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Assessment of Spermatic Chromatin Decondensation by the Toluidine Blue Assay in Infertile Patients in Cotonou

Advances in Reproductive Sciences 2022年第2期10卷 37-48页

作者： Yaude Alfred Azonbakin Simon Aweh Bruno dangbemey patrice Sissoko Sidi Boula Dossou Jean-Paul Flore Gangbo Laleye Anatole Laboratory of Histology Reproductive Biology Cytogenetics and Medical Genetics Faculty of Health Sciences Cotonou Benin Department of Gynaecology-Obstetrics Mother and Child Teaching Hospital of Cotonou Cotonou Benin Pathological Anatomy and Cytology Department of the point’s G Teaching Hospital in Bamako Mali Laboratory of Andrology Human Reproduction and Demography Research Center CERRHUD Cotonou Benin

Background: A high level of sperm chromatin decondensation results in loss of DNA quality and it is associated with poor embryonic prognosis in Assisted Reproductive Technology (ART). This had lead to introduction of sperm DNA compaction testing in assessment of clinical male infertility. Toluidine blue assay is one of most commonly used tests to measure chromatin decondensation in research studies and also in clinical routine use. So the objective of our study was to assess the level of sperm chromatin decondensation by toluidine blue assay in men dealing with couple infertility. Methods: The sperm samples of 96 patients referred for infertility, over a 4-month period from September 2020 to January 2021, were stained with toluidine blue and observed under an optical microscope. These were evaluated according to the World Health Organization. Results: The 25 - 34 age group was the most represented among infertile men. There was a non-significant correlation between age and the level of spermatic chromatin condensation (r = 0.0348). Spermatic parameters had averages above standards norms, apart from that of low vitality. Spermatic chromatin decondenization affected 96% of infertile patients. Asthenozoospermia was the most common abnormality. Among standard parameters of spermogram, only the concentration of spermatozoa in the semen was weakly correlated (r = 0.18) with sperm chromatin decondensation. Conclusion: The level of sperm chromatin condensation is, on the one hand, a parameter independent of the age of the subject; on the other hand, allows to evaluate male infertility, like the classic parameters of the spermogram and spermocytogram. However, in view of the high probability of changes in the nuclear quality of sperm intrinsic to the analysis process and sperm concentration, an improvement of the toluidine blue test using the swim-up technique and associated with image processing software is possible.

关键词： Male Infertility Decondensation Spermatic Chromatin Toluidine Blue

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Epidemiological, Diagnostic and Therapeutic Aspects of Locally Advanced and/or Metastatic Breast Cancers at the Chu-Mel of Cotonou

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Advances in Breast Cancer Research 2022年第4期11卷 195-205页

作者： Sèdjro Raoul Atade patrice dangbemey Roger Klipezo Donald Adjagba David Lionel Togbenon Kabibou Salifou Benjamin Hounkpatin Justin Lewis Denakpo Mother and Child Department Institute of Nursing and Obstetrical Care (IFSIO) University of Parakou Parakou Benin Mother and Child Department Faculty of Health Sciences (FSS) University of Abomey Calavi Godomey Benin Mother and Child Department Faculty of Medicine (FM) University of Parakou Parakou Benin

Introduction: Breast cancer mortality remains high in most developing countries. Benin Republic does not yet have a technical platform required for the diagnosis and effective management of breast cancer “according to the recommendations”. Objective: To study the epidemiological, diagnostic and therapeutic aspects of locally advanced and/or metastatic breast cancers at the Centre Hospitalier Universitaire-de la Mère et de l’Enfant Lagune (CHU-MEL) of Cotonou from 2018 to 2021. Study Methods: This was a retrospective cross-sectional study with a descriptive purpose, carried out from January 1, 2018 to September 30, 2021 in the Gynaecology-Obstetrics Section of the CHU-MEL of Cotonou. The study population was patients diagnosed with locally advanced and/or metastatic breast cancers. Results: At the end of the study, 63 cases of locally advanced and/or metastatic breast cancer were recorded in 80 cases of breast cancer;a 74.11% prevalence of locally advanced and metastatic breast cancer. The mean age of the patients was 42.6 years. The main reason for consultation was the discovery of a mass in the breast (65.1%). Clinically, an orange peel was noted in 39.6%. Mammography (47.6%) and breast ultrasonography (42.9%) were the reference imaging workups for breast cancer diagnosis. Histopathologically, infiltrating ductal carcinoma (94.1%) was the predominant type with Scarff-Bloom and Richardson (SBR) grade II found in 35.3%. Progesterone and estrogen receptors were present in 42.9%. Mastectomy with axillary node dissection was the surgical treatment performed (80%) after neoadjuvant chemotherapy (39.6%). Only one patient had received radiotherapy. No patient received hormone therapy. Conclusion: Locally advanced and metastatic cancers remain a real public health problem. It is essential that major investments be made in order to improve both their diagnosis and management.

