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Amyloid-β-induced disruption of axon-initial-segment mitochondria localization:consequences for tAU missorting in Alzheimer's disease pathology

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Neural Regeneration Research 2025年第5期20卷 1407-1408页

作者： daniel Adam Felix Langerscheidt Hans Zempel Institute of Human Genetics University Hospital CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany

tAU is a neuronal microtubule-associated protein preferentially located in *** a battery of neurodegenerative diseases termed"tauopathies,"including Alzheimer's disease (AD),tAU is missorted and abnormally phosphorylated,leading to filamentous accumulations of hyperphosphorylated tAU,a pathological hallmark and potential disease driver of AD and related tauopathies (Zempel,2024).

关键词： Alzheimer tau diseases

Determining minimum sample size for the conditioned Latin hypercube sampling algorithm

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Pedosphere 2024年第3期34卷 530-539页

作者： daniel D.SAUREttE Asim bISWAS Richard J.HECK Adam W.GILLESPIE Aaron A.bERG School of Environmental Sciences University of Guelph50 Stone Rd EastGuelph ON N1G 2W1(Canada) Ontario Ministry of Agriculture Food and Rural Affairs1 Stone Rd WestGuelph ON N1G 2Y4(Canada) Geography Environment&GeomaticsUniversity of Guelph50 Stone Rd EastGuelph ON N1G 2W1(Canada)

In digital soil mapping(DSM),a fundamental assumption is that the spatial variability of the target variable can be explained by the predictors or environmental *** to adequately sample the predictors have been well documented,with the conditioned Latin hypercube sampling(cLHS)algorithm receiving the most attention in the DSM *** advances in sampling design,a critical gap remains in determining the number of samples required for DSM *** propose a simple workflow and function coded in R language to determine the minimum sample size for the cLHS algorithm based on histograms of the predictor variables using the Freedman-Diaconis rule for determining optimal bin *** preprocessing was included to correct for multimodal and non-normally distributed data,as these can affect sample size determination from the *** on a user-selected quantile range(QR)for the sample plan,the densities of the histogram bins at the upper and lower bounds of the QR were used as a scaling factor to determine minimum sample *** technique was applied to a field-scale set of environmental covariates for a well-sampled agricultural study site near Guelph,Ontario,Canada,and tested across a range of *** results showed increasing minimum sample size with an increase in the QR *** sample size increased from 44 to 83 when the QR increased from 50% to 95% and then increased exponentially to 194 for the 99%*** technique provides an estimate of minimum sample size that can be used as an input to the cLHS algorithm.

关键词： bin width digital soil mapping normal distribution quantile range sampling design

Alcohol and illicit drugs:prevalence of alcohol and illicit drug use and their predictors in young people from Argentina,bulgaria,Chile and Romania

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Global Health Journal 2024年第1期8卷 16-23页

作者： daniel Vankov David Jankovszky borislav Vankov Martin Galanternik Claudia Rodriguez Michiel de Ruyter Scientific Organization from Partium Oradea 410204Romania Queensland University of technology BrisbaneQueensland 4001Australia Association for Youth and Students in Partium Oradea 410102Romania Community Centre bright Day-2009 Vidin 3700Bulgaria MiNU Civil.Association Buenos Aires 4918Argentina ONG No Chat Santiago 832000Chile

background:Alcohol and illicit drugs(AID)continue to be a major global health *** preventable,AID is linked to millions of deaths annually *** situation is particularly grave for young people,with AID being a major direct risk factor for disability-adjusted youth life-years lost and *** further contributes to assaults,road crashes,accidental poisoning,and suicide,leading to long-term issues and public health ***:this study aimed at disclosing current AID prevalence data for Argentinian,bulgarian,Chilean and Romanian *** shed light on the predictors of AID in young people from those ***:the study used an online survey to gather data from people aged 18 to 25(n=1,297).the survey was underpinned by the theory of planned behaviour(tPb).Predictors were investigated separately for drinking alcohol and using illicit ***:Our data revealed that across the four target countries,49%to 90%of the participants drank alcohol,and 8%to 35%used illicit drugs in the past three *** 20%and 91%of them intended to drink,and between 8%and 31%intended to use illicit drugs in the following three *** tPb model predicted statistically significant(Pts of variance in drinking alcohol(between 61%and 72%)and using illicit drugs(between 20.3%and 74.4%).Intention was consistent in significantly predicting both *** around the predictive validity of self-efficacy,age and gender was mixed across the investigated ***:this research provided an update on the scarce AID epidemiological *** also supplied evidence about what theoretically-informed measures might be useful targets of interventions in the case of Argentina,bulgaria,Chile and *** new knowledge of understanding substance abuse determinants and prevalence may help researchers and practitioners better meet young people's health prevention needs.

