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Toward optical coherence tomography on a chip: in vivo three-dimensional human retinal imaging using photonic integrated circuit-based arrayed waveguide gratings

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Light(Science & Applications) 2021年第1期10卷 71-85页

作者： Elisabet A.Rank Ryan Sentosa danielle j.harper Matthias Salas Anna Gaugutz Dana Seyringer Stefan Nevlacsil Alejandro Maese-Novo Moritz Eggeling Paul Muellner Rainer Hainberger Martin Sagmeister jochen Kraft Rainer ALeitgeb Wolfgang Drexler Center for Medical Physics and Biomedical Engineering Medical University of ViennaWaehringer Guertel 18-20/4 L1090 ViennaAustria Research Centre for Microtechnology Vorarlberg University of Applied SciencesHochschulstrasse 16850 DornbirnAustria AIT Austrian Institute of Technology GmbH Gieffinggasse 41210 ViennaAustria ams AG Tobelbader Strasse 308141 PremstaettenAustria

In this work,we present a significant step toward in vivo ophthalmic optical coherence tomography and angiography on a photonic integrated *** diffraction gratings used in spectral-domain optical coherence tomography can be replaced by photonic integrated circuits comprising an arrayed waveguide *** arrayed waveguide grating designs with 256 channels were tested,which enabled the first chip-based optical coherence tomography and angiography in vivo three-dimensional human retinal *** 1 supports a bandwidth of 22nm,with which a sensitivity of up to 91 dB(830μW) and an axial resolution of 10.7 pm was *** 2 supports a bandwidth of 48 nm,with which a sensitivity of 90 dB(480μW) and an axial resolution of 6.5μm was *** silicon nitride-based integrated optical waveguides were fabricated with a fully CMOS-compatible process,which allows their monolithic co-integration on top of an optoelectronic silicon *** a benchmark for chip-based optical coherence tomography,tomograms generated by a commercially available clinical spectral-domain optical coherence tomography system were compared to those acquired with on-chip *** similarities in the tomograms demonstrate the significant clinical potential for further integration of optical coherence tomography on a chip system.

关键词： waveguide arrayed optical

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Four buildings and a flush:Lessons from degraded water quality and recommendations on building water management

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Environmental Science and Ecotechnology 2024年第2期18卷 104-113页

作者： Kyungyeon Ra Caitlin Proctor Christian Ley danielle Angert Yoorae Noh Tolulope Odimayomi Andrew j.Whelton Lyles School of Civil Engineering Purdue University550 Stadium Mall DriveWest LafayetteIN47907USA Agricultural and Biological Engineering Division of Environmental and Ecological EngineeringPurdue UniversityWest LafayetteIN47907USA Division of Environmental and Ecological Engineering Purdue UniversityWest LafayetteIN47907USA Civil and Environmental Engineering University of Colorado1111 Engineering DriveBoulderCO80309USA Civil Architectural and Environmental EngineeringUniversity of Texas301E E Dean Keeton StreetAustinTX78712USA Civil and Environmental Engineering Virginia Tech750 Drillfield DriveBlacksburgVA24061USA Lyles School of Civil Engineering Division of Environmental and Ecological EngineeringPurdue University550 Stadium Mall DriveWest LafayetteIN47907USA

