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Role of lipids in the control of autophagy and primary cilium signaling in neurons

Neural Regeneration Research 2024年第2期19卷 264-271页

作者： María Paz Hernández-Cáceres daniela pinto-Nuñez Patricia Rivera Paulina Burgos Francisco Díaz-Castro Alfredo Criollo Maria Jose Yañez Eugenia Morselli Instituto de Investigación en Ciencias Odontológicas(ICOD) Facultad de OdontologíaUniversidad de ChileSantiagoChile Department of Basic Sciences Faculty of Medicine and ScienceUniversidad San SebastiánSantiagoChile Physiology Department Faculty of Biological SciencesPontificia Universidad Católica de ChileSantiagoChile Advanced Center for Chronic Diseases(ACCDiS) Facultad de Ciencias Químicas y Farmacéuticas&Facultad de MedicinaUniversidad de ChileSantiagoChile Autophagy Research Center SantiagoChile

The brain is,after the adipose tissue,the organ with the greatest amount of lipids and diversity in their composition in the human *** neurons,lipids are involved in signaling pathways controlling autophagy,a lysosome-dependent catabolic process essential for the maintenance of neuronal homeostasis and the function of the primary cilium,a cellular antenna that acts as a communication hub that transfers extracellular signals into intracellular responses required for neurogenesis and brain development.A crosstalk between primary cilia and autophagy has been established;however,its role in the control of neuronal activity and homeostasis is barely *** this review,we briefly discuss the current knowledge regarding the role of autophagy and the primary cilium in *** we review the recent literature about specific lipid subclasses in the regulation of autophagy,in the control of primary cilium structure and its dependent cellular signaling in physiological and pathological conditions,specifically focusing on neurons,an area of research that could have major implications in neurodevelopment,energy homeostasis,and neurodegeneration.

关键词： autophagic flux cholesterol fatty acids GPCR lysosomal storage diseases neurons NPC1 phosphoinositides primary cilium

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Hospital-Adapted Clonal Complex 17 <i>Enterococcus Faecium</i>Found among Sand Enterococcal Isolates

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Journal of Environmental Protection 2012年第1期3卷 74-82页

作者： daniela pinto Marta Ruivo Peter Vandamme Maria de F. S. Lopes 不详

Though poorly studied, sand is an environment with an extended degree of interaction with man. Enterococcal strains can be found in sand but we do not know to what extent these ubiquitous opportunistic nosocomial pathogens isolated from sand carry antimicrobial resistances and virulence traits. In an attempt to fill in this knowledge gap, two distinct types of sand (beach and children playground) were examined concerning composition in enterococcal species, genetic diversity of isolates and abundance of resistance to antimicrobials and virulence traits. Five different species were found, namely Enterococcus faecium, Enterococcus faecalis, Enterococcus hirae, Enterococcus flavescens and Enterococcus casseliflavus. Although genetic diversity was evident, two different E. faecium clones, common to the two types of sand, were detected, suggesting the existence of clones well adapted to this specific environment or from a common source. E. faecium was associated with multiple antibiotic resistances, including to fluoroquinolones and tetracycline that are commonly used by veterinarians and clinicians. Among the multiresistant E. faecium strains from beach sand, two were from sequence type (ST) 442, which belongs to the wide-spread Hospital-adapted clade CC17. They both carried the esp gene and the genomic island associated with CC17. The other virulence factors screened were disseminated among E. faecalis strains, but seldom detected in the other species, evidencing the existence, in these environments, of E. faecalis strains carrying the same virulence factors as the clinical ones. The present work thus stresses the need to follow-up the presence and characterization of enterococcal strains from both beach and children playground sands and of including these environments in the epidemiological global analysis of enterococcal isolates.

