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Relationship between the rs2241766 ADIPOQ Polymorphism in a Black African Population and the Occurrence of Type 2 Diabetes

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American Journal of Molecular Biology 2024年第2期14卷 97-106页

作者： Aude Syntia Mbang Bengone Rosalie Nikiema-Ndong Elisabeth Lendoye Alvine Sibylle Batou Edwige Nnegue Edzo Serge Bekale daniela Nsame Frédéric Da Dari Félix Ovono Abessolo Department of Chemistry-Biochemistry Faculty of Medicine University of Health Sciences Libreville Gabon Laboratory of Research in Biochemistry (LAREBIO) University of Sciences and Technology of Masuku Franceville Gabon Endocrinology Department University Hospital of Libreville Libreville Gabon Research Institute of Health Sciences Bobodioulasso Burkina Faso

Background: Type 2 diabetes mellitus (T2DM) is a metabolic disease, characterized by chronic hyperglycemia. This pathology is linked to various genes whose interaction with the environment promotes its development. The aim of this work was to determine the relationship between the rs2241766 (T/G) polymorphism of the ADIPOQ gene with type 2 diabetes in the black population. Material and Methods: This work was a case-control study, involving type 2 diabetics subjects (n = 94) and controls (n = 82). The study took place from September 2022 to September 2023. Patients were recruited in the Endocrinology Department of the Libreville University Hospital Center. Analysis was performed in the Biochemistry laboratory of the University of Health Sciences in Libreville and at the Research Institute of Health Sciences of Bobodioulasso. Genomic DNA was extracted using the protocol Qiagen kit and the PCR-RFLP method was used to determine the rs2241766 (T/G) polymorphism of the ADIPOQ gene. Results: Only 2 genotypes were found in this population, the TT genotype and the GT genotype. The proportions were not different between the two groups (p = 0.1095) neither the distribution of G and T alleles (p = 0.1095). On the other hand, the HDL hypocholesterolemia was frequent in subjects with the GT genotype compared to TT heterozygous (51.1% vs 48.9%, p = 0.0280;OR = 0.55 [0.30 - 1.01]). Conclusion: There was no association between the rs2241766 (T/G) variant of the ADIPOQ gene and the occurrence of type 2 diabetes in this population. On the other hand, a relationship between HDL hypocholesterolemia and the GT genotype has been established.

关键词： Type 2 Diabetes Mellitus Polymorphism rs2241766 ADIPOQ PCR-RFLP

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Nano-confinement of biomolecules： Hydrophilic confinement promotes structural order and enhances mobility of water molecules

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Nano Research 2016年第2期9卷 273-281页

作者： Bachir Aoun daniela Russo Argonne National Laboratory Chicago IL 60439 USA CNR-IOM c/o Institut Laue-Langevin 38400 Grenoble France Institut Lumiere Matiere Universite de Lyon 69622 Lyon France

Molecular dynamics simulations have been used to investigate the confinement packing characteristics of small hydrophilic （N-acetyl-glycine-methylamide, Nagma） and hydrophobic （N-acetyl-leucine-methylamide, Nalma） biomolecules in large diameter single-wall carbon nanotubes （SWCNTs）. We find that hydrophilic biomolecules easily fill the nanotube and self organize into a geometrical configuration which reminds the water structural organization under SWCNT confinement. The packing of hydrophilic biomolecules inside the cylinder confines all water molecules in its core, which enhances their mobility. Conversely, hydrophobic biomolecules accommodate into the nanotubes with a trend for homogeneous filling, which generate unstable small pockets of water and drive toward a state of dehydration. These results shed light on key parameters important for the encapsulation of biomolecules with direct relevance for long-term storage and prevention of degradation.

