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Amyloid-β-induced disruption of axon-initial-segment mitochondria localization:consequences for TAU missorting in Alzheimer's disease pathology

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Neural Regeneration Research 2025年第5期20卷 1407-1408页

作者： daniel Adam Felix Langerscheidt Hans Zempel Institute of Human Genetics University Hospital CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany

TAU is a neuronal microtubule-associated protein preferentially located in *** a battery of neurodegenerative diseases termed"tauopathies,"including Alzheimer's disease (AD),TAU is missorted and abnormally phosphorylated,leading to filamentous accumulations of hyperphosphorylated TAU,a pathological hallmark and potential disease driver of AD and related tauopathies (Zempel,2024).

关键词： Alzheimer tau diseases

Vascular endothelial growth factor:a double-edged sword in the development of white matter lesions

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Neural Regeneration Research 2025年第1期20卷 191-192页

作者： Narek Manukjan daniel Fulton Zubair Ahmed WMatthijs Blankesteijn Sébastien Foulquier Department of Pharmacology and Toxicology Maastricht UniversityMaastrichtThe Netherlands CARIM-School for Cardiovascular Diseases Maastricht UniversityMaastrichtThe Netherlands Neuroscience and Ophthalmology Institute of Inflammation and AgeingUniversity of BirminghamEdgbastonBirminghamUK Centre for Trauma Sciences Research University of BirminghamEdgbastonBirminghamUK MHeNs-School for Mental Health and Neuroscience Maastricht UniversityMaastrichtThe Netherlands Department of Neurology Maastricht University Medical CenterMaastrichtThe Netherlands

As the population ages,the burden of age-related diseases becomes ***,over 55 million people suffer from dementia worldwide,with Alzheimer’s disease being the most common ***,it is becoming clearer that underlying vascular pathology such as cerebral small vessel disease(cSVD)may be a more detrimental cause for dementia(Cuadrado-Godia et al.,2018).It is estimated that 10%-30%of the elderly population and 35%-90%of all dementia patients exhibit signs of *** term cSVD refers to pathology affecting the small vessels of the brain,which can lead to lacunar cerebral infarcts,enlarged perivascular spaces,and cortical hemorrhages(Cuadrado-Godia et al.,2018).CSVD is often associated with cognitive decline,gait problems,and dementia(Cuadrado-Godia et al.,2018).

关键词： pathology becoming white

Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez daniel Refai Gerald R.Rodts Christian Mustroph David Gimbel Jonathan Grossberg daniel L.Barrow Matthew F.Gary Ali M.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

Regulator of G protein signaling 6 mediates exercise-induced recovery of hippocampal neurogenesis,learning,and memory in a mouse model of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2969-2981页

作者： Mackenzie M.Spicer Jianqi Yang daniel Fu Alison N.DeVore Marisol Lauffer Nilufer S.Atasoy Deniz Atasoy Rory A.Fisher Department of Neuroscience and Pharmacology University of Iowa Carver College of MedicineIowa CityIAUSA Iowa Neuroscience Institute University of Iowa Carver College of MedicineIowa CityIAUSA Interdisciplinary Graduate Program in Molecular Medicine University of Iowa Carver College of MedicineIowa CityIAUSA Neural Circuits and Behavior Core University of Iowa Carver College of MedicineIowa CityIAUSA

Hippocampal neuronal loss causes cognitive dysfunction in Alzheimer’s *** hippocampal neurogenesis is reduced in patients with Alzheimer’s *** stimulates adult hippocampal neurogenesis in rodents and improves memory and slows cognitive decline in patients with Alzheimer’s ***,the molecular pathways for exercise-induced adult hippocampal neurogenesis and improved cognition in Alzheimer’s disease are poorly ***,regulator of G protein signaling 6(RGS6)was identified as the mediator of voluntary running-induced adult hippocampal neurogenesis in ***,we generated novel RGS6fl/fl;APP_(SWE) mice and used retroviral approaches to examine the impact of RGS6 deletion from dentate gyrus neuronal progenitor cells on voluntary running-induced adult hippocampal neurogenesis and cognition in an amyloid-based Alzheimer’s disease mouse *** found that voluntary running in APP_(SWE) mice restored their hippocampal cognitive impairments to that of control *** cognitive rescue was abolished by RGS6 deletion in dentate gyrus neuronal progenitor cells,which also abolished running-mediated increases in adult hippocampal *** hippocampal neurogenesis was reduced in sedentary APP_(SWE) mice versus control mice,with basal adult hippocampal neurogenesis reduced by RGS6 deletion in dentate gyrus neural precursor ***6 was expressed in neurons within the dentate gyrus of patients with Alzheimer’s disease with significant loss of these RGS6-expressing ***,RGS6 mediated voluntary running-induced rescue of impaired cognition and adult hippocampal neurogenesis in APP_(SWE) mice,identifying RGS6 in dentate gyrus neural precursor cells as a possible therapeutic target in Alzheimer’s disease.

