检索结果-南通市图书馆

Targeting the body to protect the brain:inducing neuroprotection with remotely-applied near infrared light

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2015年第3期10卷 349-351页

作者： daniel m.johnstone John mitrofanis Jonathan Stone Bosch Institute University of Sydney Discipline of Physiology University of Sydney Discipline of Anatomy & Histology University of Sydney

The incidence of intractable age-related neurodegenerative conditions such as Alzheimer＇s and Parkinson＇s diseases and age-related macular degeneration is projected to increase substantially over the coming decades with the ageing of the global population. While the burden of disease associ- ated with other chronic conditions has decreased in recent times due to improved diagnosis and treatment, current therapies for neurodegenerative diseases still fall short in that they are only effective in treating signs and symptoms - they do little to slow or prevent disease progress. Thus, there is an urgent need for treatments that address disease progression.

关键词： body mPTP Targeting the body to protect the brain mSCs

Comprehensive review of hepatocellular carcinoma with portal vein tumor thrombus:State of art and future perspectives

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 221-227页

作者： Paschalis Gavriilidis Timothy m Pawlik daniel Azoulay Department of Surgery Colchester General HospitalTurner RoadColchester CO45JLUK Department of Surgery The Ohio State Wexner Medical CenterJames Comprehensive Cancer CenterColumbusOHUSA Department of Hepato-Biliary and Liver Transplantation surgery Paul Brousse University HospitalParis-Saclay UniversityVillejuif 94800France

Background:Despite advances in the diagnosis of patients with hepatocellular carcinoma(HCC),70%-80%of patients are diagnosed with advanced stage *** vein tumor thrombus(PVTT)is among the most ominous signs of advanced stage disease and has been associated with poor survival if *** sources:A systematic search of mEDLINE(Pubmed),Embase,Cochrane Library and Database for Systematic Reviews(CDSR),Google Scholar,and National Institute for Health and Clinical Excellence(NICE)databases until December 2022 was conducted using free text and meSH terms:hepatocellular carcinoma,portal vein tumor thrombus,portal vein thrombosis,vascular invasion,liver and/or hepatic resection,liver transplantation,and systematic ***:Centers of surgical excellence have reported promising results related to the individualized surgical management of portal thrombus versus arterial chemoembolization or systemic *** elements to the individualized surgical management of HCC and portal thrombus include precise classification of the portal vein tumor thrombus,accurate identification of the subgroups of patients who may benefit from resection,as well as meticulous surgical *** review addressed five specific areas:(a)formation of PVTT;(b)classifications of PVTT;(c)controversies related to clinical guidelines;(d)surgical treatments versus non-surgical approaches;and(e)characterization of surgical techniques correlated with classifications of ***:Current evidence from Chinese and Japanese high-volume centers demonstrated that patients with HCC and associated PVTT can be managed with surgical resection with acceptable results.

关键词： Hepatectomy Liver surgery Liver neoplasms Portal vein tumor thrombus

Use of DREAm to assess relative risks of presence of pharmaceuticals and personal care products from a wastewater treatment plant

在线全文

学校读者我要写书评

暂无评论

Frontiers of Environmental Science & Engineering 2024年第9期18卷 91-104页

作者： daniela m.Pampanin daniel Schlenk matteo Vitale Pierre Liboureau magne O Sydnes Department of Chemistry Bioscience and Environmental EngineeringUniversity of StavangerStavanger 224021Norway Department of Environmental Sciences University of California RiversideRiversideCA 92521USA

Concerns related to environmental risks associated with pharmaceuticals and personal care products(PPCPs)have led researchers to seek methods for assessing and monitoring these contaminants in the aquatic *** and validating risk assessment tools that can evaluate ecological concerns and risks associated with PPCPs is ***,the suitability of a dose-related risk and effect assessment model,which estimates predicted environmental concentrations and allowed comparisons with predicted no effect concentrations determined,in combination with in vitro analyses of the whole effluent toxicity,was verified for the characterization of a PPCP *** of the most utilized PPCPs in Norway were measured in influent and effluent samples and used to parameterize the fate *** than 90%removal was attained for 12 out of 22 detected *** was not dependent on the class or the concentration of the specific substance and varied between 12%and 100%.The PPCPs detected in the discharged wastewater were utilized to assess individual contributions to the risk of the effluent,and no risk was identified for the targeted 30 *** simulations provided valuable information regarding the discharge plume distribution over time,which can aid planning of future environmental monitoring ***(using fish liver cells,PLHC-1)were used for assessing overall effluent toxicity,through cell viability,production of reactive oxygen species,and ethoxyresorufin-O-deethylase(EROD)*** present study may allow regulators to use risk-based strategies over removal criteria for monitoring studies and confirms the importance to take PPCP contamination into consideration when establishing environmental regulations.

