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Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez daniel Refai Gerald R.Rodts Christian Mustroph David Gimbel Jonathan Grossberg daniel l.Barrow Matthew F.Gary Ali M.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

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Amyloid-β-induced disruption of axon-initial-segment mitochondria localization:consequences for TAU missorting in Alzheimer's disease pathology

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Neural Regeneration Research 2025年第5期20卷 1407-1408页

作者： daniel Adam Felix langerscheidt Hans Zempel Institute of Human Genetics University Hospital CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany

TAU is a neuronal microtubule-associated protein preferentially located in *** a battery of neurodegenerative diseases termed"tauopathies,"including Alzheimer's disease (AD),TAU is missorted and abnormally phosphorylated,leading to filamentous accumulations of hyperphosphorylated TAU,a pathological hallmark and potential disease driver of AD and related tauopathies (Zempel,2024).

关键词： Alzheimer tau diseases

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Vascular endothelial growth factor:a double-edged sword in the development of white matter lesions

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Neural Regeneration Research 2025年第1期20卷 191-192页

作者： Narek Manukjan daniel Fulton Zubair Ahmed WMatthijs Blankesteijn Sébastien Foulquier Department of Pharmacology and Toxicology Maastricht UniversityMaastrichtThe Netherlands CARIM-School for Cardiovascular Diseases Maastricht UniversityMaastrichtThe Netherlands Neuroscience and Ophthalmology Institute of Inflammation and AgeingUniversity of BirminghamEdgbastonBirminghamUK Centre for Trauma Sciences Research University of BirminghamEdgbastonBirminghamUK MHeNs-School for Mental Health and Neuroscience Maastricht UniversityMaastrichtThe Netherlands Department of Neurology Maastricht University Medical CenterMaastrichtThe Netherlands

As the population ages,the burden of age-related diseases becomes ***,over 55 million people suffer from dementia worldwide,with Alzheimer’s disease being the most common ***,it is becoming clearer that underlying vascular pathology such as cerebral small vessel disease(cSVD)may be a more detrimental cause for dementia(Cuadrado-Godia et al.,2018).It is estimated that 10%-30%of the elderly population and 35%-90%of all dementia patients exhibit signs of *** term cSVD refers to pathology affecting the small vessels of the brain,which can lead to lacunar cerebral infarcts,enlarged perivascular spaces,and cortical hemorrhages(Cuadrado-Godia et al.,2018).CSVD is often associated with cognitive decline,gait problems,and dementia(Cuadrado-Godia et al.,2018).

关键词： pathology becoming white

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Wafer-Scale Ag₂S-Based Memristive Crossbar Arrays with Ultra-low Switching-Energies Reaching Biological Synapses

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NANO-MICRO lETTERS 2025年第1期17卷 1-12页

作者： Zhu, Yuan Nyberg, Tomas Nyholm, leif Primetzhofer, daniel Shi, Xun Zhang, Zhen Uppsala Univ Dept Elect Engn Div Solid State Elect S-75121 Uppsala Sweden Uppsala Univ Dept Chem Uppsala Sweden Uppsala Univ Dept Phys & Astron Uppsala Sweden Chinese Acad Sci Shanghai Inst Ceram State Key Lab High Performance Ceram & Superfine M Shanghai 200050 Peoples R China

Memristive crossbar arrays (MCAs) offer parallel data storage and processing for energy-efficient neuromorphic computing. However, most wafer-scale MCAs that are compatible with complementary metal-oxide-semiconductor (CMOS) technology still suffer from substantially larger energy consumption than biological synapses, due to the slow kinetics of forming conductive paths inside the memristive units. Here we report wafer-scale Ag2S-based MCAs realized using CMOS-compatible processes at temperatures below 160 degrees C. Ag2S electrolytes supply highly mobile Ag+ ions, and provide the Ag/Ag2S interface with low silver nucleation barrier to form silver filaments at low energy costs. By further enhancing Ag+ migration in Ag2S electrolytes via microstructure modulation, the integrated memristors exhibit a record low threshold of approximately - 0.1 V, and demonstrate ultra-low switching-energies reaching femtojoule values as observed in biological synapses. The low-temperature process also enables MCA integration on polyimide substrates for applications in flexible electronics. Moreover, the intrinsic nonidealities of the memristive units for deep learning can be compensated by employing an advanced training algorithm. An impressive accuracy of 92.6% in image recognition simulations is demonstrated with the MCAs after the compensation. The demonstrated MCAs provide a promising device option for neuromorphic computing with ultra-high energy-efficiency.