关键词： Cancer Breast Metastasis Ultrasonography Mammography

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Seroprevalence, Importance of Rapid Testing and Factors Associated with HBsAg Carriage in Pregnancy in Three Referral Maternity Hospitals in Mono (Benin), in 2020

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Open Journal of Gastroenterology 2023年第9期13卷 279-298页

作者： Aboudou Raïmi Kpossou Djima patrice dangbemey Véronique Mèdessè Tognifodé Barnard Acakpo Jean Sehonou Josiane Angeline Tonato Bagnan Faculty of Health Sciences University of Abomey-Calavi Cotonou Republic of Benin Hepato-Gastroenterology Department National and University Hospital Hubert Koutoukou Maga (CNHU-HKM) Cotonou Repub-lic of Benin Obstetrics Gynecology Department Lagune Mother-Child University Hospital Center (CHU MEL) Cotonou Republic of Benin

Introduction Difficulties in accessing the screening test for viral hepatitis B in maternity wards could be a factor in underestimating the prevalence of anti-HBV antibodies. The rapid diagnostic orientation test (RDOT) could improve seroprevalence and obstetrical prognosis. The aim of this study was to use the rapid diagnostic orientation test (RDOT) to determine the seroprevalence of HBs antigen carriage in pregnant women while highlighting the associated factors. Methods This was a cross-sectional and descriptive study that took place from October to December 2020 (three months) in three (03) reference maternities in western Benin (Mono). Consenting pregnant women received in prenatal consultation had been screened by RDOT. Positive cases were confirmed by ELISA test. The follow-up of these cases made it possible to establish the obstetrical prognosis. Results Of 201 women studied, 11 (5.5%) were positive for RDOT HBV and confirmed by the ELISA test. The factors associated with HBsAg carriage during pregnancy were multiple sexual partnerships (p = 0.01), female circumcision (p = 0.0001), and ignorance of prior HBV serological status (p = 0.0001). No influence of hepatitis B on pregnancy was noted. Conclusion The seroprevalence of hepatitis B in pregnancy was intermediate in the reference maternities of western Benin. The associated factors were multiple sexual partnerships, female circumcision and unawareness of prior HBV status. Free RDOT in maternity wards would improve early detection and management of viral hepatitis B in pregnancy.

关键词： Hepatitis B Seroprevalence Associated Factors Rapid Test Benin

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Maternal Hospital Mortality in Cotonou: Incidence, Care-Associated Adverse Events and Causes

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Open Journal of Obstetrics and Gynecology 2023年第10期13卷 1688-1698页

作者： Djima patrice dangbemey Cedric Bigot Ogourindé Mathieu Ogoudjobi Moufalilou Aboubakar Raoul Atade Paterne Kpoviessi Hounkpatin Benjamin Christiane Tshabu-Aguemon Josiane Angeline Tonato-Bagnan Justin Lewis Denakpo Facultty of Health Sciences Abomey-Calavi University Abomey-Calavi Benin Gynecology-Obstétrics Department Hospital and University Center for Mother and Child Lagune Cotonou Benin University Clinic of Gynecology and Obstetrics of the CNHU-HLM Cotonou Benin Nursing and Midwifery Training Institute University of Parakou Parakou Benin

