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An Improved Channel Model for ADSL and VDSL Systems

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An Improved Channel Model for ADSL and VDSL Systems

Amyloid-β-induced disruption of axon-initial-segment mitochondria localization:consequences for TAU missorting in Alzheimer's disease pathology

2000 International Conference on Communication Technology(WCC2000·ICCT2000)

作者： daniel franklin Jiangtao Xi Joe Chicharo School of Electrical Computer and Telecommunications EngineeringUniversity of WollongongNSWAustralia

＜正＞This paper examines existing channel models used with xDSL systems and identifies a key shortcoming-namely,the implicit assumption that all impulse noise originates at the transmitter. Based on extensive data collected from the local loop,a new model is proposed which addresses this problem by combining a digital filter model of the transmission line with a distributed noise *** better reflects the nature of a real telephone line,and thus provides a more solid basis for simulation and optimisation of xDSL systems.

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Neural Regeneration Research 2025年第5期20卷 1407-1408页

作者： daniel Adam Felix Langerscheidt Hans Zempel Institute of Human Genetics University Hospital CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany

TAU is a neuronal microtubule-associated protein preferentially located in *** a battery of neurodegenerative diseases termed"tauopathies,"including Alzheimer's disease (AD),TAU is missorted and abnormally phosphorylated,leading to filamentous accumulations of hyperphosphorylated TAU,a pathological hallmark and potential disease driver of AD and related tauopathies (Zempel,2024).

关键词： Alzheimer tau diseases

Bioresorbable Multilayer Photonic Cavities as Temporary Implants for Tether-Free Measurements of Regional Tissue Temperatures

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Biomedical Engineering Frontiers 2021年第1期2卷 89-102页

作者： Wubin Bai Masahiro Irie Zhonghe Liu Haiwen Luan daniel franklin Khizar Nandoliya Hexia Guo Hao Zang Yang Weng Di Lu Di Wu Yixin Wu Joseph Song Mengdi Han Enming Song Yiyuan Yang Xuexian Chen Hangbo Zhao Wei Lu Giuditta Monti Iwona Stepien Irawati Kandela Chad R.Haney Changsheng Wu Sang Min Won Hanjun Ryu Alina Rwei Haixu Shen Jihye Kim Hong-Joon Yoon Wei Ouyang Yihan Liu Emily Suen Huang-yu Chen Jerry Okina Jushen Liang Yonggang Huang Guillermo A.Ameer Weidong Zhou John A.Rogers Department of Materials Science and Engineering Northwestern UniversityEvanstonIllinois 60208USA Querrey Simpson Institute for Bioelectronics Northwestern UniversityEvanstonIllinois 60208USA Department of Electrical Engineering University of Texas at ArlingtonArlingtonTX 76019USA Department of Mechanical Engineering Northwestern UniversityEvanstonIllinois 60208USA Department of Chemistry Northwestern UniversityEvanstonIllinois 60208USA Department of Biomedical Engineering Northwestern UniversityEvanstonIllinois 60208USA Department of Materials Science and Engineering University of Illinois Urbana-ChampaignUrbanaIllinois 61801USA Academy for Advanced Interdisciplinary Studies Peking UniversityBeijingChina Department of Aerospace and Mechanical Engineering University of Southern CaliforniaLos AngelesCA 90089USA The Center for Developmental Therapeutics Northwestern UniversityEvanstonIllinois 60208USA Center for Advanced Molecular Imaging Northwestern UniversityEvanstonIllinois 60208USA Department of Electrical and Computer Engineering Sungkyunkwan UniversitySuwonRepublic of Korea School of Advanced Materials Science and Engineering Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Department of Neurobiology Northwestern UniversityEvanstonIllinois 60208USA Department of Chemical Engineering Northwestern UniversityEvanstonIllinois 60208USA Department of Civil and Environmental Engineering Northwestern UniversityEvanstonIllinois 60208USA Department of Electrical Engineering and Computer Science Northwestern UniversityEvanstonIllinois 60208USA Northwestern Medicine Feinberg School of MedicineNorthwestern UniversityEvanstonIllinois 60208USA Center for Advanced Regenerative Engineering Northwestern UniversityEvanstonIllinois 60208USA

