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Amyloi.-β-i.duced di.rupti.n of axon-i.i.i.l-segment mi.ochondri. locali.ati.n:consequences for TAU mi.sorti.g i. Alzhei.er's di.ease pathology

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Neural Regenerati.n Research 2025年第5期20卷 1407-1408页

作者： daniel Adam Feli. Langerschei.t Hans Zempel i.sti.ute of Human Geneti.s University Hospital CologneCologneGermany Center for Molecular Medi.i.e Cologne(CMMC) University of CologneCologneGermany

TAU i. a neuronal mi.rotubule-associ.ted protei. preferenti.lly located i. *** a battery of neurodegenerati.e di.eases termed"tauopathi.s,"i.cludi.g Alzhei.er's di.ease (AD),TAU i. mi.sorted and abnormally phosphorylated,leadi.g to fi.amentous accumulati.ns of hyperphosphorylated TAU,a pathologi.al hallmark and potenti.l di.ease dri.er of AD and related tauopathi.s (Zempel,2024).

关键词： Alzhei.er tau di.eases

Vascular endotheli.l growth factor:a double-edged sword i. the development of whi.e matter lesi.ns

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Neural Regenerati.n Research 2025年第1期20卷 191-192页

作者： Narek Manukjan daniel Fulton Zubai. Ahmed WMatthi.s Blankestei.n Sébasti.n Foulqui.r Department of Pharmacology and Toxi.ology Maastricht UniversityMaastrichtThe Netherlands CARi.-School for Cardi.vascular Di.eases Maastricht UniversityMaastrichtThe Netherlands Neurosci.nce and Ophthalmology Institute of Inflammation and AgeingUniversity of BirminghamEdgbastonBirminghamUK Centre for Trauma Sci.nces Research University of BirminghamEdgbastonBirminghamUK MHeNs-School for Mental Health and Neurosci.nce Maastricht UniversityMaastrichtThe Netherlands Department of Neurology Maastricht University Medical CenterMaastrichtThe Netherlands

As the populati.n ages,the burden of age-related di.eases becomes ***,over 55 mi.li.n people suffer from dementi. worldwi.e,wi.h Alzhei.er’s di.ease bei.g the most common ***,i. i. becomi.g clearer that underlyi.g vascular pathology such as cerebral small vessel di.ease(cSVD)may be a more detri.ental cause for dementi.(Cuadrado-Godi. et al.,2018).i. i. esti.ated that 10%-30%of the elderly populati.n and 35%-90%of all dementi. pati.nts exhi.i. si.ns of *** term cSVD refers to pathology affecti.g the small vessels of the brai.,whi.h can lead to lacunar cerebral i.farcts,enlarged peri.ascular spaces,and corti.al hemorrhages(Cuadrado-Godi. et al.,2018).CSVD i. often associ.ted wi.h cogni.i.e decli.e,gai. problems,and dementi.(Cuadrado-Godi. et al.,2018).

关键词： pathology becomi.g whi.e

Wafer-Scale Ag₂S-Based Memri.ti.e Crossbar Arrays wi.h Ultra-Low Swi.chi.g-Energi.s Reachi.g Bi.logi.al Synapses

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NANO-Mi.RO LETTERS 2025年第1期17卷 1-12页

作者： Zhu, Yuan Nyberg, Tomas Nyholm, Lei. Pri.etzhofer, daniel Shi. Xun Zhang, Zhen Uppsala Uni. Dept Elect Engn Div Solid State Elect S-75121 Uppsala Sweden Uppsala Uni. Dept Chem Uppsala Sweden Uppsala Uni. Dept Phys & Astron Uppsala Sweden Chi.ese Acad Sci Shanghai Inst Ceram State Key Lab High Performance Ceram & Superfine M Shanghai 200050 Peoples R China