Introduction: Despite the many efforts made to combat preventable maternal deaths, these still remain high in Benin. It was therefore important to revisit the causes but especially the adverse events associated with care (EIS) in maternity. Objective: Determine the incidence, adverse events associated with care and causes of intra hospital maternal mortality in cotonou. Methods: This was a cross-sectional maternal mortality review study with retrospective data collection. It covered all cases of maternal death recorded between 2017 and 2021 in two (2) reference university maternities in Cotonou. Adverse events associated with care and the patient were analyzed using the maternal death audit grid validated for Benin. SPSS.26 software was used for data analysis. Results: The in-hospital maternal mortality ratio in Cotonou was 2028 maternal deaths per 100,000 live births in 2021. Only 7.2% (n = 36) of deaths were audited. The deceased mothers were 29.8 ± 7.4 years old, with no fixed monthly income in 82.7% (n = 420). Serious adverse events associated with care were: delay in decision to refer in 37% (n = 188), non-medical referral in 85.8% (n = 436) of cases, inadequate pre-referral treatment in 25.7% of cases. In receiving maternities, delay in diagnosis and inappropriate treatment at the receiving maternity were noted respectively in 22.9% and 28.6% of cases of maternal death. The direct causes of maternal death were dominated by serious obstetric hemorrhage in 43.9% (n = 223). As for the indirect causes, they were dominated by anemia excluding obstetric hemorrhages in 21.5% (n = 109). Conclusion: The in-hospital maternal mortality ratio was very high in Cotonou. The main cause was severe obstetric hemorrhage. There were several serious healthcare-associated adverse events whose correct management would significantly reduce the incidence of maternal deaths.

关键词： Maternal Mortality Adverse Events Care Cotonou

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Dysfunctions in the Management of Patients Whose Outcome Was Classified as “Maternal Death” from 2017 to 2021, at the Departemental University Teaching Hospital of Borgou Alibori (Chud-Ba), Benin

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Open Journal of Obstetrics and Gynecology 2023年第12期13卷 1928-1937页

作者： Atade Sèdjro Raoul Klipezo Roger dangbemey patrice Amoussa Abdoul Fadil Togbenon Lionel David Gogan Merveille Bouraima Kassirath Bakari Hikmath Sale Leilath Hounkponou Fanny Salifou Kabibou Mother and Child Department Institute of Nursing and Midwifery University of Parakou (IFSIO-UP) Parakou Benin Mother and Child Department Faculty of Medicine University of Parakou (FM-UP) Parakou Benin Mother and Child Department Faculty of Health Sciences University of Abomey Calavi (FSS) Cotonou Benin Department of Health Policy and Systems Centre of Human Reproduction and Demography Research (CERRHUD) Cotonou Benin

Background: Maternal death is a major public health problem worldwide, particularly in sub-Saharan Africa. Objective: This study sought to investigate dysfunctions in the management of patients whose outcome was classified as “maternal death” in the Gynaecology-Obstetrics section of the Departmental University Teaching Hospital of Borgou Alibori (CHUD-BA) from 2017 to 2021. Method: This was a retrospective cross-sectional study with descriptive and analytical purposes. The study population consisted of pregnant women, parturients and puerperas admitted into the CHUD-BA maternity ward from 2017 to 2021. Result: A total of 2011 patients were included in this study. The in-hospital maternal mortality ratio was 1526 per 100,000 live births. The dysfunctions identified were the amount of time spent in the referring center (more than 48 hours) (p = 0.001), delay of more than 2 hours between referral and admission into the referral center (p < 0.001), means of transport (motorcycle or public transport) (p compliance to the protocol for emergency obstetric and neonatal care (SONU) (p < 0.001) and delay of more than 2 hours in the etiological management of pregnant women (p Conclusion: Particular attention should be paid to the management of pregnant women in our healthcare system if we are looking forward to reducing maternal mortality.

关键词： Maternal Death Dysfunction Obstetric Care Parakou Benin

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Epidemiology and Clinical Signs of Gynecological Cancers in an African Country South of the Sahara: Case of the Republic of Benin in 2022

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Open Journal of Obstetrics and Gynecology 2023年第12期13卷 2021-2032页

作者： Djima patrice dangbemey Raoul Atade Mahublo Vinadou Vodouhe Ameyo Ayoko Ketevi Samiath Bakary Ogourindé Mathieu Ogoudjobi Moufalilou Aboubakar Simon Azonbakin Christiane Tshabu-Aguemon Benjamin Hounkpatin Angeline Tonato-Bagnan Justin Lewis Denakpo Faculty of Health Sciences University of Abomey-Calavi Cotonou Benin Nursing and Midwifery Training Institute University of Parakou Parakou Benin Faculty of Health Sciences University of Lomé Lomé Togo

