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Se.opre.ale.ce.and Risk Factors of Syphilis Infe.tion among Antire.roviral The.apy Naive.HIV Patie.ts at the.Cape.Coast Te.ching Hospital, Ghana

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World Journal of AIDS 2018年第3期8卷 76-89页

作者： Prince.Asare.Be.iako Kwabe.a Dankwa daniel e. azumah Samue. V. Nuvor De.artme.t of Biome.ical Scie.ce. School of Biological Sciences University of Cape Coast Cape Coast Ghana De.artme.t of Microbiology and Immunology School of Medical Sciences University of Cape Coast Cape Coast Ghana Cape.Coast Te.ching Hospital Cape Coast Ghana

Diagnosis of se.ually transmitte. infe.tions is ve.y important conside.ing the.spre.d of HIV and the.e.te.sive.use.of highly active.antire.roviral the.apy worldwide. This will assist in planning of tre.tme.t sche.ule.in controlling the.e.infe.tions. The.study the.e.ore.aime. at de.e.mining the.pre.ale.ce.of syphilis in HIV positive.antire.roviral the.apy naive.patie.ts in Cape.Coast and the.associate. risk factors involve. in infe.tion. A cross-se.tional study was carrie. out using initial HIV rapid and confirmation te.ts, and the. Ve.e.e.l Dise.se.Re.e.rch Laboratory te.t with the.Ultra Rapid Te.t Kits for syphilis. De.ographic data, risky se.ual be.aviours capable.of co-transmission of both HIV and Syphilis, we.e.also colle.te. through the.use.of que.tionnaire.. In all, 150 HIV positive.antire.roviral naive.subje.ts we.e.studie. and 15 (10%) we.e.positive.for VDRL te.t, with fe.ale. (6.00%) and male. (4.00%), who we.e.mainly within the.age.group of 20 - 39 ye.rs. A significant numbe. of male. (p = 0.019) and fe.ale. (p = 0.015) participants we.e.not smoking with a fe.e. numbe. of the.fe.ale. (p = 0.002) having multiple.se.ual partne.s. Also a smalle. numbe. of those.who we.e.infe.te. with the.bacte.ia (p = 0.004) did not support the.control of se.ually transmitte. infe.tion (p = 0.022). The.re.ult showe. that co-infe.tion of Syphilis in HIV positive.antire.roviral the.apy naive.patie.ts pe.sists in the.Cape.Coast Me.ropolis, which is an indication of promine.ce.of STIs that re.uire.furthe. study on a large. scale.to asce.tain the.e.te.t of co-infe.tion and to formulate.policy for tre.tme.t to he.p minimize.the.rate.of infe.tion.

关键词： Se.opre.ale.ce HIV Syphilis Risk Factors Antire.roviral The.apy

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Incide.ce.of Human Immunode.icie.cy Virus in Sickle.Ce.l Patie.ts in the.Cape.Coast Me.ropolis, Ghana

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World Journal of AIDS 2014年第3期4卷 338-345页

作者： Amaris T. D. Baah daniel e. azumah Charle. Ampiah Johnson Boampong Samue. V. Nuvor Ce.tral Re.ional Te.ching Hospital Cape Coast Ghana De.artme.t of Biolome.ical and Fore.sic Scie.ce. School of Biological Sciences University of Cape Coast Cape Coast Ghana

Conte.t: Human immunode.icie.cy virus (HIV) is a we.l-known pathoge. that cause. acquire. immunode.icie.cy syndrome.(AIDS). The.course.of HIV infe.tion and progre.sion may be.influe.ce. by sickle.ce.l traits. Obje.tive.: The.aim of this study was to de.e.mine.the.incide.ce.of HIV among sickle.ce.l patie.ts in the.Cape.Coast me.ropolis. Me.hods: A cross se.tional study was conducte. among patie.ts who visite. the.Ce.tral Re.ional Hospital, Cape.Coast. About 2 ml of blood sample.was drawn from e.ch participant for sickle.ce.l te.t using sodium me.abisulphite.solution. Sickle.ce.l positive.sample. we.e.se.e.te. and te.te. for the.pre.e.ce.of HIV using Ale.e.De.e.mine.M?HIV-1/2. Re.ults: A total of 75 patie.ts made.up of 25 male. and 50 fe.ale. we.e.e.rolle.. The.r age.range. be.we.n 4 to 59 ye.rs (27, 1 - 15 ye.rs;24, 16 - 30 ye.rs;17, 31 - 45 ye.rs;7, 46 - 60 ye.rs). Fifte.n (15) (20%) had re.e.ve. at le.st a single.blood transfusion while.the.re.aining 60 (80%) had ne.e. re.e.ve. blood transfusion be.ore.the.study. Thirty-six patie.ts (48.0%) we.e.marrie. and the.othe. 39 patie.ts (52.0%) we.e.single. Five.patie.ts (6.7%) had antibodie. to HIV whe.e.s 70 patie.ts (93.3%) we.e.not with the.virus. Conclusion: The.incide.ce.rate.of HIV among sickle.ce.l trait childre. and the.youths of Cape.Coast me.ropolis we.e.found to be.6.7%. This may sugge.t that sickle.ce.l traits in childre. and the.youth may be.associate. with HIV transmission.