关键词： Pharmaceuticals Wastewater effluent Ciprofloxacin metoprolol Amitriptyline Carbamazepine modelling Risk assessment monitoring

Charting the course to solid-state dual-ion batteries

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Carbon Energy 2024年第3期6卷 132-177页

作者： Habtom D.Asfaw Antonia Kotronia Nuria Garcia-Araez Kristina Edström daniel Brandell Department of Chemistry Ångström LaboratoryUppsala UniversityUppsalaSweden Department of Chemistry University of SouthamptonSouthamptonUK

An electrolyte destined for use in a dual-ion battery(DIB)must be stable at the inherently high potential required for anion intercalation in the graphite electrode,while also protecting the Al current collector from anodic dissolution.A higher salt concentration is needed in the electrolyte,in comparison to typical battery electrolytes,to maximize energy density,while ensuring acceptable ionic conductivity and operational *** recent years,studies have demonstrated that highly concentrated organic electrolytes,ionic liquids,gel polymer electrolytes(GPEs),ionogels,and water-in-salt electrolytes can potentially be used in *** can help reduce the use of solvents and thus lead to a substantial change in the Coulombic efficiency,energy density,and long-term cycle life of ***,GPEs are suited to manufacture compact DIB designs without separators by virtue of their mechanical strength and electrical *** this review,we highlight the latest advances in the application of different electrolytes in DIBs,with particular emphasis on GPEs.

关键词： anion intercalation concentrated electrolytes dual-ion battery graphite ionic liquids polymer electrolyte

Testing and modelling of transient adhesion phenomena in rolling-sliding contacts

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Friction 2024年第5期12卷 1016-1027页

作者： daniel KVARDA Alexander mEIERHOFER Klaus SIX Faculty of mechanical Engineering Brno University of TechnologyBrno61669Czech Republic Virtual Vehicle Research GmbH Graz8010Austria

Transient adhesion effects in rolling–sliding contacts influence all aspects of train–track *** is of high importance specifically when these effects result in critically low adhesion,which poses a risk to traction and braking of railway *** study presents a model that can replicate the transient changes of the coefficient of adhesion with tested water and solid particle *** experimental data for the model are measured using a commercial ball-on-disc *** experimental results showed a liquid reservoir in front of the contact area that slowly reduces in *** observation was used in the modelling approach to divide the calculation into two stages where the reservoir is present and when it *** model was able to reproduce the occurrence of low adhesion region seen in experimental results with different particle concentrations.

关键词： coefficient of adhesion tribology transient effects wheel-rail contact

Intraocular pressure before and after capsulorhexis using two viscoelastic substances and two surgical approaches in enucleated porcine eyes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2024年第6期17卷 1156-1160页

作者： Chiraz Ben Abdallah Walter Sekundo markus SLadewig daniel m.Handzel Augenzentrum Osthessen Fulda 36037Germany University Eye Hospital Philipps-University Marburg 35043Germany University Eye Hospital Philipps-University Campus FuldaFulda 36043Germany

