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Conservative management of an early abdominal complication during a Tullio percutaneous endoscopic excision of renal pelvis urothelial carcinoma:A case report

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World Journal of Clinical Urology 2024年第1期13卷 1-6页

作者： Massimiliano Bernabei NicolòFabbri danila Romeo Elisa Paiolo Martina Bandi Maurizio Simone Department of Urology Azienda USL di FerraraFerrara 44100Italy Department of Surgery University of FerraraAzienda USL of FerraraAzienda USL of FerraraFerrara 44100FerraraItaly Local Health Agency of Ferrara Ferrara 44100Italy

BACKGROUND Upper tract urothelial carcinoma(UTUC)representing only a small fraction of all urothelial *** predominantly affects the renal pelvis in men,often coexisting with bladder *** displays a more aggressive genetic profile compared to bladder neoplasms,with the majority of patients presenting with advanced ***,about a quarter of UTUC cases exhibit high-grade subtypes,associated with a worse *** use and past exposure to aromatic amines are significant risk factors for *** modalities such as Uro-computed tomography and magnetic resonance imaging play crucial roles in *** is vital for direct visualization and biopsy sampling,but its limited sampling capacity presents challenges in determining tumor depth and ***,nephroureterectomy with bladder cuff excision has been the gold-standard treatment for *** conservative treatment has recently emerged as a viable option for selected patients,offering comparable oncological outcomes to radical *** access is also feasible for larger intrarenal *** SUMMARY We present a case of an 84-year-old woman who underwent percutaneous endoscopic excision of a renal pelvis neoplasm using the Tullio *** successful tumor removal,the patient experienced a postoperative complication with abdominal fluid *** management effectively resolved the *** the patient's age and refusal for radical surgery,the conservative approach proved to be a valid therapeutic *** Overall,UTUC remains a diagnostic and therapeutic challenge due to its ***,advances in endoscopic and percutaneous techniques provide valuable alternatives for selected patients,warranting further exploration in this evolving field.

关键词： Upper tract urothelial carcinoma Endoscopic treatment Damage management Case report

The RhoA nuclear localization changes in replicative senescence:New evidence from in vitro human mesenchymal stem cells studies

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BIOCELL 2022年第9期46卷 2053-2058页

作者： danila BOBKOV ANASTASIA POLYANSKAYA ANASTASIA MUSORINA GALINA POLJANSKAYA Collection of Vertebrate Cell Cultures Institute of CytologyRussian Academy of SciencesSt.Petersburg194064Russia Laboratory of Intracellular Signaling and Transport Smorodintsev Research Institute of InfluenzaSt.Petersburg197376Russia Research Laboratory of Translational Oncology Almazov National Research CentreSt.Petersburg197341Russia

All non-immortalized mesenchymal stem cells have a limited proliferative potential,that is,replicative senescence(RS)is an integral characteristic of the life of all mesenchymal stem cells(MSCs).It is known that one of the important signs of RS is a decrease of cell motility,and that violations of migration processes contribute to the deterioration of tissue ***,the characterization of the properties of the cell line associated with RS is a prerequisite for the effective use of MSCs in restorative *** of the key proteins regulating cell motility is the small GTPase *** main purpose of this work was to study the nuclear-cytoplasmic redistribution of the RhoA protein during RS in MSC lines recently obtained and characterized in our *** study found that a comparative analysis of the intracellular localization of RhoA in three cell lines(MSCWJ-1,FetMSC,DF2)showed a decrease in the nuclear localization of RhoA during RS.