关键词： Antibiotic Resistance Beach Sand Clonal Complex 17 Enterococcus Playground Sand Virulence Factors

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Targeted molecular therapy (modified RIST regimen) in relapsed high risk stage Ⅳ neuroblastoma: two cases report

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Theory and Clinical Practice in Pediatrics 2018年第1期2卷 2-4页

作者： Paolo Indolfi Selim Corbacioglu Silverio Perrotta Francesca Rossi Antonio Marte Elvira Pota Martina Di Martino daniela Di pinto Cristiana Indolfi Fiorina Casale Unit of Pediatric Oncology Pediatric DepartmentSecond University of Naplesvia Luigi De Crecchio 280138 NaplesItaly Department of Pediatrics and Adolescent Medicine University of RegensburgRegensburgGermany Unit of Pediatric Oncology Department of Women-Children and General and Specialistic SurgeryUniversity of Campania “Luigi Vanvitelli”NaplesItaly Department of Pediatric Surgery University of Campania “Luigi Vanvitelli”NaplesItaly

The prognosis for children with recurrent or refractory neuroblastoma remains a significant clinical challenge,and currently there are no known curative salvage *** this paper we investigated the effect of imatinib with rapamycin and the chemotherapeutic agents temozolomide and *** treated two children with recurrent neuroblastoma with this so called RIST *** patients,off therapy for 15 and 31 months,respectively are well,and developing normally,without any *** findings suggest that a combination regimen of RIST may provide a therapeutic benefit with a favorable toxicity profile to a unfortunate subset of patients with neuroblastoma.

关键词： RIST therapy Neuroblastoma Pediatric cancer

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Gastrointestinal complications after kidney transplantation

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World Journal of Gastroenterology 2020年第38期26卷 5797-5811页

作者： Rossella Gioco daniela Corona Burcin Ekser Lidia Puzzo Gaetano Inserra Flavia pinto Chiara Schipa Francesca Privitera Pierfrancesco Veroux Massimiliano Veroux General Surgery Unit University Hospital of CataniaCatania 95123Italy Department of Biomedical and Biotechnological Sciences University of CataniaCatania 95123Italy Department of Surgery Indiana University School of MedicineIndianapolisIN 46202United States Pathology Unit Department of Medical and Surgical Sciences and Advanced TechnologiesUniversity of CataniaCatania 95123Italy Gastroenterology Unit Department of Clinical and Experimental MedicineUniversity of CataniaCatania 95100Italy Organ Transplant Unit University Hospital of CataniaCatania 95123Italy General Surgery Unit Organ Transplant UnitUniversity Hospital of CataniaCatania 95123Italy Department of Medical and Surgical Sciences and Advanced Technologies University Hospital of CataniaCatania 95123Italy

Gastrointestinal complications are common after renal transplantation,and they have a wide clinical spectrum,varying from diarrhoea to post-transplant inflammatory bowel disease(IBD).Chronic immunosuppression may increase the risk of post-transplant infection and medication-related injury and may also be responsible for IBD in kidney transplant re-cipients despite *** the various forms of post-transplant colitis is challenging,since most have similar clinical and histological ***-related colitis are the most frequently encountered colitis after kidney transplantation,particularly those related to the chronic use of mycophenolate mofetil,while de novo IBDs are quite *** review will explore colitis after kidney transplantation,with a particular focus on different clinical and histological features,attempting to clearly identify the right treatment,thereby improving the final outcome of patients.

关键词： Inflammatory bowel disease Kidney transplantation Solid organ transplantation Crohn disease Ulcerative colitis Mycophenolate mofetil colitis Mycophenolate mofetil Colitis Cytomegalovirus

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When sepsis affects the heart: A case report and literature review

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World Journal of Clinical Cases 2015年第8期3卷 743-750页

作者： Giuseppe Clemente Antonino Tuttolomondo daniela Colomba Rosaria Pecoraro Chiara Renda Vittoriano Della Corte Carlo Maida Irene Simonetta Antonio pinto U.O.C.di Medicina Interna e Cardioangiologia University of Palermo