A reduction in building occupancy can lead to stagnant water in plumbing,and the potential consequences for water quality have gained increasing *** investigate this,a study was conducted during the COVID-19 pandemic,focusing on water quality in four institutional *** of these buildings were old(>58 years)and large(>19,000 m2),while the other two were new(>13 years)and small(<11,000 m2).The study revealed significant decreases in water usage in the small buildings,whereas usage remained unchanged in the large *** analysis found that residual chlorine was rarely detectable in cold/drinking water ***,the pH,dissolved oxygen,total organic carbon,and total cell count levels in the first draw of cold water samples were similar across all ***,the ranges of heavy metal concentrations in large buildings were greater than observed in small ***(Cu),lead(Pb),and manganese(Mn)sporadically exceeded drinking water limits at cold water fixtures,with maximum concentrations of 2.7 mg Cu L^(-1),45.4 mg Pb L^(-1),1.9 mg Mn L^(-1).Flushing the plumbing for 5 min resulted in detectable residual at fixtures in three buildings,but even after 125 min of flushing in largest and oldest building,no residual chlorine was detected at the fixture closest to the building's point of *** the pandemic,the building owner conducted fixture flushing,where one to a few fixtures were operated per visit in buildings with hundreds of fixtures and multiple ***,further research is needed to understand the fundamental processes that control faucet water quality from the service line to the *** the absence of this knowledge,building owners should create and use as-built drawings to develop flushing plans and conduct periodic water testing.

关键词： COVID-19 pandemic Stagnation Drinking water quality Flushing

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Weight regain after intragastric balloon for pre-surgical weight loss

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World journal of Gastrointestinal Surgery 2024年第7期16卷 2040-2046页

作者： danielle Abbitt Kevin Choy Alexandra Kovar Teresa S jones Krzysztof j Wikiel Edward L jones Department of Surgery University of ColoradoAuroraCO 80045United States Department of Surgery Rocky Mountain Regional Veteran Affairs Medical CenterAuroraCO 80045United States

BACKGROUND Over one-third of Americans carry the diagnosis of obesity,many also with obesity-related *** can place patients at increased risk of operative and postoperative *** intragastric balloon has been shown to aid in minor weight loss,however its weight recidivism in patients requiring short interval weight loss has not been well *** To evaluate weight loss,ability to undergo successful elective surgery after intragastric balloon placement,and weight management after balloon *** This study is a retrospective review of patients in a single academic institution undergoing intragastric balloon placement from 2019-2023 to aid in weight loss prior to undergoing elective *** outcomes including weight loss,duration of balloon placement,successful elective surgery,weight regain postballoon and post-procedure complications were *** criteria included those with balloon in place at time of *** Thirty-three patients completed intragastric balloon therapy from 2019-2023 as a bridge to elective *** patients were required to participate in a 12-month weight management program to be eligible for balloon *** surgeries included incisional hernia repair,umbilical hernia repair,inguinal hernia repair,and knee and hip *** average age at placement was 53 years±11 years,majority(91%)were *** average duration of intragastric balloon therapy was 186 days±41 *** average weight loss was 14.0 kg±7.4 kg and with an average percent excess body weight loss of 30.0%(7.9%-73.6%).Over half of the patients(52.0%)achieved the goal of 30-50 lbs(14-22 kg)weight ***-one patients(64%)underwent their intended elective surgery,2 patients(6%)deferred surgery due to symptom relief with weight loss ***-one of the patients(64%)have documented weights in 3 months after balloon removal,in these patients the majority(76%)gained weight after balloon *** pat

关键词： Intragastric balloon Weight loss Obesity Bariatric Body mass index

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Drought can offset potential water use efficiency of forest ecosystems from rising atmospheric CO2

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journal of Environmental Sciences 2020年第4期32卷 262-274页

作者： Ning Liu jatin Kala Shirong Liu Vanessa Haverd Bernard Dell Keith R.j.Smettem Richard j.harper Environmental and Conservation Sciences Murdoch UniversityMurdochWA 6150 Australia Research Institute of Forest Ecology Environment and ProtectionChinese Academy of ForestryBeijing 10091 China CSIRO Oceans&Atmosphere ACT 2600 Australia