关键词： Mesenchymal stem cells RhoA Actin cytoskeleton Replicative senescence

Histone deacetylase inhibitors for treatment of hepatocellular carcinoma

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Acta Pharmacologica Sinica 2005年第9期26卷 1025-1033页

作者： danila CORADINI Annalisa SPERANZA UO Tumor Biology and Experimental Therapy Department of Experimental Oncology Istituto Nazionale per lo Studio e la Cura dei Tumori 20133 Milan Italy UO Tumor Biology and Experimental Therapy Department of Experimental Oncology Istituto Nazionale per lo Studio e la Cura dei Tumori 20133 Milan Italy

Hepatocellular carcinoma(HCC)is one of the most common cancers in the *** resection has been considered the optimal treatment approach,but onlya small proportion of patients are suitable candidates for surgery,and the relapserate is *** to prevent recurrence,including chemoemboliza-tionbefore and adjuvant therapy after surgery,have proven to have a limited benefit;liver transplantation is successful in treating limited-stage HCC because only aminority of patients qualify for ***,new therapeutic strat-egies are urgently *** in addition to the classical genetic mecha-nisms of deletion or inactivating point mutations,epigenetic alterations,such ashyperacetylation of the chromatin-associated histones(responsible for genesilencing),are believed to be involved in the development and progression ofHCC,novel compounds endowed with a histone deacetylase(HDAC)inhibitoryactivity are an attractive therapeutic *** particular,pre-clinical resultsobtained using HA-But,an HDAC inhibitor in which butyric acid residues areesterified to a hyaluronic acid backbone and characterized by a high affinity forthe membrane receptor CD44,indicated that this class of compounds may repre-sent a promising approach for hepatocellular carcinoma treatment.

关键词： hepatocellular carcinoma histone deace-tylase inhibitors cancer therapy

Mechanism of the Initial Stage of Thermal Decomposition of Nitroguanidine

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火炸药学报 2023年第1期46卷 31-40页

作者： Boris E.Krisyuk danila A.Markin Timofey M.Sypko Viktor V.Zakharov Nikita V.Chukanov Boris L.Korsunskiy Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry Russian Academy of Sciences142432prosp.Academician Semenov1ChernogolovkaMoscow RegionRussia Plekhanov Russian University of Economics Department of Chemistry and Physics36 Stremyanny laneMoscow 117997Russia Lomonosov Moscow State University Faculty of Fundamental Physical and Chemical engineeringGSP-11 Leninskie Goryp.51Moscow 119991Russia N.N.Semenov Federal Research Center for Chemical Physics Russian Academy of Science 4 Kosygina StreetBuilding 1Moscow 119991Russia

A theoretical and experimental study of the thermal decomposition of nitroguanidine(NQ) has been carried out. Various thermolysis channels were studied by quantum chemistry methods at the CCSD(or DLPNO-CCSD) level using the aug-cc-pVDZ basis set. It is shown that the lowest activation enthalpies(170-180kJ/mol) are characteristic of the reactions of NO2abstraction from the initial NQ and the reaction channel with the transfer of oxygen from the nitro group to carbon in the limiting stage. Additionally, the thermolysis of NQ was studied experimentally in a nonisothermal mode with heating rates from 1 to 10K/min. In these experiments, the weight loss of the sample, thermal effects, and mass spectra of the products were recorded. An analysis of the experimental data confirmed the results of a theoretical study of the mechanism of thermal decomposition of NQ. The main thermolysis products are N2O, HNCO, NH3, and NO2, which fully corresponds to quantum chemical calculations.

关键词： primary thermolysis steps quantum-chemical calculation mass spectrometry DSC TG

The role of maintenance proteins in the preservation of epithelial cell identity during mammary gland remodeling and breast cancer initiation

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Chinese Journal of Cancer 2014年第2期33卷 51-67页

作者： danila Coradini Saro Oriana Department of Clinical and Community Health Sciences Medical Statistics Biometry and BioinformaticsUniversity of Milan20133 Italy Senology Center Casa di Cura Ambrosiana Istituto Sacra FamigliaCesano BosconeMilan Italy