A 59-year-old nursing home patient with Down syndrome was brought to the internal medicine department of our hospital due to fever, cough without expectorate, and dyspnea. A thoracic computed tomography revealed the presence of bilateral basal parenchymal opacities. Her condition deteriorated after admission and troponin reached a peak serum concentration of 16.9 ng/m L. The patient was in cardiogenic shock. In addition to fluid resuscitation, vaso-active amine infusion was administered to achieve hemodynamic stabilization. The differential diagnosis investigated possible pulmonary embolism, myocardial infarction, and myocarditis. Furthermore, a second transthoracic echocardiogram suggested Tako-Tsubo syndrome. This is a septic patient. The purpose of this manuscript is to review studies which formerly examined the possible association between high levels of troponin and mortality to see if it can be considered a positive predictive factor of fatal prognosis as the case of thrombocytopenia, already a positive independent predictive factor of multiple organ failure syndrome, and generally to characterize risk profile in a septic patient.

关键词： Sepsis Shock Hypotension Troponin Myocardial dysfunction

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Clinical hematological and biochemical parameters in Swiss,BALB/c,C57BL/6 and B6D2F1 Mus musculus

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Animal Models and Experimental Medicine 2020年第4期3卷 304-315页

作者： Giorgio Silva-Santana Juliet Cunha Bax Débora Cristina Silva Fernandes daniela Tendler Leibel Bacellar Cleber Hooper Alexandre Alves Souza Oliveira Dias Cristina Barbosa Silva Aline Moreira de Souza Simone Ramos Ricardo Alexandre Santos Thainara Ramos pinto Mariana Antunes Ramão Ana Luíza Mattos-Guaraldi Health Sciences Center Institute of Microbiology Paulo de GóesFederal University of Rio de JaneiroRio de JaneiroRJBrazil Laboratory of Diphtheria and Corynebacteria of Clinical Relevance Faculty of Medical SciencesUniversity of the State of Rio de JaneiroRio de JaneiroRJBrazil The Collaborating Centre for Reference and Research on Diphtheria/National Health Foundation/Ministry of Health Rio de JaneiroRJBrazil Laboratory of Clinical Research and Molecular Diagnostic Prof.Marcílio Dias do Nascimento Department of Clinical Practice and PathologyFluminense Federal UniversityNiteróiRJBrazil Laboratory Bacterial Vaccines Department of ImmunologyNational Institute for Quality Control in HealthOswaldo Cruz FoundationRio de JaneiroRJBrazil Institute of Science and Technology in Biomodels Oswaldo Cruz FoundationRio de JaneiroRJBrazil Institute of Biology Federal Fluminense UniversityNiteróiRJBrazil Biomedical Center College of Medical SciencesUniversity of the State of Rio de JaneiroRio de JaneiroRJBrazil

Background:Animal models are widely used in scientific research in order to obtain information from a whole organism under a specific set of experimental *** lineages of mice have been used to investigate diseases and new therapeutic strategies,and,consequently,hematological and biochemical tests in these laboratory animals are essential to validate scientific *** study seeks to establish reference values for hematological and biochemical parameters of four lineages of ***:We evaluated the hematological and biochemical profiles of 20 males and 20 females from the lineages Swiss(heterogeneous),BALB/c and C57BL/6(isogenic),and B6D2F1(hybrid),totaling 160 *** were standardized using the systems pocH-100iV Diff™for 19 hematological parameters and VITROS®350 for 12 biochemical ***:Results are shown as means and standard deviation,grouped by lineage and *** the values obtained in this study with the values from previous studies,some variations were detected,which could be explained by differences in methodologies or individual ***:Thus our study shows that knowledge and disclosure of the values of physiological parameters of laboratory animals is necessary,and emphasises the importance of considering variations influenced by gender,lineage and genotype in the choice of the best experimental model.

