrane potential and caspase-3 activation were also demonstrated in this study.Furthermore,quercetin induced HepG2 cell apoptosis through ROS-mediated phosphorylated ataxia-telangiectasia mutated,c-Jun Nterminal kinases,signal transducer,and activator of transcription 3(STAT-3),and Bax signaling pathways.These results suggest that quercetin has the potential to become an effective drug against the tumor.

关键词： Quercetin Caspase-3 Reactive oxygen species Apoptosis

OsMAPK6 Affects Male Fertility by Reducing Microspore Number and Delaying Tapetum Degradation in Oryza sativa L.

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Phyton-International Journal of Experimental Botany 2022年第4期91卷 727-744页

作者： Wuzhong Yin Hongxia Yang Yantong Wang Ping Feng Yao Deng Yang Liu danyang chen Yijie Ban Weichi Liu Guanghua He Nan Wang Key Laboratory of Application and Safety Control of Genetically Modified Crops College of Agronomy and BiotechnologySouthwest UniversityChongqing100715China

The mitogen-activated protein kinase(MAPK)cascade is important in stress signal transduction and plant development.In the present study,we identified a rice(Oryza sativa L.)mutant with reduced fertility,Oryza sativa mitogen-activated protein kinase 6(osmapk6),which harbored a mutated MAPK gene.Scanning and transmission electron microscopy,quantitative RT-PCR analysis,TUNEL assays,RNA in situ hybridization,longitudinal and transverse histological sectioning,and map-based cloning were performed to characterize the osmapk6 mutant.The gene OsMAPK6 was expressed throughout the plant but predominantly in the microspore mother cells,tapetal cells,and microspores in the anther sac.Compared with the wild type,the total number of microspores was reduced in the osmapk6 mutant.The formation of microspore mother cells was reduced in the osmapk6 anther sac at an early stage of anther development,which was the primary reason for the decrease in the total number of microspores.Programmed cell death of some tapetal cells was delayed in osmapk6 anthers and affected exine formation in neighboring microspores.These results suggest that OsMAPK6 plays pivotal roles in microspore mother cell formation and tapetal cell degradation.

关键词： Mitogen-activated protein kinase tapetal programmed cell death microspore mother cell formation male sterility rice

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嘉陵江沿线古城“山-水-城”景观特征研究

中国园林 2024年第6期40卷 6-14页

作者：杜春兰陈丹阳重庆大学建筑城规学院重庆400045 重庆大学山地城镇建设与新技术教育部重点实验室重庆400045

嘉陵江是长江水系中第二大支流,空间上连接南北丝绸之路,是巴蜀地区重要的文化廊道。在典型山地曲流环境中,其沿线古城蕴含了丰富的山水营建智慧。从自然环境、文化环境、行政建制三方面梳理了嘉陵江沿线古城的形成基础,并以上、中、下... 详细信息

嘉陵江是长江水系中第二大支流,空间上连接南北丝绸之路,是巴蜀地区重要的文化廊道。在典型山地曲流环境中,其沿线古城蕴含了丰富的山水营建智慧。从自然环境、文化环境、行政建制三方面梳理了嘉陵江沿线古城的形成基础,并以上、中、下游8个古城为例,通过历史文献系统梳理及结合GIS平台的历史地图空间转译,提炼其“山-水-城”景观特征。具体为“宏观格局把控”方面“巴蜀要冲,控扼形胜”的城市选址、“襟江带河,群山四望”的山水格局、“江山聚结,生气聚集”的风水脉络;“中微观空间结构塑造”方面“迎山接水,不拘一格”的城市空间结构、“依形江山,因地制宜”的城市功能营建;以及“沿江山集群,南北人文关联”的“跨尺度风景审美经营”等在地特征,以期为巴蜀文化遗产保护与传承、西南山地宜居城乡建设提供参考。

关键词：风景园林嘉陵江流域古城 “山-水-城” 景观特征巴蜀文化走廊

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