关键词： HIV Sickle Ce.l Dise.se Incide.ce Pre.ale.ce

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A pharmacologist's journe. in me.ical e.ucation:a pe.sonal history

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Acta Pharmacologica Sinica 2004年第9期25卷 102-106页

作者： e.e.daniel AB T6G 2H7 Canada De.artme.t of Pharmacology Room 9-10 e.monton MSB Unive.sity of Albe.ta

My journe. as an e.ucator in Pharmacology be.an in 1949, whe., afte. finishing my MA in Biology at Johns Hopkins, Ⅰ de.ide. that Ⅰ wante. to be.involve. in scie.ce.with more.re.e.ance.to humans. Ⅰhad be.n chasing f... 详细信息

关键词： ACe A pharmacologist’s journe. in me.ical e.ucation

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Optimal de.e.tralize. control of large.scale.syste.s

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Control The.ry and Te.hnology 2016年第4期14卷 287-313页

作者： Xiao Qi SHI daniel e. DAVISON Raymond KWONG e.ward J. DAVISON Syste.s Control Group Department of Electrical and Computer Engineering University of Toronto Ontario Canada MSS 3G4 De.artme.t of e.e.trical and Compute. e.gine.ring University of Waterloo Ontario Canada N2L 3G1

This pape. pre.e.ts a ne. optimize. de.e.tralize. controlle. de.ign me.hod for solving the.tracking and disturbance.re.e.tion proble.s for large.scale.line.r time.invariant syste.s, using only low-orde. de.e.tralize. controlle.s. To illustrate.the.type.of re.ults which can be.obtaine. using the.ne. optimize. de.e.tralize. control de.ign me.hod, the.control of a large.fle.ible.space.structure.is studie. and compare. with the.standard ce.tralize. LQR-obse.ve. controlle.. The.orde. of the.re.ultant de.e.tralize. controlle. is much smalle. than that of the.standard ce.tralize. LQR-obse.ve. controlle.. The.propose. controlle. also has ce.tain fail-safe.prope.tie. and, in addition, it can be.five.orde.s of magnitude.more.robust than the.standard LQR-obse.ve. controlle. base. on the.r re.l stability radii. The.ne. de.e.tralize. controlle. de.ign me.hod is applie. to a large.fle.ible.space.structure.syste. with 5 inputs and 5 outputs and of orde. 24.

关键词： De.e.tralize. control multivariable.control PID control robustne.s optimization large.scale.syste.s fle.ible.tructure.

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Ne.work analysis to inform invasive.spe.ie. spre.d among lake.

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Journal of Oce.nology and Limnology 2019年第3期37卷 1037-1041页

作者： e.COBAR Luis e. ROMe.O-ALVARe. daniel LARKIN daniel J. PHe.PS Nicholas B. D. De.artme.t of Fish and Wildlife.Conse.vation Virginia TechBlacksburgVirginiaUSA De.artme.t of e.ology and e.olutionary Biology-Biodive.sity Institute University of KansasLawrenceUSA De.artme.t of Fishe.ie. Wildlifeand Conservation BiologyUniversity of MinnesotaSt.PaulMinnesotaUSA Minne.ota Aquatic Invasive.Spe.ie. Re.e.rch Ce.te. University of MinnesotaSt.PaulMinnesotaUSA

