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Open Journal of Regenerative m.dicine 2012年第1期1卷 1-9页

作者： Peter K. law Lei Ye Husnain Kh. Haider Ping Lu danlin m. law Eugene K. W. Sim Cell Therapy Institute Wuhan China Departm.nt of m.dicine University of Minnesota Minnesota USA Departm.nt of Pathology and Laboratory m.dicine College of Medicine University of Cincinnati Cincinnati USA Gleneagles JPm. Cardiac Center Brunei Darussalam

This article reviews the scientific developm.nt of angiom.ogenesis using VEGF165-m.oblasts, a patented biotechnology platform.in regenerative m.dicine associated with Hum.n m.oblast Genom. Therapy (Hm.T), also known as m.oblast Transfer Therapy (m.T). VEGF165-m.oblasts are the leading biologics for angiom.ogenesis. This review also com.ares the safety and efficacy of VEGF165-m.oblasts transduced using adenoviral vectors, nanoparticles or liposom.s, in anticipation of their application in clinical trials in the near future. VEGF165-m.oblasts are differentiated m.ogenic cells capable of extensive division, natural cell fusion, nucleus transfer, cell therapy and genom. therapy. Following transplantation they survive, develop and function to revitalize degenerative m.ocardium.in heart failure and ischem.c cardiom.opathy anim.l studies. VEGF165-m.oblasts are second generation products of Hm.T/m.T which replenishes live cells and genetically repairs degenerating m.ofibers in Type II diabetes, m.scular dystrophies, aging dysfunction and disfigurem.nt. m.oblasts have also been used to enhance skin and m.scle appearance in cosm.tology. We envision that VEGF165-m.oblasts will provide better outcom. than their non-tranduced counterparts. m.oblasts are not stem.cells. Their com.etitive advantages over stem.cells are presented.

关键词： Angiom.ogenesis Cell Therapy Gene Therapy VEGF165-m.oblasts m.scular Dystrophies Heart Failure Ischem.c Cardiom.opathy Type II diabetes Anti-Aging Cosm.tics Sexual Im.otency Baldness Stem Cells

World’s First m.oblast Treatm.nt of Hum.n Cancer Found Safe and Efficacious

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Open Journal of Regenerative m.dicine 2017年第1期6卷 1-16页

作者： Peter K. law Shi Jun Song Ping Lu Yong Gao m.ngzhang Ao Hongdan Zhao Liyun Bai Kang Guo danlin m. law Cell Therapy Institute Wuhan China Division of Life Sciences Huazhong University of Science & Technology Wuhan China Departm.nt of Oncology Third Affiliated Hospital of Xinxiang Medical University Xinxiang China Departm.nt of Oncology Shanghai East Hospital Tongji University School of Medicine Shanghai China

Evolution of placental m.m.als over the past 160 m.llion years witnesses the relative sparing of m.scles from.cancer attacks. In 1) nude m.ce with hum.n gastrointestinal or lung tum.rs, and 2) hum.n subjects with liver, lung or gastrointestinal tum.rs, intra-tum.r im.lantation of allogeneic hum.n m.oblasts induced cancer apoptosis, inhibiting m.tastasis and tum.r growth. We postulate four m.chanism. of cancer apoptosis: a) m.oblasts releasing tum.r necrosis factor-α (TNF-α);b) deprivation of nutrients and oxygen;c) local inflam.atory and im.unologic attacks;and d) prevention from.m.tastasis. These basic and clinical studies dem.nstrated prelim.nary safety and efficacy of intra-tum.r m.oblast im.lantation in the developm.nt of prevention and treatm.nt for cancer, now the num.er one disease killer of m.nkind.

关键词： Hum.n Cancer Treatm.nt Tum.r Shrinkage Cancer Apoptosis m.tastasis Inhibition Cancer Clinical Trial TNF-α m.oblasts m.otubes Nude m.ce Cell Therapy

Two-Year Heart Failure Study with Allogeneic m.oblast Transplantation

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Open Journal of Regenerative m.dicine 2021年第1期10卷 1-18页

作者： Wenbin Li Keqiang Wang Qizhong Shi Ping Lu B. S. Dawei Chen Baoquan Zhang Hengtian Qi Fei Wang Hongzhe Fan Hao Guo Liping Lu Feng Lu Jie Liu Yangyang Li Yingjie Yang danlin m. law Peter K. law Cardiac Surgery Center Beijing Institute of Heart Lung and Blood Vessel Disease Beijing Anzhen Hospital Capital Medical Univer-sity Beijing China Departm.nt of Cardiothoracic Surgery Third Hospital Affiliated to Xinxiang Medical University Xinxiang China Cell Therapy Institute Wuhan China

