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Prevalence, risk factors, and BRAF mutation of colorectal sessile serrated lesions among Vietnamese patients

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World Journal of Clinical Oncology 2024年第2期15卷 290-301页

作者： Nhu Thi Hanh Vu Huy Minh Le Diem Thi-Ngoc Vo hoang Anh Vu Nhan Quang Le Dung dang Quy ho Duc trong Quach Department of Internal Medicine University of Medicine and Pharmacy at Ho Chi Minh CityHo Chi Minh 700000Viet Nam GI Endoscopy Department University Medical Center at Ho Chi Minh CityHo Chi Minh 700000Viet Nam Department of Histology-Embryology and Pathology University of Medicine and Pharmacy at Ho Chi Minh CityHo Chi Minh 700000Viet Nam Center for Molecular Biomedicine University of Medicine and Pharmacy at Ho Chi Minh CityHo Chi Minh 700000Viet Nam Department of Endoscopy Cho Ray HospitalHo Chi Minh 700000Viet Nam

BACKGROUND Sessile serrated lesions(SSLs)are considered precancerous colorectal lesions that should be detected and removed to prevent colorectal *** studies in Vietnam mainly investigated the adenoma pathway,with limited data on the serrated *** To evaluate the prevalence,risk factors,and BRAF mutations of SSLs in the Vietnamese *** This is a cross-sectional study conducted on patients with lower gastrointestinal symptoms who underwent colonoscopy at a tertiary hospital in *** were diagnosed on histopathology according to the 2019 World Health Organi-zation *** mutation analysis was performed using the Sanger DNA sequencing *** multivariate logistic regression model was used to determine SSL-associated *** There were 2489 patients,with a mean age of 52.1±13.1 and a female-to-male ratio of 1:*** prevalence of SSLs was 4.2%[95%confidence interval(CI):3.5-5.1].In the multivariate analysis,factors significantly associated with SSLs were age≥40[odds ratio(OR):3.303;95%CI:1.607-6.790],male sex(OR:2.032;95%CI:1.204-3.429),diabetes mellitus(OR:2.721;95%CI:1.551-4.772),and hypertension(OR:1.650,95%CI:1.045-2.605).The rate of BRAF mutations in SSLs was 35.5%.CONCLUSION The prevalence of SSLs was 4.2%.BRAF mutations were present in one-third of *** risk factors for SSLs included age≥40,male sex,diabetes mellitus,and hypertension.

关键词： Colorectal cancer Sessile serrated lesion BRAF mutation Risk factors Diabetes mellitus Hypertension

Fresh and hardened properties of high-performance fiber-reinforced concrete containing fly ash and rice husk ash:Influence of fiber type and content

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Frontiers of Structural and Civil Engineering 2022年第12期16卷 1621-1632页

作者： Nguyen-trong ho Viet Quoc dang Minh-Hieu NGUYEN Chao-Lung HWANG trong-Phuoc HUYNH Faculty of Civil Engineering VSB-Technical University of OstravaOstrava-Poruba 70800Czech Republic Faculty of Bridge and Road Construction Mientrung University of Civil Engineering(MUCE)Tuy Hoa City 56100Vietnam Vinh Long Department of Construction Vinh Long City 85000Vietnam Taiwan Building Technology Center Taiwan University of Science and TechnologyTaipei 10607China Faculty of Civil Engineering College of EngineeringCan Tho UniversityCan Tho City 94000Vietnam

Although fibers are used only infrequently as an additive in concrete in the construction industry,fiberenhanced concrete is known to provide a wide range of advantages over conventional *** main objective of this study was to investigate the influences of fiber type and content on the mechanical properties and durability of highperformance fiber-reinforced concrete(HPFRC)designed using a novel densified mixture design algorithm with fly ash and rice husk *** types of fiber,including polypropylene(PP)fiber,steel fiber(SF),and hybrid fiber(HF),were *** on the results,the inclusion of fibers decreased HPFRC flowability,regardless of fiber *** the compressive strength of HPFRC with 1.6%PP fiber content was 11.2%below that of the reference HPFRC specimen at 91 d of curing age,the 91-d compressive strengths of both SF and HF-enhanced HPFRC specimens were significantly better than that of the reference HPFRC ***,the HPFRC specimens incorporating SF and HF both exhibited better splitting tensile and flexural strengths as well as less drying shrinkage than the HPFRC specimens incorporating PP ***,the fiber-enhanced specimens,especially those with added SF,registered less surface electrical resistivity and greater vulnerability to chloride ion penetration than the reference HPFRC specimen.