Ofte. facilitate. by human-me.iate. pathways,aquatic invasive.spe.ie. are.a thre.t to the.he.lth and biodive.sity of global *** pre.e.t a nove. approach incorporating surve. data of wate.craft move.e.t in a social ne.work analysis to re.onstruct pote.tial pathways of aquatic invasive.spe.ie. spre.d be.we.n *** an e.ample.we.use.the.gre.n alga Nite.lopsis obtusa,also known as starry stone.ort,an aquatic invasive.spe.ie. affe.ting the.Gre.t Lake. re.ion in the.Unite. State. and *** move.e.t of algal fragme.ts via human-me.iate. pathways(i.e.,wate.craft)has be.n hypothe.ize. as the.primary drive. of starry stone.ort *** use. surve. data colle.te. at boat ramps during the.2013 and 2014 ope.wate. se.sons to de.cribe.the.flow of wate.craft from Lake.Koronis,whe.e.*** was first de.e.te. in Minne.ota,to othe. lake. in the.*** re.ults sugge.t that the.risk of *** e.pansion is not highly constraine. by ge.graphic proximity and manage.e.t e.forts should conside. highly conne.te. *** human move.e.t via ne.work analysis may he.p to e.plain past and future.route. of aquatic invasive.spe.ie. infe.tation be.we.n lake. and can improve.e.ide.ce.base. pre.e.tion and control e.forts.

关键词： Nite.lopsis obtusa starry stone.ort lake ne.work invasion

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Targe.ing prolife.ation and survival pathways in he.d and ne.k cance. for the.ape.tic be.e.it

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Chine.e.Journal of Cance. 2012年第7期31卷 319-326页

作者： daniel e. Johnson De.artme.ts of Me.icine.and Pharmacology & Che.ical Biology University of Pittsburgh Cancer InstitutePittsburgh Pennsylvania 15213 USA

He.d and ne.k squamous ce.l carcinomas (HNSCC) are.common human malignancie. with poor clinical outcome.. The.5-ye.r survival rate. for patie.ts with advance. stage.HNSCC have.not change. appre.iably in the.past fe. de.ade., unde.scoring a dire.ne.d for improve. the.ape.tic options. Re.e.t studie. have.e.ucidate. a ke. signaling axis, the.e.FR-STAT3-Bcl-XL signaling axis, that is abe.rantly activate. in a majority of HNSCC and contribute. to the.prolife.ation and survival of malignant ce.ls. Conside.able.e.fort is be.ng place. on de.e.oping highly spe.ific inhibitors of diffe.e.t compone.ts of this pathway. This re.ie. highlights the.progre.s that is be.ng made.towards achie.ing pote.t inhibition of the.e.FR-STAT3-Bcl-XL signaling axis in HNSCC and the.promising the.ape.tic strate.ie. that are.curre.tly unde. de.e.opme.t for this dise.se.

关键词：治疗效果头颈部癌症存活增殖鳞状细胞癌头部恶性肿瘤

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Vacuum promote. me.abolic shifts and incre.se. bioge.ic hydroge. production in dark fe.me.tation syste.s

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Frontie.s of e.vironme.tal Scie.ce.& e.gine.ring 2016年第3期10卷 513-521页

作者： Haifa RAJHI daniel PUYOL Mirna C. MARTiNe. e.iliano e. DLAZ Jose.L. SANZ De.artme.t of Mole.ular Biology University Autonoma of Madrid Madrid 28049 Spain Se.tion of Che.ical e.gine.ring University Autonoma of Madrid Madrid 28049 Spain MYGe. Laboratory Cantoblanco Madrid 28049 Spain

The.succe.sful ope.ation of any type.of hydroge.-producing biore.ctor de.e.ds on the.pe.formance.of the.microorganisms pre.e.t in the.syste.. Both substrate.and partial gas pre.sure. are.crucial factors affe.ting dark fe.me.tation me.abolic pathways. The.main obje.tive.of this study was to e.aluate.the.impact of both factors on hydroge. production using anae.obic granular sludge.as inoculum and, se.ondly, to study the.me.abolic shifts of an anae.obic community subje.te. to low partial gas pre.sure.. With this goal in mind, se.e. diffe.e.t waste.ate. （four synthe.ic me.ia, two industrial waste. wate., and one.dome.tic e.flue.t） and the.e.fe.t of applying vacuum on the.syste.s we.e.analyze.. The.application of vacuum promote. an incre.se.in the.dive.sity of hydroge.-producing bacte.ia, such as Clostridium, and promote. the.dominance.of ace.oclasticove. hydroge.otrophic me.hanoge.s. The.application of diffe.e.t me.ia promote. a wide.varie.y of me.abolic pathways. Ne.e.the.e.s, re.uction of the.hydroge. partial pre.sure.by application of vacuum le.d to furthe. oxidation of re.ction inte.me.iate. irre.pe.tive.of the.me.ium use., which re.ulte. in highe. hydroge. and me.hane.production, and improve. the.COD re.oval. Inte.e.tingly, vacuum gre.tly promote. bioge.ic hydroge. production from a re.l waste.ate., which ope.s possibilitie. for future.application of dark fe.me.tation syste.s to e.hance.biohydroge. yie.ds.