Objective and Impact ***-time monitoring of the temperatures of regional tissue microenvironments can serve as the diagnostic basis for treating various health conditions and *** thermal sensors allow measurements at surfaces or at near-surface regions of the skin or of certain body *** at depth require implanted devices connected to external readout electronics via physical interfaces that lead to risks for infection and movement constraints for the ***,surgical extraction procedures after a period of need can introduce additional risks and ***,we report a wireless,bioresorbable class of temperature sensor that exploits multilayer photonic cavities,for continuous optical measurements of regional,deep-tissue microenvironments over a timeframe of interest followed by complete clearance via natural body *** designs decouple the influence of detection angle from temperature on the reflection spectra,to enable high accuracy in sensing,as supported by in vitro experiments and optical *** with devices implanted into subcutaneous tissues of both awake,freely moving and asleep animal models illustrate the applicability of this technology for in vivo *** results demonstrate the use of bioresorbable materials in advanced photonic structures with unique capabilities in tracking of thermal signatures of tissue microenvironments,with potential relevance to human healthcare.

关键词： signature constraints multilayer

Current status and trends of carbon-based electrodes for fully solution-processed perovskite solar cells

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Journal of Energy Chemistry 2022年第5期31卷 222-246页

作者： Laura MGonzález daniel Ramirez franklin Jaramillo Centro de Investigación Innovacióny Desarrollo de MaterialesCIDEMATFacultad de IngenieríaUniversidad de Antioquia UdeACalle 70 No.52-21Medellín 050010Colombia

Perovskite solar cells(PSCs) have revolutionized photovoltaic research. As a result, a certified power conversion efficiency(PCE) of 25.5% was recorded in late 2020. Although this efficiency is comparable with silicon solar cells;some issues remain partially unsolved, such as lead toxicity, instability of perovskite materials under continuous illumination, moisture and oxygen, and degradation of the metallic counter electrodes. As an alternative to tackle this last concern, carbon materials have been recently used, due to their good electrical and thermal conductivity, and chemical stability, which makes them one of the most promising materials to replace metallic counter electrodes in the fabrication of PSCs. This review highlights the recent advances of carbon-based PSCs, where the carbon electrode(CE) is the main *** have become very promising candidates for PSCs;they are mainly fabricated using a simple combination of graphite and carbon black powders embedded in a binder matrix, giving a paste that is then solution-processable, resulting in devices with improved quality stability, when compared to metallic electrodes. In this review, CE’s composition is emphasized, since it can give both, high and lowtemperature processed electrodes, compatible with different device configurations. Finally, the tendencies and opportunities to use CE in PSCs devices are presented.

关键词： Perovskite solar cells Carbon electrodes Scaling up Stability Solution processing

Vascular endothelial growth factor:a double-edged sword in the development of white matter lesions

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Neural Regeneration Research 2025年第1期20卷 191-192页

作者： Narek Manukjan daniel Fulton Zubair Ahmed WMatthijs Blankesteijn Sébastien Foulquier Department of Pharmacology and Toxicology Maastricht UniversityMaastrichtThe Netherlands CARIM-School for Cardiovascular Diseases Maastricht UniversityMaastrichtThe Netherlands Neuroscience and Ophthalmology Institute of Inflammation and AgeingUniversity of BirminghamEdgbastonBirminghamUK Centre for Trauma Sciences Research University of BirminghamEdgbastonBirminghamUK MHeNs-School for Mental Health and Neuroscience Maastricht UniversityMaastrichtThe Netherlands Department of Neurology Maastricht University Medical CenterMaastrichtThe Netherlands

As the population ages,the burden of age-related diseases becomes ***,over 55 million people suffer from dementia worldwide,with Alzheimer’s disease being the most common ***,it is becoming clearer that underlying vascular pathology such as cerebral small vessel disease(cSVD)may be a more detrimental cause for dementia(Cuadrado-Godia et al.,2018).It is estimated that 10%-30%of the elderly population and 35%-90%of all dementia patients exhibit signs of *** term cSVD refers to pathology affecting the small vessels of the brain,which can lead to lacunar cerebral infarcts,enlarged perivascular spaces,and cortical hemorrhages(Cuadrado-Godia et al.,2018).CSVD is often associated with cognitive decline,gait problems,and dementia(Cuadrado-Godia et al.,2018).