关键词： adult hippocampal neurogenesis Alzheimer’s disease dentate gyrus exercise learning/memory neural precursor cells regulator of G protein signaling 6(RGS6)

A lateral ankle sprain during a lateral backward step in badminton:A case report of a televised injury incident

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Journal of Sport and Health Science 2023年第1期12卷 139-144页

作者： daniel T.P.Fong Kam-Ming Mok Isobel M.thompson Yuehang Wang Wei Shan Mark A.King National Centre for Sport and Exercise Medicine School of SportExercise and Health SciencesLoughborough UniversityLoughboroughLE113TUUK Office of Student Affairs Lingnan UniversityHong Kong 999077China Department of Orthopaedics and Traumatology Prince of Wales HospitalFaculty of MedicineThe Chinese University of Hong KongHong Kong 999077China China Institute of Sport and Health Science Beijing Sport UniversityBeijing 100084China

Background:This study presents a kinematic analysis of an acute lateral ankle sprain incurred during a televised badminton *** kinematics of this injury were compared to those of 19 previously reported cases in the published ***:Four camera views of an acute lateral ankle sprain incurred during a televised badminton match were synchronized and rendered in3-dimensional animation software.A badminton court with known dimensions was built in a virtual environment,and a skeletal model scaled to the inj ured athlete’s height was used for skeletal *** ankle joint angle and angular velocity profiles of this acute injury were compared to the summarized findings from 19 previously reported cases in the published ***:At foot strike,the ankle joint was 2° everted,33° plantarflexed,and 18° internally *** inversion of 114° and internal rotation of 69° was achieved at 0.24 s and 0.20 s after foot strike,*** the foot strike,the ankle joint moved from an initial position of plantarflexion to dorsiflexion-from 33° plantarflexion to 53° dorsiflexion(range=86°).Maximum inversion,dorsiflexion,and internal rotation angular velocity were 1262°/s,961°/s,and 677°/s,respectively,at 0.12 s after foot ***:A forefoot landing posture with a plantarflexed and internally rotated ankle joint configuration could incite an acute lateral ankle sprain injury in *** of lateral ankle sprains in badminton should focus on the control and stability of the ankle joint angle during forefoot landings,especially when the athletes perform a combined lateral and backward step.

关键词： Ankle Biomechanics Injury prevention Ligament injuries Sports medicine

Micro-porous PLGA/β-TCP/TPU scaffolds prepared by solvent-based 3D printing for bone tissue engineering purposes

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Regenerative Biomaterials 2023年第1期10卷 1538-1551页

作者： Luan P.Hatt Sylvie Wirth Aapo Ristaniemi daniel J.Ciric Keith thompson David Eglin Martin J.Stoddart Angela R.Armiento AO Research Institute Davos 7270 Davos PlatzSwitzerland Institute for Biomechanics ETH Zurich8093 ZurichSwitzerland UCB Pharma SL13WE SloughUK Mines Saint-Etienne Universitede LyonUniversite´Jean MonnetINSERMU105942023 SainbioseSaint-EtienneFrance Medical Center Faculty of MedicineAlbert-Ludwigs-University of Freiburg79106 FreiburgGermany

The 3D printing process of fused deposition modelling is an attractive fabrication approach to create tissue-engineered bone substitutes to regenerate large mandibular bone defects,but often lacks desired surface porosity for enhanced protein adsorption and cell ***-based printing leads to the spontaneous formation of micropores on the scaffold’s surface upon solvent removal,without the need for further post *** aim is to create and characterize porous scaffolds using a new formulation composed of mechanically stable poly(lactic-co-glycol acid)and osteoconductiveβ-tricalcium phosphate with and without the addition of elastic thermoplastic polyurethane prepared by solvent-based 3D-printing ***-scale regenerative scaffolds can be 3D-printed with adequate fidelity and show porosity at multiple levels analysed via micro-computer tomography,scanning electron microscopy and N_(2) *** mechanical properties compared to a commercially available calcium phosphate ink are demonstrated in compression and screw pull out *** assessments including cell activity assay and live-dead staining prove the scaffold’s *** properties are demonstrated by performing an osteogenic differentiation assay with primary human bone marrow mesenchymal stromal *** propose a versatile fabrication process to create porous 3D-printed scaffolds with adequate mechanical stability and osteoconductivity,both important characteristics for segmental mandibular bone reconstruction.