关键词： high-performance fiber-reinforced concrete fly ash rice husk ash durability mechanical strength

Biomass accumulation of Panax vietnamensis in cell suspension cultures varies with addition of plant growth regulators and organic additives

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Asian Pacific Journal of Tropical Medicine 2017年第9期10卷 907-915页

作者： Tuan Tran trong Dieu-Hien Truong hoang Chinh Nguyen Dieu-Thai Tran Huyen-Trang Nguyen Thi Giap Do dang ho Nguyen huu Plant Cell Technology Department Institute of Tropical BiologyVietnam Academy of Science and Technology9/621 Ha Noi HighwayLinh TrungThu DucHo Chi Minh CityViet Nam Faculty of Applied Sciences Ton Duc Thang University19 Nguyen Huu ThoTan PhongDistrict 7Ho Chi Minh CityViet Nam Genetic Engineering Department Institute of Tropical BiologyVietnam Academy of Science and Technology9/621 Ha Noi HighwayLinh TrungThu DucHo Chi Minh CityViet Nam

Objective: To evaluate the impact of plant growth regulators including kinetin(KN),benzyl adenine and naphthalene acetic acid, yeast extract and casein hydrolyzate on biomass accumulation of Vietnamese ginseng Panax vietnamensis(P. vietnamensis) in cell suspension ***: Cell suspension cultures were established from friable calluses derived from leaves and petioles of 3-year-old in-vitro P. vietnamensis plants. The cell suspension cultures were grown in Murashige and Skoog basal media supplemented with various concentrations of KN, benzyl adenine, naphthalene acetic acid, and yeast extract and casein ***: All tested factors generated an increase in the cell biomass of P. vietnamensis in suspension culture, but the impact of each varies depended on the factor type, concentration, and incubation period. Addition of 2.0 mg/L KN resulted in the largest biomass increase after 24 d,(57.0 ± 0.9) and(3.1 ± 0.1) mg/m L fresh and dry weight, respectively,whereas addition of benzyl adenine or naphthalene acetic acid produced optimum levels of Panax cell biomass at 1.0 and 1.5 mg/L, respectively. Addition of the elicitor yeast extract led to a 1.4–2.4 fold increase in biomass of P. vietnamensis, while addition of casein hydrolyzate enhanced biomass accumulation 1.8–2.6 ***: The addition of each factor causes significant changes in biomass accumulation of P. vietnamensis. The largest biomass accumulation is from cultures grown in MS media containing 2.0 mg/L KN for 24 d. The outcome of the present study provides new insights into the optimal suspension culture conditions for studies on the in vitro cell biomass production of P. vietnamensis.

关键词： Panax vietnamensis Plant cell suspension culture Plant regulators Yeast extract Casein hydrolyzate Biomass

Is convenience really king? Comparative evaluation of catastrophic costs due to tuberculosis in the public and private healthcare sectors of Viet Nam: a longitudinal patient cost study

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贫困所致传染病(英文) 2024年第2期13卷 1-12页

作者： Nguyen hoa Binh Quang Vo Luan Nguyen Forse Rachel Jeanette Wiemers Anja Maria Christine Huynh Huy Ba Dong Thuy Thi Thu Phan Yen Thi hoang Creswell Jacob dang Thi Minh Ha Nguyen Lan huu Shedrawy Jad L?nnroth Knut Nguyen Tuan Dinh Van Dinh Luong Annerstedt Kristi Sidney Codlin Andrew James National Lung hospital Ha Noi Viet Nam Friends for International TB Relief Ha Noi Viet Nam Department of Global Public Health WHO Collaboration Centre On Tuberculosis and Social Medicine Karolinska Institute Stockholm Sweden Stop TB Partnership Geneva Switzerland Pham Ngoc Thach hospital Ho Chi Minh City Viet Nam