关键词： pathology becoming white

Variable retention harvesting in the Douglas-fir region

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Ecological Processes 2020年第1期9卷 83-92页

作者： Jerry F.franklin daniel C.Donato School of Environmental and Forest Science College of the EnvironmentUniversity of WashingtonSeattleWA 98195USA Washington Department of Natural Resources OlympiaWA 98504USA

Variable retention harvesting evolved in the Douglas-fir region of the Pacific Northwest gradually in response to increasing dissatisfaction with the ecological consequences of clear-cutting,from the standpoint of wildlife habitat and other important forest *** is a harvesting technique that can provide for retention(continuity)of such structures as large and old live trees,snags,and *** retention is based on the natural model of the biological legacies that are typically left behind following natural disturbances,such as wildfire,wind,and *** retention is also an important technique for fulfilling the first silvicultural principle of ecological forestry,that of providing for continuity in structure,function,and composition between forest *** history and current application of variable retention approaches on forests in western Washington and Oregon states(USA),where many of the fundamental concepts were first developed and applied,is described in this article.

关键词： Biological legacies Ecological forestry Biodiversity conservation Long-term sustainability Washington and Oregon states

Understanding the precursor chemistry for one-step deposition of mixed cation perovskite solar cells by methylamine route

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Journal of Energy Chemistry 2021年第6期30卷 386-391,I0010页

作者： Manuel Vásquez-Montoya Juan F.Montoya daniel Ramirez franklin Jaramillo Centro de Investigación Innovación y Desarrollo de Materiales CIDEMATUniversidad de Antioquia UdeACalle 70 No.52-21MedellínColombia

Upscaling perovskite solar cell fabrication is one of the key challenges in the pathway for *** slow evaporation of frequently used solvents(DMF or DMSO) limits the fast perovskite layer crystallization,hindering their implementation in large scale deposition ***,methylamine-based precursors have demonstrated rapid crystallization,leading to uniform and specular ***,their application has been limited to MAPbI3 perovskites with limited efficiency and *** this work,we report the requirements for stabilizing α-phase of mixed cation perovskites with high amount of formamidinium by using a methylamine-based *** found that even though,there are many methods for incorporating the methylamine(MA) in precursors or films;the MA content determines stabilization of the α-phase and therefore the viscous-solution route is the only method to incorporate high amounts of *** low amounts of MA,perovskite tend to crystallize in 1D dimensional FA_(3)(MA)PbI5 phases due to the incomplete solvation of the *** contrast,high MA ratio induces a full solvation of the clusters,leading to a rapid crystallization and a full stabilization of the active 3D α-*** results open a window in the development and understanding of new precursors for the fabrication of high efficient,stable and scalable perovskite devices.

关键词： Methylamine Stabilizingα-phase Mixed cation perovskite precursor Formamidinium Upscaling Perovskite Solar cells

Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez daniel Refai Gerald R.Rodts Christian Mustroph David Gimbel Jonathan Grossberg daniel L.Barrow Matthew F.Gary Ali M.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

Global Wheat Head Detection Challenges:Winning Models and Application for Head Counting

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Plant Phenomics 2023年第3期5卷 460-473页

作者： Etienne David franklin Ogidi daniel Smith Scott Chapman Benoit de Solan Wei Guo Frederic Baret Ian Stavness UMR 1114 EMMAH INRAEAvignonFrance Arvalis–Institut du Végétal ParisFrance Department of Computer Science University of SaskatchewanSaskatoonCanada School of Food and Agricultural Sciences University of QueenslandBrisbaneAustralia Graduate School of Agricultural and Life Sciences The University of TokyoTokyoJapan

Data competitions have become a popular approach to crowdsource new data analysis methods for general and specialized data science *** competitions have a rich history in plant phenotyping,and new outdoor field datasets have the potential to embrace solutions across research and commercial *** developed the Global Wheat Challenge as a generalization competition in 2020 and 2021 to find more robust solutions for wheat head detection using field images from different *** analyze the winning challenge solutions in terms of their robustness when applied to new *** found that the design of the competition had an influence on the selection of winning solutions and provide recommendations for future competitions to encourage the selection of more robust solutions.

关键词： Wheat specialized competition