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New In Vitro Studies on the Bioprofile of Genista tenera Antihyperglycemic Extract

Natural Products and Bioprospecting 2015年第6期5卷 277-285页

作者： daniela batista Pedro L.Falé Maria L.Serralheiro Maria E.Araújo Paulo J.A.Madeira Carlos Borges Isabel Torgal Margarida Goulart Jorge Justino Alice Martins Amélia P.Rauter Centro de Química e Bioquímica Faculdade de CiênciasUniversidade de LisboaCampo Grande1749-016 LisbonPortugal Institute of Pharmaceutical Science King’s College London150 Stamford StreetLondon SE19NHUK Escola Superior Agrária de Santarém Quinta do Galinheiro2001-904 SantarémPortugal

The inhibition of a-glucosidase and glucose-6-phosphatase,two enzymes involved in the carbohydrate metabolism,is an important target to control glycaemia on individuals with type 2 *** this work we report for the first time the inhibition of both enzymes by the antihyperglycemic n-butanol extract from Genista tenera(Fabaceae).This extract decreased a-glucosidase and glucose-6-phosphatase activities to 0.97 and 80.25%,respectively,being more effective than acarbose,and phlorizin,the positive controls,which reduced enzymes activities only to 17.39 and 96.06%.Once inflammation and oxidative stress are related to diabetic impairments,the anti-inflammatory activity of the extract was also evaluated,through its inhibitory activity over COX-1 enzyme(47.5%inhibition).Moreover,after induction of oxidative stress by UV radiation,the viability of irradiated rat liver hepatoma cells exposed to the extract was significantly higher(67.82%)than that promoted by ascorbic acid,the positive control(45.05%).In addition,the stability of the extract under gastrointestinal conditions was evaluated by HPLC–DAD-ESI–MS/*** diglycosides were identified as the main constituents of the extract,and no alterations in the chemical composition nor in the antioxidant activity were observed after in vitro digestion with artificial gastric and pancreatic juices.

关键词： a-Glucosidase inhibition In vitro digestion HPLC-DAD-ESI-MS/MS Antioxidant activity Flavonoid glycosides

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Optimal velocity functions for car-following models

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第7期11卷 520-529页

作者： Milan batista Elen TWRDY Faculty of Maritime Studies and Transport University of Ljubljana

The integral part of the optimal velocity car-following models is the optimal velocity function (OVF), which can be derived from measured velocity-spacing data. This paper discusses several characteristics of the OVF and presents regression analysis on two classical datasets, the Lincoln and Holland tunnels, with different possible OVFs. The numerical simulation of the formation of traffic congestion is conducted with three different heuristic OVFs, demonstrating that these functions give results similar to those of the famous Bando OVF (Bando et al., 1995). Also an alternative method is present for determining the sensitivity and model parameters based on a single car driving to a fixed barrier.

关键词： Traffic flow Car following Optimal velocity function

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The RNA Modification N^6-methyladenosine and Its Implications in Human Disease

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Genomics, Proteomics & Bioinformatics 2017年第3期15卷 154-163页

作者： Pedro J.batista Laboratory of Cell Biology Center for Cancer ResearchNational Cancer InstituteNational Institutes of HealthBethesda MD 20892USA

Impaired gene regulation lies at the heart of many disorders, including developmental diseases and cancer. Furthermore, the molecular pathways that control gene expression are often the target of cellular parasites, such as viruses. Gene expression is controlled through multiple mechanisms that are coordinated to ensure the proper and timely expression of each gene. Many of these mechanisms target the life cycle of the RNA molecule, from transcription to translation. Recently, another layer of regulation at the RNA level involving RNA modifications has gained renewed interest of the scientific community. The discovery that N6-methyladenosine （m6A）, a mod- ification present in mRNAs and long noncoding RNAs, can be removed by the activity of RNA demethylases, launched the field of epitranscriptomics; the study of how RNA function is regulated through the addition or removal of post-transcriptional modifications, similar to strategies used to regulate gene expression at the DNA and protein level. The abundance of RNA post-transcriptional modifications is determined by the activity of writer complexes （methylase） and eraser （RNA demethylase） proteins. Subsequently, the effects of RNA modifications materialize as changes in RNA structure and/or modulation of interactions between the modified RNA and RNA binding proteins or regulatory RNAs. Disruption of these pathways impairs gene expression and cellular function. This review focuses on the links between the RNA modification m6A and its implications in human diseases.

