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Non-Darcy Flow in Molding Sands

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Numerical Analysis of Slag Carry-Over during Molten Steel Draining

Open Journal of Applied Sciences（应用科学） 2024年第4期 976页

作者： Miguel A.Barron-Meza Joan Reyes-Miranda daniel flores-sanchez

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Open Journal of Applied Sciences 2017年第11期7卷 611-616页

作者： daniel flores-sanchez Miguel A. Barron Departmento De Materiales Universidad Autonoma Metropolitana Mexico City Mexico

Slag carry-over during the draining of molten steel from a teeming ladle is numerically studied here. Two-phase isothermal transient 3D Computational Fluid Dynamics simulations were employed to simulate the draining process. Two nozzle diameters, two nozzle positions and three slag heights were considered. From mass balances, the slag carry-over in terms of mass flow rate was obtained for each of the above variables. Besides, the draining times of the teeming ladle were estimated from theoretical considerations and CDF simulations, and compared.

关键词： CFD Simulations Draining Time Multiphase Flow Slag Carry-Over Teeming Ladle

Association between Helicobacter pylori infection,mismatch repair,HER2 and tumor-infiltrating lymphocytes in gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2487-2503页

作者： Carlos A Castaneda Miluska Castillo Luis A Bernabe Joselyn sanchez Matteo Fassan Katherine Tello Ignacio Ivan Wistuba Ivan Chavez Passiuri Eloy Ruiz Juvenal sanchez Fernando Barreda daniel Valdivia Yaqueline Bazan Milagros Abad-Licham Claudio Mengoa Hugo Fuentes Paola Montenegro Ebert Poquioma Raul Alatrista Claudio J flores Luis Taxa Faculty of Health Sciences Universidad Cientifica del SurLima 15038Peru GECO PERU Grupo de Estudios Clinicos Oncologicos del PeruLima 15038Peru Department of Research Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Faculty of Human Medicine Universidad Ricardo PalmaLima 15039Peru Department of Medicine Surgical Pathology&Cytopathology UnitUniversity of PaduaPadua 35121Italy Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer CenterHoustonTX 77030United States Department of Abdominal Surgery Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Pathology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Medical Specialties Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Pathology Instituto Regional de Enfermedades Neoplasicas del NorteTrujillo 13001Peru Faculty of Human Medicine Universidad Privada Antenor OrregoTrujillo 13008Peru Department of Surgery Instituto Regional de Enfermedades Neoplasicas del SurArequipa 04002Peru Department of Medical Oncology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Epidemiology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Unidad de Investigación Básica y Traslacional Oncosalud-AUNALima 15038Peru Faculty of Medicine Universidad San Martin de PorresLima 15008Peru

BACKGROUND The influence of Helicobacter-pylori(***)infection and the characteristics of gastric cancer(GC)on tumor-infiltrating lymphocyte(TIL)levels has not been extensively *** of infiltrating-immune-cell subtypes as well as survival is necessary to obtain comprehensive *** To determine the rates of deficient mismatch-repair(dMMR),HER2-status and *** infection and their association with TIL levels in *** Samples from 503 resected GC tumors were included and TIL levels were evaluated following the international-TILs-working-group recommendations with assessment of the intratumoral(IT),stromal(ST)and invasive-border(IB)*** density of CD3,CD8 and CD163 immune cells,and dMMR and HER2-status were determined by immunohistochemistry(IHC).*** infection was evaluated by routine histology and quantitative PCR(qPCR)in a subset of *** dMMR was found in 34.4%,HER2+in 5%and ***-positive in 55.7%of *** IT-TIL was associated with grade-3(P=0.038),while ST-TIL with grade-1(P<0.001),intestinal-histology(P<0.001)and no-recurrence(P=0.003).dMMR was associated with high TIL levels in the ST(P=0.019)and IB(P=0.01)compartments,and STCD3(P=0.049)and ST-CD8(P=0.05)***2-was associated with high IT-CD8(P=0.009).*** was associated with high IT-TIL levels(P=0.009)when assessed by routine-histology,and with high TIL levels in the 3 compartments(P=0.002-0.047)and CD8 density in the IT and ST compartments(P=0.001)when assessed by qPCR.A longer overall survival was associated with low IT-CD163(P=0.003)and CD8/CD3(P=0.001 in IT and P=0.002 in ST)and high IT-CD3(P=0.021),ST-CD3(P=0.003)and CD3/CD163(P=0.002).CONCLUSION TIL levels were related to dMMR and *** CD8/CD3 and high CD163/CD3 were associated with lower recurrence and longer survival.