关键词： nano-confinement protein folding hydration water carbon nanotube drug delivery

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Problems in screening colorectal cancer in the elderly

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World Journal of Gastroenterology 2003年第10期9卷 2335-2337页

作者： DavidoviM.Mladen Milosevic P.Dragoslav Zdravkovic Sanja bojic Bozidar Djurica Snezana Center of Geriatric Medicine 11050 BeogradRifata Burdzevica 31Yugoslavia

AIM:To explore the problems in the screening of colorecta carcinoma in the elderly. METHODS:Three models of colorectal cancer prevention were examined:standard screening,active check-up of suspected cases and summons to have endoscopic check- up for previously diagnosed colorectal *** study was performed among three groups of elderly individuals: Group 1 (167 cases),hospitalized asymptomatic individuals without symptoms in large *** 2 (612 cases): old individuals at home for the aged,out of which 32 showed symptoms of colon disorders;Group 3 (44 cases):elderly people with diagnosed *** a result of 1788 rectosigmoidoscopies,we identified 61 individuals with polyps,out of which 44 patients were over 65 years old. However,only 9 of these 44 individuals agreed to have the endoscopy performed again. RESULTS:One cancer and 13 polyps were detected in Group 1,and two polyps in Group ***,it should be noted that only eleven individuals from Group 2 agreed to have the *** Group 3,there were no relapses of the polyps among the nine individuals who came back for the endoscopy. CONCLUSION:Poor understanding of the screening procedures is one of the greatest problems in early detection of the cancer in the ***,the cooperation is better with hospitalized patients,than with 'successfully old' persons.

关键词： Aged Aged, 80 and over Colonic Polyps control Colonoscopy Colorectal Neoplasms Humans Mass Screening Motivation Patient Acceptance of Health Care Patient Compliance

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Characterising populations living close to intensive farming and composting facilities in England

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Frontiers of Environmental Science & Engineering 2021年第3期15卷 97-109页

作者： Philippa Douglas daniela Fecht Deborah Jarvis National Heart and Lung Institute MRC Centre for Environment and HealthImperial College LondonLondonSW36LZUK Centre for Radiation Chemical and Environmental HazardsPublic Health EnglandHarwell CampusDidcotOxfordshireOX 11 ORQUK UK Small Area Health Statistics Unit MRC Centre for Environment and HealthSchool of Public HealthImperial College LondonLondonW2 IPGUK

Bioaerosol exposure has been linked to adverse respiratory *** farming and composting facilities are important anthropogenic sources of *** aimed to characterise populations living close to intensive farming and composting *** also infer whether the public are becoming more concerned about anthropogenic bioaerosol emissions,using reports of air pollution related incidents attributed to *** mapped the location of 1,257 intensive farming and 310 composting facilities in England in relation to the resident population and its characteristics(sex and age),area characteristics(deprivation proxy and rural/urban classification)and school locations stratified by pre-defined distance bands from these bioaerosol *** also calculated the average number of air pollution related incidents per year per *** found that more than 16%of the population and 15%of schools are located within 4,828 m of an intensive farming facility or 4,000 m of a composting facility;few people(0.01%)live very close to these sites and tend to be older *** to composting facilities,populations are more likely to be urban and more *** number of incidents were attributed to a small proportion of facilities;population characteristics around these facilities were *** indicate that populations living near composting facilities(particularly>250 to≤4,000 m)are mostly located in ur6an areas(80188%of the population),which supports the need for more community health studies to be *** could also be used to inform risk management strategies at facilities with higher numbers of incidents.

关键词： Composting Intensive farming Bioaerosol Population characteristics Public health

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fFabrication of three-dimensional proteinaceous micro- and nano-structures by femtosecond laser cross-linking

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Opto-Electronic Advances 2018年第4期1卷 12-29页

作者： daniela Serien Koji Sugioka Advanced Laser Processing Research Team RIKEN Center for Advanced Photonics 2-1 Hirosawa Wako Saitama 351-0198 Japan

Proteins are a class of biomaterials having a vast array of functions, including the catalysis of metabolic reactions, DNA replication, stimuli response and transportation of molecules. Recent progress in laser-based fabrication technologies has enabled the formation of three-dimensional （3D） proteinaceous micro- and nano-structures by femtosecond laser cross-linking, which has expanded the possible applications of proteins. This article reviews the current knowledge andrecent advancements in the femtosecond laser cross-linking of proteins. An overview of previous studies related to fabri-cation using a variety of proteins and detailed discussions of the associated mechanisms are provided. In addition, ad-vances and applications utilizing specific protein functions are introduced. This review thus provides a valuable summaryof the 3D micro- and nano-fabrication of proteins for biological and medical applications.