关键词： N6-methyladenosine Epitranscriptomics Cancer Viral replication Metabolic disease

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A new species of Atelopus(Amphibia:Bufonidae)from eastern Panama

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Zoological Research 2021年第3期42卷 272-279页

作者： Milan Vesely Abel batista Department of Zoology Faculty of Natural SciencesPalacky UniversityOlomouc 77146Czech Republic Universidad Autónoma de Chiriquí Ciudad Universitaria El Cabrero DavidChiriquí427Panama Asociacion ADOPTA el Bosque Panamá Gamboa 119xPanama Fundacion Los Naturalistas DavidChiriquí426-01459Panama

A new species of the genus Atelopus,Atelopus fronterizo ***.,from eastern Panama is described herein based on molecular,morphological,and bioacoustic *** new species can be distinguished from its congeners occurring in the region by a combination of the following characters:(1)phalangeal reduction in thumb;(2)SVL(females only)(35.1-50.1;n=13),HW/SVL(0.23-0.34;n=59),EYND/HW(0.27-0.39;n=60),TIBL/SVL(0.41-0.56;n=58),and HAL/SVL(0.22-0.28;n=49);(3)dorsal color pattern with green or yellow background and extensive dark olive blotches forming transversal bands or mottling;(4)advertisement call duration 176-235 ms with 19-34 pulses,average pulse rate 131.69 pulses/s,and dominant frequency 2422.50-2606.50 *** new species is nested within the Central American clade of *** minimum Kimura‐2‐parameter(K2P)genetic divergence between Atelopus fronterizo *** its most phylogenetically similar congeners(*** and ***)is>2.6%for 16S and>4.9%for COI(Table 1).The phylogenetic relationship is strongly supported by ultrafast bootstrap values for the maximum-likelihood trees of both genetic markers(16S,96;COI,100,Figure 1A).Bayesian analysis of the concatenated sequences resulted in a tree with similar topology and high posterior probability support(0.99;Supplementary Figure S1).In addition,haplotype networks inferred from COI and 16S(Supplementary Figure S2)showed a well-separated clade containing the new species(two for COI,four for 16S).

关键词： 16S Figure eastern

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Analysis of the Most Likely Regions of Stability of an NCS and Design of the Corresponding Event-driven Controller

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International Journal of Automation and computing 2018年第1期15卷 39-51页

作者： Ana Paula batista Fabio Goncalves Jota Centre for Intelligent Energy Research Federal Centre of Technological Education of Minas Gerais Belo Horizonte Brazil Graduate Program in Electrical Engineering Federal University of Minas Gerais Belo Horizonte Brazil

In this paper, some issues related to design and analysis of real networked control systems （NCS） under the focus of the most likely region of stability are addressed. Such a system is cumbersome due to its inherent variable time delays, ranging from microseconds to hours. To show the influence of such huge variations in the control performance, a laboratory-scale luminosity system has been setup using the Internet as part of the control loop with dominant time constant in the order of milliseconds. Proportional and integral （PI） control strategies with and without explicit compensation for the time-delay variations were implemented using an event-driven controller. Using the well-known Monte Carlo method and subsequent analyses of time responses, it has been possible to identify the most likely region of stability. Some experimental results show the influence of the statistical parameters of the delays on the determination of the most likely regions of stability of the NCS and how these can be used in assessment and redesign of the control system. The experiments show that much larger delays than one sample period can be supported by real NCSs without becoming unstable.

关键词： Networked control systems real NCS delay compensation most likely regions of stability delay statistics.