During normal postnatal mammary gland development and adult remodeling related to the menstrual cycle, pregnancy, and lactation, ovarian hormones and peptide growth factors contribute to the delineation of a definite epithelial cell identity. This identity is maintained during cell replication in a heritable but DNAindependent manner. The preservation of cell identity is fundamental, especially when cells must undergo changes in response to intrinsic and extrinsic signals. The maintenance proteins, which are required for cell identity preservation, act epigenetically by regulating gene expression through DNA methylation, histone modification, and chromatin remodeling. Among the maintenance proteins, the Trithorax(TrxG) and Polycomb(PcG) group proteins are the best characterized. In this review, we summarize the structures and activities of the TrxG and PcG complexes and describe their pivotal roles in nuclear estrogen receptor activity. In addition, we provide evidence that perturbations in these epigenetic regulators are involved in disrupting epithelial cell identity, mammary gland remodeling, and breast cancer initiation.

关键词：上皮细胞乳腺癌蛋白质保存表观遗传学组蛋白修饰雌激素受体引发

3D imaging lipidometry in single cell by in-flow holographic tomography

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Opto-Electronic Advances 2023年第1期6卷 10-25页

作者： Daniele Pirone Daniele Sirico Lisa Miccio Vittorio Bianco Martina Mugnano danila del Giudice Gianandrea Pasquinelli Sabrina Valente Silvia Lemma Luisa Iommarini Ivana Kurelac Pasquale Memmolo Pietro Ferraro CNR-ISASI Institute of Applied Sciences and Intelligent Systems“E.Caianiello”Via Campi Flegrei 34PozzuoliNapoli 80078Italy Department of Electrical Engineering and Information Technologies University of Naples“FedericoⅡ”via Claudio 21Napoli 80125Italy Department of Chemical Materials and Production Engineering of the University of Naples FedericoⅡPiazzale Tecchio 80Napoli 80125Italy Department of Mathematics and Physics University of Campania“Luigi Vanvitelli”Caserta 81100Italy Biotechnology and Methods in Laboratory Medicine Department of ExperimentalDiagnostic and Specialty Medicine(DIMES)University of BolognaBologna 40126Italy Subcellular Nephro-Vascular Diagnostic Program Pathology Unit S.Orsola IRCCSUniversity of BolognaBologna 40126Italy Unit of Medical Genetics Department of Medical and Surgical Sciences(DIMEC)University of BolognaVia Massarenti 9Bologna 40138Italy Study and Research Center on Gynecological Neoplasias Department of Medical and Surgical Sciences(DIMEC)University of BolognaVia Massarenti 9Bologna 40138Italy Center for Applied Biomedical Research(CRBA) University of BolognaBologna 40138Italy Department of Pharmacy and Biotechnology(FABIT) University of BolognaBologna 40126Italy

The most recent discoveries in the biochemical field are highlighting the increasingly important role of lipid droplets(LDs)in several regulatory mechanisms in living *** are dynamic organelles and therefore their complete characterization in terms of number,size,spatial positioning and relative distribution in the cell volume can shed light on the roles played by *** now,fluorescence microscopy and transmission electron microscopy are assessed as the gold standard methods for identifying LDs due to their high sensitivity and ***,such methods generally only provide 2D assays and partial ***,both can be destructive and with low productivity,thus limiting analysis of large cell numbers in a *** we demonstrate for the first time the capability of 3D visualization and the full LD characterization in high-throughput with a tomographic phase-contrast flow-cytometer,by using ovarian cancer cells and monocyte cell lines as models.A strategy for retrieving significant parameters on spatial correlations and LD 3D positioning inside each cell volume is *** information gathered by this new method could allow more in depth understanding and lead to new discoveries on how LDs are correlated to cellular functions.

