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SARS-CoV-2 interaction with Siglec-1 mediates trans-infection by dendritic cells

Cellular & Molecular Immunology 2021年第12期18卷 2676-2678页

作者： daniel perez-zsolt Jordana Muñoz-Basagoiti Jordi Rodon Marc Elosua-Bayes Dàlia Raïch-Regué Cristina Risco Martin Sachse Maria Pino Sanjeev Gumber Mirko Paiardini Jakub Chojnacki Itziar Erkizia Xabier Muñiz-Trabudua Ester Ballana Eva Riveira-Muñoz Marc Noguera-Julian Roger Paredes Benjamin Trinité Ferran Tarrés-Freixas Ignacio Blanco Victor Guallar Jorge Carrillo JuliàBlanco Amalio Telenti Holger Heyn Joaquim Segalés Bonaventura Clotet Javier Martinez-Picado Júlia Vergara-Alert Nuria Izquierdo-Useros IrsiCaixa AIDS Research Institute 089BadalonaSpain IRTA Centre de Recerca en Sanitat Animal(CReSAIRTA-UAB)Campus de la UAB08193Bellaterra(Cerdanyola del Vallès)Spain CNAG-CRG Centre for Genomic Regulation(CRGBarcelona Institute of Science and Technology(BIST)08028BarcelonaSpain Centro Nacional de Biotecnología CSIC28049MadridSpain Division of Microbiology and Immunology Yerkes National Primate Research CenterEmory UniversityAtlantaGAUSA Department of Pathology and Laboratory Medicine School of MedicineEmory UniversityAtlantaGeorgiaUSA Division of Pathology Yerkes National Primate Research CenterEmory UniversityAtlantaGeorgiaUSA Germans Trias i Pujol Research Institute(IGTP) Can Ruti Campus089BadalonaSpain Barcelona Supercomputing Center(BSC) 08034BarcelonaSpain Catalan Institution for Research and Advanced Studies(ICREA) 08010BarcelonaSpain University of Vic-Central University of Catalonia(UVic-UCC) Vic08500Spain Department of Integrative Structural and Computational Biology Scripps ResearchLa JollaCA92037USA Universitat Pompeu Fabra(UPF) BarcelonaSpain UAB CReSA(IRTA-UAB)Campus de la UAB08193Bellaterra(Cerdanyola del Vallès)Spain Departament de Sanitat i Anatomia Animals Facultat de VeterinàriaUAB08193Bellaterra(Cerdanyola del Vallès)Spain

Antigen-presenting cells(APCs)may be resistant to SARS-CoV-2 infection but still contribute to viral *** such as sialic acid-binding Ig-like lectin 1(Siglec-1/CD169)mediate the attachment of viruses to ***,we show that APCs effectively capture SARS-CoV-2 within compartments via recognition of *** receptor interacts with sialylated gangliosides on membranes of SARS-CoV-2 variants.

关键词： infection Antigen media

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Author Correction to: SARS-CoV-2 interaction with Siglec-1 mediates trans-infection by dendritic cells

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Cellular & Molecular Immunology 2022年第8期19卷 965-966页