Memri.ti.e crossbar arrays (MCAs) offer parallel data storage and processi.g for energy-effi.i.nt neuromorphi. computi.g. However, most wafer-scale MCAs that are compati.le wi.h complementary metal-oxi.e-semi.onductor (CMOS) technology sti.l suffer from substanti.lly larger energy consumpti.n than bi.logi.al synapses, due to the slow ki.eti.s of formi.g conducti.e paths i.si.e the memri.ti.e uni.s. Here we report wafer-scale Ag2S-based MCAs reali.ed usi.g CMOS-compati.le processes at temperatures below 160 degrees C. Ag2S electrolytes supply hi.hly mobi.e Ag+ i.ns, and provi.e the Ag/Ag2S i.terface wi.h low si.ver nucleati.n barri.r to form si.ver fi.aments at low energy costs. By further enhanci.g Ag+ mi.rati.n i. Ag2S electrolytes vi. mi.rostructure modulati.n, the i.tegrated memri.tors exhi.i. a record low threshold of approxi.ately - 0.1 V, and demonstrate ultra-low swi.chi.g-energi.s reachi.g femtojoule values as observed i. bi.logi.al synapses. The low-temperature process also enables MCA i.tegrati.n on polyi.i.e substrates for appli.ati.ns i. flexi.le electroni.s. Moreover, the i.tri.si. noni.eali.i.s of the memri.ti.e uni.s for deep learni.g can be compensated by employi.g an advanced trai.i.g algori.hm. An i.pressi.e accuracy of 92.6% i. i.age recogni.i.n si.ulati.ns i. demonstrated wi.h the MCAs after the compensati.n. The demonstrated MCAs provi.e a promi.i.g devi.e opti.n for neuromorphi. computi.g wi.h ultra-hi.h energy-effi.i.ncy.

关键词： Wafer-scale Ag2S fi.ms Reacti.e sputter Si.ver nucleati.n Ag+ mi.rati.n Energy-effi.i.nt neuromorphi. computi.g

Complement-dependent neuroi.flammati.n i. spi.al cord i.jury:from pathology to therapeuti. i.pli.ati.ns

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Neural Regenerati.n Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali.Tfai.y Fi.as Kobei.sy Juanmarco Guti.rrez Gonzalez daniel Refai.Gerald R.Rodts Chri.ti.n Mustroph Davi. Gi.bel Jonathan Grossberg daniel L.Barrow Matthew F.Gary Ali.M.Alawi.h Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spi.al cord i.jury remai.s a major cause of di.abi.i.y i. young adults,and beyond acute decompressi.n and rehabi.i.ati.n,there are no pharmacologi.al treatments to li.i. the progressi.n of i.jury and opti.i.e recovery i. thi. *** the thorough i.vesti.ati.n of the complement system i. tri.geri.g and propagati.g cerebral neuroi.flammati.n,a si.i.ar role for complement i. spi.al neuroi.flammati.n i. a focus of ongoi.g *** thi. work,we survey the current li.erature i.vesti.ati.g the role of complement i. spi.al cord i.jury i.cludi.g the sources of complement protei.s,tri.gers of complement acti.ati.n,and role of effector functi.ns i. the *** study relevant data demonstrati.g the di.ferent tri.gers of complement acti.ati.n after spi.al cord i.jury i.cludi.g di.ect bi.di.g to cellular debri.,and or acti.ati.n vi. anti.ody bi.di.g to damage-associ.ted molecular *** effector functi.ns of complement have been i.pli.ated i. spi.al cord i.jury,and we cri.i.ally evaluate recent studi.s on the dual role of complement anaphylatoxi.s i. spi.al cord i.jury whi.e emphasi.i.g the lack of pathophysi.logi.al understandi.g of the role of opsoni.s i. spi.al cord *** thi. pathophysi.logi.al revi.w,we systemati.ally revi.w the di.ferent translati.nal approaches used i. precli.i.al models of spi.al cord i.jury and di.cuss the challenges for future translati.n i.to human *** revi.w emphasi.es the need for future studi.s to di.sect the roles of di.ferent complement pathways i. the pathology of spi.al cord i.jury,to evaluate the phases of i.volvement of opsoni.s and anaphylatoxi.s,and to study the role of complement i. whi.e matter degenerati.n and regenerati.n usi.g translati.nal strategi.s to supplement geneti. models.

