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Magnetic nanotechnologies for early cancer diagnostics with liquid biopsies:a review

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Journal of Cancer Metastasis and Treatment 2020年第1期6卷 188-208页

作者： Diqing Su Kai wu Renata Saha Jinming Liu jian-Ping wang Department of Chemical Engineering and Material Science University of MinnesotaMinneapolisMN 55455USA Department of Electrical and Computer Engineering University of MinnesotaMinneapolisMN 55455USA

Liquid biopsy has become an emerging technology in the detection of cancer related biomarkers as well as the continuous monitoring of cancer *** has been extensive research on the applications of magnetic nanotechnologies in liquid biopsies from the separation of target analytes to the detection of cancer *** separation plays an important role in increasing both the efficiency and sensitivity of the liquid biopsy *** detection of cancer biomarkers through magnetic nanosensors also possesses many advantages such as low background noise,high sensitivity,short assay time,and the ability to detect multiple biomarkers at the same *** review focuses on the recent advances of magnetic nanotechnologies in liquid biopsies for cancer detection and its future potential in comparison with other technologies.

关键词： Liquid biopsy magnetic cancer nanotechnology biosensor

Reliable experimental model of hepatic veno-occlusive disease caused by monocrotaline

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Hepatobiliary & Pancreatic Diseases International 2008年第4期7卷 395-400页

作者： Miao-Yan chen jian-Ting Cai Qin Du Liang-Jing wang Jia-Min chen Li-Ming Shao Department of Gastroenterology and Hepatology Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310009 China.

BACKGROUND:Hepatic veno-occlusive disease(HVOD)is a severe complication of chemotherapy before hematopoietic stem cell transplantation and dietary ingestion of pyrrolizidine *** experimental models were established to study its mechanisms or therapy,but few are *** work aimed at evaluating a rat model of HVOD induced by monocrotaline to help advance research into this disease. METHODS:Thirty-two male rats were randomly classified into 5 groups,and PBS or monocrotaline was administered (100 mg/kg or 160 mg/kg).They were sacrificed on day 7(groups A,B and D)or day 10(groups C and E).Blood samples were collected to determine liver enzyme *** weight of the liver and body and the amount of ascites were *** changes of liver tissue on light microscopy were assessed by a modified Deleve scoring *** positivity of proliferating cell nuclear antigen(PCNA)was estimated. RESULTS:The rats that were treated with 160 mg/kg monocrotaline presented with severe clinical symptoms (including two deaths)and the histopathological picture of *** the other hand,the rats that were fed with 100 mg/kg monocrotaline had milder and reversible *** of the rats sacrificed on day 10 with those sacrificed on day 7 showed that the positivity of PCNA increased,especially that of ***:Monocrotaline induces acute,dose- dependent HVOD in *** model is potentially reversible with a low dose,but reliable and irreversible with a higher *** modified scoring system seems to be more accurate than the traditional one in reflecting the histopathology of *** enhancement of PCNA positivity may be associated with hepatic tissue undergoing recovery.

关键词： hepatic veno-occlusive disease monocrotaline proliferating cell nuclear antigen

Sarcoidosis mimicking metastases in an echinoderm microtubuleassociated protein-like 4 anaplastic lymphoma kinase positive nonsmall-lung cancer patient:A case report

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World Journal of Clinical Cases 2021年第13期9卷 3140-3146页

作者： Xi chen Jie wang Wei-Li Han Kui Zhao Zhen chen jian-Ying Zhou Yi-Hong Shen Department of Respiratory Diseases The First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310003Zhejiang ProvinceChina Department of Lung Transplantation The First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310003Zhejiang ProvinceChina Positron Emission Tomography Center The First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310003Zhejiang ProvinceChina Department of Pathology The First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310003Zhejiang ProvinceChina