Introduction: Gynaecological cancers are the deadliest of the women’s cancers in the Republic of Benin. Late diagnosis is the most common reason. Objective: This paper aims to describe the epidemiological characteristics, and clinical and pathological signs of gynaecological cancers treated in the Republic of Benin between 2018 and 2022. Patients and Methods: This was a cross-sectional, descriptive, retrospectively collected study of patient data treated between 2018 and 2022 in two university gynaecology departments in Cotonou. All gynaecological cancers that have histological evidence were included. The epidemiological, clinical and pathological characteristics of the cancers were assessed. Results: Cervical, endometrial and ovarian cancers were the most common in the proportions of 62.0%, 24.1%, 12.0% and 1.8% respectively. The mean age at diagnosis was 54 years. The victims were uneducated and had low economic power in 81% and 85% of cases, respectively. The consultation was late in 82.1% of cases. Metrorrhagia, postmenopausal metrorrhagia and pelvic cluster headache were the common reasons for consultation for cervical, endometrial and ovarian cancer, respectively. Diagnosis was late in 66.7% (n = 71). The most common histological types were squamous cell carcinoma, endometrioid adenocarcinoma, and serous cystadenocarcinoma for cervical, endometrial, and ovarian cancers, respectively. Conclusion: Gynaecological cancers were common and their consultation time was delayed. The diagnosis was made at the advanced stage and there were several reasons for this.

关键词： Gynaecological Cancers Epidemiology Signs Benin

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Knowledge of Risk Factors and Means of Breast Cancer Screening by Women Seen in Gynecological Consultation at Sylvanus Olympio University Hospital-Lome Togo

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Journal of Cancer Therapy 2023年第12期14卷 465-477页

作者： Ameyo Ayoko Ketevi Djima patrice dangbemey Edem Logboh-Akey Komlan Alessi Andele Bingo M’Bortche Akila Bassowa Achraf Adou Rahim Akou Sodina Gblomatsi Baguilane Douaguibe Dare Tchin Abdoul Samadou Aboubakari Koffi Akpadza Department of Gynecology-Obstetrics Health Sciences Faculty University of Lome Lome Togo Department of Gynecology-Obstetrics Health Sciences Faculty University of Abomey-Calavi Abomey-Calavi Bénin Department of Gynecology-Obstetrics Health Sciences Faculty University of Kara Kara Togo Bingo M’Bortche-Principal Clinic of the Togolese Association of Family Well-Being Planning (ATBEF) Lome Togo Department of Pathology University Teaching Hospital of Lome Lome Togo

Background: In Togo, awareness is very low and patients regularly present with advanced stages of breast cancer. Objective: Determine the knowledge of risk factors and means of breast cancer screening by women seen in gynecological consultation of the Sylvanus Olympio University Hospital (CHU SO). Methods: This was a descriptive cross-sectional study conducted at the gynecology-obstetrics clinic of the CHU SO of Lomé, from March 1 to July 15, 2022. Results: We surveyed 1,566 gynaecological outpatients. Six hundred (600) patients agreed to answer our questions freely, giving a participation rate of 38.3%. The average age of the respondents was 31.9 years old. In 25.5% of cases, the respondents were high school graduates. Five hundred and forty-five of the respondents, or 90.8% had already heard of breast cancer. The most frequent sources of information were medical staff in 34.1% of cases. The presence of nodule in the breast was cited as a clinical sign in 68.4% of cases, breast self-examination as a means of screening in 72.6% of cases, personal history of breast cancer in 51.7% of the cases has non-modifiable risks and smoking as a modifiable risk factor by 58.9% of the respondents. In 31% of cases, they performed breast cancer screening on their own. Breast self-examination was performed by 27.7% of them. Occupation and level of study were statistically associated with women’s knowledge of breast cancer. Conclusion: Most women recognize the existence of breast cancer but their knowledge about signs and risk factors remains low. Few of them, practice screening.

关键词： Breast Cancer Screening Women Knowledge Togo

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Determinants of the Frequency of Prenatal Consultations among Women Giving Birth in the Maternity Wards of the Commune of Agbangnizoun (Zou), Benin

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Open Journal of Obstetrics and Gynecology 2023年第7期13卷 1127-1132页

作者： Klikpézo Roger Hounkponou Nouéssewa Fanny Maryline Atadé Sèdjro Raoul dangbemey Djima patrice Flénon-Yévidé Aubierge Joelle Ahouingnan Yeyinou Salifou Badaryatou Enassouan Marius Joseph Flénon Ouendo Marius Salifou Kabibou Faculty of Medicine University of Parakou Parakou Benin Faculty of Health Sciences University of Abomey-Calavi Cotonou Benin Regional Institute of Public Health Ouidah Benin