关键词： complement neuroi.flammati.n neuroplasti.i.y regenerati.n spi.al cord i.jury targeted therapy

Regulator of G protei. si.nali.g 6 medi.tes exerci.e-i.duced recovery of hi.pocampal neurogenesi.,learni.g,and memory i. a mouse model of Alzhei.er’s di.ease

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Neural Regenerati.n Research 2025年第10期20卷 2969-2981页

作者： Mackenzi. M.Spi.er Ji.nqi.Yang daniel Fu Ali.on N.DeVore Mari.ol Lauffer Ni.ufer S.Atasoy Deni. Atasoy Rory A.Fi.her Department of Neurosci.nce and Pharmacology University of Iowa Carver College of MedicineIowa CityIAUSA i.wa Neurosci.nce i.sti.ute University of Iowa Carver College of MedicineIowa CityIAUSA i.terdi.ci.li.ary Graduate Program i. Molecular Medi.i.e University of Iowa Carver College of MedicineIowa CityIAUSA Neural Ci.cui.s and Behavi.r Core University of Iowa Carver College of MedicineIowa CityIAUSA

Hi.pocampal neuronal loss causes cogni.i.e dysfuncti.n i. Alzhei.er’s *** hi.pocampal neurogenesi. i. reduced i. pati.nts wi.h Alzhei.er’s *** sti.ulates adult hi.pocampal neurogenesi. i. rodents and i.proves memory and slows cogni.i.e decli.e i. pati.nts wi.h Alzhei.er’s ***,the molecular pathways for exerci.e-i.duced adult hi.pocampal neurogenesi. and i.proved cogni.i.n i. Alzhei.er’s di.ease are poorly ***,regulator of G protei. si.nali.g 6(RGS6)was i.enti.i.d as the medi.tor of voluntary runni.g-i.duced adult hi.pocampal neurogenesi. i. ***,we generated novel RGS6fl/fl;APP_(SWE) mi.e and used retrovi.al approaches to exami.e the i.pact of RGS6 deleti.n from dentate gyrus neuronal progeni.or cells on voluntary runni.g-i.duced adult hi.pocampal neurogenesi. and cogni.i.n i. an amyloi.-based Alzhei.er’s di.ease mouse *** found that voluntary runni.g i. APP_(SWE) mi.e restored thei. hi.pocampal cogni.i.e i.pai.ments to that of control *** cogni.i.e rescue was aboli.hed by RGS6 deleti.n i. dentate gyrus neuronal progeni.or cells,whi.h also aboli.hed runni.g-medi.ted i.creases i. adult hi.pocampal *** hi.pocampal neurogenesi. was reduced i. sedentary APP_(SWE) mi.e versus control mi.e,wi.h basal adult hi.pocampal neurogenesi. reduced by RGS6 deleti.n i. dentate gyrus neural precursor ***6 was expressed i. neurons wi.hi. the dentate gyrus of pati.nts wi.h Alzhei.er’s di.ease wi.h si.ni.i.ant loss of these RGS6-expressi.g ***,RGS6 medi.ted voluntary runni.g-i.duced rescue of i.pai.ed cogni.i.n and adult hi.pocampal neurogenesi. i. APP_(SWE) mi.e,i.enti.yi.g RGS6 i. dentate gyrus neural precursor cells as a possi.le therapeuti. target i. Alzhei.er’s di.ease.

关键词： adult hi.pocampal neurogenesi. Alzhei.er’s di.ease dentate gyrus exerci.e learni.g/memory neural precursor cells regulator of G protei. si.nali.g 6(RGS6)

Parallel Molecular Dynami.s on the Connecti.n Machi.es

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Wuhan Uni.ersi.y Journal of Natural Sci.nces 1996年第Z1期1卷 337-343页

作者： daniel i. Okunbor

Abstract Abstract:We have demonstrated usi.g vectori.ed parallel Lennard-Jones flui. program that vectori.i.g general-purpose parallel molecular package for si.ulati.g bi.molecules whi.h currently runs on the Connecti.n Machi.e CM-5 usi.g CMMD message passi.g would offer a si.ni.i.ant i.provement over 4 non-vectori.ed versi.n. Our results i.di.ate that the Lennard-Jones flui. program wri.ten i. C*/CMNi. i. fi.e ti.es faster than the same program wri.ten i. C/CMMD.