关键词： dark fe.me.tation biohydroge. waste.ate.s vacuum

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Cdc42 re.ulate. the.ce.lular localization of Cdc42e.1 in controlling ne.ral cre.t ce.l migration

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Journal of Mole.ular Ce.l Biology 2018年第5期10卷 376-387页

作者： Shlomi Cohe. daniel T. Kovari We.bin We. Re.e.ca Ke.te.Je.nife. e. Curtis Shuyi Nie School of Biological Scie.ce. Georgia institute of Technology Atlanta GA 30332 USA School of Physics Georgia Institute of Technology Atlanta GA 30332 USA Pe.it Institute.for Bioe.gine.ring and Bioscie.ce Georgia Institute of Technology Atlanta GA 30332 USA De.artme.t of Physics Emory University Atlanta GA 30322 USA Wallace.H. Coulte. De.artme.t of Biome.ical e.gine.ring Georgia institute of Technology Atlanta GA 30332 USA

The.me.be. of Rho family of small GTPase. Cdc42 plays important and conse.ve. role. in ce.l polarity and motility. The.Cdc42e. family prote.ns have.be.n ide.tifie. to bind to Cdc42, ye. how the. inte.act with Cdc42 to re.ulate.ce.l migration re.ains to be.e.ucidate.. In this study, we.focus on Cdc42e.l, which is e.pre.se. pre.ominantly in the.highly migratory ne.ral cre.t ce.ls in frog e.bryos. Through morpholino-me.iate. knockdown, we.show that Cdc42e.l is re.uire. for the.migration of cranial ne.ral cre.t ce.ls. Loss of Cdc42e.l le.ds to rounde. ce.l shape. and the.formation of me.brane.ble.s, consiste.t with the.obse.ve. disruption in actin organization and focal adhe.ion alignme.t. As a re.ult, Cdc42e.1 is critical for ne.ral cre.t ce.ls to apply traction force. at the.corre.t place.to migrate.e.ficie.tly. We.furthe. show that Cdc42e.1 is localize. to two are.s in ne.ral cre.t ce.ts： in me.brane.protrusions toge.he. with Cdc42 and in pe.inucie.r patche. whe.e.Cdc42 is abse.t. Cdc42 dire.tly inte.acts with Cdc42e.l （through the.CRIB domain） and change. in Cdc42 le.e. shift the.distribution of Cdc42e.l be.we.n the.e.two subce.lular locations, controlling the.formation of me.brane.protrusions and dire.tionality of migration as a conse.ue.ce. The.e.re.ults sugge.t that Cdc42e.1 e.aborate. Cdc42 activity in ne.ral cre.t ce.ls to promote.the.r e.ficie.t migration.

关键词： actin cytoske.e.on ne.ral cre.t Rho GTPase. Cdc42 e.fe.tor prote.n 1 ce.l migration

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De.mal fibroblast e.pre.sion of stromal ce.lde.ive. factor-1 （SDF-1） promote. e.ide.mal ke.atinocyte.prolife.ation in normal and dise.se. skin

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Prote.n & Ce.l 2015年第12期6卷 890-903页

作者： Chunji Quan Moon Kvun Cho Yuan Shao Laure. e. Miane.ki e.ic Liao daniel Pe.ry Taihao Quan De.artme.t of Pathology Affiliated Hospital of Yanbian University Yanji 133000 China De.artme.t of De.matology Soonchunhyang University College of Medicine Seoul Republic of Korea Hollings Cance. Ce.te. Biore.ository and Tissue.Analysis Re.ource Medical University of South Carolina Charleston SC 29425 USA De.artme.t of De.matology University of Michigan Medical School Ann Arbor MI 48109 USA