关键词： Lymphocytes Macrophages Gastric cancer Helicobacter pylori HER2 Mismatch repair

Vegetation Response To Soil And Morphological Properties In An Arid Region Alluvial Fan Landscape. Pre-Andes Of San Juan， Argentina

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Journal of Earth Science 2024年

作者： flores daniel Germán OCA?A Raúl Emmanuel MELIáN Edgardo ORTEG Andrés ESPER ANGILLIERI María Yanina PITTALUGA María Alejandra CIGEOBIO (CONICET-UNSJ) Av.José I.de la Roza y Meglioli Gabinete de Geología Ambiental， INGEO， Universidad Nacional de San Juan， Av.José I.de la Roza y Meglioli

The Monte Desert is characterized by a great diversity of landforms created with fluvial， alluvial which the vegetation patterns are related to. The present work has the following objectives: 1: determine whether topographical attributes， surface characteristics， soil properties and vegetation patterns vary between alluvial landforms， and 2: define whether morphometric， soil and surface properties influence vegetation patterns along alluvial landscape. Morphometric data were obtained by processing a 5 m digital elevation model. The coverage of rock fragments， fine sediments and mulch was quantified. Observations and descriptions of the soil profiles were restricted to the uppermost 50 cm. Vegetation properties were calculated using a Point Quadrat Method. The relationship between variables was evaluated through multivariate statistical analysis. The main results show the presence of 45 plant species distributed in 19 families， where shrubs are dominant. The wind effect， topographic wetness and dissection of the landscape are limiting factors of diversity. The coverage of superficial rock fragments influence vegetation coverage through the distribution and availability of rainwater. Furthermore， the different soil textures reveal that the silt content favors an increase in vegetation coverage. The presence of V horizon could condition the installation and development of vegetation in the early stages of growth.

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Low-Cost and Biodegradable Thermoelectric Devices Based on van der Waals Semiconductors on Paper Substrates

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Energy & Environmental Materials 2024年第1期7卷 201-206页

作者： Gulsum Ersu Carmen Munuera Federico J.Mompean daniel Vaquero Jorge Quereda João Elias F.S.Rodrigues Jose A.Alonso Eduardo flores Jose R.Ares Isabel J.Ferrer Abdullah M.Al-Enizi Ayman Nafady Sruthi Kuriakose Joshua O.Island Andres Castellanos-Gomez Materials Science Factory Instituto de Ciencia de Materiales de Madrid(ICMM-CSIC)Madrid E-28049Spain Nanotechnology Group USAL-NanolabUnivesidad de SalamancaSalamanca Junta de Castilla y León 37007Spain GISC Departamento de Física de MaterialesUniversidad Complutense de MadridMadrid E-28040Spain Departamento de Física Aplicada Centro de Investigación y Estudios AvanzadosMérida 97310Mexico MIRE Group Departamento de Física de MaterialesUniversidad Autónoma de MadridMadrid E-28049Spain Instituto Nicolás Cabrera Universidad Autónoma de MadridMadrid E-28049Spain Department of Chemistry College of ScienceKing Saud UniversityRiyadh 11451Saudi Arabia Department of Physics and Astronomy University of Nevada Las VegasLas Vegas NV 89154USA