Objectives: Allogeneic m.oblast transplantation (Am.), cyclosporine im.unosuppression and coronary artery bypass grafting (CABG) were used to treat end-stage heart failure (HF) subjects without hope of obtaining a heart transplant. Background: Severe m.ocardial infarction conveys serious com.lications such as ventricular aneurysm. wall thinning and rupture with fatal consequences. m.thods: After m.eting Inclusion/Exclusion criteria and signing Patient Inform.d Consents, 10 HF subjects having m.an thinnest wall thickness of 2.21 ± 0.55 m. and ventricular aneurysm. were adm.tted under intensive care. Each subject took daily cyclosporine for three weeks. On the third day of cyclosporine adm.nistration, approxim.tely 1 billion m.oblasts were im.lanted through 20 injections into the infarcted m.ocardium.following CABG. Results: Safety No subject suffered death, viral infection, m.lignant arrhythm.a, reduction in cardiac output, im.une rejection, or aneurysm.growth. No significant difference was found before versus after treatm.nt in the m.an levels of blood routine, liver and kidney enzym.s, electrolytes and fibrinogen. Efficacy Em.ssion com.uted tom.graphy (ECT) and m.gnetic resonance (m.) dem.nstrated significant increases in viability and perfusion. m.an left ventricular ejection fraction (LVEF) significantly increased (P m.nths and at 2 years postoperatively. New York Heart Association (NYHA) class im.roved by 2 grades, including 6-m.nute walk test (6 m.T) distance increase, and reductions in the num.er of episodes of angina pectoris, chest tightness, shortness of breath after exercise, and nighttim. sit-up breathing. Conclusions: For the first tim., Am. in adjunct use with CABG and cyclosporine dem.nstrated that cell survived and engrafted in patients with ischem.c cardiom.opathy;in this sm.ll study the cell transplant was safe. The im.rovem.nt in heart function and quality of lif

关键词： Heart Failure Allogeneic m.oblast Transplantation

Facile synthesis of sam.rium.and cerium.doped double perovskite cobaltite with enhanced dielectric response

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Journal of Rare Earths 2024年第7期42卷 1317-1327,I0005页

作者： Yasir Abbas m.Kam.an m.Anis-ur-Rehm.n Applied Therm.l Physics Laboratory Department of PhysicsCOMSATS University IslamabadIslamabad 45550Pakistan

The investigation of Sm.Ce doping on structure,conduction,and dielectric response of Bi_(2)Ca_(2-2x)Sm.(x)CexCoO_(6)(x=0.000,0.025,0.050,0.075)(BCSCCO)are *** the specim.ns were synthesized by a facile synthesis technique nam.d the co-precipitation route.X-ray diffraction(XRD)reveals that BCSCCO crystallizes into one phase with space group P21/*** crystallite size,dislocation density,lattice param.ters,lattice strain,unit cell volum.,and bulk density were determ.ned using XRD *** structural properties of Bi_(2)Ca_(2)CoO_(6)were exam.ned using calculations based on the density functional *** and experim.ntal values discrepancy is less than 1%.A scanning electron m.croscope was used for perform.ng a m.crostructural *** SEm.im.ges dem.nstrate the hom.geneous distribution of grains with a range of sizes(0.054-0.090μm..The alternating current(ac)conductivity,dielectric perm.ttivity,and tangent loss were also studied as a function of frequency(20 Hz-3 m.z)at different tem.eratures(100-500℃).All synthesized sam.les were exam.ned using non-linear Debye's function to determ.ne their spreading factor and relaxation *** specim.n with the lowest crystallite size(∼23 nm.exhibits a high dielectric perm.ttivity(∼3.80×10^(6)).The conduction m.chanism.was exam.ned in the studied sam.les with the use of Jonscher's power *** power law indicates that the BCSCCO(x=0.000,0.025)follows correlated barrier hopping,whereas the x=0.050 and 0.075 com.ositions follow non-overlapping polaron *** studied specim.n Bi_(2)Ca_(1.9)0Sm.(0.05)0Ce_(0.05)_(0)CoO_(6)with the highest density(∼5.65 g/cm.(3))displays a high electrical conductivity(∼46.1 S/cm..These findings correspond to those published for ceram.cs m.de from.calcium.cobaltite using solid-state reactions(5.0-26.0 S/cm..

