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Dermal fibroblast expression of stromal cellderived factor-1 （SDF-1） promotes epidermal keratinocyte proliferation in normal and diseased skin

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Protein & Cell 2015年第12期6卷 890-903页

作者： Chunji Quan Moon Kvun Cho Yuan Shao Laurel E. Mianecki Eric Liao daniel perry Taihao Quan Department of Pathology Affiliated Hospital of Yanbian University Yanji 133000 China Department of Dermatology Soonchunhyang University College of Medicine Seoul Republic of Korea Hollings Cancer Center Biorepository and Tissue Analysis Resource Medical University of South Carolina Charleston SC 29425 USA Department of Dermatology University of Michigan Medical School Ann Arbor MI 48109 USA

Stromal cells provide a crucial microenvironment for overlying epithelium. Here we investigated the expression and function of a stromal cell-specific protein, stromal cell-derived factor-1 （SDF-1）, in normal human skin and in the tissues of diseased skin. Immunohistology and laser capture microdissection （LCM）-coupled quantitative real- time RT-PCR revealed that SDF-1 is constitutively and predominantly expressed in dermal stromal cells in nor- mal human skin in vivo. To our surprise, an extremely high level of SDF-1 transcription was observed in the dermis of normal human skin in vivo, evidenced by much higher mRNA expression level than type I collagen, the most abundant and highly expressed protein in human skin. SDF-1 was also upregulated in the tissues of many human skin disorders including psoriasis, basal cell carcinoma （BCC）, and squamous cell carcinoma （SCC）. Double immunostaining for SDF-1 and HSP47 （heat shock protein 47）, a marker of fibroblasts, revealed that fibroblasts were the major source of stroma-cell-derived SDF-1 in both normal and diseased skin. Functionally, SDF-1 activates the ERK （extracellular-signal-regulated kinases） pathway and functions as a mitogen to stimulate epidermalkeratinocyte proliferation. Both overexpression of SDF-1 in dermal fibroblasts and treatment with rhSDF-1 to the skin equivalent cultures significantly increased the number of keratinocyte layers and epidermal thickness. Con- versely, the stimulative function of SDF-1 on keratinocyte proliferation was nearly completely eliminated by inter- fering with CXCR4, a specific receptor of SDF-1, or by knock-down of SDF-1 in fibroblasts. Our data reveal that extremely high levels of SDF-1 provide a crucial microenvironment for epidermal keratinocyte proliferation in both physiologic and pathologic skin conditions.

关键词： SDF-1 dermal fibroblast keratinocyte,proliferation skin cancer psoriasis

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21世纪促进健康和预防疾病的新模式

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英国医学杂志中文版 2008年第4期11卷 236-238页

作者： Robert N Butler Richard A Miller daniel perry Bruce A Cames T Franklin William Christine Cassel Jacob Brody Marie A Bernard Linda Partridge Thomas Kirkwood George M Martin S Jay Olshansky 周财亮(译) 张拓红(校) International Longevity Center New York USA University of Michigan Arm Arbor MI USA Alliance for Aging Resea Washington DCUSA University of Oklahoma Oklahoma City OKUSA University of Rochester School of Medicineand Denfistry NY USA American Board oflntemal Medicine Philadelphia PA USA University of Illinois at Chicago 1603 West Taylor Street Chicago IL 60612 USA Institute of Healthy Ageing University College London London Institute for Ageing and Health Newcastle University Newcastle American Federation for Aging Research Scatde WA USA 不详

随着年龄的增长，人类患病的可能性逐渐增加。因此，本文作者Robert Butler和他的同事认为干预人体衰老进程比治疗单个疾病更有效。

关键词：预防疾病健康衰老进程治疗单

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Direct laser writing of volumetric gradient index lenses and waveguides

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Light(Science & Applications) 2020年第1期9卷 89-102页

作者： Christian R.Ocier Corey A.Richards daniel A.Bacon-Brown Qing Ding Raman Kumar Tanner J.Garcia Jorik van de Groep Jung-Hwan Song Austin J.Cyphersmith Andrew Rhode Andrea N.perry Alexander J.Littlefield Jinlong Zhu Dajie Xie Haibo Gao Jonah F.Messinger Mark L.Brongersma Kimani C.Toussaint Jr Lynford L.Goddard Paul V.Braun Department of Materials Science and Engineering University of Illinois at Urbana-ChampaignUrbanaILUSA Materials Research Laboratory University of Illinois at Urbana-ChampaignUrbanaILUSA Beckman Institute for Advanced Science and Technology University of Illinois at Urbana-ChampaignUrbanaILUSA Department of Electrical and Computer Engineering University of Illinois at Urbana-ChampaignUrbanaILUSA Department of Materials Science and Engineering Stanford UniversityStanfordCAUSA Carl R.Woese Institute for Genomic Biology University of Illinois at Urbana-ChampaignUrbanaILUSA Department of Mechanical Science and Engineering University of Illinois at Urbana-ChampaignUrbanaILUSA