We present a method to fabricate handcrafted thermoelectric devices on standard office paper *** devices are based on thin films of WS_(2),Te,and BP(P-type semiconductors)and TiS_(3)and TiS_(2)(N-type semiconductors),deposited by simply rubbing powder of these materials against *** thermoelectric properties of these semiconducting films revealed maximum Seebeck coefficients of(+1.32±0.27)mV K^(-1)and(-0.82±0.15)mV K^(-1)for WS_(2)and TiS_(3),***,Peltier elements were fabricated by interconnecting the P-and N-type films with graphite electrodes.A thermopower value up to 6.11 mV K^(-1)was obtained when the Peltier element were constructed with three *** findings of this work show proof-of-concept devices to illustrate the potential application of semiconducting van der Waals materials in future thermoelectric power generation as well as temperature sensing for low-cost disposable electronic devices.

关键词： paper-based electronics Seebeck effect semiconductors thermoelectrics van der Waals materials

IL-10 and TNF-α promoter haplotypes are associated with childhood Crohn’s disease location

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World Journal of Gastroenterology 2009年第30期15卷 3776-3782页

作者： Rocio sanchez Emile Levy Florin Costea daniel Sinnett Research Center Sainte-Justine University health centerMontreal H3T 1C5Canada Research Center Sainte-Justine University health centerDepartment of NutritionUniversity of MontrealMontreal H3T 1C5Canada Research Center Sainte-Justine University health centerDepartment of PediatricsUniversity of MontrealMontreal H3T 1C5Canada

AIM： To determine the distribution and frequencies of the genotypes and haplotypes of the genes encoding for the glucocorticoid receptor （GR）, the tumor necrosis factor （TNF）-α and the interleukin （IL）-10 in childhood Crohn＇s disease （CD） and to assess the impact of the corresponding DNA variants on clinical and disease phenotypes.METHODS： Ten variants in GR, TNF-a and IL-10 were genotyped in 113 childhood CD cases and 95 healthy subjects, both of French-Canadian origin.RESULTS： For the GR polymorphisms （R23K and N363S） and IL-10 variants in the 5＇flanking region （-1082 G 〉 A, -819 T 〉 C and -592 A 〉 C）, no difference was observed in allele and genotype frequencies between CD patients and controls. At the haplotype level, we found three IL-10 haplotypes previously described in Caucasians （GCC, ACC and ATA） and three novel haplotypes only present in IBD patients. When we analyzed the haplotype distribution with the anatomical location of the disease, the GCC haplotype was associated with the colonic and the ACC haplotype with the terminal ileum location, respectively. The genotyping of five polymorphisms in the promoter region of the TNF-α gene （-1031 T 〉 C, -863 A 〉 C, -857 T 〉 C, -308 A 〉 G and -238 A 〉 G） revealed a significant overrepresentation of homozygous -1031 CC among CD patients （OR = 9.9） and an association with the colonic location. For TNF-α, eleven haplotypes were inferred, including two frequent ones, TCCGG and CACGG, which were significantly observed more frequently in controls and cases, respectively.CONCLUSION： This is one of the first studies investigating the association between haplotype structure and disease location in a CD pediatric cohort. Our results will help to increase our understanding of the genetic determinants of childhood CD.

关键词： Haplotype Polymorphism Crohn’s disease Glucocorticoid receptor Interleukin-10 Tumor necrosis factor-α

Simulation of consumers decision-making process using agent-based model approach

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International Journal of Modeling, Simulation, and Scientific Computing 2019年第6期10卷 30-47页

作者： daniel Soto Forero Yony F.Ceballos German sanchez Torres Engineer Faculty University of Antioquia Calle 67 No.53-108Medell`inColombia Engineer Faculty University of Magdalena Carrera 32 No.22-08Santa MartaColombia

This paper describes a model to simulate the decision-making process of consumers that adopts technology within a dynamic social *** proposed model use theories and tools from the psychology of consumer behavior,social networks and complex dynamical systems like the Consumat framework and fuzzy *** model has been adjusted using real data,tested with the automobile market and it can recreate trends like those described in the world market.