Increasing atmospheric CO2 is both leading to climate change and providing a potential fertilisation effect on plant ***,southern Australia has also experienced a significant decline in rainfall over the last 30 years,resulting in increased vegetative water *** better understand the dynamics and responses of Australian forest ecosystems to drought and elevated CO2,the magnitude and trend in water use efficiency(WUE)of forests,and their response to drought and elevated CO2 from 1982 to 2014 were analysed,using the best available model estimates constrained by observed fluxes from simulations with fixed and time-varying *** ratio of gross primary productivity(GPP)to evapotranspiration(ET)(WUEe)was used to identify the ecosystem scale WUE,while the ratio of GPP to transpiration(Tr)(WUEc)was used as a measure of canopy scale *** increased significantly in northern Australia(p<0.001)for woody savannas(WSA),whereas there was a slight decline in the WUE of evergreen broadleaf forests(EBF)in the southeast and southwest of *** lag of WUEc to drought was consistent and relatively short and stable between biomes(<3 months),but notably varied for WUEe,with a long time-lag(mean of 10 months).The dissimilar responses of WUEe and WUEc to climate change for different geographical areas result from the different proportion of Tr in ***2 fertilization and a wetter climate enhanced WUE in northern Australia,whereas drought offset the CO2 fertilization effect in southern Australia.

关键词： Water use efficiency Elevated CO2 Carbon sequestration,drought Forest Australia

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Desialylated Platelet Clearance in the Liver is a Novel Mechanism of Systemic Immunosuppression

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Research 2024年第3期2023卷 35-50页

作者： june Li danielle Karakas Feng Xue Yingyu Chen Guangheng Zhu Yeni H.Yucel Sonya A.MacParland Haibo Zhang john W.Semple john Freedman Qizhen Shi Heyu Ni Department of Laboratory Medicine and Pathobiology University of TorontoTorontoONCanada Toronto Platelet Immunobiology Group TorontoONCanada Keenan Research Centre for Biomedical Science of St.Michael's Hospital TorontoONCanada Canadian Blood Services Centre for Innovation TorontoONCanada Departments of Pediatrics Medical College of WisconsinMilwaukeeWIUSA Blood Research Institute Versiti WisconsinMilwaukeeWIUSA Departments of Ophthalmology and Vision Sciences Medicine University of TorontoTorontoONCanada Faculty of Engineering and Architectural Science Ryerson UniversityTorontoONCanada Multi-Organ Transplant Program Toronto General Hospital Research InstituteTorontoONCanada Department of Immunology University of TorontoTorontoONCanada Critical Care Medicine Department ofAnesthesiology and PainUniversity of TorontoTorontoONCanada Department of Physiology University of TorontoTorontoONCanada Department of Pharmacology University of TorontoTorontoONCanada. Division of Hematology and Transfusion Medicine Lund UniversityLundSweden clinical Immunology and Transfusion Medicine Ofice of Medical ServicesRegion SkaneLundSweden Department of Medicine University of TorontoTorontoONCanada Children's Research Institute Children's WisconsinWauwatosaWIUSA Midwest Athletes Against Childhood Cancer Fund Research Center MilwaukeeWIUSA.

Platelets are small, versatile blood cells that are critical for hemostasis/thrombosis. Local platelet accumulation is a known contributor to proinflammation in various disease states. However, the anti-inflammatory/immunosuppressive potential of platelets has been poorly explored. Here, we uncovered, unexpectedly, desialylated platelets (dPLTs) down-regulated immune responses against both platelet-associated and -independent antigen challenges. Utilizing multispectral photoacoustic tomography, we tracked dPLT trafficking to gut vasculature and an exclusive Kupffer cell-mediated dPLT clearance in the liver, a process that we identified to be synergistically dependent on platelet glycoprotein Ibα and hepatic Ashwell–Morell receptor. Mechanistically, Kupffer cell clearance of dPLT potentiated a systemic immunosuppressive state with increased anti-inflammatory cytokines and circulating CD4+ regulatory T cells, abolishable by Kupffer cell depletion. Last, in a clinically relevant model of hemophilia A, presensitization with dPLT attenuated anti-factor VIII antibody production after factor VIII ( infusion. As platelet desialylation commonly occurs in daily-aged and activated platelets, these findings open new avenues toward understanding immune homeostasis and potentiate the therapeutic potential of dPLT and engineered dPLT transfusions in controlling autoimmune and alloimmune diseases.