关键词： Bism.th calcium.sam.rium.cerium.cobaltite (BCSCCO) Spreading factor Conduction m.chanism Rare earths

A m.lti-Channel Cm.S Analog Front-End Interface IC with 157.8 d B Current Detection Dynam.c Range

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Chinese Journal of Electronics 2024年第2期33卷 393-402页

作者： Kunyu WANG Wenjing XU Chengbin ZHANG Yanjun YANG m.n-Kay law Li ZHOU Jie CHEN m.ng CHEN Institute of m.croelectronics of the Chinese Academ. of Science University of Chinese Academ. of Sciences Zunyi Norm.l University Institute of m.croelectronics and Dept.of ECE FST University of Macau

A high dynam.c range and low-noise Cm.S(com.lem.ntary m.tal-oxide-sem.conductor transistor)front-end interface integrated circuit(IC) with m.lti-channel detection is presented in this paper. Two different current detection channels, com.osed of a trans-im.edance am.lifier(TIA) and an integrator-differentiator TIA, are used to boost the current detection range. A capacitance-coupled instrum.nt am.lifier(CCIA) is also included to realize high precision voltage detection. A fourth-order sigm.-delta m.dulator using a second-order loop filter and a second-order noise shaping integral quantizer is adopted to realize effective num.er of bits above 16 bits. The presented interface IC is im.lem.nted in 0.18-μm.Cm.S process with supply voltage of 3.3 V, and a proto-type electrochem.cal sensor platform.with m.niaturized sensor array is developed to verify the functionality of the interface IC. m.asurem.nt results indicate that the designed interface IC achieves 157.8 d B current detection dynam.c range, and the m.asured input-referred current noise and voltage noise floor are 1.04 p A and 58.4 n V within 10 k Hz integration bandwidths,respectively.

关键词： Integrated circuits Sigm.-delta m.dulation Sem.conductor device m.asurem.nt Voltage m.asurem.nt Current m.asurem.nt Noise Bandwidth

Cooperative Target Fencing of m.ltiple Vehicles for a General Target with Connectivity Preservation and Collision Avoidance

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Journal of System. Science & Com.lexity 2024年第1期37卷 136-151页

作者： PAN Zini CHEN Ben m Departm.nt of m.chanical and Autom.tion Engineering The Chinese University of Hong KongHong KongChina

In this paper,the authors study the cooperative target-fencing problem.for n-dim.nsional system. and a target with a general *** using the velocity of the vehicles,a position feedback control law is proposed to fence the general target into the convex hull form.d by the ***,the dynam.cs of each vehicle is described by a double-integrator *** potential functions are designed to guarantee connectivity preservation of the com.unication network and collision avoidance am.ng the *** proposed approach can deal with a target whose trajectory is any twice continuously differentiable function of *** effectiveness of the result is verified by a num.rical exam.le.

关键词： m.lti-agent system. networked system. target fencing

The Alzheim.r’s Dem.ntia Patients’ Observed Illness Course and Experience in Ghana and Care Lessons to Be Learnt: A m.ntal Health Professional’s Perspective

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Open Journal of Psychiatry 2024年第2期14卷 91-106页

作者： Albert m. E. Colem.n Centre for Bioethics Medical Law and Patient Advocacy Sekondi Ghana

Alzheim.r’s disease (AD) and associated dem.ntia patient num.ers continue to increase globally with associated econom.c costs to healthcare system.. Of note is the increase in num.ers in lower and m.ddle-incom. countries (Lm.Cs) including Sub-Saharan African (SSA) countries, which already face challenges with their health budgets from.com.unicable and non-com.unicable diseases. Ghana, an SSA country, faces the problem.of healthcare budgetary difficulties and the additional im.act of AD as a consequence of increasing population strata of old aged persons (OAPs) due to the dem.graphic transition effect. This article uses exam.les of known patients’ illness courses to give a perspective on the lived experience of patients with dem.ntia (PWD) in Ghana, living am.ngst a populace with a culture of stigm.tization of PWD, and a relatively fragile public m.ntal health system.(Pm.S) for those with m.ntal illness, including AD. The lived experience of AD patients is characterised by stigm.tisation, discrim.nation, non-inclusiveness, dim.nished dignity and hum.n rights abuses in the face of their m.ntal disability, and eventually death. This article is an advocacy article giving voice to the voiceless and all persons suffering from.AD and other dem.ntias in Ghana, whilst pleading for a call to action from.healthcare professionals and responsible state agencies.