关键词： Young people Alcohol Ilicit drugs Intention Self-efficacy

Constructing on-demand single/multi-color transitioning fabrics with photocatalysis/photothermal-armed deficient semiconductors

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Nano Research 2024年第5期17卷 3633-3643页

作者： daniel K.Macharia Shamima Sarker Meng Liu Zeyulong Wen Nuo Yu Meifang Zhu Zhigang Chen State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua UniversityShanghai 201620China

On-demand color switching systems that utilize synchronized semiconductor-catalyzed reduction and photothermal-accelerated oxidation in liquid/solid are highly ***,on-demand single/multi-color switching fabrics have been constructed by using defective SnO_(2):Sb-based color switching ***_(2):Sb nanocrystals with the suitable doping concentration accord lattices with abundant free electrons,conferring high photocatalytic and photothermal performances.A well-crafted set of dual light-responsive semiconductor-catalyzed systems with rapid color change can be attained via the homogenous mixture of SnO_(2):Sb with suitable redox dyes to produce single-color(RGb(red,green,blue))and multi-color transitioning(purple and green)*** illumination of these systems by 450 nm light triggers rapid photocatalytic discoloration,while irradiation by 980 nm light confers the photothermal effect that accelerates recoloration in ***,the inks can be extended to rewritable fabrics by embedding the nanocrystals and redox dyes into hydroxyethyl cellulose(as the polymer matrix)and then coating on hydrophobic cotton fabrics to produce photo-switchable fabrics with excellent single/multi-color *** exploiting the dual light interactions with the semiconductor-mediated systems,various images/letters can be remotely printed and erased on the rewritable fabrics which show promise for potential applications as information storage media and visual ***,the present rewritable fabric shows good stability and *** present work provides insights into the development of novel color-switching materials.

关键词： color switching defective semiconductor photocatalysis photothermal rewritable fabrics

Fatty acids derived from oviposition systems guide female black soldier flies(Hermetia illucens)toward egg deposition sites

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Insect Science 2024年第4期31卷 1231-1248页

作者： Patrick Klüber Emna Arous Jeanny Jerschow Marco Fraatz daniel bakonyi Martin Rühl Holger Zorn Department bioresources Fraunhofer Institute for Molecular Biology and Applied EcologyGiessenGermany Institute of Food Chemistry and Food biotechnology Justus Liebig University GiessenGiessenGermany

the black soldier fly,Hermetia illucens,comes with big promises for industrial purposes since its larvae feed polyphagously on a broad spectrum of organic ***,research focusing on adult flies is scarce,which is inconsistent with their reproductive relevance within the rearing *** particular,directed oviposition is a challenge in artificial ***,decomposing organic matter is commonly used as oviposition substrate,which has extensive potential for improvement in view of the lack of standardization and the risk of microbial ***,we identified three fatty acids and one fatty acid methyl ester derived from the surface of old oviposition sites and targeted to elucidate their effect on preference behavior and oviposition site selection using Y-olfactometry and prepared oviposition sites,*** to tetradecanoic acid attracted gravid females and stimulated oviposition most strongly,while decanoic acid demonstrated a repulsive *** kept in mixed-sex populations were attracted by tetradecanoic acid,resulting in a higher egg mass found in the compound box(3.0–11.4 fold),a≥2.3 fold reduction of nonspecifically deposited eggs,and the highest total egg ***,decanoic and dodecanoic acid caused females to lay a greater proportion of eggs nonspecifically outside both *** data suggest that fatty acids,especially tetradecanoic acid,are important cues for oviposition site selection in black soldier *** order to achieve a directed oviposition behavior,the role of further short-and long-chain fatty acids as attractants should be examined.