关键词： Platelet transfusion homeostasis

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The role of ginseng as an anti-asthmatic agent

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Acupuncture and Herbal Medicine 2024年第3期4卷 358-366页

作者： Kailynn j.Yang Liana Y.A.Bautista danielle G.Iben Dana H.Tran Loyola University of Chicago Stritch School of Medicine MaywoodILUSA

Introduction Asthma is an inflammatory obstructive respiratory lung disease characterized by limited *** is estimated that more than 300 million people worldwide are affected by asthma,and this number is expected to increase over the next few years[1].Uncontrolled asthma is associated with a severely impaired quality of life and increased mortality rates[2].Other adverse effects of poorly controlled asthma include obesity,pneumonia.

关键词： asthma impaired mortality

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Ecological factors influencing the beneficial endosymbionts of the hemlock woolly adelgid (Hemiptera:Adelgidae)

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Insect Science 2019年第1期26卷 97-107页

作者： Angela M.Mech Sherilyn j.harper Nathan P.Havill Carol D.von Dohlen Gaelen R.Burke Department of Entomology University of GeorgiaAthensGeorgiaUSA School of Environmental and Forest Sciences University of WashingtonSeattleWashingtonUSA USDA Forest Service Northern Research StationHamdenConnecticutUSA Department of Biology Utah State UniversityLoganUtahUSA

Bacterial endosymbionts of sap-sucking insects provide their host with a num- ber of beneficial qualities,including the supply of nutrition,defense against parasitoids, and protection from heat *** to these bacterial associates can therefore have a negative impact on the fitness of their insect *** evaluated observational and experi- mental factors regarding the normative hemlock woolly adelgid (Adelges tsugae Annand) (Hemiptera:Adelgidae)to help understand the roles of its three recently identified symbionts,including under heat stress *** prevalence of ***'s facultafive symbiont (Serratia symbiotica)was examined at different spatial scales to determine how variable infection rates are for this *** was no significant difference found in infection rates between adelgids on a tree,within a plot,or within a ***, significantly more adelgids in Georgia (95%)had *** compared to those in New York (68%).Microsatellite genotyping of the adelgids found that this difference was most likely not the result of a second introduction *** into eastern North *** *** proportions between first and fourth instars showed that symbiont absence did not affect the ability *** to survive *** of sym- biont densities within each adelgid found that when *** was absent,the density of obligate symbionts was significantly *** to heat stress (32.5℃)was not consistently correlated with changes in symbiont densities over a 4-d ***,we have shown that symbiont prevalence and densities vary within the broad population of *** in eastern North America,with potentially significant effects upon the ecology of this important pest.

关键词： Adelges tsugae Anncindia adelgestsuga bacterial endosymbionts Serratia symbiotica Pseudomonas adelgestsugas

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SARS-CoV-2 RBD and Its Variants Can Induce Platelet Activation and Clearance:Implications for Antibody Therapy and Vaccinations against COVID-19

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Research 2024年第3期2023卷 1-15页

