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Mitochondrial neuronal uncoupling proteins:a target for potential disease-modification in Parkinson’s disease Philip

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Translational Neurodegeneration 2012年第1期1卷 11-19页

作者： WL Ho Jessica WM Ho Hui-Fang Liu danny hf so Zero HM Tse Koon-Ho Chan David B Ramsden Shu-Leong Ho Division of Neurology Department of MedicineUniversity of Hong KongPokfulamHong Kong SARChina School of Medicine and School of Biosciences University of BirminghamBirminghamUK Research Centre of Heart BrainHormone and Healthy Aging(HBHA)University of Hong KongPokfulamHong Kong SARChina

This review gives a brief insight into the role of mitochondrial dysfunction and oxidative stress in the converging pathogenic processes involved in Parkinson’s disease(PD).Mitochondria provide cellular energy in the form of ATP via oxidative phosphorylation,but as an integral part of this process,superoxides and other reactive oxygen species are also *** free radical production contributes to oxidative *** have evolved to handle such stress via various endogenous anti-oxidant *** such family of proteins is the mitochondrial uncoupling proteins(UCPs),which are anion carriers located in the mitochondrial inner *** are five known homologues(UCP1 to 5),of which UCP4 and 5 are predominantly expressed in neural *** a series of previous publications,we have shown how these neuronal UCPs respond to 1-methyl-4-phenylpyridinium(MPP+;toxic metabolite of MPTP)and dopamine-induced toxicity to alleviate neuronal cell death by preserving ATP levels and mitochondrial membrane potential,and reducing oxidative *** also showed how their expression can be influenced by nuclear factor kappa-B(NF-B)signaling pathway specifically in ***,we previously reported an interesting link between PD and metabolic processes through the protective effects of leptin(hormone produced by adipocytes)acting via UCP2 against MPP+-induced *** is increasing evidence that these endogenous neuronal UCPs can play a vital role to protect neurons against various pathogenic stresses including those associated with *** expression,which can be induced,may well be a potential therapeutic target for various drugs to alleviate the harmful effects of pathogenic processes in PD and hence modify the progression of this disease.

关键词： uncoupling proteins mitochondria Parkinson??s disease ATP oxidative stress neuroprotection

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Feasibility of achieving net-zero energy performance in high-rise buildings using solar energy

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Energy and Built Environment 2024年第6期5卷 946-956页

作者： Mehrdad Shirinbakhsh L.D.danny Harvey University of Toronto 100St.George StreetTorontoONM5S 3G3Canada

As part of a broad strategy to reach net-zero greenhouse gas emissions and limit global warming,many countries are requiring all new buildings to have net-zero energy *** requires that on-site energy use not exceed on-site generation of renewable energy(taken here to be solar energy),or equivalently,that the building Energy Use Intensity(EUI,kWh/m^(2)a)not exceed the supply of on-site solar energy(electricity and heat)per m^(2)of floor area per *** this basis,we find that achieving net-zero energy performance in an archetype 40-story square building in 16 different cities of North America requires EUI of 17–24 kWh/m^(2)a using PV panels,and 19–28 kWh/m^(2)a using PVT *** building orientation to a non-square floor shape can improve maximum permitted EUI by up to 50%in PV and 60%in PVT ***,the best-performing residential and commercial buildings have EUIs of 50–75 kWh/m^(2)*** if building heights are limited to 5–10 floors does the available solar energy,and thus the permitted EUI,reach 50–75 kWh/m^(2)***,we recommend that policymakers not require high-rise buildings to be net-zero energy,unless they are prepared to limit building heights to 5–10 floors.

关键词： High-rise net-zero energy buildings Building geometry Building height solar NZEB

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Cold Cloud Over Paris Olympics

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Beijing Review 2024年第34期67卷 22-23页

作者： danny Haiphong 不详

The Olympic Games are a rare occasion where representatives from the world's nations come together to compete in *** the intense competition,the world's largest sporting event promotes a spirit of peace and *** athletes and national teams take great pride in displaying their talent,skill and dedication on the world ***,the Olympics can also become a platform for political tensions.

关键词： peace spite Olympics

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Why Young Americans Stand With Gaza

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Beijing Review 2024年第19期67卷 28-29页

作者： danny Haiphong the United States

Scenes from college campuses across the *** shocked the *** Columbia University to the University of Texas at Austin,riot police and other heavily-armed security forces have been deployed to suppress encampments of peaceful pro-Palestine *** of students and professors have been *** and college administrators have threatened to call the National Guard to break up the encampments.