关键词： black soldier fly Hermetia illucens fatty acids insects as food and feed oviposition oviposition site selection tetradecanoic acid

Characteristics of patients with Wilson disease in the United States: An insurance claims database study

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World Journal of Hepatology 2024年第5期16卷 791-799页

作者： thomas daniel-Robin Pradeep Kumar bernard benichou Jean-Philippe Combal Vivet therapeutics Paris 75008France Clarivate Noida 201301Uttar PradeshIndia

bACKGROUND Wilson disease(WD)is a progressive,potentially fatal degenerative disease affecting the liver and central nervous *** its low prevalence,collecting data on large cohorts of patients with WD is *** insur-ance claims databases provide powerful tools to collect retrospective data on large numbers of patients with rare *** to describe patients with WD in the United States,their treatment and clinical outcome,using a large insurance claims *** this retrospective,longitudinal study was performed in the Clarivate Real-World Data Product *** patients with≥2 claims associated with an Interna-tional Classification of Diseases 10(ICD-10)diagnostic code for WD(E83.01)between 2016 and 2021 were included and followed until death or study *** were divided into two groups by whether or not they were documented to have received a specific treatment for *** manifestations,hospital-isations,liver transplantation and death were *** Overall,5376 patients with an ICD-10 diagnostic code for WD were *** mean age at inclusion was 41.2 years and 52.0%were men.A specific WD treatment was documented for 885 patients(15.1%),although the number of patients taking zinc salts may be underestimated due to over the counter *** inclusion,the mean age of patients with a documented treatment was 36.6±17.8 years vs 42.2±19.6 years in those without a documented *** follow-up,273 patients(5.1%)*** with the American general population,the standardised mortality ratio was *** proportion of patients with a documented WD-specific treatment who died during follow-up was 4.0%and the mean age at death 52.7 *** Patients treated for WD in the United States had an excess early mortality compared with the American *** findings indicate that there is a significant unmet need for effective treatment for WD in the United States.

关键词： Wilson disease Mortality treatment Copper chelators Zinc acetate United States

Assessment of the performance of the tOPGNSS and ANN-Mb antennas for ionospheric measurements using low-cost u-blox GNSS receivers

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Geodesy and Geodynamics 2024年第3期15卷 291-301页

作者： daniel Okoh Aderonke Obafaye Oluwakemi Dare-Idowu babatunde Rabiu Anton Kashcheyev Claudio Cesaroni John bosco Habarulema bruno Nava United Nations African Regional Centre for Space Science and technology Education-English(UN-ARCSStE-E) Obafemi Awolowo University CampusIle IfeNigeria National Institute for Geophysics and Volcanology(INGV) 00143 RomeItaly Institute for Space Science and Engineering African University of Science and TechnologyAbujaNigeria University of New brunswick FrederictonCanada South African National Space Agency(SANSA) P.O Box 32Hermanus 7200South Africa Department of Physics and Electronics Rhodes University6140 MakhandaSouth Africa the Abdus Salam International Centre for theoretical Physics Strada Costiera11I-34151 TriesteItaly