Direct laser writing(DLW)has been shown to render 3D polymeric optical components,including lenses,beam expanders,and mirrors,with submicrometer ***,these printed structures are limited to the refractive index and dispersive properties of the ***,we present the subsurface controllable refractive index via beam exposure(SCRIBE)method,a lithographic approach that enables the tuning of the refractive index over a range of greater than 0.3 by performing DLW inside photoresist-filled nanoporous silicon and silica *** the laser exposure during printing enables 3D submicron control of the polymer infilling and thus the refractive index and chromatic *** SCRIBE’s unprecedented index range and 3D writing accuracy has realized the world’s smallest(15μm diameter)spherical Luneburg lens operating at visible ***’s ability to tune the chromatic dispersion alongside the refractive index was leveraged to render achromatic doublets in a single printing step,eliminating the need for multiple photoresins and writing *** also has the potential to form multicomponent optics by cascading optical elements within a *** a demonstration,stacked focusing structures that generate photonic nanojets were fabricated inside porous ***,an all-pass ring resonator was coupled to a subsurface 3D *** measured quality factor of 4600 at 1550 nm suggests the possibility of compact photonic systems with optical interconnects that traverse multiple *** is uniquely suited for constructing such photonic integrated circuits due to its ability to integrate multiple optical components,including lenses and waveguides,without additional printed supports.

关键词： index refractive render

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走进五角大楼

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作者： (美)派瑞·M.史密斯(perry M.Smith) 丹尼尔·M.格斯坦(daniel M.Gerstein)

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Exposure to dietary mercury alters cognition and behavior of zebra finches

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Current Zoology 2017年第2期63卷 213-219页

作者： John R SWADDLE Tessa R. DIEHL Capwell E, TAYLOR Aaron S. FANAEE Jessica L. BENSON Neil R. HUCKSTEP daniel A. CRISTOL Biology Department College of William and Mary Institute for Integrative Bird Behavior Studies Williamsburg VA 23187-8795 USA Biological Sciences Virginia Tech 1405 Perry Street Blacksburg VA 24061 USA

Environmental stressors can negatively affect avian cognitive abilities, potentially reducing fitness, for example by altering response to predators, display to mates, or memory of locations of food. We expand on current knowledge by investigating the effects of dietary mercury, a ubiquitous environmental pollutant and known neurotoxin, on avian cognition. Zebra finches were dosed for their entire lives with sub-lethal levels of mercury, at the environmentally relevant dose of 1.2 parts per million. In our first study, we compared the dosed birds with controls of the same age using tests of three cognitive abilities: spatial memory, inhibitory control, and color association. In the spatial memory assay, birds were tested on their ability to learn and remember the location of hidden food in their cage. The inhibitory control assay measured their ability to ignore visible but inaccessible food in favor of a learned behavior that provided the same reward. Finally, the color association task tested each bird's ability to associate a specific color with the presence of hidden food. Dietary mercury negatively affected spatial memory ability but not inhibitory control or color association. Our second study focused on three behavioral assays not tied to a specific skill or problem-solving: activity level, neophobia, and social dominance. Zebra finches exposed to dietary mercury throughout their lives were subordinate to, and more active than, control birds. We found no evidence that mercury exposure influenced our metric of neophobia. Together, these results suggest that sub-lethal exposure to environmental mercury selectively harms neurological pathways that control different cognitive abilities, with complex effects on behavior and fitness.

关键词： animal behavior cognition ecotoxicology mercury spatial memory zebra finch.

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007的水下浪漫

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模型世界 2020年第8期 66-71页

作者： daniel Zamarbide

两栖型莲花SplitS1是007传奇中最具代表性的车型之一,对于车迷和收藏家来说,它仍然是一款令人兴奋和向往的车型。它的首次露面是在1977年的电影《007之海底城》里,片中它冲进水里并立即转变成潜艇,把观众惊得目瞪口呆。该车由位于佛罗...

两栖型莲花SplitS1是007传奇中最具代表性的车型之一,对于车迷和收藏家来说,它仍然是一款令人兴奋和向往的车型。它的首次露面是在1977年的电影《007之海底城》里,片中它冲进水里并立即转变成潜艇,把观众惊得目瞪口呆。该车由位于佛罗里达里维拉海滩的佩里海洋学有限公司(perry Oceanographics Ltd)公司量身打造,拥有4个螺旋桨,主底盘来自于莲花Esprit S1跑车。埃隆·马斯克,拥有Space X的亿万富翁,如今是这辆汽车的主人。当然,特斯拉也是他的。

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