关键词： Austin peace Guard

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MOF-mediated synthesis of novel PtFeCoNiMn high-entropy nanoalloy as bifunctional oxygen electrocatalysts for zinc-air battery

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Nano Research 2024年第6期17卷 5288-5297页

作者： Mingkuan Xie Xin Xiao Duojie Wu Cheng Zhen Chunsheng Wu Wenjuan Wang Hao Nian Fayan Li Meng danny Gu Qiang Xu Shenzhen Key Laboratory of Micro/Nano-Porous Functional Materials(SKLPM) Shenzhen 518055China Department of Chemistry Southern University of Science and TechnologyShenzhen 518055China Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen 518055China SUSTech-Kyoto University Advanced Energy Materials Joint Innovation Laboratory(SKAEM-JIL) Shenzhen 518055China Key University Laboratory of Highly Efficient Utilization of solar Energy and Sustainable Development of Guangdong Southern University of Science and TechnologyShenzhen 518055China Eastern Institute for Advanced Study Eastern Institute of TechnologyNingbo 315200China

High-entropy alloy(HEA)-based materials are expected to be promising oxygen electrocatalysts due to their exceptional *** electronic structure regulation of HEAs plays a pivotal role in enhancing their elctrocatalytic ***,PtFeCoNiMn nanoparticles(NPs)with subtle lattice distortions are constructed on metal-organic framework-derived nitrogen-doped carbon by an ultra-rapid Joule heating *** to the modulated electronic structure and the inherent cocktail effect of HEAs,the as-synthesized PtFeCoNiMn/NC exhibits superior bifunctional electrocatalytic performance with a positive half-wave potential of 0.863 V *** hydrogen electrode(RHE)for oxygen reduction reaction and a low overpotential of 357 mV at 10 mA·cm^(-2)for oxygen evolution *** assembled quasi-solid-state zinc-air battery using PtFeCoNiMn/NC as air electrode shows a high peak power density of 192.16 mW·cm^(-2),low charge−discharge voltage gap,and excellent durability over 500 cycles at 5 mA·cm^(-2).This work demonstrates an effective route for rational design of bifunctional nanostructured HEA electrocatalysts with favorable electronic structures,and opens up a fascinating directions for energy storage and conversion,and beyond.

关键词： oxygen reduction reaction oxygen evolution reaction high-entropy nano-alloy zinc-air battery

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Organoid intelligence:Integration of organoid technology and artificial intelligence in the new era of in vitro models

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Medicine in Novel Technology and Devices 2024年第1期21卷 39-44页

作者： Huaiyu Shi Andrew Kowalczewski danny Vu Xiyuan Liu Asif Salekin Huaxiao Yang Zhen Ma Department of Biomedical&Chemical Engineering Syracuse UniversitySyracuseNYUSA BioInspired Institute for Material and Living Systems Syracuse UniversitySyracuseNYUSA Department of Mechanical&Aerospace Engineering Syracuse UniversitySyracuseNYUSA Department of Electrical Engineering&Computer Science Syracuse UniversitySyracuseNYUSA Department of Biomedical Engineering University of North TexasDentonTXUSA

Organoid Intelligence ushers in a new era by seamlessly integrating cutting-edge organoid technology with the power of artificial ***,three-dimensional miniature organ-like structures cultivated from stem cells,offer an unparalleled opportunity to simulate complex human organ systems in *** the convergence of organoid technology and AI,researchers gain the means to accelerate discoveries and insights across various *** intelligence algorithms enable the comprehensive analysis of intricate organoid behaviors,intricate cellular interactions,and dynamic responses to *** synergy empowers the development of predictive models,precise disease simulations,and personalized medicine approaches,revolutionizing our understanding of human development,disease mechanisms,and therapeutic *** Intelligence holds the promise of reshaping how we perceive in vitro modeling,propelling us toward a future where these advanced systems play a pivotal role in biomedical research and drug development.

关键词： Organoids Machinelearning Deep learning Artificial intelligence Stem cells

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加速的体验性动力学心理治疗的现状与进展

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医学与哲学 2024年第16期45卷 30-34,44页

作者：王娟 danny Yeung 郭增瑞陈端颖湖北医药学院卫生管理与卫生事业发展研究中心湖北十堰442000 湖北医药学院应用心理系湖北十堰442000 多伦多大学医学院加拿大安大略L5L 1C6

通过对加速的体验性动力学心理治疗的理论基础、理论模型、治疗策略进行综述与分析,阐明了心理治疗的基本架构。聚焦转化力和促进转化是治疗的根本;最差自体行使功能(精神病源)模型与最佳自体行使功能(蓬勃成长)模型是解释最差自体和最... 详细信息

通过对加速的体验性动力学心理治疗的理论基础、理论模型、治疗策略进行综述与分析,阐明了心理治疗的基本架构。聚焦转化力和促进转化是治疗的根本;最差自体行使功能(精神病源)模型与最佳自体行使功能(蓬勃成长)模型是解释最差自体和最佳自体形成的理论基础;22个治疗策略是促进核心情感体验、建立安全依恋关系以及最终实现治疗目标的具体方法。通过对加速的体验性动力学心理治疗实证与理论研究最新进展的介绍,证实了治疗的有效性和先进性,并总结了7个显著贡献。