Low-cost GNSS receivers have recently been gaining reliability as good candidates for ionospheric studies. In line with these gains are genuine concerns about improving the performance of these receivers. In this work, we present a comprehensive investigation of the performances of two antennas(the u-blox ANN-Mb and the tOPGNSS tOP-106) used on a low-cost GNSS receiver known as the u-blox ZED-F9P. the two antennas were installed on two identical and co-located u-blox receivers. Data used from both receivers cover the period from January to June 2022. Results from the study indicate that the signal strengths are dominantly greater for the receiver with the tOPGNSS antenna than for the receiver with the ANN-Mb antenna, implying that the tOPGNSS antenna is better than the ANN-Mb antenna in terms of providing greater signal strengths. Summarily, the tOPGNSS antenna also performed better in minimizing the occurrence of cycle slips on phase tEC measurements. there are no conspicuous differences between the variances(computed as 5-min standard deviations) of phase tEC measurements for the two antennas, except for a period around May-June when the tOPGNSS gave a better performance in terms of minimizing the variances in phase tEC. Remarkably, the ANN-Mb antenna gave a better performance than the tOPGNSS antenna in terms of minimizing the variances in pseudorange tEC for some satellite observations. For precise horizontal(North and East) positioning, the receiver with the tOPGNSS antenna gave better results, while the receiver with the ANN-Mb antenna gave better vertical(Up) positioning. the errors for the receivers of both antennas are typically within about 5 m(the monthly mean was usually smaller than 1 m) in the horizontal direction and within about 10 m(the monthly mean was usually smaller than 4 m) in the vertical direction.

关键词： GNSS Ionosphere Low-cost Antenna tOPGNSS U-blox

Suppressive effects of exercise-conditioned serum on cancer cells:A narrative review of the influence of exercise mode,volume,and intensity

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Journal of Sport and Health Science 2024年第4期13卷 484-498,F0003页

作者： Francesco bettariga Dennis R.taaffe daniel A.Galvao Chris bishop Jin-Soo Kim Robert U.Newton Exercise Medicine Research Institute Edith Cowan UniversityJoondalupWA 6027Australia School of Medical and Health Sciences Edith Cowan UniversityJoondalupWA 6027Australia London Sport Institute School of Science and TechnologyMiddlesex UniversityLondonNW44BTUK School of Human Movement and Nutrition Sciences University of QueenslandSt.LuciaQLD 4072Australia

Cancer is a major cause of morbidity and mortality worldwide,and the incidence is increasing,highlighting the need for effective strategies to treat this *** has emerged as fundamental therapeutic medicine in the management of cancer,associated with a lower risk of recur-rence and increased *** avenues of research demonstrate reduction in growth,proliferation,and increased apoptosis of cancer cells,including breast,prostate,colorectal,and lung cancer,when cultured by serum collected after exercise in vitro(i.e.,the cultivation of cancer cell lines in an experimental setting,which simpliﬁes the biological system and provides mechanistic insight into cell responses).the underlying mechanisms of exercise-induced cancer suppressive effects may be attributed to the alteration in circulating factors,such as skeletal muscle-induced cytokines(i.e.,myokines)and ***,exercise-induced tumor suppressive effects and detailed information about training interventions are not well investigated,constraining more precise application of exercise medicine within clinical *** date,it remains unclear what role different training modes(i.e.,resistance and aerobic training)as well as volume and intensity have on exercise-condi-tioned serum and its effects on cancer ***,the available evidence is that a single bout of aerobic training at moderate to vigorous intensity has cancer suppressive effects,while for chronic training interventions,exercise volume appears to be an inﬂuential candidate driving cancer inhibitory effects regardless of training *** for future research investigating training modes,volume and intensity are provided to further our understanding of the effects of exercise-conditioned serum on cancer cells.

关键词： Cancer cells High intensity interval training Moderate intensity continuous training Resistance training Myokines

the Construction and Analysis of Linear Ring Spaces

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Advances in Pure Mathematics 2024年第9期14卷 759-767页

作者： daniel A. Jaffa American Community School Beirut Lebanon

this paper proposes the novel algebraic structure of a linear ring space. A linear ring space is an order triad consisting of two rings, and a linear map between the two rings. the definition of quasi-linearity is discussed, in addition to the examination of properties and classifications of linear ring spaces. Particularly, the ring of holomorphic functions on a region of the complex plane is examined, and the manner in which it generates an iterated linear ring space under the complex derivative operator. this notion is then generalized to all rings with n th order linear and surjective operators. basic operator theory regarding the classifications of linear ring maps is also covered.

关键词： Ring theory Group theory Commutative Algebra Operator theory Holomorphic Functions