作者： daniel perez-zsolt Jordana Muñoz-Basagoiti Jordi Rodon Marc Elosua-Bayes Dàlia Raïch-Regué Cristina Risco Martin Sachse Maria Pino Sanjeev Gumber Mirko Paiardini Jakub Chojnacki Itziar Erkizia Xabier Muñiz-Trabudua Ester Ballana Eva Riveira-Muñoz Marc Noguera-Julian Roger Paredes Benjamin Trinité Ferran Tarrés-Freixas Ignacio Blanco Victor Guallar Jorge Carrillo JuliàBlanco Amalio Telenti Holger Heyn Joaquim Segalés Bonaventura Clotet Javier Martinez-Picado Júlia Vergara-Alert Nuria Izquierdo-Useros IrsiCaixa AIDS Research Institute 08916 Badalona Spain IRTA Centre de Recerca en Sanitat Animal (CReSA IRTA-UAB) Campus de la UAB 08193 Bellaterra (Cerdanyola del Vallès) Spain CNAG-CRG Centre for Genomic Regulation (CRG) Barcelona Institute of Science and Technology (BIST) 08028 Barcelona Spain Centro Nacional de Biotecnología CSIC 28049 Madrid Spain Division of Microbiology and Immunology Yerkes National Primate Research Center Emory University Atlanta GA USA Department of Pathology and Laboratory Medicine School of Medicine Emory University Atlanta GA USA Division of Pathology Yerkes National Primate Research Center Emory University Atlanta GA USA Germans Trias i Pujol Research Institute (IGTP) Can Ruti Campus 08916 Badalona Spain Barcelona Supercomputing Center (BSC) 08034 Barcelona Spain Catalan Institution for Research and Advanced Studies (ICREA) 08010 Barcelona Spain University of Vic—Central University of Catalonia (UVic-UCC) Vic 08500 Spain Department of Integrative Structural and Computational Biology Scripps Research La Jolla CA 92037 USA Universitat Pompeu Fabra (UPF) Barcelona Spain UAB CReSA (IRTA-UAB) Campus de la UAB 08193 Bellaterra (Cerdanyola del Vallès) Spain Departament de Sanitat i Anatomia Animals Facultat de Veterinària UAB 08193 Bellaterra (Cerdanyola del Vallès) Spain

Correction to:Cellular&Molecular Immunology https://***/10.1038/s41423-021-00794-6,published online 15 November 2021 In the version of this correspondence initially published,one of the SARS-CoV-2 variants used in Fig.1B,which was originally described in the article as the SARS-CoV-2 variant‘B.1.***.248.2 Gamma’,is actually the‘P.2 Zeta’SARS-CoV-2 variant of *** GISAID accession ID EPI_ISL_1831696 provided is correct。

关键词： interaction media initially

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Amyloid-β-induced disruption of axon-initial-segment mitochondria localization:consequences for TAU missorting in Alzheimer's disease pathology

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Neural Regeneration Research 2025年第5期20卷 1407-1408页

作者： daniel Adam Felix Langerscheidt Hans Zempel Institute of Human Genetics University Hospital CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany

TAU is a neuronal microtubule-associated protein preferentially located in *** a battery of neurodegenerative diseases termed"tauopathies,"including Alzheimer's disease (AD),TAU is missorted and abnormally phosphorylated,leading to filamentous accumulations of hyperphosphorylated TAU,a pathological hallmark and potential disease driver of AD and related tauopathies (Zempel,2024).

关键词： Alzheimer tau diseases

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Vascular endothelial growth factor:a double-edged sword in the development of white matter lesions

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Neural Regeneration Research 2025年第1期20卷 191-192页

作者： Narek Manukjan daniel Fulton Zubair Ahmed WMatthijs Blankesteijn Sébastien Foulquier Department of Pharmacology and Toxicology Maastricht UniversityMaastrichtThe Netherlands CARIM-School for Cardiovascular Diseases Maastricht UniversityMaastrichtThe Netherlands Neuroscience and Ophthalmology Institute of Inflammation and AgeingUniversity of BirminghamEdgbastonBirminghamUK Centre for Trauma Sciences Research University of BirminghamEdgbastonBirminghamUK MHeNs-School for Mental Health and Neuroscience Maastricht UniversityMaastrichtThe Netherlands Department of Neurology Maastricht University Medical CenterMaastrichtThe Netherlands

As the population ages,the burden of age-related diseases becomes ***,over 55 million people suffer from dementia worldwide,with Alzheimer’s disease being the most common ***,it is becoming clearer that underlying vascular pathology such as cerebral small vessel disease(cSVD)may be a more detrimental cause for dementia(Cuadrado-Godia et al.,2018).It is estimated that 10%-30%of the elderly population and 35%-90%of all dementia patients exhibit signs of *** term cSVD refers to pathology affecting the small vessels of the brain,which can lead to lacunar cerebral infarcts,enlarged perivascular spaces,and cortical hemorrhages(Cuadrado-Godia et al.,2018).CSVD is often associated with cognitive decline,gait problems,and dementia(Cuadrado-Godia et al.,2018).

