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Obesity and bariatric surgery in kidney transplantation:A clinical review

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World Journal of Diabetes 2021年第9期12卷 1563-1575页

作者： Massimiliano Veroux Edoardo Mattone Matteo Cavallo Rossella Gioco daniela corona Alessio Volpicelli Pierfrancesco Veroux Department of Medical and Surgical Sciences and Advanced Technologies GF Ingrassia University of CataniaCatania 95123Italy Vascular Surgery and Organ Transplant Unit University Hospital of CataniaCatania 95123Italy General Surgery Unit University Hospital of CataniaCatania 95123Italy Department of General Surgery and Medical Specialities University of CataniaCatania 95123Italy

Obesity is increasing worldwide,and this has major implications in the setting of kidney *** with obesity may have limited access to transplantation and increased posttransplant morbidity and *** transplant centers incorporate interventions aiming to target obesity in kidney transplant candidates,including dietary education and lifestyle *** those failing nutritional restriction and medical therapy,the use of bariatric surgery may increase the transplant candidacy of patients with obesity and endstage renal disease(ESRD)and may potentially improve the immediate and late *** surgery in ESRD patients is associated with weight loss ranging from 29.8% to 72.8% excess weight loss,with reported mortality and morbidity rates of 2% and 7%,*** most commonly performed bariatric surgical procedures in patients with ESRD and in transplant patients are laparoscopic sleeve gastrectomy(LSG)and laparoscopic Roux-en-Y gastric ***,the correct timing of bariatric surgery and the ideal type of surgery have yet to be determined,although pretransplant LSG seems to be associated with an acceptable risk-benefit *** review the impact of obesity on kidney transplant candidates and recipients and in potential living kidney donors,exploring the potential impact of bariatric surgery in addressing obesity in these populations,thereby potentially improving posttransplant outcomes.

关键词： End-stage renal disease Living donor Gastric bypass Sleeve gastrectomy Waiting list Deceased donor

Gastrointestinal complications after kidney transplantation

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World Journal of Gastroenterology 2020年第38期26卷 5797-5811页

作者： Rossella Gioco daniela corona Burcin Ekser Lidia Puzzo Gaetano Inserra Flavia Pinto Chiara Schipa Francesca Privitera Pierfrancesco Veroux Massimiliano Veroux General Surgery Unit University Hospital of CataniaCatania 95123Italy Department of Biomedical and Biotechnological Sciences University of CataniaCatania 95123Italy Department of Surgery Indiana University School of MedicineIndianapolisIN 46202United States Pathology Unit Department of Medical and Surgical Sciences and Advanced TechnologiesUniversity of CataniaCatania 95123Italy Gastroenterology Unit Department of Clinical and Experimental MedicineUniversity of CataniaCatania 95100Italy Organ Transplant Unit University Hospital of CataniaCatania 95123Italy General Surgery Unit Organ Transplant UnitUniversity Hospital of CataniaCatania 95123Italy Department of Medical and Surgical Sciences and Advanced Technologies University Hospital of CataniaCatania 95123Italy

Gastrointestinal complications are common after renal transplantation,and they have a wide clinical spectrum,varying from diarrhoea to post-transplant inflammatory bowel disease(IBD).Chronic immunosuppression may increase the risk of post-transplant infection and medication-related injury and may also be responsible for IBD in kidney transplant re-cipients despite *** the various forms of post-transplant colitis is challenging,since most have similar clinical and histological ***-related colitis are the most frequently encountered colitis after kidney transplantation,particularly those related to the chronic use of mycophenolate mofetil,while de novo IBDs are quite *** review will explore colitis after kidney transplantation,with a particular focus on different clinical and histological features,attempting to clearly identify the right treatment,thereby improving the final outcome of patients.

关键词： Inflammatory bowel disease Kidney transplantation Solid organ transplantation Crohn disease Ulcerative colitis Mycophenolate mofetil colitis Mycophenolate mofetil Colitis Cytomegalovirus

Kidney transplantation from donors with hepatitis C infection

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World Journal of Gastroenterology 2014年第11期20卷 2801-2809页

作者： Massimiliano Veroux daniela corona Nunziata Sinagra Alessia Giaquinta Domenico Zerbo Burcin Ekser Giuseppe Giuffrida Pietro Caglià Riccardo Gula Vincenzo Ardita Pierfrancesco Veroux Vascular Surgery and Organ Transplant Unit Department of SurgeryTransplantation and Advanced TechnologiesUniversity Hospital of Catania95123 CataniaItaly

The increasing demand for organ donors to supply the increasing number of patients on kidney waiting lists has led to most transplant centers developing protocols that allow safe utilization from donors with special clinical situations which previously were regarded as contraindications. Deceased donors with previous hepatitis C infection may represent a safe resource to expand the donor pool. When allocated to serology-matched recipients, kidney transplantation from donors with hepatitis C may result in an excellent short-term outcome and a significant reduction of time on the waiting list. Special care must be dedicated to the pre-transplant evaluation of potential candidates, particularly with regard to liver functionality and evidence of liver histological damage, such as cirrhosis, that could be a contraindication to transplantation. Pre-transplant antiviral therapy could be useful to reduce the viral load and to improve the long-term results, which may be affected by the progression of liver disease in the recipients. An accurate selection of both donor and recipient is mandatory to achieve a satisfactory long-term outcome.