Antenatal care is a safe way to prevent pregnancy-related health problems, difficult deliveries and even further to anticipate low birth weight [1]. But pregnant women, especially in Africa, do not attend antenatal clinics as recommended by the WHO. The general objective of this study was to study the norm in terms of Antenatal Consultation (ANC) frequency as well as the determinants of the frequency among women who gave birth in the maternity hospitals of Agbangnizoun. Our research was a cross-sectional, descriptive, retrospective and quantitative type, which was carried out among 335 women in Agbangnizoun, Benin from 1 February to 3 April 2020 (3 months), in order to find out the general or specific characteristics of women that we associate with the frequency of prenatal consultation. At the end of the study, we found that 60%, 68% and 15% of the surveyed population had received ANC in the first, second and third trimesters, respectively. Ethnicity, income level of spouses over the three trimesters as well as the level of their knowledge and overall practice of ANC are determinants of the frequency of prenatal consultation.

关键词： Determinants Frequency Prenatal Consultation Agbangnizoun Zou Benin

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Practice of the Caesarean Section in Four Maternities in Benin Using Robson Classification

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Open Journal of Obstetrics and Gynecology 2020年第1期10卷 65-75页

作者： Benjamin Hounkpatin Moufalilou Aboubakar patrice dangbemey Veronique Tognifode Clémence Schantz Alexandre Dumont René-Xavier René-Perrin University-Associated Hospital for the Mother and Child-Lagoon (CHU-MEL) Cotonou Benin Population and Development Center-Development Research Institute Paris France

Objective: To measure for each of the ten (10) groups of women defined in Robson’s classification, the cesarean section rate, group size and its contribution to the overall cesarean section rate in four maternities in Benin. Methods: This was a retrospective study over a period of 3 years, from January 1, 2014 to December 31, 2016. Two workshops were organized for training in data collection and interpretation of results. Results: A total of 5442 files were included for the four health facilities during the study period. The overall cesarean section rate was 43.9%. The most represented group (30.3%) was multiparous women without scarred uterus, with a single term fetus, in cephalic presentation, and spontaneous labour (Group 3). The largest contributor to the overall cesarean section rate was that of multiparous women with at least one uterine scar with a single fetus, eventually in cephalic presentation (Group 5) with 29.5%. Conclusion: Caesarean section rates are high in groups of women with a favourable prognosis for vaginal delivery. It is also high in women with scarred uterus (Group 5).

关键词： Caesarean Section Robson Classification Benin

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Exclusive Hormonal Therapy in Breast Cancer in Elderly Women:Clinical Response and Survival over 10 Years

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Journal of Pharmacy and Pharmacology 2021年第9期9卷 296-302页

作者： Bintcha Walter Schmitt Andy dangbemey patrice Tadrist Brahim Minsili Hervé Adje Yves Bagnan Tonato Unitéde gynécologie et Obstétrique/FSS-universitéd’Abomey Calavi CotonouBP 188Bénin Facultédes sciences médicales et paramédicales-Aix-Marseille université 13284 Marseille Cedex 07France Centre hospitalier Intercommunal Aix-Pertuis 13616 Aix en Provence Cedex 01France Département de santépublique/FSS-universitéd’Abomey Calavi CotonouBP 188Bénin

Breast cancer is the first cancer of women in the world and in *** very elderly patients,the treatment options are often very *** hormone therapy has shown similar or even better results than *** is why we decided to evaluate the clinical response following exclusive hormonal therapy and the 5,then 10 years survival in these very elderly *** was a retrospective,longitudinal cohort-type study with descriptive and analytical *** study population consisted of 59 patients,with an average age of 85 ***(15,25%)of our patients had a complete clinical response after two years of treatment,16(27%)a partial clinical response,23(39%)lesion stabilization and 5(9%)cancer *** presence of metastasis at diagnosis increased the risk of cancer progression by *** 5-year survival was 72.5%,and breast cancer mortality 5.88%.The 10-year survival was 27.5%and breast cancer mortality 15%.In the age group 85 and over increased the risk of death by 3.25 in the first 10 years of *** clinical response after 2 years was marked by a low rate of cancer *** over 5 and 10 years was mostly related to patient comorbidities.

关键词： Exclusive hormonal therapy neoadjuvant hormonal therapy elderly women breast cancer clinical response cancer survival cancer mortality cancer France

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