关键词： laser direct write femtosecond laser cross-linking protein 3D fabrication microfluidics actuation scaffold

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Hybrid ultrasound imaging techniques(fusion imaging)

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World Journal of Gastroenterology 2011年第1期17卷 49-52页

作者： daniela Larisa Sandulescu daniela Dumitrescu Ion Rogoveanu Adrian Saftoiu Research Center of Gastroenterology and Hepatology University of Medicine and Pharmacy CraiovaCraiova 200638Romania

Visualization of tumor angiogenesis can facilitate noninvasive evaluation of tumor vascular characteristics to supplement the conventional diagnostic imaging goals of depicting tumor location,size,and *** imaging techniques combine anatomic [ultrasound,computed tomography(CT),and/or magnetic resonance imaging(MRI)] and molecular(single photon emission CT and positron emission tomography) imaging *** example is real-time virtual sonography,which combines ultrasound(grayscale,colour Doppler,or dynamic contrast harmonic imaging) with contrast-enhanced CT/*** benefits of fusion imaging include an increased diagnostic confidence,direct comparison of the lesions using different imaging modalities,more precise monitoring of interventional procedures,and reduced radiation exposure.

关键词： Hybrid imaging Real time virtual sonography Angiogenesis Focal liver lesions

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Disaster Risk Governance as Assemblage: The Chilean Framework of the 1985 San Antonio Earthquake

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International Journal of Disaster Risk Science 2022年第6期13卷 878-889页

作者： daniela P.González Architecture and Urban Studies Pontifcal Catholic University of Chile7520245 SantiagoChile

The purpose of this article is to analyze disaster risk governance through assemblage theory, identifying how-during the altered political context of a military regime with a centralized disaster risk management as in the case of Chile in 1985-new actors emerge during the disaster response phase as a de/reterritorialization effect that is influenced by their agencies and relationships, disfiguring the edges of the assemblage. Based on this conceptualization, it is possible to investigate the interactions between the different actors, their power relations, and their reconfigurations in the governance exercise. For this purpose, we reviewed the response phase of the 1985 San Antonio earthquake that affected the central zone of Chile, where strategic functions, institutions, and forms of power are *** describe and visualize the actors during the response phase in the disaster risk governance framework, a map of actors was developed that identifies the existing relationships and their different weights. The central scale proved to be dominant and occupied a political space that was transfigured by its overrepresentation-enforced by allies such as the banking system and business associations-enhancing a neoliberal agenda. The leaps in scale from the central scale to the local scale cancel agency of the last, destabilizing its capacity to deal with the effects of the earthquake and isolating it from the decision-making processes. Consequently,delays in providing aid demonstrate that authoritarian governments do not provide better management in the disaster response phase.

关键词： Assemblage Chile Disaster response phase Disaster risk governance San Antonio earthquake

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Influence of Doping Ions on the Antibacterial Activity of Biomimetic Coating on CoCrMo Alloy

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Journal of Bionic Engineering 2015年第4期12卷 583-591页

作者： Georgeta Totea daniela Ionita Ioana Demetrescu Faculty of Applied Chemistry and Materials Science Department of General Chemistry University Politehnica of Bucharest 1-7 Polizu district 1 Bucharest Ro-O 11061 Romania