关键词： pathology becoming white

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Wafer-Scale Ag₂S-Based Memristive Crossbar Arrays with Ultra-Low Switching-Energies Reaching Biological Synapses

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NANO-MICRO LETTERS 2025年第1期17卷 1-12页

作者： Zhu, Yuan Nyberg, Tomas Nyholm, Leif Primetzhofer, daniel Shi, Xun Zhang, Zhen Uppsala Univ Dept Elect Engn Div Solid State Elect S-75121 Uppsala Sweden Uppsala Univ Dept Chem Uppsala Sweden Uppsala Univ Dept Phys & Astron Uppsala Sweden Chinese Acad Sci Shanghai Inst Ceram State Key Lab High Performance Ceram & Superfine M Shanghai 200050 Peoples R China

Memristive crossbar arrays (MCAs) offer parallel data storage and processing for energy-efficient neuromorphic computing. However, most wafer-scale MCAs that are compatible with complementary metal-oxide-semiconductor (CMOS) technology still suffer from substantially larger energy consumption than biological synapses, due to the slow kinetics of forming conductive paths inside the memristive units. Here we report wafer-scale Ag2S-based MCAs realized using CMOS-compatible processes at temperatures below 160 degrees C. Ag2S electrolytes supply highly mobile Ag+ ions, and provide the Ag/Ag2S interface with low silver nucleation barrier to form silver filaments at low energy costs. By further enhancing Ag+ migration in Ag2S electrolytes via microstructure modulation, the integrated memristors exhibit a record low threshold of approximately - 0.1 V, and demonstrate ultra-low switching-energies reaching femtojoule values as observed in biological synapses. The low-temperature process also enables MCA integration on polyimide substrates for applications in flexible electronics. Moreover, the intrinsic nonidealities of the memristive units for deep learning can be compensated by employing an advanced training algorithm. An impressive accuracy of 92.6% in image recognition simulations is demonstrated with the MCAs after the compensation. The demonstrated MCAs provide a promising device option for neuromorphic computing with ultra-high energy-efficiency.

关键词： Wafer-scale Ag2S films Reactive sputter Silver nucleation Ag+ migration Energy-efficient neuromorphic computing

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Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez daniel Refai Gerald R.Rodts Christian Mustroph David Gimbel Jonathan Grossberg daniel L.Barrow Matthew F.Gary Ali M.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

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Regulator of G protein signaling 6 mediates exercise-induced recovery of hippocampal neurogenesis,learning,and memory in a mouse model of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2969-2981页

作者： Mackenzie M.Spicer Jianqi Yang daniel Fu Alison N.DeVore Marisol Lauffer Nilufer S.Atasoy Deniz Atasoy Rory A.Fisher Department of Neuroscience and Pharmacology University of Iowa Carver College of MedicineIowa CityIAUSA Iowa Neuroscience Institute University of Iowa Carver College of MedicineIowa CityIAUSA Interdisciplinary Graduate Program in Molecular Medicine University of Iowa Carver College of MedicineIowa CityIAUSA Neural Circuits and Behavior Core University of Iowa Carver College of MedicineIowa CityIAUSA