BACKGROUND Rearrangements of the anaplastic lymphoma kinase(ALK)gene(ALK-positive)represent an oncogenic driver in approximately 3%-5%of non-small-lung cancer(NSCLC)*** is a multisystem disease,and its reported incidence in Asia is 1 or less per 100000 people per *** co-occurrence of sarcoidosis and ALK-positive NSCLC is rare,and ALK-positive lung cancer is likely to spread ***,the co-occurrence of sarcoidosis is more easily misdiagnosed as metastatic lung cancer by radiological *** SUMMARY A 50-year-old man had a nodule in the left superior lobe,many small nodules in left superior and right lungs,and enlarged bilateral hilar,mediastinal,and right supraclavicular lymph *** tomography-guided pulmonary biopsy of the nodule in the left superior lobe revealed echinoderm microtubuleassociated protein-like 4 gene-ALK positive NSCLC with concomitant noncaseating *** patient was treated with *** days later,a chest computed tomography scan revealed a dramatic decrease in the size of the left superior lobe nodule;however,the lesions in the right lung *** right supraclavicular lymph nodes showed granulomas,and no tumor cells were identified in the specimens. The angiotensin-converting enzyme level was *** 1 wk of methylprednisolone treatment, a significant response of all lesionswas revealed. Following radical resection of the lung cancer, noncaseatinggranulomas were observed in both lung tissues and lymph nodes, which resultedin a diagnosis of echinoderm microtubule-associated protein-like 4-ALK positiveNSCLC accompanied with *** experience illustrates that pathological evidence is needed to confirmmetastatic disease, especially when some suspected metastatic lesions arenegative for malignancy.

关键词： Lung cancer Sarcoidosis Anaplastic lymphoma kinase Echinoderm microtubule-associated protein-like 4 anaplastic lymphoma kinase Metastasis Case report

CPFD modeling of hydrodynamics,combustion and NOx emissions in an industrial CFB boiler

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Particuology 2023年第10期81卷 174-188页

作者： jian Chang Xinrui Ma Xin wang Xiaohang Li School of Energy Power and Mechanical EngineeringNorth China Electric Power UniversityBeijing102206China Bluestar(Beijing)Chemical Machinery Co. LtdBeijing100176China

The ultra-low NOx emission requirement(50 mg/m^(3))brings great challenge to CFB boilers in *** further tap the NOx abatement potential,full understanding the fundamentals behind CFB boilers is *** achieve this,a comprehensive CPFD model is established and verified;gas-solid flow,combustion,and NOx emission behavior in an industrial CFB boiler are elaborated;influences of primary air volume and coal particle size on furnace performance are *** results indicate that there exists a typical core-annular flow structure in the boiler *** temperature is highest in the bottom dense-phase zone(about 950℃)and decreases gradually along the furnace ***-deficient combustion results in high CO concentration and strong reducing atmosphere in the lower *** concentration gradually increases in the bottom furnace,reaches maximum at the elevation of secondary air inlet,and then decreases slightly in the upper *** decreasing the primary air volume and coal particle size would increase the CO concentration and intensify the in-furnace reducing atmosphere,which favors for NOx reduction and low NOx emission from CFB boilers.

关键词： Hydrodynamics Combustion NOx emission CFB boiler CPFD

Rational synthesis of CaCo_2O_4 nanoplate as an earth-abundant electrocatalyst for oxygen evolution reaction

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Journal of Energy Chemistry 2019年第4期28卷 125-131页

作者： Xiao Lin Jing Zhou Dehua Zheng chengzhi Guan Guoping Xiao Ning chen Qing Liu Hongliang Bao jian-Qiang wang Shanghai Institute of Applied Physics Chinese Academy of Sciences University of Chinese Academy of Sciences Key Laboratory of Eco-chemical Engineering College of Chemistry and Molecular Engineering Qingdao University of Science and Technology Canadian Light Source University of Saskatchewan

To accelerate the kinetics of oxygen evolution reaction(OER)regarding the energy conversion and storage approaches,the discovery of desirable cost-effective and highly efficient electrocatalysts is of prime *** study demonstrates a layered CaCo_2O_4with a two-dimensional nanoplate structure,which possesses electrocatalytic activity for *** OER activity was achieved on CaCo_2O_4with a Tafel slope of 71 mV dec^(-1)and a current density of 10 mA cm^(-2)at an overpotential of 371 mV,which was more active than the similar structure LiCoO_*** with X-ray absorption fine structure and density functional theory calculations,the enhanced OER activity and stability are mainly attributed to the unique electronic structure derived from the interaction of Ca and Co,and improved electrical ***_2O_4can be developed as a highly active and earth-abundant catalyst for OER in energy conversion and storage technologies.