作者： Xiaoying Ma jady Liang Guangheng Zhu Preeti Bhoria Aron A.Shoara Daniel T.MacKeigan Christopher j.Khoury Sladjana Slavkovicl Lisha Lin danielle Karakas Ziyan Chen Viktor Prifti Zhenze Liu Chuanbin Shen Yuchong Li Cheng Zhang jiayu Dou Zack Rousseau jiamin Zhang Tiffany Ni Xi Lei Pingguo Chen Xiaoyu Wu Hamed Shaykhalishahi Samira Mubareka Kim AConnelly Haibo Zhang Ori Rotstein Heyu Ni Department of Laboratory Medicine and Pathobiology University of TorontoTorontoONCanada Department of Laboratory Medicine Keenan Research Centre for Biomedical Science of St.Michael’s HospitalTorontoONCanada Toronto Platelet Immunobiology Group TorontoONCanada Department of Physiology University of TorontoTorontoONCanada CCOA Therapeutics Inc. TorontoONCanada Canadian Blood Services Centre for Innovation TorontoONCanada The State Key Laboratory of Respiratory Disease Guangzhou Institute of Respiratory DiseaseThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdongChina Department of Laboratory Medicine The Second Affliated Hospital of Guangzhou University of Chinese MedicineGuangzhouChina Advanced Pharmaceutics&Drug Delivery Laboratory Leslie Dan Faculty of PharmacyUniversity of TorontoTorontoONCanada Department of Medical Microbiology and Infectious Disease Sunnybrook Health Science CentreToronto ONCanada Department of Medicine University of TorontoTorontoONCanada Division of Cardiology.St.Michael's Hospital TorontoONCanada Department of Anesthesiology and Pain Medicine and Division of Critical Care Medicine University of TorontoTorontoONCanada interdepartmental Division of Critical Care Medicine University of TorontoTorontoONCanada Department of Surgery University of Toronto TorontoONCanada.

The COVID-19 pandemic caused by SARS-CoV-2 virus is an ongoing global health *** cases of COVID-19 and the rare cases of COVID-19 vaccine-induced-thrombotic-thrombocytopenia(VITT)are both associated with thrombosis and thrombocytopenia;however,the underlying mechanisms remain inadequately *** infection and vaccination utilize the spike protein receptor-binding domain(RBD)of *** found that intravenous injection of recombinant RBD caused significant platelet clearance in *** investigation revealed the RBD could bind platelets,cause platelet activation,and potentiate platelet aggregation,which was exacerbated in the Delta and Kappa *** RBD–platelet interaction was partially dependent on theβ3 integrin as binding was significantly reduced inβ3−/−***,RBD binding to human and mouse platelets was significantly reduced with relatedαIIbβ3 antagonists and mutation of the RGD(arginine-glycine-aspartate)integrin binding motif to RGE(arginine-glycine-glutamate).We developed anti-RBD polyclonal and several monoclonal antibodies(mAbs)and identified 4F2 and 4H12 for their potent dual inhibition of RBD-induced platelet activation,aggregation,and clearance in vivo,and SARS-CoV-2 infection and replication in Vero E6 *** data show that the RBD can bind platelets partially thoughαIIbβ3 and induce platelet activation and clearance,which may contribute to thrombosis and thrombocytopenia observed in COVID-19 and *** newly developed mAbs 4F2 and 4H12 have potential not only for diagnosis of SARS-CoV-2 virus antigen but also importantly for therapy against COVID-19.

关键词： Antibody diagnosis vaccine

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Environmental determinants of social wasp diversity and assemblage structure in an Amazonian archipelagic landscape

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Zoological Research(Diversity and Conservation) 2024年第2期1卷 121-129页

作者： jose Victor Alves Ferreira Alexandre Somavilla Maíra Benchimol Ana Filipa Palmeirim Carlos A.Peres danielle Storck-Tonon Laboratório de Ecologia Aplicada àConservação Universidade Estadual de Santa CruzIlhéus 45662-900Brazil Instituto Nacional de Pesquisas da Amazônia Coordenação de BiodiversidadeManaus 69067-001Brazil CIBIO Centro de Investigação em Biodiversidade e Recursos GenéticosInBIO Laboratório AssociadoCampus de VairãoUniversidade do PortoVairão 4485-661Portugal BIOPOLIS Program in Genomics Biodiversity and Land PlanningCIBIOCampus de VairãoVairão 4485-661Portugal School of Environmental Sciences University of East AngliaNorwich NR47TJUK Instituto juruá Manaus69057-060Brazil Programa de Pós-Graduação em Ambiente e Sistemas de Produção Agrícola(PPGASP) Universidade do Estado de Mato GrossoTangaráda Serra 78300-970Brazil

