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Testicular ultrasound inhomogeneity is an informative parameter for fertility evaluation

Asian Journal of Andrology 2020年第3期22卷 302-308页

作者： Giorgia Spaggiari Antonio R M Granata daniele Santi Unit of Endocrinology Department of BiomedicalMetabolic and Neural SciencesUniversity of Modena and Reggio EmiliaModena 41126Italy Unit of Endocrinology Department of Medical SpecialtiesAzienda Ospedaliero-Universitaria of ModenaOspedale Civile of BaggiovaraModena 41126Italy.

Testicular volume(TV)is proposed to be a positive predictor of male fertility status,because of the relation known between the TV and the seminiferous tubule *** of the measurement methodology,the role of TV and testicular ultrasound(US)assessments is still debated in andrological clinical *** this retrospective cohort study,we evaluated TV and testis US role in the diagnostic workup of andrological *** consecutive outpatients undergoing single-operator testis US(Modena,Italy)from March 2012 to March 2018 were enrolled,matching sonographic,hormonal,and seminal data.A total of 302 men were referred and evaluated for gynecomastia,suspected hypogonadism,couple infertility(Cl),or sexual *** the hypogonadal group,TV was lower compared to that in other groups(P<0.001),and a significant,direct correlation between TV and testosterone level was observed in nonandrogen-treated patients(R=0.911,P<0.001),suggesting that testicular size could be related to the testosterone-secreting *** the Cl group,normozoospermic patients showed higher TV compared to men with impaired semen quality(P=0.003)and azoospermia(P=0.003).However,TV was not able to discriminate between patients presenting normal and altered semen *** the contrary,testis US inhomogeneity was more frequent in patients with impaired sperm quality(55.0%;P=0.007)and azoospermia(40.0%;P=0.012),compared to patients with normozoospermia(5%),identifying thereby the sonographic pattern as an informative parameter of the fertility ***,in the Cl workup,US evaluation seems to be more informative than the TV assessment alone.

关键词： male hypogonadism male infertility testicular diseases testis

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On the calibration of rotational augmentation models for wind turbine load estimation by means of CFD simulations

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Acta Mechanica Sinica 2020年第2期36卷 306-319页

作者： Belen Soledad Burgos Tafur Elia daniele Bernhard Stoevesandt Philipp Thomas Fraunhofer IWES Am Seedeich 4527572 BremerhavenGermany Flensburg University of Applied Sciences Wind Energy Technology InstituteNordstraße224943 FlensburgGermany

In this work the improved version of an engineering model which accounts for rotational augmentation effects by means of computational fluid dynamics(CFD)calibration is explored and *** on an analysis of the NREL Phase VI wind turbine,the novel modeling is presented,which uses as base line the formulation proposed by Chaviaropoulos and *** model is calibrated based on CFD simulations using *** corresponding correction of the two dimensional polars is straightforward implemented within MoWiT,an in-house software for load *** novel formulation results in improved lift and drag coefficients prediction in all considered cases,reducing the deviation with respect to the rotating CFD cases down to few *** optimal configuration including the correction for tip effects of Shen shows better agreements at the very tip of the *** the range of applicability for large wind turbine rotor blades based on a virtual 10MW rotor model is discussed.

关键词： calculation. rotational correction

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Large Eddy Simulation of the By-pass Transition Process under Different Inlet Turbulence Conditions

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Journal of Thermal Science 2021年第6期30卷 2112-2121页

作者： BARSI Dario COSTA Carlo LENGANI Davide SIMONI daniele UBALDI Marina DIME-University of Genova Via Montallegro 11-16145 GenovaItaly

The transition process of the boundary layer developing over a flat plate with elevated inlet Free Stream Turbulence Intensity(FSTI)has been studied by means of Large Eddy Simulation(LES).To this purpose,four cases with different inflow disturbances have been tested varying the magnitude and the length scale of *** has been performed by using the finite-volume ANSYS Fluent *** computational domain,which was constituted by a rectangular domain with a zero thickness plate,was based on an ERCOFTAC test case in order to provide a validation with a well-known set of data by comparing the boundary layer integral parameters and mean and fluctuating streamwise velocity *** four cases were discussed within the paper by looking at classical statistical properties as well as advanced post-processing *** was shown that the decrease in the free stream turbulence level postpones the transition location,whereas the variation of the integral length scale has a very low influence on the distribution of the time-mean flow *** Orthogonal Decomposition(POD)has been applied to the instantaneous LES flow fields in order to provide a statistical representation of the structures responsible for transition and their response to free-stream turbulence intensity and length *** presence of vortical filaments parallel to the wall,typically referred as boundary layer streaks,is clearly identified;their characteristic dimensions and how they change as a function of FSTI properties were analyzed within the paper.