In this study biomimetic fluoridated phosphate doped hydrophilic coatings with various ions on CoCrMo alloy were pre- pared by electrodeposition. Cu and Zn ions were chosen for doping because of their well known antibacterial activity. The struc^xes of the coatings were identified using Fourier-transform Infrared （FTIR） analysis. X-ray Diffraction （XRD） analysis was performed to evaluate crystallite dimensions of the specimen surface. The contact angle was measured in order to establish the hydrophilic/hydrophobic balance and to compute surface energy. All studied samples have a hydrophilic character which is weaken after doping. The time evolution of ions releasing from the coatings was evaluated with an inductively plasma mass spectrometer after immersion in saline phosphate. The hemolytic experiments indicate that except the fluoridated coatings doped with Zn which is slightly hemolytic, all other samples are non hemolytic. The test for antibacterial activity for Staphy- lococcus aureus and Pseudomonas aeruginosa indicated that the fluoridated biomimetic coating doped with various positive ions increases bacterial growth inhibition level significantly. Fluoridated phosphate coating doped with Cu has best antibacterial activity

关键词： phosphate coating electrodeposition CoCrMo alloy doping ions antibacterial activity

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Analysis of hydrodynamic effects on biofilm thickness in fluidized-bed tapered bioreactors

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Particuology 2021年第5期19卷 48-57页

作者： daniela Maria Koerich Leonardo Machado da Rosa Chemical Engineering Department University of Blumenau(FURB)3250 Sao Paulo Street89030-000 BlumenauSanta CatarinaBrazil

Fluidized beds in tapered geometries provide advantages such as a broad range of optimum operating ***,the dynamics of the flow inside these bioreactors is significantly more complex,as they promote non-uniform bioparticles *** this end,the CFD technique can give a detailed description of the flow in the ***,the aim of this work is to assess the influence of the hydrodynamic on the steady-state biofilm thickness through numerical simulations of liquid–solid fluidized *** geometries of tapered bioreactors in the operating conditions used to develop *** were run to solve the two-phase RANS equations using the open-source software OpenFOAM in *** SST k−ω model was used to estimate the turbulent features of the *** and bioparticles distribution inside the reactor were analyzed for different inlet velocities,while bioparticles collision frequency and shear stresses were evaluated for various operating *** comparison between the turbulent kinetic energy and the granular temperature indicated that the fluid flow is more turbulent than the bioparticles *** hydrodynamics influence on the steady-state biofilm thickness was assessed,and results led to the conclusion that biofilm is more sensitive to hydrodynamic shear stress than bioparticles collisions.

关键词： Liquid-solid fluidization Shear stress Particles collisions Computational fluid dynamics Biofilm Tapered bioreactors

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LVMH路威酪轩集团董事会主席兼CEO 伯纳德·阿尔诺:我们的每项计划都着眼于未来

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商业周刊（中文版） 2024年第12期 42-49页

作者： BRAD STONE ANGELINA RASCOUET RUVEN AFANADOR(摄影) Jeannette Neumann Natalie Wong daniela Wei Shirley Zhao 杨飞(译) 不详

LVMH路威酪轩集团已将全球众多奢侈品牌收入囊中,如今又成为2024年巴黎奥运会的最大赞助商。阿尔诺认为,该集团作为法国文化旗手,有责任让奥运会取得成功每周六早上,伯纳德·阿尔诺(BernardArnault)都会在副手、保镖和子女轮流担当的随... 详细信息

LVMH路威酪轩集团已将全球众多奢侈品牌收入囊中,如今又成为2024年巴黎奥运会的最大赞助商。阿尔诺认为,该集团作为法国文化旗手,有责任让奥运会取得成功每周六早上,伯纳德·阿尔诺(BernardArnault)都会在副手、保镖和子女轮流担当的随从陪同下,花几个小时的时间巡查他供奉着手袋、时装、珠宝和昂贵手表的时尚神殿。

关键词：集团董事会奢侈品牌阿尔诺奥运会伯纳德 CEO 赞助商

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