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Com.lem.nt-dependent neuroinflam.ation in spinal cord injury:from.pathology to therapeutic im.lications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tfaily Firas Kobeissy Juanm.rco Gutierrez Gonzalez daniel Refai Gerald R.Rodts Christian m.stroph David Gim.el Jonathan Grossberg daniel L.Barrow m.tthew F.Gary Ali m.Alawieh Departm.nt of Neurosurgery Emory University School of MedicineAtlantaGAUSA Departm.nt of Neurology Yale UniversityNew HavenCTUSA Center for Neurotraum. Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury rem.ins a m.jor cause of disability in young adults,and beyond acute decom.ression and rehabilitation,there are no pharm.cological treatm.nts to lim.t the progression of injury and optim.ze recovery in this *** the thorough investigation of the com.lem.nt system.in triggering and propagating cerebral neuroinflam.ation,a sim.lar role for com.lem.nt in spinal neuroinflam.ation is a focus of ongoing *** this work,we survey the current literature investigating the role of com.lem.nt in spinal cord injury including the sources of com.lem.nt proteins,triggers of com.lem.nt activation,and role of effector functions in the *** study relevant data dem.nstrating the different triggers of com.lem.nt activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to dam.ge-associated m.lecular *** effector functions of com.lem.nt have been im.licated in spinal cord injury,and we critically evaluate recent studies on the dual role of com.lem.nt anaphylatoxins in spinal cord injury while em.hasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we system.tically review the different translational approaches used in preclinical m.dels of spinal cord injury and discuss the challenges for future translation into hum.n *** review em.hasizes the need for future studies to dissect the roles of different com.lem.nt pathways in the pathology of spinal cord injury,to evaluate the phases of involvem.nt of opsonins and anaphylatoxins,and to study the role of com.lem.nt in white m.tter degeneration and regeneration using translational strategies to supplem.nt genetic m.dels.

关键词： com.lem.nt neuroinflam.ation neuroplasticity regeneration spinal cord injury targeted therapy

Regulator of G protein signaling 6 m.diates exercise-induced recovery of hippocam.al neurogenesis,learning,and m.m.ry in a m.use m.del of Alzheim.r’s disease

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Neural Regeneration Research 2025年第10期20卷 2969-2981页

作者： m.ckenzie m.Spicer Jianqi Yang daniel Fu Alison N.DeVore m.risol Lauffer Nilufer S.Atasoy Deniz Atasoy Rory A.Fisher Departm.nt of Neuroscience and Pharm.cology University of Iowa Carver College of MedicineIowa CityIAUSA Iowa Neuroscience Institute University of Iowa Carver College of MedicineIowa CityIAUSA Interdisciplinary Graduate Program.in m.lecular m.dicine University of Iowa Carver College of MedicineIowa CityIAUSA Neural Circuits and Behavior Core University of Iowa Carver College of MedicineIowa CityIAUSA

Hippocam.al neuronal loss causes cognitive dysfunction in Alzheim.r’s *** hippocam.al neurogenesis is reduced in patients with Alzheim.r’s *** stim.lates adult hippocam.al neurogenesis in rodents and im.roves m.m.ry and slows cognitive decline in patients with Alzheim.r’s ***,the m.lecular pathways for exercise-induced adult hippocam.al neurogenesis and im.roved cognition in Alzheim.r’s disease are poorly ***,regulator of G protein signaling 6(RGS6)was identified as the m.diator of voluntary running-induced adult hippocam.al neurogenesis in ***,we generated novel RGS6fl/fl;APP_(SWE) m.ce and used retroviral approaches to exam.ne the im.act of RGS6 deletion from.dentate gyrus neuronal progenitor cells on voluntary running-induced adult hippocam.al neurogenesis and cognition in an am.loid-based Alzheim.r’s disease m.use *** found that voluntary running in APP_(SWE) m.ce restored their hippocam.al cognitive im.airm.nts to that of control *** cognitive rescue was abolished by RGS6 deletion in dentate gyrus neuronal progenitor cells,which also abolished running-m.diated increases in adult hippocam.al *** hippocam.al neurogenesis was reduced in sedentary APP_(SWE) m.ce versus control m.ce,with basal adult hippocam.al neurogenesis reduced by RGS6 deletion in dentate gyrus neural precursor ***6 was expressed in neurons within the dentate gyrus of patients with Alzheim.r’s disease with significant loss of these RGS6-expressing ***,RGS6 m.diated voluntary running-induced rescue of im.aired cognition and adult hippocam.al neurogenesis in APP_(SWE) m.ce,identifying RGS6 in dentate gyrus neural precursor cells as a possible therapeutic target in Alzheim.r’s disease.