关键词： by-pass transition Large Eddy Simulation(LES) Proper Orthogonal Decomposition(POD) boundary layer streaks

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On the origin of plasticity-induced microstructure change under sliding contacts

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Friction 2023年第3期11卷 473-488页

作者： Yilun XU Daniel S.BALINT Christian GREINER daniele DINI Department of Mechanical Engineering Imperial College LondonLondon SW72AZUK Department of Materials Imperial College LondonLondon SW72AZUK Karlsruhe Institute of Technology(KIT) Institue for Applied Materials(IAM)Kaisertrasse 12Karlsruhe 76131Germany KITIAM-CMS MicroTribology Center(μTC) Strasse am Forum 5Karlsruhe 76131Germany

Discrete dislocation plasticity(DDP)calculations are carried out to investigate the response of a single crystal contacted by a rigid sinusoidal asperity under sliding loading conditions to look for causes of microstructure change in the dislocation *** mechanistic driver is identified as the development of lattice rotations and stored energy in the subsurface,which can be quantitatively correlated to recent tribological experimental *** of surface slip initiation and substrate permanent deformation obtained from DDP calculations for varying contact size and normal load suggest ways of optimally tailoring the interface and microstructural material properties for various frictional loads.

关键词： discrete dislocation plasticity sliding size effect microstructure change

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Enhancer-promoter communication:unraveling enhancer strength and positioning within a given topologically associating domain(TAD)

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Signal Transduction and Targeted Therapy 2022年第9期7卷 3161-3162页

作者： Benedetto daniele Giaimo Tilman Borggrefe Institute of Biochemistry Justus-Liebig-University GiessenFriedrichstrasse 2435392 GiessenGermany

In a recent study published in Nature,Zuin et *** the molecular mechanisms of how enhancer positioning and strength affect gene expression levels.'Cell-type-specific transcription factors(TFs)and ubiquitously expressed cofactors regulate the complex network of eukar-yotic gene transcription in an exquisitely specific and sensitive *** DNA elements bound by TFs are called enhancers and can be located close to the transcription start site(TSS)or far away.

关键词： al. strength topological

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New treatments for chronic hepatitis C:an overview for paediatricians

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World Journal of Gastroenterology 2014年第43期20卷 15965-15974页

作者： daniele Serranti Giuseppe Indolfi Massimo Resti Department of Health Sciences University of Florence Paediatric and Liver Unit Meyer Children’s University Hospital of Florence

Pegylated interferon (IFN) α-2a or 2b in combination with ribavirin for children aged 3 years and older is the standard treatment for paediatric chronic hepatitis C. This treatment regimen was developed firstly in adults. In recent years, a number of direct-acting antiviral agents (DAAs) are under development for treatment of chronic hepatitis C virus (HCV) infection. These agents block viral replication inhibiting directly one of the several steps of HCV lifecycle. DAAs are classified into several categories based on their molecular target: HCV NS3/4A protease inhibitors, HCV NS5B polymerase inhibitors and HCV NS5A inhibitors. Other promising compounds are cyclophilin A inhibitors, mi-RNA122 and IFN-λ. Several new drugs associations will be developed in the near future starting from the actual standard of care. IFN-based and IFN-free regimens are being studied in adults. In this constantly evolving scenario new drug regimens targeted and suitable for children would be possible in the next future. Especially for children, it is crucial to identify the right combination of drugs with the highest potency, barrier to resistance and the best safety profile.

关键词： Hepatitis C virus Children Treatment Interferon Ribavirin Daclatasvir Sofosbuvir Efficacy Safety

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Bjorken Flow Revisited:Analytic and Numerical Solutions in Flat Space-Time Coordinates

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Communications in Computational Physics 2023年第1期33卷 174-188页

作者： daniele Simeoni Alessandro Gabbana Sauro Succi Universit`a di Ferrara and INFN-Ferrara I-44122 FerraraItaly Bergische UniversitatWuppertal D-42119WuppertalGermany University of Cyprus Physics departmentCY-1678 NicosiaCyprus Eindhoven University of Technology 5600MB EindhovenThe Netherlands Center for Life Nano Science@La Sapienza Italian Institute of TechnologyViale Regina Elena 295I-00161 RomaItaly Istituto Applicazioni del Calcolo National Research Council of ItalyVia dei Taurini 19I-00185 RomaItaly

In this work we provide analytic and numerical solutions for the Bjorken flow,a standard benchmark in relativistic hydrodynamics providing a simple model for the bulk evolution of matter created in collisions between heavy *** consider relativistic gases of both massive and massless particles,working in a(2+1)and(3+1)Minkowski space-time coordinate *** numerical results from a recently developed lattice kinetic scheme show excellent agreement with the analytic solutions.