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Machine learning assisted derivation of minimal low-energy models for metallic magnets

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npj Computational Materials 2023年第1期9卷 353-364页

作者： Vikram Sharma Zhentao Wang Cristian D.batista Department of Physics and Astronomy The University of TennesseeKnoxvilleTN 37996USA School of Physics and Astronomy University of MinnesotaMinneapolisMN 55455USA Quantum Condensed Matter Division and Shull-Wollan Center Oak Ridge National LaboratoryOak RidgeTN 37831USA Present address:Center for Correlated Matter and School of Physics Zhejiang UniversityHangzhou 310058China

We consider the problem of extracting a low-energy spin Hamiltonian from a triangular Kondo Lattice Model(KLM).The non-analytic dependence of the effective spin-spin interactions on the Kondo exchange excludes the use of perturbation theory beyond the second *** then introduce a Machine Learning(ML)assisted protocol to extract effective two-and four-spin *** resulting spin model reproduces the phase diagram of the original KLM as a function of magnetic field and single-ion anisotropy and reveals the effective four-spin interactions that stabilize the field-induced skyrmion crystal ***,this model enables the computation of static and dynamical properties with a much lower numerical cost relative to the original KLM.A comparison of the dynamical spin structure factor in the fully polarized phase computed with both models reveals a good agreement for the magnon dispersion even though this information was not included in the training data set.

关键词： Kondo dynamical derivation

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Permanence of Lung Disorders after Hospital Discharge of Patients Who Underwent Cardiac Surgery: An Integrative Review

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Health 2020年第2期12卷 194-203页

作者： daniela Di Bernardi Marcos Bagrichevsky Christiani Decker batista Bonin Instituto de Ensino Superior (IES) Florianópolis Brasil Departmento de Medicina Universidade Regional de Blumenau (FURB) Blumenau Brasil

Patients are more likely to develop lung disorders after cardiac surgery. Pulmonary dysfunction resulting from cardiac surgery in the hospital phase is well documented. However, there is a scarcity of studies related to the permanence of pulmonary disorders in the period following hospital discharge. The objective of this study was to verify in a database investigation the permanence of pulmonary dysfunctions after hospital discharge of patients who underwent cardiac surgery. A literature review with an integrative approach was carried out in the National Library of Medicine (Pubmed) and Scientific Electronic Library Online (Scielo) databases from 1978 to 2019. 4523 articles were found and after applying the inclusion and exclusion criteria, the sample was composed of 14 articles relevant to the subject and that were available in full. The results demonstrated the presence of atelectasis, pleural effusion, diaphragmatic dysfunction, respiratory symptoms such as cough, phlegm, wheezing, and dyspnea, reduced static and dynamic lung volumes, reduced diffusion capacity and respiratory muscle strength, in the period that ranged from three weeks to one year after cardiac surgery. Further studies are needed to elucidate the mechanisms that lead to the permanence of pulmonary dysfunctions after hospital discharge in patients who underwent cardiac surgery.

关键词： Thoracic Surgery Cardiac Surgery Pulmonary Function Test Respiratory Function Tests

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The effect of salinity on Fucus ceranoides (Ochrophyta,Phaeophyceae) in the Mondego River(Portugal)

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Journal of Oceanology and Limnology 2019年第3期37卷 881-891页

作者： COTAS Joao FIGUEIRINHA Artur PEREIRA Leonel batista Teresa Department of Life Sciences University of CoimbraCoimbra 3001-456Portugal MARE-Marine and Environmental Sciences Centre Faculty of Science and TechnologyUniversity of CoimbraCoimbra 3000-548Portugal Laboratory of Pharmacognosy Faculty of PharmacyUniversity of CoimbraCoimbra 3000-548Portugal LAQV REQUIMTEFaculty of PharmacyUniversity of CoimbraCoimbra 3000-548Portugal CIEPQPF Department of Chemical EngineeringFaculty of Science and TechnologyUniversity of CoimbraCoimbra 3030-790Portugal