关键词： B6D2F1 BALB/c biochemical C57BL/6 hematological Swiss

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Neuromuscular Electrical Stimulation in Intensive Care Unit Patients:Integrative Review

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Modern Research in Inflammation 2019年第2期8卷 11-27页

作者： Miriam Viviane Baron Marcus Vinicius de Mello pinto Janine Koepp Cristine Brandenburg Paulo Ricardo Martins Amanda Correa dos Santos daniela Moraes Carolina Goncalves Pinheiro Nathália Ken Pereira Iketani Bartira Ercilia Pinheiro da Costa Nephrology Laboratory Department of Postgraduate of Medicine and Health SciencesSchool of MedicinePontifical Catholic University of Rio Grande do SulPorto AlegreBrazil Celulare Institute Rio de JaneiroBrazil Nursing Course Department of Nursing and DentistryUniversity of Santa Cruz do SulSanta Cruz do SulBrazil Postgraduate Program in Brazilian Education Department of Fundamentals of EducationFederal University of CearáFortalezaBrazil School of Medicine Pontifical Catholic University of Rio Grande do SulPorto AlegreBrazil Physiotherapy Course Department of PhysiotherapyVale do Salgado FacultyIcóBrazil Department of Physiotherapy Dom Luiz I Hospital-Portuguese Beneficent of BelemParaBrazil

Intensive care units’ acquired muscle weakness is present in approximately 50% of the patients. Although active muscle training can attenuate weakness, a large proportion of critical patients cannot participate in any active mobilization. Neuromuscular electrical stimulation may be an alternative strategy to reverse muscle weakness. The objective of the study was to review the scientific publications on the use of neuromuscular electrical stimulation and its parameters and the main results in patients hospitalized in intensive care units. This is an integrative review surveying studies in online databases. The studies were selected from the following descriptors: neuromuscular electrical stimulation AND parameters AND intensive care units AND muscle weakness. The inclusion criteria included articles that addressed the topic of neuromuscular electrical stimulation and the parameters used in patients admitted to intensive care units, aged 18 years or older. Exclusion criteria were studies involving animals, case reports, letters to the editor and book chapters. The search comprised articles in the Portuguese, English and Spanish languages from January 2013 to March 2019. Of the 185 articles identified, nine met the eligibility criteria. The studies were evaluated assessing the level of evidence, and the relevant information was presented in the table and discussed. The parameters of the neuromuscular electrical stimulation employed in the studies showed positive results for the maintenance of strength and muscle mass. There was evidence of benefits in the local and systemic microcirculation, potentially mobilizing endothelial stem cells, to prevent atrophy, to reduce mechanical ventilation time and stay in intensive care unit;and when incorporated into the usual physiotherapy care, proved to be more effective than usual care. Its use is safe and viable in critically ill patients.

关键词： Muscle Weakness Critical Illness Polyneuropathy Sepsis Electric Stimulation Therapy Physical Therapy Modalities

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CTNS Molecular Genetics Profile in a Portuguese Cystinosis Population

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Open Journal of Genetics 2018年第4期8卷 91-100页

作者： Filipa Ferreira Ines Leal David Sousa Teresa Costa Conceicao Mota Ana Marta Gomes daniela Lopes Maria do Carmo Macario Isabel Tavares Helena pinto Joao Paulo Oliveira Rita Magrico Celia Carmona Sonia Ramos Raquel Neiva Ana Marcao Laura Vilarinho Newborn Screening Metabolism and Genetics UnitHuman Genetics DepartmentNational Institute of Health Dr Ricardo JorgePortoPortugal Centro Hospitalar Lisboa Norte Hospital de Santa MariaLisboaPortugal Centro Hospitalar Universitario do Porto PortoPortugal Centro Hospitalar Vila Nova de Gaia EspinhoPortugal Centro Hospitalar Universitario de Coimbra CHUCCoimbraPortugal Servico de Genetica Medica Centro Hospitalar de Sao JoaoPortoPortugal Unidade de Genetica Faculdade de Medicina da Universidade do PortoPortoPortugal I3S—Instituto de Investigacao e Inovacao em Saude PortoPortugal Servico de Nefrologia do Hospital Garcia de Orta AlmadaPortugal Research and Development Unit Department of Human GeneticsNational Institute of Health Dr Ricardo JorgePortoPortugal