关键词： Relativistic hydrodynamics heavy-ion collisions Bjorken flow lattice kinetic solvers

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Fully integrated and broadband Si-rich silicon nitride wavelength converter based on Bragg scattering intermodal four-wave mixing

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Photonics Research 2024年第3期12卷 I0001-I0010页

作者： VALERIO VITALI THALÍA DOMÍNGUEZ BUCIO HAO LIU JOSÉMANUEL LUQUE GONZÁLEZ FRANCISCO JURADO-ROMERO ALEJANDRO ORTEGA-MOÑUX GLENN CHURCHILL JAMES C.GATES JAMES HILLIER NIKOLAOS KALFAGIANNIS daniele MELATI JENS H.SCHMID ILARIA CRISTIANI PAVEL CHEBEN J.GONZALO WANGÜEMERT-PÉREZ ÑIGO MOLINA-FERNÁNDEZ FREDERIC GARDES COSIMO LACAVA PERIKLIS PETROPOULOS Optoelectronics Research Centre University of SouthamptonSouthampton SO171BJUK Electrical Computer and Biomedical Engineering DepartmentUniversity of PaviaPavia 27100Italy Telecommunication Research Institute(TELMA) Universidad de MálagaCEI Andalucı´a TECHE.T.S.I.Telecomunicación29010 MálagaSpain School of Science and Technology Nottingham Trent UniversityNottingham NG118NSUK Department of Electrical Engineering Eindhoven University of TechnologyEindhoven 5600 MBThe Netherlands Department of Materials Science and Engineering University of IoanninaIoannina 45110Greece Centre de Nanosciences et de Nanotechnologies UniversitéParis-SaclayCNRS91120 PalaiseauFrance Advanced Electronics and Photonics Research Center National Research Council CanadaOttawaOntario K1A 0R6Canada

Intermodal four-wave mixing(FWM)processes have recently attracted significant interest for all-optical signal processing applications thanks to the possibility to control the propagation properties of waves exciting distinct spatial modes of the same *** allows,in principle,to place signals in different spectral regions and satisfy the phase matching condition over considerably larger bandwidths compared to intramodal ***,the demonstrations reported so far have shown a limited bandwidth and suffered from the lack of on-chip components designed for broadband manipulation of different *** demonstrate here a silicon-rich silicon nitride wavelength converter based on Bragg scattering intermodal FWM,which integrates mode conversion,multiplexing and de-multiplexing functionalities *** system enables wavelength conversion between pump waves and a signal located in different telecommunication bands(separated by 60 nm)with a 3 dB bandwidth exceeding 70 nm,which represents,to our knowledge,the widest bandwidth ever achieved in an intermodal FWM-based system.

关键词： scattering pump modal

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A Semi-Lagrangian Spectral Method for the Vlasov-Poisson System Based on Fourier, Legendre and Hermite Polynomials

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Communications on Applied Mathematics and Computation 2019年第3期1卷 333-360页

作者： Lorella Fatone daniele Funaro Gianmarco Manzini Dipartimento di Matematica University degli Studi di CamerinoCamerinoItaly Dipartimento di Scienze Chimiche e Geologiche Universita degli Studi di Modena e Reggio EmiliaModenaItaly Group T-5 Applied Mathematics and Plasma PhysicsTheoretical DivisionLos Alamos National LaboratoryLos AlamosNMUSA

In this work, we apply a semi-Lagrangian spectral method for the Vlasov-Poisson system, previously designed for periodic Fourier discretizations, by implementing Legendre polynomials and Hermite functions in the approximation of the distribution function with respect to the velocity variable. We discuss second-order accurate-in-time schemes, obtained by coupling spectral techniques in the space-velocity domain with a BDF timestepping scheme. The resulting method possesses good conservation properties, which have been assessed by a series of numerical tests conducted on some standard benchmark problems including the two-stream instability and the Landau damping test cases. In the Hermite case, we also investigate the numerical behavior in dependence of a scaling parameter in the Gaussian weight. Confirming previous results from the literature, our experiments for different representative values of this parameter, indicate that a proper choice may significantly impact on accuracy, thus suggesting that suitable strategies should be developed to automatically update the parameter during the time-advancing procedure.

关键词： Spectral methods Semi-Lagrangian methods High-order Hermite functions Vlasov-Poisson equations Mass conservation

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Measuring and understanding global human settlements patterns and processes:innovation,progress and application

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International Journal of Digital Earth 2020年第1期13卷 2-8页

作者： Ehrlich daniele Balk Deborah Richard Sliuzas 不详

Human settlements–the places where people live and work–are rapidly *** of the processes driving the physical changes in human settlements are population and economic growth,rural-urban migration,and in-situ urban transformation that also includes the envelopment of small settlements by larger ones and land-expansive *** some parts of the world,particularly the global South,urbanization occurs at rates that generate unprecedented city sizes(WUP 2018).

关键词： settlement development sizes

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