关键词： Oxygen evolution reaction CaCo2O4 2D nanoplates Electrocatalysts

人工股骨头置换术与全髋关节置换术改善股骨颈骨折患者髋关节功能的作用研究

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中国医疗器械信息 2024年第1期30卷 132-134页

作者：陈晓剑王成周宇康昭河姚磊上海市东方医院吉安医院江西吉安343000

目的:探讨人工股骨头置换术与全髋关节置换术改善股骨颈骨折患者髋关节功能的作用。方法:纳入2020年1月~2022年5月上海市东方医院吉安医院收治的股骨颈骨折患者55例为研究对象,以随机数字表法将患者分为两组,对照组(n=27)接受人工股骨... 详细信息

目的:探讨人工股骨头置换术与全髋关节置换术改善股骨颈骨折患者髋关节功能的作用。方法:纳入2020年1月~2022年5月上海市东方医院吉安医院收治的股骨颈骨折患者55例为研究对象,以随机数字表法将患者分为两组,对照组(n=27)接受人工股骨头置换术;观察组(n=28)接受全髋关节置换术。随访时间6个月,比较两组各项指标。结果:术后6个月,观察组、对照组髋关节功能优良率进行比较,观察组更高;术前、术后3d,观察组、对照组血清白细胞介素-6、降钙素原、C反应蛋白水平进行比较均升高,组间比较,观察组更低;随访期间观察组、对照组并发症总发生率进行比较,观察组更低;术前、术后6个月,观察组、对照组生活质量评分进行比较均升高,组间比较,观察组更高,统计学差异有显著性(P<0.05)。结论:股骨颈骨折患者应用全髋关节置换术可有效提高髋关节功能优良率,降低炎症反应,减少并发症,改善生活质量。

关键词：股骨颈骨折人工股骨头置换术全髋关节置换术髋关节功能

Joining SiO_(2)based ceramics:recent progress and perspectives

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Journal of Materials Science & Technology 2022年第13期108卷 110-124页

作者： Haohan wang Jinghuang Lin Junlei Qi jian Cao State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001China

Nowadays,SiO_(2)based material is one of the widest used materials in optical,microelectromechanical system,aerospace and some other *** practical application,SiO_(2)based materials are required to be joined with themselves or other heterogeneous materials to assemble products with various *** the joining quality directly affects the mechanical performances and functional properties of assembled *** many researchers studied different joining technologies,explored the microstructure of joining interface and tested after-joining properties,a review that summarizes the recent cutting-edge researches and development tendency of joining technologies for SiO_(2)based ceramics is still ***,according to different applications and requirements,this review summarizes the widely used joining technologies and discusses corresponding joining mechanisms,current research progress and suitable *** to the wide applications in specific industry,laser welding,anodic bonding and wafer bonding are discussed in ***,brazing,the widest used method in SiO_(2)joining,has been elaborated deeply in its wetting mechanism,residual stress control,interfacial microstructure and mechanical performance *** the end,this review proposed the future development trends of SiO_(2)ceramics joining,aiming at offering a full-view of potential improvements in SiO_(2)ceramic joining technologies.

关键词： SiO_(2)joining current research progress brazing future development trend

长期碳酸盐碱度胁迫对脊尾白虾生长及卵巢发育的影响

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水产学报 2024年第4期48卷 257-267页

作者：张秀红李吉涛王佳佳王成伟秦桢葛倩倩刘萍李健上海海洋大学水产科学国家级实验教学示范中心中国水产科学研究院黄海水产研究所海水养殖生物育种与可持续产出全国重点实验室青岛海洋科技中心海洋渔业科学与食物产出过程功能实验室

为探讨碳酸盐碱度对脊尾白虾生长及卵巢发育的影响。本研究设置3 mmol/L （对照组）、5 mmol/L和8 mmol/L三种碳酸盐碱度梯度养殖脊尾白虾60 d，比较不同碳酸盐碱度胁迫对脊尾白虾生长性能、组织结构、酶活性以及卵巢发育的影响，结果... 详细信息