AIm:To investigate the influence of ophthalmic viscoelastic devices(OVDs)and different surgical approaches on the intraocular pressure(IOP)before and after creation of the curvilinear circular capsulorhexis(CCC)as a measure for anterior chamber stability during this ***:Prospective experimental WetLab study carried out on enucleated porcine *** was measured before and after CCC with the iCare Rebound tonometer(iCare ic200;iCare Finland Oy,Vantaa,Finland).The OVDs used were a cohesive one[Z-Hyalin,Carl Zeiss meditec AG,Germany;hyaluronic acid(HA)]and a dispersive[Z-Celcoat,Carl Zeiss meditec AG,Germany;hydroxy propylmethylcellulosis(HPmC)].The CCC was created using Utrata forceps or 23 g microforceps in different combinations with the ***:Using the Utrata forceps the IOP dropped from 63.65±6.44 to 11.25±3.63 mm Hg during the *** use of different OVDs made no *** the 23 g microforceps the IOP dropped from 65.35±8.15 to 36.55±6.09 mm *** difference between IOP drop using either Utrata forceps or 23 g microforceps was highly significant regardless of the OVD ***:Using the sideport for the creation of the capsulorhexis leads to a lesser drop in IOP during this maneuver compared to the main incision in enucleated porcine *** use of different OVD has no significant influence on IOP drop.

关键词： cataract surgery ophthalmosurgical viscoelastic device intraocular pressure capsulorhexis enucleated porcine eye

Energy model based on solar potential and the production of electrical energy through living plants' photosynthesis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

CLEAN ENERGY 2024年第3期8卷 116-126页

作者： martinez, Raymond daniel Rodriguez Univ metropolitana Fac Engn Dept Ind Prod Caracas 1073 Venezuela

Developing a sustainable energy model is imperative considering the current trend towards decarbonizing sectors worldwide. For this purpose, Venezuela was used as a reference to propose an energy model focused on taking advantage of plant photosynthesis through microbial-vegetable fuel cells together with an agro-photovoltaic system to enhance energy and agricultural production. Energy production from the cells was estimated using an average power density of 264 mW/m(2) over 4% of the areas destined for crops in the entire Venezuelan region, obtaining an annual production of 19.889 GWh/year. In contrast, the energy production of the agro-photovoltaic system was modelled using PVsyst software on 50% of the area used for the cells distributed throughout the states of Anzo & aacute;tegui, Gu & aacute;rico, monagas and Portuguesa according to their meteorological conditions, solar irradiation and agricultural activity, resulting in 3 703 417 GWh/year. The resulting whole system proved to be able to cover >10 times the installed electricity generation capacity at a national level and, together with the tremendous scalability of the microbial fuel cells, it shows that Venezuela has a high potential for the production and distribution of clean energy. [GRAPHICS]

关键词： ecosystems microbial fuel cell microorganisms renewable sustainability RESOURCES

Beyond the code:the role of histone methylation in cancer resistance and therapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第7期9卷 2837-2839页

作者： daniel Noerenberg Frederik Damm Charité–Universitätsmedizin Berlin corporate member of Freie Universität BerlinHumboldt Universität zu Berlinand Berlin Institute of HealthDepartment of HematologyOncologyand Cancer ImmunologyBerlinGermany German Cancer Consortium(Deutsches Konsortium für Translationale Krebsforschung DKTK)Partner SiteBerlinGermany

In a recently published paper in Nature,Yamagishi et *** a comprehensive exploration on the mechanistic basis and subsequent emergence of resistance of targeting histone H3 lysine trimethylation(H3K27me3)using the EZH... 详细信息

关键词： EZH2 resistance

Assessment of scale interactions associated with wake meandering using bispectral analysis methodologies

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Theoretical & Applied mechanics Letters 2024年第2期14卷 65-75页

作者： Dinesh Kumar Kinjangi daniel Foti Department of mechanical Engineering University of MemphisMemphisTennesseeUSA

Large atmospheric boundary layer fluctuations and smaller turbine-scale vorticity dynamics are separately hypothesized to initiate the wind turbine wake meandering phenomenon,a coherent,dynamic,turbine-scale oscillation of the far *** interactions,the mechanism of energy transfers between scales,manifest as triples of wavenumbers or frequencies and can be characterized through bispectral *** bispectrum,which correlates the two frequencies to their sum,is calculated by two recently developed multi-dimensional modal decomposition methods:scale-specific energy transfer method and bispectral mode ***-eddy simulation of a utility-scale wind turbine in an atmospheric boundary layer with a broad range of large length-scales is used to acquire instantaneous velocity *** bispectrum from both methods identifies prominent upwind and wake meandering interactions that create a broad range of energy scales including the wake meandering *** coherent kinetic energy associated with the interactions shows strong correlation between upwind scales and wake meandering.

关键词： Wind turbine wake mode decomposition Bispectral analysis