关键词：加速的体验性动力学心理治疗整合心理治疗转化力核心情感安全依恋

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Investigation of contact behavior on a model of the dual-mobility artificial hip joint for Asians in different inner liner thicknesses

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World Journal of Orthopedics 2024年第4期15卷 321-336页

作者： Taufiq Hidayat Muhammad Imam Ammarullah Rifky Ismail Eko Saputra M danny Pratama Lamura Chethan K N Athanasius Priharyoto Bayuseno J Jamari Department of Mechanical Engineering Universitas Muria KudusKudus 59352Central JavaIndonesia Department of Mechanical Engineering Universitas DiponegoroSemarang 50275Central JavaIndonesia Undip Biomechanics Engineering&Research Centre Universitas DiponegoroSemarang 50275Central JavaIndonesia Center for Biomechanics Biomaterials Biomechatronics and Biosignal Processing Universitas DiponegoroSemarang 50275Central JavaIndonesia Department of Mechanical Engineering Politeknik Negeri SemarangSemarang 50275Central JavaIndonesia Department of Aeronautical and Automobile Engineering Manipal Institute of TechnologyManipalManipal Academy of Higher EducationManipal 576104KarnatakaIndia

BACKGROUND The four components that make up the current dual-mobility artificial hip joint design are the femoral head,the inner liner,the outer liner as a metal cover to prevent wear,and the acetabular *** acetabular cup and the outer liner were constructed of 316L stainless *** the same time,the inner liner was made of ultra-high-molecular-weight polyethylene(UHMWPE).As this new dual-mobility artificial hip joint has not been researched extensively,more tribological research is needed to predict *** thickness of the inner liner is a significant component to consider when calculating the contact *** To make use of finite element analysis to gain a better understanding of the contact behavior in various inner liner thicknesses on a new model of a dual-mobility artificial hip joint,with the ultimate objective of determining the inner liner thickness that was most suitable for this particular type of dual-mobility artificial hip *** In this study,the size of the femoral head was compared between two diameters(28 mm and 36 mm)and eight inner liner thicknesses ranging from 5 mm to 12 *** the finite element method,the contact parameters,including the maximum contact pressure and contact area,have been evaluated in light of the Hertzian contact *** simulation was performed statically with dissipated energy and asymmetric *** types of interaction were surface-to-surface contact and normal contact *** The maximum contact pressures in the inner liner(UHMWPE)at a head diameter of 28 mm and 36 mm are between 3.7-13.5 MPa and 2.7-10.4 MPa,*** maximum von Mises of the inner liner,outer liner,and acetabular cup are 2.4–11.4 MPa,15.7–44.3 MPa,and 3.7–12.6 MPa,respectively,for 28 mm *** the maximum von Mises stresses of the 36 mm head are 1.9-8.9 MPa for the inner liner,9.9-32.8 MPa for the outer liner,and 2.6-9.9 MPa for the acetabular cup.A head with a diameter of 28 mm should have an inner line

关键词： Contact behavior Contact pressure Finite element analysis Dual-mobility Artificial hip joint

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Instagram:数字时代的视觉乐趣

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品质 2024年第7期 30-34页

作者： danny 磨盘(图) 不详

Instagram以独特的图像分享功能、流行的视觉内容而广受欢迎。该平台的用户可以通过发布照片和视频来与粉丝和关注者分享生活点滴、创意作品和见闻。

关键词：视觉内容生活点滴创意作品数字时代视频分享

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Shake Shack:纽约麦迪逊广场走出来的上市公司

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品质 2024年第8期 25-29页

作者： danny 磨盘(图) 不详

Shake Shack的故事始于2001年,当时Union Square Hospitality Group(USHG)的创始人danny Meyer在纽约麦迪逊广场公园设立了一个热狗摊,以支持公园的翻新项目。这个临时摊位迅速获得了公众的喜爱,促使Meyer决定将其扩展为一个永久性的餐... 详细信息

Shake Shack的故事始于2001年,当时Union Square Hospitality Group(USHG)的创始人danny Meyer在纽约麦迪逊广场公园设立了一个热狗摊,以支持公园的翻新项目。这个临时摊位迅速获得了公众的喜爱,促使Meyer决定将其扩展为一个永久性的餐饮品牌。2004年,第一家Shake Shack在麦迪逊广场公园正式开业,以其高质量的汉堡、奶昔和热狗吸引了大量顾客。

关键词：餐饮品牌麦迪逊上市公司纽约 Meyer

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