为探讨碳酸盐碱度对脊尾白虾生长及卵巢发育的影响。本研究设置3 mmol/L （对照组）、5 mmol/L和8 mmol/L三种碳酸盐碱度梯度养殖脊尾白虾60 d，比较不同碳酸盐碱度胁迫对脊尾白虾生长性能、组织结构、酶活性以及卵巢发育的影响，结果显示，5 mmol/L组与对照组体长增长率、体重增长率以及成活率差异不显著，8 mmol/L组体长增长率、体重增长率以及成活率显著低于对照组。肝胰腺组织切片显示，5 mmol/L组中部分B细胞体积增大，部分转运泡内出现颗粒物质，8 mmol/L组管腔的形态结构严重变形。鳃组织切片显示，5 mmol/L组出现轻微鳃丝肿大现象，角质层略有变形，且角质层下间隙扩张变长，上皮细胞与支柱细胞排列紊乱；8 mmol/L组鳃丝肿大，排列不规则，出现血细胞肿胀现象，鳃丝上皮细胞严重破坏，毛细血管网结构形态改变，角质层下间隙变形。肌肉组织酶活性测定结果显示，5 mmol/L组的碳酸酐酶活性显著高于对照组，Na+/K+-ATP酶活性在肌肉中差异不显著；肝胰腺组织酶活性测定结果显示，碳酸酐酶在肝胰腺组织中差异不显著，8 mmol/L组Na+/K+-ATP酶活性显著低于其他组，鳃组织中，5和8 mmol/L组鳃组织中和Na+/K+-ATP酶活性均显著高于对照组，且两组间差异显著。卵巢发育统计结果显示，三组脊尾白虾卵巢均能发育，其发育至Ⅱ期的百分比分别为20.51%、10.52%和6.25%，其中5mmol/L组与对照组间无显著差异，8 mmol/L组显著低于对照组；3 mmol/L组和5 mmol/L组均有卵巢发育至Ⅲ期的脊尾白虾，但两组差异不显著，8 mmol/L组未见有卵巢发育至Ⅲ期的脊尾白虾。卵巢组织切片显示，8 mmol/L组卵原细胞细胞排列疏松，周围滤泡细胞排列疏松且数量较少。研究表明，脊尾白虾可以在低于8 mmol/L的碳酸盐碱度中生长发育，但高碳酸盐碱度可能会造成脊尾白虾鳃和肝胰腺组织损伤，导致其生长受到影响，同时猜测高碳酸盐碱度可能也会影响卵巢的发育速率。本研究可为开展脊尾白虾在盐碱水中的增养殖提供基础数据和参考信息。

关键词：脊尾白虾碳酸盐碱度胁迫生长组织切片酶活性卵巢发育

Revisited dynamic modeling and eigenvalue analysis of the cable-stayed beam

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Acta Mechanica Sinica 2020年第4期36卷 950-963页

作者： Lianhua wang Xiaoyu Zhang Kai He jian Peng College of Civil Engineering Hunan UniversityChangsha 410082China Key Laboratory for Wind and Bridge Engineering of Hunan Province Hunan UniversityChangsha 410082China Guangxi Communications Design Group Co. LtdNanning 530022China Hunan Provincial Key Laboratory of Structures for Wind Resistance and Vibration Control Hunan University of Science and TechnologyXiangtan 411201China

In this study,the Hamilton’s principle is applied to revisit the dynamic modeling of the cable-stayed beam,and the motion equations governing the nonlinear response of the cable-stayed beam are *** corresponding boundary terms are transformed to the dynamic equilibrium conditions through the continuity of the displacement at the anchoring *** the standard condensation procedure,the condensed model of the cable-stayed beam is *** eigenvalue analysis is performed to determine the closed-form eigenvalue solution of the linear problems,and two types of eigenvalue solution are *** is shown that the frequency spectrum of the cable-stayed beam exhibits the curve veering and crossover *** to these phenomena,the mode shapes of the cable-stayed beam may exhibit the coupling ***,the discrete model of the cable-stayed beam is determined,and the possible nonlinear interactions are discussed.

关键词： Cable-stayed beam Dynamic modeling Natural frequencies Mode shapes Curve veering