Hippocampal neuronal loss causes cognitive dysfunction in Alzheimer’s *** hippocampal neurogenesis is reduced in patients with Alzheimer’s *** stimulates adult hippocampal neurogenesis in rodents and improves memory and slows cognitive decline in patients with Alzheimer’s ***,the molecular pathways for exercise-induced adult hippocampal neurogenesis and improved cognition in Alzheimer’s disease are poorly ***,regulator of G protein signaling 6(RGS6)was identified as the mediator of voluntary running-induced adult hippocampal neurogenesis in ***,we generated novel RGS6fl/fl;APP_(SWE) mice and used retroviral approaches to examine the impact of RGS6 deletion from dentate gyrus neuronal progenitor cells on voluntary running-induced adult hippocampal neurogenesis and cognition in an amyloid-based Alzheimer’s disease mouse *** found that voluntary running in APP_(SWE) mice restored their hippocampal cognitive impairments to that of control *** cognitive rescue was abolished by RGS6 deletion in dentate gyrus neuronal progenitor cells,which also abolished running-mediated increases in adult hippocampal *** hippocampal neurogenesis was reduced in sedentary APP_(SWE) mice versus control mice,with basal adult hippocampal neurogenesis reduced by RGS6 deletion in dentate gyrus neural precursor ***6 was expressed in neurons within the dentate gyrus of patients with Alzheimer’s disease with significant loss of these RGS6-expressing ***,RGS6 mediated voluntary running-induced rescue of impaired cognition and adult hippocampal neurogenesis in APP_(SWE) mice,identifying RGS6 in dentate gyrus neural precursor cells as a possible therapeutic target in Alzheimer’s disease.

关键词： adult hippocampal neurogenesis Alzheimer’s disease dentate gyrus exercise learning/memory neural precursor cells regulator of G protein signaling 6(RGS6)

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Direct costs of carcinoid syndrome diarrhea among adults in the United States

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World Journal of Gastroenterology 2019年第47期25卷 6857-6865页

作者： Arvind Dasari Vijay N Joish Raul perez-Olle Samyukta Dharba Kavitha Balaji daniel M Halperin Department of Gastrointestinal Medical Oncology The University of Texas MD Anderson Cancer CenterHoustonTX 77030United States Lexicon Pharmaceuticals Inc.The WoodlandsTX 77381United States

BACKGROUND The burden of carcinoid syndrome(CS)among patients with neuroendocrine tumors is substantial and has been shown to result in increased healthcare resource use and *** incremental burden of CS diarrhea(CSD)is less well understood,particularly among working age adults who make up a large proportion of the population of patients with *** To estimate the direct medical costs of CSD to a self-insured employer in the United *** CS patients with and without CSD were identified in the IBM®MarketScan®Database,including the Medicare Supplemental Coordination of Benefits *** patients had≥1 medical claim for CS with continuous health plan enrollment for≥12 mo prior to their first CS diagnosis and for≥30 d after,no claims for acromegaly,and no clinical trial participation during the study period(2014-2016).Baseline demographic and clinical characteristics,including comorbidities and treatment,were analyzed using descriptive *** of healthcare resource use and costs were compared between patients with and without CSD,including Emergency Department(ED)visits,hospital admissions and length of stay,physician office visits,outpatient services,and prescription claims,using univariate and multivariate analyses to evaluate associations of CSD with healthcare resource use and costs,controlling for baseline *** Overall,6855 patients with CS were identified of which 4,043 were eligible for the analysis(1352 with CSD,2691 with CS only).Baseline demographic and clinical characteristics were similar between groups with the exception of age,underlying tumor type,and health insurance *** with CSD were older,had more comorbidities,and received more somatostatin analog therapy at *** with CSD required greater use of healthcare resources and incurred higher costs than their peers without CSD,including hospitalizations(44%vs 25%)and ED visits(55%vs 31%).The total adjusted annual healthcare costs

关键词： Carcinoid syndrome Carcinoid syndrome diarrhea Healthcare costs Neuroendocrine tumors

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Tailoring RGD local surface density at the nanoscale toward adult stem cell chondrogenic commitment

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Nano Research 2017年第6期10卷 1959-1971页