关键词： Decision-making process bounded rationality agent-based models social networks fuzzy logic model consumers

Strain-induced band gap engineering in layered TiS3

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Nano Research 2018年第1期11卷 225-232页

作者： Robert Biele Eduardo flores Jose Ramon Ares Carlos sanchez Isabel J. Ferrer Gabino Rubio-Bollinger Andres Castellanos-Gomezs Roberto D'Agosta Nano-Bio Spectroscopy Group and European Theoretical Spectroscopy Facility (EFSF) Universidad del Pals Vasco 20018 San Sebastidn Spain Materials of Interest in Renewable Energies Group (MIRE Group) Dpto. de Fisica de Materiales Universidad Aut6noma de Madrid 28049 Madrid Spain Instituto de Ciencia de Materiales "Nicolds Cabrera" Campus de Cantoblanco 28049 Madrid Spain Dpto. de Ffsica de la Materia Condensada Condensed Matter Physics Center (IFIMAC) Universidad Aut6noma de Madrid Campus de Cantoblanco 28049 Madrid Spain Instituto de Ciencia de los Materiales de Madrid (ICMM-CSIC) Cantoblanco 28049 Madrid Spain IKERBASQUE Basque Foundation for Science 48013 Bilbao Spain

By combining ab initio calculations and experiments, we demonstrate how the band gap of the transition metal trichalcogenide TiS3 can be modified by inducing tensile or compressive strain. In addition, using our calculations, we predicted that the material would exhibit a transition from a direct to an indirect band gap upon application of a compressive strain in the direction of easy electrical transport. The ability to control the band gap and its nature could have a significant impact on the use of TiS3 for optical applications. We go on to verify our prediction via optical absorption experiments that demonstrate a band gap increase of up to 9% （from 0.99 to 1.08 eV） upon application of tensile stress along the easy transport direction.

关键词： band gap engineering titanium trisulfide 2-D materials strain

Predictors of vitamin D deficiency in inflammatory bowel disease and health: A Mississippi perspective

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World Journal of Gastroenterology 2017年第4期23卷 638-645页

作者： Kumar Pallav daniel Riche Warren L May Patrick sanchez Nitin K Gupta Division of Digestive Diseases University of Mississippi Medical Center Department of Pharmacy Practice University of Mississippi Medical Center

AIMTo identify the predictors of vitamin D deficiency in patients with and without inflammatory bowel disease (IBD).METHODSPatients with ulcerative colitis (UC) or Crohn’s disease (CD) related diagnostic codes who received medical care at University of Mississippi Medical Center between July 2012 and 2015 were identified. After thorough chart review, we identified patients with biopsy proven IBD who had also been tested for serum 25-hydroxyvitamin D [25(OH)D] concentration. We compared these patients to a previously studied cohort of healthy controls who also had vitamin D concentration checked. Logistic regression analysis was performed to determine the association between vitamin d deficiency and UC, CD, race, age, gender and body mass index (BMI).RESULTSWe identified 237 patients with confirmed IBD. Of these, only 211 had a serum 25(OH)D concentrations available in the medical record. The group of healthy controls consisted of 98 individuals with available serum 25(OH)D concentration. 43% of IBD patients were African American (AA). Patients with CD were more likely to have vitamin D concentration checked. Bivariate analysis showed that AA (51% vs 21%, P = 0.00001), subjects with BMI >30 kg/m2 (39% vs 23% P = 0.01) and CD (40% vs 26%, P = 0.04) were more likely to be vitamin D deficient than vitamin D sufficient. Those with Age > 65 were more likely to be vitamin D sufficient (46% vs 15%, P = 0.04). Multiple regression showed that only BMI > 30 kg/m2 and AA race are associated with vitamin D *** > 30 kg/m2 and AA race are predictive of vitamin D deficiency. Gender, age and diagnosis of IBD are not predictive of vitamin D deficiency.

关键词： Vitamin D deficiency Inflammatory bowel disease Body mass index Ulcerative colitis Crohn’ s disease African American