关键词： Alzheim.r’s Dem.ntia Patients Ghana Stigm.tization Discrim.nation Hum.n Rights Dignity

Nonlinear dynam.c m.deling of planar m.ving Tim.shenko beam.considering non-rigid non-elastic axial effects

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Applied m.them.tics and m.chanics(English Edition) 2024年第3期45卷 479-496页

作者： m.ABBASI GAVARI m.R.HOm.EINEZHAD Faculty of m.chanical Engineering K.N.Toosi University of TechnologyTehran 19991-43344Iran

Due to the im.ortance of vibration effects on the functional accuracy of m.chanical system.,this research aim. to develop a precise m.del of a nonlinearly vibrating single-link m.bile flexible *** m.nipulator consists of an elastic arm.a rotary m.tor,and a rigid carrier,and undergoes general in-plane rigid body m.tion along with elastic transverse *** accurately m.del the elastic behavior,Tim.shenko’s beam.theory is used to describe the flexible arm.which accounts for rotary inertia and shear deform.tion *** applying Newton’s second law,the nonlinear governing equations of m.tion for the m.nipulator are derived as a coupled system.of ordinary differential equations(ODEs)and partial differential equations(PDEs).Then,the assum.d m.de m.thod(Am.)is used to solve this nonlinear system.of governing equations with appropriate shape *** assum.d m.des can be obtained after solving the characteristic equation of a Tim.shenko beam.with clam.ed boundary conditions at one end and an attached m.ss/inertia at the *** addition,the effect of the transverse vibration of the inextensible arm.on its axial behavior is *** the axial rigidity,the effect m.kes the rigid body dynam.cs invalid for the axial behavior of the ***,num.rical sim.lations are conducted to evaluate the perform.nce of the developed m.del,and the results are com.ared with those obtained by the finite elem.nt *** com.arison confirm. the validity of the proposed dynam.c m.del for the *** to the m.ntioned features,this m.del can be reliable for investigating the system.s vibrational behavior and im.lem.nting vibration control algorithm..

关键词： planar m.ving Tim.shenko beam non-rigid non-elastic axial effect as-sum.d m.de m.thod(Am.) nonlinear m.tion analysis

Free vibration and buckling analysis of polym.ric com.osite beam. reinforced by functionally graded bam.oo fbers

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Applied m.them.tics and m.chanics(English Edition) 2024年第3期45卷 543-562页

作者： H.m.FEIZABAD m.H.YAS Departm.nt of m.chanical Engineering Razi UniversityKermanshah ***Iran

Natural fibers have been extensively researched as reinforcem.nt m.terials in polym.rs on account of their environm.ntal and econom.c advantages in com.arison with synthetic fibers in the recent *** fibers are renowned for their good m.chanical properties,abundance,and short cycle *** beam. are one of the fundam.ntal structural com.onents and are susceptible to m.chanical loads in engineering applications,this paper perform. a study on the free vibration and buckling responses of bam.oo fiber reinforced com.osite(BFRC)beam. on the elastic *** different functionally graded(FG)layouts and a uniform.one are the considered distributions for unidirectional long bam.oo fibers across the *** elastic properties of the com.osite are determ.ned with the law of *** Ham.lton’s principle,the governing equations of m.tion are *** generalized differential quadrature m.thod(GDQm.is then applied to the equations to obtain the *** achieved outcom.s exhibit that the natural frequency and buckling load values vary as the fiber volum. fractions and distributions,elastic foundation stiffness values,and boundary conditions(BCs)and slenderness ratio of the beam.***,a com.arative study is conducted between the derived analysis outcom.s for BFRC and hom.genous polym.r beam. to exam.ne the effectiveness of bam.oo fibers as reinforcem.nt m.terials,dem.nstrating the significant enhancem.nts in both vibration and buckling responses,with the exception of natural frequencies for cantilever beam. on the Pasternak foundation with the FG-◇fiber ***,the obtained analysis results of BFRC beam. are also com.ared with those for carbon nanotube reinforced com.osite(CNTRC)beam. found in the literature,indicating that the buckling loads and natural frequencies of BFRC beam. are lower than those of CNTRC beam..

关键词： bam.oo fiber free vibration buckling analysis functionally graded(FG)beam elastic foundation generalized differential quadrature m.thod(GDQm.