Algae(and their extracts)are increasingly important for pharmaceutical applications due to the diversity of useful compounds they *** genus Fucus contains one of the most studied species,Fucus *** species *** differs from the others of the genus by presenting longitudinal air-vesicles and a capacity to survive at low *** is an alga that inhabits the Mondego River estuary(Portugal),at the southern limit of its distribution,and can serve as a role model to understand the effect of a salt gradient on the production of bioactive *** assessed the phenolic content and antioxidant activity of different *** extracts(***,aqueous and polysaccharide)prepared from samples harvested from two different zones to evaluate if the adaptation of *** to different salinity levels influenced its chemical *** antioxidant activity of the extracts was determined using 1,2-diphenyl-picrylhydrazyl(DPPH)and 2.2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)(ABTS)*** assays demonstrated that the methanolic extract of lyophilized *** that grew at low salinities was the most bioactive,***(IC 50=50.39μg/mL)and ABTS(TEAC=2.42).The total phenolic content(Folin-Ciocalteu method)and the methanolic extract of the lyophilized *** collected from a low salinity habitat exhibited the highest phenolic content(PGE=49.48μg/mg of lyophilized extract)amongst those *** layer chromatography(TLC)and Fourier transform infrared spectroscopy(FTIR)were used for the identification of compounds in the *** characterization allowed confirmation that the various extracts contained almost the same compounds but with notable quantitative *** on these results,we conclude that there were differences in the quantity of the compounds due to the effect of *** drying methods used were also found to have influenced the quality of the extracted compounds.

关键词： Fucus ceranoides salinity gradient sequential extractions phenolic content dependent bioactivities spectroscopic analysis

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Proportionally Modular Diophantine Inequalities and Their Multiplicity

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Acta Mathematica Sinica,English Series 2010年第11期26卷 2059-2070页

作者： José Carlos ROSALES Manuel batista BRANCO Paulo VASCO Departamento de lgebra Universidad de Granada Departamento de Matemática Departamento de Matemática Universidade de Trás-os-Montes e Alto Douro

Let I be an interval of positive rational numbers. Then the set S （I） = T ∩ N, where T is the submonoid of （Q0＋, ＋） generated by T, is a numerical semigroup. These numerical semigroups are called proportionally modular and can be characterized as the set of integer solutions of a Diophantine inequality of the form ax rood b 〈 cx. In this paper we are interested in the study of the maximal intervals I subject to the condition that S （I） has a given multiplicity. We also characterize the numerical semigroups associated with these maximal intervals.

关键词： Numerical semigroup Diophantine inequality multiplicity Frobenius number

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Determination of the physical and interaction properties of sorghum grains:Application to computational fluid dynamics-discrete element method simulations of the fluid dynamics of a conical spouted bed

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Particuology 2021年第1期19卷 91-101页

作者： J.N.M.batista D.A.Santos R.Bettega Federal University of São Carlos Department of Chemical EngineeringSPBrazil Institute of Chemistry Federal University of GoiásGOBrazil

Computational simulation is an important tool for design and improvement of industrial *** fluid dynamics(CFD)coupled with the discrete element method(DEM)has been applied to simulate drying equipment that usually involves gas-solid *** reliable results of CFD-DEM simulations,the properties related to the interactions of the material within the industrial equipment,such as the restitution or friction coefficients,must be *** this study,CFD-DEM was applied to simulate the fluid dynamics inside a conical spouted bed operating with sorghum *** physical properties of the particulate phase and the particle-particle and particle-wall interaction parameters were determined by the direct measurement approach and applied to *** interaction parameters were experimentally determined,including the particle-particle interaction parameters ofη=0.46,μ^(S)=0.79,andμ_(R)=0.70,and the particle-wall interaction parameters ofη=0.56,μ_(S)=0.75,andμ_(R)=*** simulated minimum spouting velocity and characteristic curves were compared with the experimental *** was good agreement between the simulated and experimental results.

关键词： Restitution coefficient Static friction coefficient Rolling friction coefficient CFD DEM

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