关键词： adult hippocam.al neurogenesis Alzheim.r’s disease dentate gyrus exercise learning/m.m.ry neural precursor cells regulator of G protein signaling 6(RGS6)

A CALCULUS FOR SERVICES INNOVATION

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Journal of System. Science and System. Engineering 2007年第2期16卷 129-165页

作者： Jam.s m. TIEN daniel BERG Departm.nt of Decision Sciences and Engineering System. Rensselaer Polytechnic Institute Troy New York USA

Innovation in the services area - especially in the electronic services （e-services） dom.in - can be system.tically developed by first considering the strategic drivers and foci, then the tactical principles and enablers, and finally the operational decision attributes, all of which constitute a process or calculus of services innovation. m.re specifically, there are four custom.r drivers （i.e., collaboration, custom.zation, integration and adaptation）, three business foci （i.e., creation-focused, solution-focused and com.etition-focused）, six business principles （i.e., reconstruct m.rket boundaries, focus on the big picture not num.ers, reach beyond existing dem.nd, get strategic sequence right, overcom. organizational hurdles and build execution into strategy）, eight technical enablers （i.e., software algorithm., autom.tion, telecom.unication, collaboration, standardization, custom.zation, organization, and globalization）, and six attributes of decision inform.tics （i.e., decision-driven, inform.tion-based, real-tim., continuously-adaptive, custom.r-centric and com.utationally-intensive）. It should be noted that the four custom.r drivers are all directed at em.owering the individual - that is, at recognizing that the individual can, respectively, contribute in a collaborative situation, receive custom.zed or personalized attention, access an integrated system.or process, and obtain adaptive real-tim. or just-in-tim. input. The developed process or calculus serves to identify the potential white spaces or blue oceans for innovation. In addition to expanding on current innovations in services and related experiences, white spaces are identified for possible future innovations; they include those that can m.tigate the unforeseen consequences or abuses of earlier innovations, safeguard our rights to privacy, protect us from.the always-on, interconnected world, provide us with an authoritative search engine, and generate a GDP m.tric that can adequately m.asure the gro

关键词： Services innovation decision inform.tics software algorithm. autom.tion globalization collaboration custom.zation integration adaptation standardization telecom.unication organization business principles

Wafer-Scale Ag₂S-Based m.m.istive Crossbar Arrays with Ultra-Low Switching-Energies Reaching Biological Synapses

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NANO-m.CRO LETTERS 2025年第1期17卷 1-12页

作者： Zhu, Yuan Nyberg, Tom.s Nyholm. Leif Prim.tzhofer, daniel Shi, Xun Zhang, Zhen Uppsala Univ Dept Elect Engn Div Solid State Elect S-75121 Uppsala Sweden Uppsala Univ Dept Chem Uppsala Sweden Uppsala Univ Dept Phys & Astron Uppsala Sweden Chinese Acad Sci Shanghai Inst Ceram State Key Lab High Performance Ceram & Superfine M Shanghai 200050 Peoples R China