作者： Anna Lagunas Iro Tsintzou Yolanda Vida daniel Collado Ezequiel perez-Inestrosa Cristina Rodriguez Pereira Joana Magalhaes Jose A. Andrades Josep Samitier Networking Biomedical Research Center (CIBER) C/Monforte de Lemos 3-5 Pabellon 11 Planta 0 Madrid 28029 Spain Institute for Bioengineering of Catalonia (IBEC) Baldiri-Reixac 10-12 Barcelona 08028 Spain Instituto de Investigacion Biomedica de Malaga (IBIMA) Department of Organic Chemistry Universidad de Malaga (UMA) Malaga 29071 Spain Andalusian Centre for Nanomedicine and Biotechnology-BlONAND Parque Tecnoldgico de Andalucia Mdlaga 29590 Spain Unidad de Bioingenieria Tisulary Terapia Celular (GBTTC-CHUAC) Grupo de Reumatologia Instituto de Investigacion Biomedica de A Coru6a (INIBIC) Complexo Hospitalario Universitario de A Coruf~a (CHUAC) Sergas Universidade da Coruna (UDC) As Xubias 84 Coruna 15006 A Spain Cell Biology Genetics and Physiology Department University de Malaga (UMA) Campus Teatinos Malaga 29071 Spain Department of Engineering Electronics University of Barcelona (UB) Marti i Franques 1-11 Barcelona 08028 Spain

Arginine-glycine-aspartic acid （RGD） dendrimer-based nanopatterns on poly（L- lactic acid） were used as bioactive substrates to evaluate the impact of the RGD local surface density on the chondrogenic induction of adult human mesenchymal stem cells. During chondrogenic commitment, active extracellular matrix （ECM） remodeling takes place, playing an instructive role in the differentiation process. Although three-dimensional environments such as pellet or micromass cultures are commonly used for in vitro chondrogenic differentiation, these cultures are rather limited with respect to their ability to interrogate cells in celI-ECM interactions. In the present study, the nanopatterns of the tunable RGD surface density were obtained as a function of the initial dendrimer concentration. The local RGD surface density was quantified through probability contour plots for the minimum interparticle distance, constructed from the corresponding atomic force microscopy images, and correlated with the cell adhesion and differentiation response. The results revealed that the local RGD surface density at the nanoscale acts as a regulator of chondrogenic commitment, and that intermediate adhesiveness of cells to the substrates favors mesenchymal cell condensation and early chondrogenic differentiation.

关键词： dendrimer arginine-glycine-asparticacid (RGD) nanopattem human mesenchymalstem cells (hMSCs) chondrogenesis

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Unusual presentation of Loeys-Dietz syndrome:A case report of clinical findings and treatment challenges

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World Journal of Clinical Cases 2022年第33期10卷 12247-12256页

作者： Shely Azrad-daniel Corina Cupa-Galvan Sion Farca-Soffer Fernando perez-Zincer Maria Elena Lopez-Acosta Department of Internal Medicine Hospital Angeles LomasHuixquilucan 52763Mexico Department of Radiology Hospital Angeles LomasMexico 52763Mexico Department of Hematology Hospital Angeles LomasMexico 52763Mexico Department of Gastroenterology-Endoscopy Hospital Angeles LomasMexico 52763Mexico

BACKGROUND Loeys-Dietz syndrome(LDS)is a rare autosomal dominant syndrome characterized by heterozygous mutations causing multisystemic *** was recently described in 2005,and today at least six different subtypes have been *** presenting with aortic root enlargement or aneurysms and craniofacial and skeletal abnormalities,with specific arterial tortuosity at any *** differential diagnosis of LDS includes atypical Marfan syndrome,vascular Ehlers-Danlos syndrome,Shprintzen-Goldberg craniosynostosis,and familial aortic aneurysm and dissection *** SUMMARY We present a case study of a 35-year-old female who came to the emergency department due to lower gastrointestinal bleeding and severe abdominal *** tomography revealed vascular tortuosity in almost every abdominal *** This case report will help us analyze the infrequent presentation of LDS type 4 and the numerous complications that it implies,underlying the importance of publishing more cases in order to expand our knowledge and offer better treatment for these *** diagnosis,clinical presentation and treatment options for this syndrome are discussed in this article.

关键词： Loeys-Dietz syndrome Pulmonary embolism Gastrointestinal bleeding Rare genetic disease Therapeutic angiography Unusual presentation Rare disease Case report

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