关键词： Kidney transplantation Deceased donor Hepatitis C virus De novo glomerulonephritis Liver failure Graft survival End-stage renal disease Hemodialysis

Magnetic resonance imaging:A new tool for diagnosis of acute ischemic colitis?

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World Journal of Gastroenterology 2012年第13期18卷 1496-1501页

作者： Francesca Iacobellis daniela Berritto Francesco Somma Carlo Cavaliere Marco corona Santolo Cozzolino Franco Fulciniti Salvatore Cappabianca Antonio Rotondo Roberto Grassi Institute of Radiology Second University of Naples80138 NaplesItaly Biotechnology Center A.O.R.N.Cardarelli80131 NaplesItaly S.S.D.di Citopatologia A.F.di Anatomia PatologicaIstituto Nazionale Tumori"Fondazione G.Pascale"80131 NaplesItaly

AIM： To define the evolution of ischemic lesions with 7T magnetic resonance imaging （7T-MRI） in an animal model of acute colonic ischemia. METHODS： Adult Sprague-Dawley rats were divided into two groups. Group I underwent inferior mesenteric artery （IMA） ligation followed by macroscopic observa- tions and histological analysis. In group H, 7T-MRI was performed before and after IMA ligation and followed by histological analysis. RESULTS： Morphological alterations started to develop 1 h after IMA ligation, when pale areas became evident in the splenic flexure mesentery and progressively wors-ened up to 8 h thereafter, when the mesentery was less pale, and the splenic flexure loop appeared very dark. The 7T-MRI results reflected these alterations, showing a hyperintense signal in both the intraperitoneal space and the colonic loop wall 1 h after IMA ligation; the lat- ter progressively increased to demonstrate a reduction in the colonic loop lumen at 6 h. Eight hours after IMA ligation, MRI showed a persistent colonic mural hyper- intensity associated with a reduction in peritoneal free fluid. The 7T-MRI findings were correlated with histolog- ical alterations, varying from an attenuated epithelium with glandular apex lesions at 1 h to coagulative necro- sis and loss of the surface epithelium detected 8 h after IMA ligation. CONCLUSION： MRI may be used as a substitute for invasive procedures in diagnosing and grading acute ischemic colitis, allowing for the early identification of pathological findings.

关键词： Ischemic colitis Animal models Sprague-Dawley rats Magnetic resonance imaging Histopathology

The Traditional Chinese Medicine Plant Schisandra Chinensis as Source of New HIV-1Reverse Transcriptase Inhibitor Scaffolds Effective also on Non-nucleoside Resistant Reverse Transcriptases

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The Traditional Chinese Medicine Plant Schisandra Chinensis ...

Nanotechnology and pancreatic cancer management:State of the art and further perspectives

第十四届全国中药和天然药物学术研讨会

作者： Xu Lijia Grandi Nicole Del Vecchio Claudia corona Angela daniela Mandas Esposito Francesca Parolin Cristina Tramontano Enzo Institute of Medicinal Plant Development (IMPLAD) University of Cagliari University of Padova

＜正＞Background HIV-1 reverse transcriptase（RT）is still an extremely attractive pharmaceutical target for the identification of new inhibitors possibly active on drug resistant *** plants are a rich source of chemical diversity and can be used to identify novel scaffolds to be further developed by chemical *** studies the Traditional Chinese Medicine fruit of

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World Journal of Gastrointestinal Oncology 2021年第4期13卷 231-237页

作者： Damiano Caputo daniela Pozzi Tommaso Farolfi Roberto Passa Roberto Coppola Giulio Caracciolo Department of General Surgery University Campus Bio-Medico di RomaRome 00128Italy Department of Molecular Medicine Sapienza University of RomeRome 00161Italy

Pancreatic ductal adenocarcinoma(PDAC)represents a leading cause of cancer death and is often diagnosticated too late to allow adequate *** of biomarkers have been discovered in lasts years but,to date,there is a lack of lowcost and non-invasive tools for PDAC early ***,drugs commonly used in PDAC treatment do not allow achieving long-term satisfying *** is gaining importance in both PDAC early detection and *** main implications of nanotechnology in cancer diagnosis lay in the ability that nanoparticles have on concentrate the alteration in human proteome caused by ***-enabled blood tests have been demonstrated to reach high rate of sensitivity(up to 85%)and specificity(up to 100%).In the field of cancer therapy nanoparticles can be used as nanocarriers able to reach specific tumour’s cells and selectively release the drug they contain into them.A literature review was carried out with the aim to assess the state of the art and highlight the future perspectives of nanotechnology in PDAC early detection and therapy.

关键词： Pancreatic ductal adenocarcinoma Biomarkers Nanotechnology Nanoparticles Protein corona Early detection