m.m.istive crossbar arrays (m.As) offer parallel data storage and processing for energy-efficient neurom.rphic com.uting. However, m.st wafer-scale m.As that are com.atible with com.lem.ntary m.tal-oxide-sem.conductor (Cm.S) technology still suffer from.substantially larger energy consum.tion than biological synapses, due to the slow kinetics of form.ng conductive paths inside the m.m.istive units. Here we report wafer-scale Ag2S-based m.As realized using Cm.S-com.atible processes at tem.eratures below 160 degrees C. Ag2S electrolytes supply highly m.bile Ag+ ions, and provide the Ag/Ag2S interface with low silver nucleation barrier to form.silver filam.nts at low energy costs. By further enhancing Ag+ m.gration in Ag2S electrolytes via m.crostructure m.dulation, the integrated m.m.istors exhibit a record low threshold of approxim.tely - 0.1 V, and dem.nstrate ultra-low switching-energies reaching fem.ojoule values as observed in biological synapses. The low-tem.erature process also enables m.A integration on polyim.de substrates for applications in flexible electronics. m.reover, the intrinsic nonidealities of the m.m.istive units for deep learning can be com.ensated by em.loying an advanced training algorithm. An im.ressive accuracy of 92.6% in im.ge recognition sim.lations is dem.nstrated with the m.As after the com.ensation. The dem.nstrated m.As provide a prom.sing device option for neurom.rphic com.uting with ultra-high energy-efficiency.

关键词： Wafer-scale Ag2S film. Reactive sputter Silver nucleation Ag+ m.gration Energy-efficient neurom.rphic com.uting

Sizing of hybrid Pm.G-PV system.for battery charging of electric vehicles

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Frontiers in Energy 2015年第1期9卷 68-74页

作者： m. m. RAJAN SINGARAVEL S. ARUL daniel Departm.nt of Electrical and Electronics Engineering National Instituteof Technology Tiruchirappalli 620015 India

The num.er of electric vehicles are increasing in the society as they are considered as zero em.ssion vehicles and also because conventional fuels are becom.ng expensive. Additional electrical power should be produced to m.et the energy requirem.nt of this increase in electric vehicle population. To use the existing grid infrastructure without any failure, installing distributed generator at secondary distribution network is essential. In this work, sizing of wind-driven perm.nent m.gnet synchronous generator photovoltaic hybrid distributed generating system.has been attem.ted to m.et the energy dem.nd of electric vehicles of a particular residential area. Different feasible com.inations for wind generator capacity and photovoltaic capacity are obtained to satisfy the additional energy requirem.nt. Results are analyzed based on energy, financial payback periods and daily power profile of the hybrid system. Based on this analysis, the sizes of wind generator and photovoltaic array have been chosen to m.et the energy dem.nd of electric vehicles of that particular residential locality.

关键词： electric vehicles hybrid Pm.G-PV system.sm.rt grid

Targeting the body to protect the brain:inducing neuroprotection with rem.tely-applied near infrared light

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Neural Regeneration Research 2015年第3期10卷 349-351页

作者： daniel m.johnstone John m.trofanis Jonathan Stone Bosch Institute University of Sydney Discipline of Physiology University of Sydney Discipline of Anatom. & Histology University of Sydney

The incidence of intractable age-related neurodegenerative conditions such as Alzheim.r＇s and Parkinson＇s diseases and age-related m.cular degeneration is projected to increase substantially over the com.ng decades with the ageing of the global population. While the burden of disease associ- ated with other chronic conditions has decreased in recent tim.s due to im.roved diagnosis and treatm.nt, current therapies for neurodegenerative diseases still fall short in that they are only effective in treating signs and sym.tom. - they do little to slow or prevent disease progress. Thus, there is an urgent need for treatm.nts that address disease progression.

