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Influence of Pre-strain on the Mechanical Properties of A6111-T4P Sheet with Bake Hardening

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Acta Metallurgica Sinica(English Letters) 2015年第6期28卷 678-683页

作者： Shan-Shan Li Jie-Shi Chen Jun Chen Cedric Xia danielle Zeng Institute of Forming Technology and Equipment School of Materials Science and Engineering Shanghai Jiao Tong University Research and Innovation Center Ford Motor Company

A6111 is an aluminum alloy, which exhibits good formability and excellent bake hardening property. This study aimed to reveal the influence of strain path, pre-strain orientation （c0 as well as pre-strain level on the mechanical properties of A6111-T4P sheet under bake treatment through uniaxial tension test. （0-5）% pre-strain, 150-170 ℃ bake temperature and 20-30 min bake time were considered in the study by referring to the actual production process. The results show that both pre-strain level and strain path play significant roles in improving the material properties. In the condition that tensile orientation （β） parallel with pre-strain orientation （β= a）, the yield strength can be remarkably improved, and much higher parameter of n in Hockett-Sherby model can be obtained than those when tensile orientation non-parallel with pre-strain orientation （a≠ β）. In addition, when the pre-strain level, paint bake process were settled and β = a, the curves obtained in five tension orientations are similar in the plastic deformation stage.

关键词： Aluminum alloy Pre-strain Bake hardening Mechanical properties

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The associations between Parkinson’s disease and cancer: the plot thickens

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Translational Neurodegeneration 2015年第1期4卷 160-173页

作者： danielle D.Feng Waijiao Cai Xiqun Chen MassGeneral Institute for Neurodegenerative Disease Department of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA Department of Epidemiology Harvard T.H.Chan School of Public HealthBostonMAUSA Key Laboratory of Cellular and Molecular Biology Huashan HospitalFudan UniversityShanghai 200040China

Epidemiological studies support a general inverse association between the risk of cancer development and Parkinson’s disease(PD).In recent years however,increasing amount of eclectic evidence points to a positive association between PD and cancers through different temporal analyses and ethnic *** positive association has been supported by several common genetic mutations in SNCA,PARK2,PARK8,ATM,p53,PTEN,and MC1R resulting in cellular changes such as mitochondrial dysfunction,aberrant protein aggregation,and cell cycle ***,we review the epidemiological and biological advances of the past decade in the association between PD and cancers to offer insight on the recent and sometimes contradictory findings.

关键词： cancer PARK thick

Implication of platelet-derived growth factor receptor alpha in prostate cancer skeletal metastasis

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Chinese Journal of Cancer 2011年第9期30卷 612-619页

作者： Qingxin Liu danielle Jernigan Yun Zhang Alessandro Fatatis Department of Pharmacology and Physiology Drexel University College of Medicine Philadelphia PA 19102 USA. Department of Pathology and Laboratory Medicine Drexel University College of Medicine Philadelphia PA 19102 USA.

Metastasis represents by far the most feared complication of prostate carcinoma and is the main cause of death for *** skeleton is frequently targeted by disseminated cancer cells and represents the sole site of spread in more than 80% of prostate cancer *** between select malignant phenotypes and the microenvironment of colonized tissues is broadly recognized as the culprit for the organ-tropism of cancer ***,we review our recent studies showing that the expression of platelet-derived growth factor receptor alpha(PDGFR a) supports the survival and growth of prostate cancer cells in the skeleton and that the soluble fraction of bone marrow activates PDGFR a in a ligand-independent ***,we offer pre-clinical evidence that this receptor is a viable target for therapy.

关键词：前列腺癌细胞生长因子受体血小板衍生并发症兼容性微环境殖民化

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通往大脑的旅程

世界科学 2024年第6期 19-21页

作者：莫庄非丹妮尔·格哈德威尔康奈尔医学院

借助定向演化的力量，科学家距离开发能穿越人类血脑屏障以提供基因治疗的病毒载体又近了一步。血脑屏障（BBB）是调控物质进出大脑的细胞堡垒。它确保大脑能够获取关键营养物质，同时保护其免受病原体和毒素侵害。另一方面，血脑屏障...

借助定向演化的力量，科学家距离开发能穿越人类血脑屏障以提供基因治疗的病毒载体又近了一步。血脑屏障（BBB）是调控物质进出大脑的细胞堡垒。它确保大脑能够获取关键营养物质，同时保护其免受病原体和毒素侵害。另一方面，血脑屏障却也阻碍了许多有潜力的治疗方法。不过眼下，基因递送载体系统升级换代，有望很快带来高效疗法。科学家正在研究脂质纳米颗粒和其他递送载体，但腺相关病毒（AAV）载体因其靶向能力超强，能在非分裂细胞内持久表达而对人类无致病性，仍是较好的体内基因治疗递送平台。

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Is direct acting antiviral therapy for hepatitis c viral infectionassociated with increased risk of hepatocellular carcinoma before or after liver transplantation?