关键词： solvent-based printing porosity regenerative scaffold osteogenesis mesenchymal stromal cells

Gastric polyps are not created equal: Know your enemy

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World Journal of Gastroenterology 2025年第2期31卷 144-146页

作者： Fady daniel Department of Gastroenterology and Hepatology American University of Beirut Medical CenterBeirut 11072020Lebanon

Gastric polyps are commonly detected during upper gastrointestinal *** are most often benign and rarely become ***,adequate knowledge,diagnostic modalities,and management strategies should be the endoscopist’s readily available“weapons”to defeat the potentially malignant“enemies”.This article sheds light on the valuable effort by Costa et al to generate a new classification system of gastric polyps as“good”,“bad”,and“ugly”.This comprehensive overview provides clinicians with a simplified decision-making process.

关键词： Gastric polyps Polypoid subepithelial lesions Early gastric cancer Endoscopic ultrasonography Electronic chromoendoscopy

Machine learning and price-based load scheduling for an optimal IoT control in the smart and frugal home

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Energy and AI 2021年第1期3卷 49-63页

作者： Rachneet Kaur Clara Schaye Kevin thompson daniel C.Yee Rachel Zilz R.S.Sreenivas Richard B.Sowers Department of Industrial and Enterprise Systems Engineering University of IllinoisUrbanaIL 61801USA Department of Electrical and Computer Engineering University of IllinoisUrbanaIL 61801USA Department of Mathematics and Department of Industrial and Enterprise Systems Engineering University of IllinoisUrbanaIL 61801USA

We pose and study a scheduling problem for an electric load to develop an Internet of Things(IoT)control system for power appliances,which takes advantage of real-time dynamic energy *** historical pricing data from a large *** supplier,we study and compare several dynamic scheduling policies,which can be implemented in a smart home to activate a major appliance(dishwasher,washing machine,clothes dryer)at an optimal time of the day,to minimize electricity *** formulate our scheduling task as a supervised machine learning classification problem which activates the load during one of two preferred time *** features used in the machine learning problem are hourly market,spot and day-ahead prices along with delayed label of the prior *** find that boosting tree-based algorithms outperform any other classification approach with measurable reduction of energy costs over certain types of naive and static *** observe that the delayed label has most predictive power across features,followed,on average,by spot,hourly market,and day-ahead energy *** further discuss implementation issues using a micro controller system coupled with cloud-based serverless computing and dynamic data *** test system includes an interactive voice interface via an intelligent personal assistant.

关键词： Power markets Load scheduling Machine learning Feature analysis Internet of Things Autonomous scheduling Serverless computing

Kernel-Based State-Space Kriging for Predictive Control

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IEEE/CAA Journal of Automatica Sinica 2023年第5期10卷 1263-1275页

作者： A.daniel Carnerero daniel R.Ramirez daniel Limon Teodoro Alamo the Department of System Engineering and Automation University of SevilleSevilla 41020Spain the School of Engineering Tokyo Institute of TechnologyTokyo 152-8552Japan Department of System Engineering and Automation University of SevilleSevilla 41020Spain

In this paper, we extend the state-space kriging(SSK) modeling technique presented in a previous work by the authors in order to consider non-autonomous systems. SSK is a data-driven method that computes predictions as linear combinations of past outputs. To model the nonlinear dynamics of the system, we propose the kernel-based state-space kriging(K-SSK), a new version of the SSK where kernel functions are used instead of resorting to considerations about the locality of the data. Also, a Kalman filter can be used to improve the predictions at each time step in the case of noisy measurements. A constrained tracking nonlinear model predictive control(NMPC) scheme using the black-box input-output model obtained by means of the K-SSK prediction method is proposed. Finally, a simulation example and a real experiment are provided in order to assess the performance of the proposed controller.

关键词： Data-driven methods model identification Kernel methods predictive control