Background In Viet Nam, tuberculosis (TB) represents a devastating life-event with an exorbitant price tag, partly due to lost income from daily directly observed therapy in public sector care. Thus, persons with TB may seek care in the private sector for its flexibility, convenience, and privacy. Our study aimed to measure income changes, costs and catastrophic cost incurrence among TB-affected households in the public and private *** Between October 2020 and March 2022, we conducted 110 longitudinal patient cost interviews, among 50 patients privately treated for TB and 60 TB patients treated by the National TB Program (NTP) in Ha Noi, Hai Phong and ho Chi Minh City, Viet Nam. Using a local adaptation of the Who TB patient cost survey tool, participants were interviewed during the intensive phase, continuation phase and post-treatment. We compared income levels, direct and indirect treatment costs, catastrophic costs using Wilcoxon rank-sum and chi-squared tests and associated risk factors between the two cohorts using multivariate *** The pre-treatment median monthly household income was significantly higher in the private sector versus NTP cohort (USD 868 vs USD 578;P=0.010). however, private sector treatment was also significantly costlier (USD 2075 vs USD 1313;P=0.005), driven by direct medical costs which were 4.6 times higher than costs reported by NTP participants (USD 754 vs USD 164;Phorts (Private: 55% vs NTP: 52%;P=0.675). Factors associated with catastrophic cost included being a single-person household [adjusted odds ratio [(aOR=13.71; 95% confidence interval (CI): 1.36–138.14;P=0.026], unemployment during treatment (aOR=10.86; 95%CI: 2.64–44.60;P<0.001) and experiencing TB-related stigma (aOR=37.90; 95%CI: 1.72–831.73;P=0.021).Conclusions Persons with TB in Viet Nam face similarly high risk of catastrophic costs whether treated in the

关键词： Tuberculosis Patient cost Catastrophic cost Private sector Comparative analysis Viet Nam

Spatiotemporal Trend Analysis of Precipitation Extremes in ho Chi Minh City, Vietnam During 1980–2017

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International Journal of Disaster Risk Science 2021年第1期12卷 131-146页

作者： Nguyen trong Quan Dao Nguyen Khoi Nguyen Xuan hoan Nguyen Ky Phung Thanh Duc dang Faculty of Environmental and Food Engineering Nguyen Tat Thanh UniversityHo Chi Minh City 700000Vietnam Faculty of Environment University of ScienceHo Chi Minh City 700000Vietnam Vietnam National University Ho Chi Minh City 700000Vietnam ho Chi Minh City University of Food Industry Ho Chi Minh City 700000Vietnam Institute for Computational Science and Technology Ho Chi Minh City 700000Vietnam Engineering Systems and Design Pillar Singapore University of Technology and DesignTampines 487372Singapore

In this study,the spatiotemporal variability of trends in extreme precipitation events in ho Chi Minh City during the period 1980–2017 was analyzed based on several core extreme precipitation indices(Rx1 day,Rx5 day,CDD,CWD,R20 mm,R25 mm,R95 p,and SDII).The nonparametric Mann–Kendall and Sen’s slope methods were used to compute the statistical strength,stability,and magnitude of trends in annual rainfall,as well as the extreme precipitation *** found that 64%of the stations had statistically significant upward trends in yearly rainfall,with high magnitudes frequently observed in the northern and southern regions of the *** the extreme precipitation indices,only SDII and R25 mm showed dominantly significant ***,there were increasing trends in the frequency and duration at the southern and central regions of the city during the study ***,El Ni?o-Southern Oscillation and Pacific Decadal Oscillation positively correlated with the duration and negatively correlated with the intensity and frequency of extreme ***,water management plans should be adjusted appropriately to reduce the severe impacts of precipitation extremes on communities and ecosystems.

关键词： Spatiotemporal trend Extreme precipitation Extreme precipitation indices ho Chi Minh City

Anti-inflammatory effects of Solanum procumbens on a low dose complete Freund's adjuvant-induced arthritis rat model

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Asian Pacific Journal of Tropical Biomedicine 2023年第5期13卷 214-221页

作者： Xuan-Hai Do trong Nghia Nguyen Thanh Chung dang Thi Thanh Mai Nguyen Trung Nhan Nguyen Van Nhat Truong Do huu Tho Le Xuan Hai Nguyen hoang Phu dang Giang-Linh Nguyen Dinh-Khanh hoang Van-Quan Le Van-Mao Can Department of Practical and Experimental Surgery Vietnam Military Medical UniversityHanoi 10000Vietnam Department of Reconstructive and Microsurgery Craniofacial and Reconstructive Surgery CentreMilitary Central Hospital 108Hanoi 10000Vietnam Department of Anatomic Pathology Military Hospital 103Vietnam Military Medical UniversityHanoi 10000Vietnam Faculty of Chemistry University of ScienceVietnam National University Ho Chi Minh CityHo Chi Minh City 70000Vietnam Faculty of Medicine University of Medicine and PharmacyVietnam National UniversityHanoi 10000Vietnam Department of Ultrasound Imaging Diagnostics CentreMilitary Hospital 103Vietnam Military Medical UniversityHanoi 10000Vietnam Department of Functional Diagnostics Military Hospital 103Vietnam Military Medical UniversityHanoi 10000Vietnam Department of Pathophysiology Vietnam Military Medical UniversityHanoi 10000Vietnam