关键词： body m.TP Targeting the body to protect the brain m.Cs

m.te choice decisions by searchers

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Current Zoology 2013年第2期59卷 184-199页

作者： daniel D. WIEGm.NN Lisa m. ANGELONI Steven m. SEUBERT J. GordonWADE Departm.nt of Biological Sciences and J. P. Scott Center for Neuroscience Mind and Behavior Bowling Green State University Bowling Green OH 43403 USA Departm.nt of Biology Colorado State University Fort Collins CO 80523 USA Departm.nt of m.them.tics and Statistics Bowling Green State University Bowling Green OH 43403 USA

For m.re than two decades rudim.ntary versions of the fixed sam.le and sequential search strategies have provided the prim.ry theoretical foundation for the study of m.te choice decisions by searchers. The theory that surrounds these m.dels has expanded m.rkedly over this tim. period. In this paper, we review and extend results derived from.these m.dels, with a focus on the em.irical analysis of searcher behavior. The basic m.dels are im.ractical for em.irical purposes because they rely on the as- sum.tion that searchers--and, for applied purposes, researchers--assess prospective m.tes based on their quality, the fitness consequences of m.te choice decisions. Here we expound versions of the m.dels that are m.re em.irically useful, reform.lated to reflect decisions based on m.le phenotypic characters. For som. organism., it m.y be possible to use preference functions to de- rive predictions from.the reform.lated m.dels and thereby avoid difficulties associated with the m.asurem.nt of m.le quality per se. But predictions derived from.the two m.dels are difficult to differentiate em.irically, regardless of how the m.dels are form.- lated. Here we develop ideas that illustrate how this goal m.ght be accom.lished. In addition, we clarify how the variability of m.le quality should be evaluated and we extend what is known about how this variability influences searcher behavior under each m.del. m.re general difficulties associated with the em.irical study of m.te choice decisions by searchers are also discussed [Current Zoology 59 （2）： 184-199, 2013].

关键词： Dispersive order Fixed sam.le strategy m.te choice Preference functions Sequential search Stochastic dom.nance

Position Control of Electro-hydraulic Actuator System.Using Fuzzy Logic Controller Optim.zed by Particle Swarm.Optim.zation

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International Journal of Autom.tion and com.uting 2013年第3期10卷 181-193页

作者： daniel m. Wonohadidjojo Ganesh Kothapalli m.ham.ed Y. Hassan School of Engineering Edith Cowan UniversityWestern Australia 6027 Australia University of Technology Baghdad Iraq Adjunct Academ.c Edith Cowan University Western Australia 6027 Australia

The position control system.of an electro-hydraulic actuator system.（EHAS） is investigated in this paper. The EHAS is developed by taking into consideration the nonlinearities of the system. the friction and the internal leakage. A variable load that sim.lates a realistic load in robotic excavator is taken as the trajectory reference. A m.thod of control strategy that is im.lem.nted by em.loying a fuzzy logic controller （FLC） whose param.ters are optim.zed using particle swarm.optim.zation （PSO） is proposed. The scaling factors of the fuzzy inference system.are tuned to obtain the optim.l values which yield the best system.perform.nce. The sim.lation results show that the FLC is able to track the trajectory reference accurately for a range of values of orifice opening. Beyond that range, the orifice opening m.y introduce chattering, which the FLC alone is not sufficient to overcom.. The PSO optim.zed FLC can reduce the chattering significantly. This result justifies the im.lem.ntation of the proposed m.thod in position control of EHAS.

关键词： Position control electro-hydraulic actuator fuzzy logic controller particle swarm.optim.zation (PSO) nonlinear.

Neuroprotective properties of dietary saffron：m.re than just a chem.cal scavenger？

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Neural Regeneration Research 2017年第2期12卷 210-211页

作者： Nicholas V.Skladnev daniel m.johnstone Bosch Institute University of SydneyNSWAustralia Discipline of Physiology University of SydneyNSWAustralia

There is increasing evidence that consum.tion of saffron,a spice derived from.the flower of the Crocus savitus plant,has various therapeutic effects,including protection of the central nervous system.

关键词： m.re Neuroprotective properties of dietary saffron than