关键词： lipid droplets label-free phase-contrast imaging in-flow tomography 3D imaging

Towards a new paradigm of microscopic colitis: Incomplete and variant forms

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World Journal of Gastroenterology 2016年第38期22卷 8459-8471页

作者： danila Guagnozzi Stefania Landolfi Maria Vicario Department of Gastroenterology Hospital Universitario Vall d’Hebron08035 BarcelonaSpain Department of Pathology Hospital Universitario Vall d’Hebron08035 BarcelonaSpain Translational Mucosal Immunology Lab Digestive Diseases Research UnitVall d’Hebron Institut de RecercaDepartment of Gastroenterology.Hospital Universitario Vall d’HebronUniversitat Autónoma de Barcelona08035 BarcelonaSpain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas(CIBERehd) 08035 BarcelonaSpain

Microscopic colitis(MC) is a chronic inflammatory bowel disease that has emerged in the last three decades as a leading cause of chronic watery diarrhoea. MC classically includes two main subtypes: lymphocytic colitis(LC) and collagenous colitis(CC). Other types of histopathological changes in the colonic mucosa have been described in patients with chronic diarrhoea, without fulfilling the conventional histopathological criteria for MC diagnosis. Whereas those unclassified alterations remained orphan for a long time, the use of the term incomplete MC(MCi) is nowadays universally accepted. However, it is still unresolved whether CC, LC and MCi should be considered as one clinical entity or if they represent three related conditions. In contrast to classical MC, the real epidemiological impact of MCi remains unknown, because only few epidemiological studies and case reports have been described. MCi presents clinical characteristics indistinguishable from complete MC with a good response to budesonide and cholestiramine. Although a number of medical treatments have been assayed in MC patients, currently, there is no causal treatment approach for MC and MCi, and only empirical strategies have been performed. Further studies are needed in order to identify their etiopathogenic mechanisms, and to better classify and treat MC.

关键词： Microscopic colitis Incomplete microscopic colitis Collagenous colitis Lymphocytic colitis

Pronormality and Submaximal X-Subgroups on Finite Groups Dedicated to celebrate the Sixtieth anniversary of USTC

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Communications in Mathematics and Statistics 2018年第3期6卷 289-317页

作者： Wenbin Guo danila O.Revin School of Mathematical Sciences University of Science and Technology of ChinaHefei 230026People’s Republic of China Sobolev Institute of Mathematics SB RAS NovosibirskRussia Novosibirsk State University NovosibirskRussia 630090

According to Hall,a subgroup H of a group G is said to be pronormal if H and H^(g) are conjugate infor every g∈*** this survey,we discuss the role of pronormality for some subgroups of finite groups:Hall subgroups,su... 详细信息

关键词： Pronormal subgroup Hallπ-subgroup Submaximal X-subgroup Subgroup of odd index

Vulnerability to Earthquake Hazard:Bucharest Case Study,Romania

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International Journal of Disaster Risk Science 2017年第2期8卷 182-195页

作者： Iuliana Armas Dragos Toma-danila Radu Ionescu Alexandru Gavris Department of Geomorphology-Pedology-Geomatics Faculty of GeographyUniversity of Bucharest National Institute for Earth Physics Department of Tourism and Geography Bucharest University of Economic Studies

Recent seismic events show that urban areas are increasingly vulnerable to seismic damage,which leads to unprecedented levels of *** are complex systems and as such their analysis requires a good understanding of the interactions between space and the socioeconomic variables characteristic of the inhabitants of urban *** is a clear need to develop and test detailed models that describe the behavior of these interactions under seismic *** article develops an overall vulnerability index to seismic hazard based on a spatial approach applied to Bucharest,Romania,the most earthquake-prone capital in the European *** methodology relies on:(1) spatial post-processed socioeconomic data from the2011 Romanian census through multicriteria analysis;and(2) analytical methods(the Improved Displacement Coefficient Method and custom-defined vulnerability functions)for estimating damage patterns,incorporated in a GIS *** computed vulnerability indices for the128 census tracts of the *** sensitivity assessment tested the robustness of spatially identified patterns of building vulnerability in the face of uncertainty in model *** results show that useful seismic vulnerability indices can be obtained through interdisciplinaryapproaches that enhance less detailed datasets,which leads lead to better targeted mitigation efforts.

关键词： Bucharest Romania Seismic loss estimation Seismic risk Spatial multicriteria analysis Vulnerability index