Objective:To investigate the anti-inflammatory and analgesic effects of Solanum procumbens on complete Freund’s adjuvantinduced arthritis rat ***:We isolated and identified five compounds in the ethanolsoluble Solanum procumbens extract(SP)with anti-inflammatory effects,including ursolic acid,β-sitosterol,hexadecanoic acid,cisvaccenic acid,and vanillic ***,we investigated the anti-inflammatory effects of SP on rheumatoid arthritis symptoms,including paw volumes,local temperatures,withdrawal latency,and mechanical withdrawal threshold at the hind paw and white blood cell(WBC)number from complete Freund’s adjuvant-induced arthritis rat ***:We have successfully established a complete Freund’s adjuvant-induced arthritis rat model at a low dose(1 mg/mL).SP extract significantly reduced paw volumes(Phold(P<0.05),but only SP extract at the dose of 300 mg/kg significantly decreased WBC ***:SP extract could be a potential medication candidate with anti-inflammatory effects for arthritis,but it requires further investigation into the mechanism of the SP and its effectiveness on other models as well as clinical trials.

关键词： Solanum procumbens Arthritis Anti-inflammation Complete Freund's adjuvant Rats

Comparative study on water-soluble inorganic ions in PM2.5 from two distinct climate regions and air quality

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Journal of Environmental Sciences 2020年第2期32卷 349-360页

作者： Duong huu Huy Le Tu Thanh To Thi Hien Norimichi Takenaka Faculty of Food Science and Technology Ho Chi Minh City University of Food Industry140 Le Trong Tan StreetTan Phu DistrictHo Chi Minh CityViet Nam Faculty of Environment University of ScienceVietnam National University–Ho Chi Minh City227 Nguyen Van Cu StreetDistrict 5Ho Chi Minh CityViet Nam Graduate School of Humanities and Sustainable System Sciences Osaka Prefecture University1-1 Gakuen-choNaka-kuSakai-shiOsaka 599-8531Japan

Recently, air quality has significantly improved in developed country, but that issue is of concern in emerging megacity in developing *** this study, aerosols and their precursor gas were collected by NILU filter pack at two distinct urban sites during the winter and summer in Osaka, Japan and dry and rainy seasons in ho Chi Minh City(HCMC),*** aims are to investigate the contribution of water-soluble inorganic ions(WSIIs) to PM2.5, thermodynamic characterization and possible formation pathway of secondary inorganic aerosol(SIA).The PM2.5 concentration in Osaka(15.8 μg/m^3) is lower than that in HCMC(23.0 μg/m^3), but the concentration of WSIIs in Osaka(9.0 μg/m^3) is two times higher than that in HCMC(4.1 μg/m^3).Moreover, SIA including NH4^+, NO3^-and SO4^2-are major components in WSIIs accounting for 90% and 76%(in molar) in Osaka and HCMC,*** models were used to understand the thermodynamic characterization of urban ***, statistical analysis results indicate that very good agreement(R2> 0.8) was found for all species, except for nitrate aerosol in *** found that when the crustal species present at high amount, those compositions should be included in model calculation(*** the HCMC situation).Finally, we analyzed the characteristics of NH4^+– NO3^-– SO4^2-system.A possible pathway to produce fine nitrate aerosol in Osaka is via the homogeneous reaction between NH3 and HNO3, while nonvolatile nitrate aerosols can be formed by the heterogeneous reactions in HCMC.