Background: Cystinosis is a multisystemic autosomal recessive deficiency of the lysosomal membrane transporter protein (cystinosin) caused by mutations in CTNS gene. Objective: This study summarizes the Portuguese experience in the diagnosis and management of patients with this rare disease over the past few years and reports recurrent mutations in the CTNS gene. Methods: Unrelated patients from different pediatric and adult hospitals all over Portugal with non-nephrotic proteinuria, hypercalciuria, hypokalemia impaired proximal reabsorption of amino acids, glycosuria and hypophosphatemia, suggestive of a Fanconi syndrome and ocular problems, were studied. Intra-leukocyte cystine levels were determined and molecular analysis was performed, to determine the presence or absence of the 57-kb deletion in CTNS, followed by direct sequencing of the coding exons of CTNS. Results: From 1998 to 2017, twenty-one cystinotic patients were biochemically diagnosed. From the remaining seventeen (four deceased), eleven were studied for CTNS gene. Five out of eleven patients were homozygous for the 57-kb deletion (10/22;45.5%), and other five were compound heterozygous for this variant (15/22;68.2%). The other mutations found were p.Q128X (c.721 C>T;2/22), p.S139F (c.755 C>T;4/22) and c.18-21delGACT (p.T7FfsX7;1/22). All of these seventeen cystinotic patients are in treatment. Approximately 84% are adults, 16% are young children, and 54.5% are kidney transplant recipient. Conclusions: The authors would like to emphasize the importance of first screening for the 57-kb deletion since it is very common in our population. This genetic study is the first in our country and it could be the basis for future genetic counseling in Portuguese population.

关键词： Cystinosis CTNS Gene Mutational Spectrum Kidney Failure 57-kb Deletion

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COVID-19: Feelings Experienced by Nurses, Physiotherapists, and Medical Doctors in a Brazilian Field Hospital

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Open Journal of Nursing 2021年第5期11卷 390-406页

作者： Joselito Adriano da Silva Giulia Catissi Leticia Bernardes de Oliveira daniela Reis Dal Fabbro Michele Jaures Elisiane Plack Gladys Cristina Borges Fábio Racy Andreia Ferreira Nunes Rose Mara Miranda Denise Tiemi Noguchi Maki Guilherme de Paula pinto Schettino Claudia Regina Laselva Eliseth Ribeiro Leão Hospital Israelita Albert Einstein S&#227 o Paulo Brazil

Facing critical situations such as the ones triggered by COVID-19 may take healthcare professionals to confront their psychological resources, which may induce a higher stress level. We aimed to understand the feelings experienced by nurses, physiotherapists, and medical doctors in a field hospital dedicated to patients with COVID-19 in the biggest city of Brazil. Methods: We performed a qualitative study in a state field hospital in S?o Paulo city, Brazil, in a sample of 25 volunteer healthcare professionals. Participants answered to a sociodemographic electronic survey and were subjected to an individual semi-structured on-site interview. Results: Participants were mostly female (68%), comprised eight nurses, eight physiotherapists, and nine medical doctors, had an average age of 36.8 years, and were professionally experienced. Speech analysis revealed two thematic categories (related to work and assistance in the pandemic) and 11 subcategories: adaptation to the scenario, stressing experience, psychological support, difficulties with workwear, safety with workwear, non-verbal communication, empathy, patient comfort, outstanding experiences, major challenges, and teamwork. Conclusion: Nurses, physiotherapists, and medical doctors’ experiences while working in the field hospital were permeated by both positive and negative feelings. Those feelings originated directly from the fear of the unknown when dealing with a new disease without well-established scientific evidence, the use of medical workwear for long periods, and communication and environmental difficulties. In contrast, positive feelings, related to teamwork and empathy, arose and overlapped with the difficulties.

关键词： Covid-19 Pandemic Healthcare Professionals Field Hospital

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