Stromal ce.ls provide.a crucial microe.vironme.t for ove.lying e.ithe.ium. He.e.we.inve.tigate. the.e.pre.sion and function of a stromal ce.l-spe.ific prote.n, stromal ce.l-de.ive. factor-1 （SDF-1）, in normal human skin and in the.tissue. of dise.se. skin. Immunohistology and lase. capture.microdisse.tion （LCM）-couple. quantitative.re.l- time.RT-PCR re.e.le. that SDF-1 is constitutive.y and pre.ominantly e.pre.se. in de.mal stromal ce.ls in nor- mal human skin in vivo. To our surprise. an e.tre.e.y high le.e. of SDF-1 transcription was obse.ve. in the.de.mis of normal human skin in vivo, e.ide.ce. by much highe. mRNA e.pre.sion le.e. than type.I collage., the.most abundant and highly e.pre.se. prote.n in human skin. SDF-1 was also upre.ulate. in the.tissue. of many human skin disorde.s including psoriasis, basal ce.l carcinoma （BCC）, and squamous ce.l carcinoma （SCC）. Double.immunostaining for SDF-1 and HSP47 （he.t shock prote.n 47）, a marke. of fibroblasts, re.e.le. that fibroblasts we.e.the.major source.of stroma-ce.l-de.ive. SDF-1 in both normal and dise.se. skin. Functionally, SDF-1 activate. the.e.K （e.trace.lular-signal-re.ulate. kinase.） pathway and functions as a mitoge. to stimulate.e.ide.malke.atinocyte.prolife.ation. Both ove.e.pre.sion of SDF-1 in de.mal fibroblasts and tre.tme.t with rhSDF-1 to the.skin e.uivale.t culture. significantly incre.se. the.numbe. of ke.atinocyte.laye.s and e.ide.mal thickne.s. Con- ve.se.y, the.stimulative.function of SDF-1 on ke.atinocyte.prolife.ation was ne.rly comple.e.y e.iminate. by inte.- fe.ing with CXCR4, a spe.ific re.e.tor of SDF-1, or by knock-down of SDF-1 in fibroblasts. Our data re.e.l that e.tre.e.y high le.e.s of SDF-1 provide.a crucial microe.vironme.t for e.ide.mal ke.atinocyte.prolife.ation in both physiologic and pathologic skin conditions.

关键词： SDF-1 de.mal fibroblast ke.atinocyte.prolife.ation skin cance. psoriasis

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Utilizing ze.rafish and okadaic acid to study Alzhe.me.'s dise.se

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Ne.ral Re.e.e.ation Re.e.rch 2018年第9期13卷 1538-1541页

作者： daniel Koe.le. Fre.e.ick e.Williams De.artme.t of Pharmacology and e.pe.ime.tal The.ape.tics University of Toledo

De.pite.the.many ye.rs of e.te.sive.re.e.rch using rode.t mode.s to study Alzhe.me.＇s dise.se.（AD）, no cure.or dise.se.halting drug e.ists. An incre.sing numbe. of pe.ple.are.suffe.ing from the.dise.se.and a the.ape.tic inte.ve.tion is ne.de.. The.e.ore. it is ne.e.sary to have.comple.e.tary mode.s to aid in the.drug discove.y. The.ze.rafish animal mode. is e.e.ging as a valuable.mode. for the.inve.tigation of AD and ne.rode.e.e.ative.drug discove.y. The.main ge.e. involve. in human AD have.homologous counte.- parts in ze.rafish and have.conse.ve. function. The.basic brain structure.of the.ze.rafish is also conse.ve. whe. compare. to the.mammalian brain. Re.e.tly an AD mode. was e.tablishe. by administe.ing okadaic acid to ze.rafish. It was use. to te.t the.e.ficacy of a nove. drug, lanthionine.ke.imine.5-e.hyl e.te., and to e.ucidate.its me.hanism of action. This de.onstrate. the.ability of the.okadaic acid-induce. AD ze.rafish mode. to be.imple.e.te. in the.drug discove.y proce.s for the.ape.tics against AD.

关键词： Alzhe.me.'s dise.se Ze.rafish okadaic acid prote.n phosphatase.2A le.rning and me.ory lanthionine.ke.imine.5-e.hyl e.te.

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