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Hepatobiliary Surgery and Nutrition 2019年第5期8卷 563-565页

作者： Ashokkumar Jain danielle Miller Zakiyah Kadry Department of Surgery Division of TransplantThe Pennsylvania State UniversityCollege of MedicineHersheyPA 17033USA

Direct acting antiviral(DAA)therapy revolutionized thecurative therapy for>90%of hepatitis C virus(HCV)infected ***,in late 2016,concerns wereraised by several European centers that DAA therapy maybe increasing the in... 详细信息

关键词： hepatocellular hepatitis curative

Zwitterionic peptides:Tunable next-generation stealth nanoparticle modifications

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Bioactive Materials 2023年第9期27卷 113-124页

作者： Clyde Overby Soomin Park Austin Summers danielle S.W.Benoit Department of Biomedical Engineering University of Rochester RochesterNYUSA Center for Musculoskeletal Research University of RochesterRochesterNYUSA Department of Biology University of Rochester RochesterNYUSA Department of Biology Duquesne UniversityPAUSA Department of Chemical Engineering University of RochesterRochesterNYUSA Materials Science Program University of RochesterRochesterNYUSA Knight Campus for Accelerating Scientific Impact Department of BioengineeringUniversity of OregonEugeneORUSA

Adsorption of proteins to nanoparticles(NPs),a complex process that results in a protein corona,is controlled by NP surface properties that define NP interactions in *** to control adsorbed protein quantity through surface modification have led to improvements in circulation time or ***,current approaches have yet to be identified to control adsorbed protein identities within the ***,we report the development and characterization of diverse zwitterionic peptides(ZIPs)for NP anti-fouling surface functionalization with specific and controllable affinity for protein adsorption profiles defined by ZIP *** serum exposure of ZIP-conjugated NPs and proteomics analysis of the resulting corona,we determined that protein adsorption profiles depend not on the exact composition of the ZIPs but on the sequence and order of charges along the sequence(charge motif).These findings pave the way for developing tunable ZIPs to orchestrate specific ZIP-NP protein adsorption profiles as a function of ZIP charge motif to better control cell and tissue specificity and pharmacokinetics and provide new tools for investigating relationships between protein corona and biological ***,overall ZIP diversity enabled by the diversity of amino acids may ameliorate adaptive immune responses.

关键词： Nanoparticles Protein corona Surface functionalization Peptide design Cellular uptake

Non-spherical multi-oscillations of a bubble in a compressible liquid

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Journal of Hydrodynamics 2014年第6期26卷 848-855页

作者： WANG Qian-xi YANG Yuan-xiang TAN danielle SU Jian TAN Soon Keat School of Mathematics University of Birmingham Maritime Research Centre School of Civil and Environmental Engineering Nanyang Technological University Sweimann Department of Mechanical Engineering National University of Singapore Nuclear Engineering Program COPPE Universidade Federal do Rio de Janeiro Nanyang Environment and Water Research Institute Nanyang Technological University

Bubble dynamics are associated with wide and important applications in cavitation erosion in many industrial systems, medical ultrasonics and underwater explosions. Two recent developments to this classical problem are reviewed in this paper. Firstly, computational studies on the problem have commonly been based on an incompressible fluid model. However, a bubble usually undergoes significantly damped oscillation due to the compressible effects. We model this phenomenon using weakly compressible theory and a modified boundary integral method. This model considers the energy loss due to shock waves emitted at minimum bubble volumes. Secondly, the computational studies so far have largely been concerned with the first-cycle of oscillation. However, a bubble usually oscillates for a few cycles before it breaks into much smaller ones. We model both the first- and second-cycles of oscillationand predict damped oscillations. Our computations correlate well with the experimental data.

关键词： compressible bubble dynamics weakly compressible theory boundary integral method

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China’s Pursuit of Soft Power with Southeast Asia

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China’s Pursuit of Soft Power with Southeast Asia

作者： danielle Tiffany Ebeling 华东师范大学

学位级别：硕士

中国软实力一直是中国内外讨论的话题。自2000年末这个术语开始在中国使用以后,引起了很多国际关注。本文将探讨一个容易被忽视的领域-中国在东南亚的软实力影响。本文将质疑和讨论:什么是软实力,中国人对软实力的看法是什么,中国软实... 详细信息

中国软实力一直是中国内外讨论的话题。自2000年末这个术语开始在中国使用以后,引起了很多国际关注。本文将探讨一个容易被忽视的领域-中国在东南亚的软实力影响。本文将质疑和讨论:什么是软实力,中国人对软实力的看法是什么,中国软实力是否有限,以及中国为何采用软实力政策。由于软实力通常基于查看数字数据和民意调查,本文将综合这两者来了解中国软实力在该地区的情况,尽管数据有限。本文使用约瑟夫奈的最初的软实力定义作为理解软实力作为这一术语的基础。研究结果表明,中国软实力的定义和使用和原始的定义不同。这是由于中国政府在实施软实力方面发挥了重要作用,中共关注中国文化软实力。文化软实力集中体现在中国的文化元素,主要是孔子价值观,核心社会主义价值观和中国梦的观念-恢复中国的地位和对世界的理解。我也发现,中国的软实力使用面临限制,因为其经济和政治力量的强弱,也因为看起来东南亚并不是中国软实力的主要关注点。此外,似乎许多东南亚国家对中国在该地区的交易缺乏信心。最后,中国继续追求软实力,有助于加强中国对中国梦的国内政策的实现。

关键词：中国的软实力东南亚中国梦

An Examination of Health Care Utilization Amongst Citizens with Bone Disease in Rural China

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An Examination of Health Care Utilization Amongst Citizens w...

作者： danielle Joy Voorhies 上海交通大学

学位级别：硕士

This research was conducted in Huaibin County and Shanghai using grounded theory *** qualitative data was collected via interviews with doctors and *** main research aim was to determine what the non-economic reasons are for Chinese rural bone disease patients’ choice of place to receive medical services especially in relation to public health care policies in order to ensure better access to health *** a county level,it was found that there are no significant non-economic reasons for urban citizens to not seek out health *** a township level,many of the patients sought out care due to knowing the hospital is better equipped than village clinics and *** a village level,childcare,farm work,and lack of knowledge about health care policies are the major reasons patients refuse to seek out care for more advanced illness.

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