Hydropower development has become an important driver of habitat loss and fragmentation across lowland tropical *** ample evidence on the detrimental effects of insular habitat fragmentation on biodiversity,invertebrate taxa,that may be critical to ecosystem functioning,have been *** assessed the assemblage-level responses of social wasps to forest insularization induced by the Balbina Hydroelectric Dam in Central Brazilian *** Malaise trapping,we captured wasps on 27 forest islands and three continuous *** constructed Generalized Linear Models and employed a model selection approach to examine the impact of local variables(fire severity(FIRE)and basal area of pioneer tree species(PIONEER))and landscape-scale variables(amount of habitat(COVER))on patterns of species richness,composition,and body size of wasps.A total of 374 individuals(29 species)were collected across all sampling *** was the main predictor of species richness,while PIONEER was the only variable that explained variation in community composition,with a negative effect on body *** results add evidence to the pervasive impacts of large hydroelectric dams on tropical forest biodiversity,and suggest that social wasps,among other invertebrates,can be used as bioindicators in infrastructure development projects.

关键词： Habitat amount hypothesis Habitat fragmentation Habitat loss Hydroelectric dams Invertebrates

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Biodiversity responses to insular fragmentation in Amazonia: Two decades of research in the Balbina Hydroelectric Reservoir

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Zoological Research(Diversity and Conservation) 2024年第2期1卷 106-116页

作者： Ana Filipa Palmeirim Maíra Benchimol danielle Storck-Tonon Anderson S.Bueno Isabel L.jones Gilmar Klein Carlos A.Peres CIBIO Research Centre of Biodiversity and Genetic ResourcesInBIO Associated LabVairão CampusUniversity of PortoVairão 4485-661Portugal BIOPOLIS Program in Genomics Biodiversity and Land PlanningCIBIOVairão CampusUniversity of PortoVairão 4485-661Portugal Laboratório de Ecologia AplicadaàConservação Universidade Estadual de Santa CruzIlhéusBahia 45662-900Brazil Programa de Pós-Graduação em Ambiente e Sistemas de Produção Agrícola(PPGASP) Universidade do Estado de Mato GrossoTangaráda SerraMato Grosso 78301-532Brazil Instituto Federal de Educação Ciência e Tecnologia FarroupilhaJúlio de CastilhosRio Grande do Sul 98130-000Brazil Biological and Environmental Sciences University of StirlingStirling FK94LAUK REBIO Uatumã/ICMBio Presidente FigueiredoAmazonas 69736-000Brazil Centre for Ecology Evolution and ConservationSchool of Environmental SciencesUniversity of East AngliaNorwich NR47TJUK juruáInstitute ManausAmazonas 69057-060Brazil

As hydropower development expands across lowland tropical forests,flooding and concomitant insular fragmentation have become important threats to *** created insular landscapes serve as natural laboratories to investigate biodiversity responses to *** of these most iconic landscapes is the Balbina Hydroelectric Reservoir in Brazilian Amazonia,occupying>400000 ha and comprising>3500 forest ***,we synthesise the current knowledge on responses of a wide range of biological groups to insular fragmentation at *** has largely concentrated on a set of 22 islands and three mainland *** total,39 studies were conducted over nearly two decades,covering 17 vertebrate,invertebrate,and plant *** species responses varied according to taxonomic group,island area was consistently included and played a pivotal role in 66.7%of all studies examining patterns of species *** persistence was further affected by species traits,mostly related to species capacity to use/traverse the aquatic matrix or tolerate habitat degradation,as noted for species of vertebrates and orchid *** research is needed to improve our understanding of such effects on wider ecosystem *** Impact Assessments must account for changes in both the remaining habitat amount and configuration,and subsequent long-term species losses.

关键词： Habitat loss Hydropower dams Landbridge Local extinctions Species-area relationships Species diversity Tropical forests

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