关键词： Wafer-scale Ag2S films Reactive sputter Silver nucleation Ag+ migration Energy-efficient neuromorphic computing

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Beginning from the end:the presynaptic terminal as a pathomechanism hub in frontotemporal dementia and amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3217-3218页

作者： laura Huggon Emma l.Clayton UK Dementia Research Institute at King’s College london LondonUK Department of Basic and Clinical Neuroscience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

Frontotemporal dementia and amyotrophic lateral sclerosis:Frontotemporal dementia(F T D)and amyo t rophic lateral sclerosis(AlS)are neurodegenerative diseases with significant overlapping *** these neurodegenerative diseases affect different neuronal populations(with FTD affecting neurons of the frontal and temporal lobes,and AlS affecting upper and lower motor neurons),these two diseases are complexly *** and AlS exist on a disease spectrum,with shared genetic causes,clinical presentations,and pathologies.

关键词： diseases amyotrophic sclerosis

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A reflection on the contrast between the Cooper pairing in iron-based and conventional superconductors

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Frontiers of physics 2011年第4期6卷 350-356页

作者： Fa Wang Dung-hal lee Department of Physics Massachusetts Institute of Technology Cambridge MA 02139 USA Department of Physics University of California at Berkeley Berkeley CA 94720 USA Materials Sciences Division Lawrence Berkeley National Laboratory Berkeley CA 94720 USA

In this Perspective article we review retrospectively the streamline of our work on iron-based superconductors, and reflect on the mechanism of Cooper pairing in conventional and unconventional, such as iron-based sup... 详细信息

关键词： Cooper pairing iron-based superconductors effective interaction renormalizationgroup

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Metabolic pathway engineering

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Synthetic and Systems Biotechnology 2018年第1期3卷 1-2页

作者： hal S.Alper Josél.Avalos McKetta Department of Chemical Engineering The University of Texas at AustinUSA Department of Chemical and Biological Engineering Andlinger Center for Energy and the EnvironmentPrinceton UniversityUSA

Organisms can be engineered to produce a wide variety of compounds by either enhancing endogenous metabolic pathways,or by introducing exogenous pathways that are either borrowed from other organism,or de novo-designed pathways unknown to *** overexpression of bottleneck enzymes and deletion of competing pathways remain at the core of metabolic pathway engineering,there are many other key elements that need to be considered to successfully develop strains for the production of valuable products.

关键词： products. introducing valuable

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On the Bifurcations of a Hamiltonian Having Three Homoclinic loops under Z_3 Invariant Quintic Perturbations

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Acta Mathematica Sinica,English Series 2007年第5期23卷 869-878页

作者： Yu hal WU Mao An HAN Department of Mathematics Jiang Su University Zhenjiang 212013 P. R. China Department of Mathematics Shanghai Normal University Shanghai 200234 P. R. China

A cubic system having three homoclinic loops perturbed by Z3 invariant quintic polynomials is considered. By applying the qualitative method of differential equations and the numeric computing method, the Hopf bifurcation, homoclinic loop bifurcation and heteroclinic loop bifurcation of the above perturbed system are studied. It is found that the above system has at least 12 limit cycles and the distributions of limit cycles are also given.

关键词： homoclinic loop bifurcation heteroclinic loop bifurcation Hopf bifurcation stability limit cycles

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State Sampling Dependence of Hopfield Network Inference

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Communications in Theoretical Physics 2012年第1期57卷 169-172页

作者： HUANG hal-Ping Key laboratory of Frontiers in Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Department of Physics Hong Kong University of Science and TechnologyHong KongChina

The fully connected Hopfield network is inferred based on observed magnetizations and pairwise *** present the system in the glassy phase with low temperature and high memory *** find that the inference error is very sensitive to the form of state *** a single state is sampled to compute magnetizations and correlations,the inference error is almost indistinguishable irrespective of the sampled ***,the error can be greatly reduced if the data is collected with state *** result holds for different disorder samples and accounts for the previously observed large fluctuations of inference error at low temperatures.

关键词： inference Hopfield network spin glass

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Highly Oxygenated Monoterpenes from Eupatorium fortunei

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Chinese Chemical letters 2005年第9期16卷 1217-1219页

作者： hal Xia JIANG Kun GAO State Key laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University Lanzhou 730000

A pair of epimers of highly-oxygenated monoterpenes were isolated from the traditional Chinese medicine Eupatorium fortunei. Their structures were elucidated on the basis of the spectral analysis as （1R＊, 2S＊, 3R＊, 4R＊, 6S＊）-1, 2, 3, 6-tetrehydroxy-p-menthane （1） and （1S＊, 2S＊, 3S＊, 4R＊, 6R＊）-1, 2, 3, 6-tetrehydroxy-p-menthane （2）.

关键词： Eupatorium fortunei traditional Chinese medicine epimer highly-oxygenated monoterpenes

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