关键词： Parallel Molecular Dynami.s on the Connecti.n Machi.es

Prepari.g wi.nesses :a practi.al gui.e for lawyers and thei. cli.nts 2nd ed. 2nd ed.

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A Compari.on of Value Eli.i.ati.n Questi.n Formats i. Multi.le-Good Conti.gent Valuati.n

2004年

作者： daniel i. Small

来源：畅想之星图书光盘版（南... 评论

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Fronti.rs of Economi.s i. Chi.a-Selected Publi.ati.ns from Chi.ese Uni.ersi.i.s 2014年第1期9卷 85-108页

作者： Chi.-Chen Li. Joseph A. Herri.es C. L. Kli.g Si.vi. Secchi.Joan i. Nassauer daniel J. Phaneuf Department of Appli.d Economi.s National University of Kaohsiung Kaohsiung 81148Taiwan China Department of Economi.s Iowa State University Ames IA 50011 USA Department of Agri.usi.ess Economi.s Southern Illinois University Carbondale IL 62901USA School of Natural Resources and Envi.onment University of Michigan Ann Arbor M148103USA Department of Agri.ultural and Appli.d Economi.s University of Wisconsin Madison WI53706 USA

Thi. paper provi.es a convergent vali.i.y test of two types of multi.omi.l choi.e questi.ns vi.-a-vi. a di.hotomous choi.e questi.n by formally testi.g whether these stated preference eli.i.ati.n questi.n formats provi.e comparable welfare esti.ates. i. parti.ular, a di.hotomous choi.e questi.n, a tradi.i.nal multi.omi.l choi.e questi.n, and a modi.i.d multi.omi.l choi.e questi.n suggested by Carson and Groves （2007） were appli.d i. spli. samples to assess the i.fluence of the i.formati.nal and i.centi.e properti.s on the respondents＇ annual wi.li.gness to accept compensati.n for adopti.g costly conservati.n practi.es i. agri.ulture that benefi. the envi.onment. Our fi.di.gs suggest that the two multi.omi.l choi.e questi.n formats eli.i. a si.i.ar mean wi.li.gness to accept di.tri.uti.ns, but they are both di.ferent from a standarddi.hotomous choi.e questi.n. Further, the wi.li.gness to accept di.tri.uti.ns deri.ed from the multi.omi.l choi.e questi.n formats are more di.persed than those from the di.hotomous choi.e questi.n.

关键词： stated preference choi.e experi.ent di.hotomous choi.e,i.centi.e compati.i.i.y multi.omi.l choi.e

Gastri. polyps are not created equal: Know your enemy

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World Journal of Gastroenterology 2025年第2期31卷 144-146页

作者： Fady daniel Department of Gastroenterology and Hepatology American University of Beirut Medical CenterBeirut 11072020Lebanon

Gastri. polyps are commonly detected duri.g upper gastroi.testi.al *** are most often beni.n and rarely become ***,adequate knowledge,di.gnosti. modali.i.s,and management strategi.s should be the endoscopi.t’s readi.y avai.able“weapons”to defeat the potenti.lly mali.nant“enemi.s”.Thi. arti.le sheds li.ht on the valuable effort by Costa et al to generate a new classi.i.ati.n system of gastri. polyps as“good”,“bad”,and“ugly”.Thi. comprehensi.e overvi.w provi.es cli.i.i.ns wi.h a si.pli.i.d deci.i.n-maki.g process.

关键词： Gastri. polyps Polypoi. subepi.heli.l lesi.ns Early gastri. cancer Endoscopi. ultrasonography Electroni. chromoendoscopy