关键词： Water-soluble inorganic ions Thermodynamic model PM2.5

Forest characteristics and population structure of Glyptostrobus pensilis, a globally endangered relict species of southeastern China

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Plant Diversity 2019年第4期41卷 237-249页

作者： Cindy Q. Tang Yongchuan Yang Arata Momohara Huan-Chong Wang hong Truong Luu Shuaifeng Li Kun Song Shenhua Qian Ben LePage Yi-Fei Dong Peng-Bin Han Masahiko Ohsawa Buu Thach Le huu dang Tran Minh Tri dang Ming-Chun Peng Chong-Yun Wang Institute of Ecology and Geobotany School of Ecology and Environmental ScienceYunnan UniversityDongwaihuan South RoadUniversity TownChenggong New DistrictKunmingYunnan 650504China The Nature Conservancy Society of Japan Mitoyo Bldg.2F1-16-10 ShinkawaChuo-kuTokyo 104-0033Japan Key Laboratory of Three Gorges Reservoir Region's Eco-Environment Ministry of EducationChongqing UniversityChongqing 400045China Graduate School of horticulture Chiba University648 MatsudoChiba 271-8510Japan Institute of Botany Yunnan UniversityKunmingYunnan 650091China Southern Institute of Ecology Vietnam Academy o f Science and TechnologyHo Chi Minh CityViet Nam Research Institute of Resource Insects Chinese Academy of ForestryKunmingYunnan 650224China School o f Ecological and Environmental Sciences East China Normal UniversityShanghai 200241China Pacific Gas and Electric Company 3401 Crow Canyon RoadSan RamonCA 94583USA The Academy of Natural Science 1900 Benjamin Franklin ParkwayPhiladelphiaPA 19W3USA

The Chinese water pine Glyptostrobus pensilis is the sole surviving species of the genus Glyptostrobus. It is endemic to southern China, central Vietnam, and eastern Laos, and today it is nearly extinct in the wild. Forest community characteristics and population structure of G. pensilis in China have remained un-known up to now. We investigated six swamp forest stands and analyzed their forest community characteristics (i.e. vertical stratification, species composition, and diversity) and population structure, including the frequency distribution of DBH (diameter at breast height) and age-classes as found in Fujian Province, southeastern China. The vertical stratifications of all the forest stands were rather simple. The remaining wild specimens ranged from roughly 15 to some 357 years for an average of ca. 85 years, with only a few individuals less than 20 years old. Compared with the stands and populations of G. pensilis in Vietnam, the taxonomic compositions of the stands in the two regions were different, except for the dominant species-G. pensilis. The Shannon-Wiener index showed the overstory of each stand had much lower diversity (0.26 on average) in Fujian Province than that (1.97 on average) in Vietnam, whereas the diversity indices were about the same (around 2.41) for the understories in the two regions. Furthermore, we discovered 18 G. pensilis seedlings at the study sites in Fujian Province. This discovery demonstrates that G. pensilis regeneration is extremely poor and its populations are declining, although these populations are rela-tively healthier than those in Vietnam.

关键词： Age-class Fujian Province Glyptostrobus Regeneration Relict plant Vietnam

Ecoregional variations of aboveground biomass and stand structure in evergreen broadleaved forests

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Journal of Forestry Research 2020年第5期31卷 1713-1722页

作者： Tran Van Do Mamoru Yamamoto Osamu Kozan Vo Dai Hai Phung Dinh Trung Nguyen Toan Thang Lai Thanh Hai Vu Thanh Nam Trieu Thai Hung hoang Van Thang Tran Duc Manh Cao Chi Khiem Vu Tien Lam Nguyen Quang Hung Tran hoang Quy Pham Quang Tuyen Trinh Ngoc Bon Nguyen Thi Thu Phuong Ninh Viet Khuong Nguyen Van Tuan dang Thi Hai Ha Tran Hai Long dang Van Thuyet dang Thinh Trieu Nguyen Van Thinh Tran Anh Hai Duong Quang Trung Nguyen Van Bich Dinh Hai dang Pham Tien Dung Nguyen Huy hoang Le Thi Hanh Phan Minh Quang Nguyen Thi Thuy Huong hoang Thanh Son Nguyen Thanh Son Nguyen Thi Van Anh Nguyen Thi hoai Anh Pham Dinh Sam hoang Thi Nhung hoang Van Thanh Nguyen huu Thinh Tran hong Van ho Trung Luong Bui Kieu Hung Research Institute for Sustainable Humanosphere Kyoto UniversityUjiKyotoJapan Silviculture Research Institute Vietnamese Academy of Forest SciencesNorth Tu LiemHanoiVietnam Center for Southeast Asian Studies Kyoto UniversityKyotoJapan Vietnamese Academy of Forest Sciences North Tu LiemHanoiVietnam Vietnam Administration of Forestry No.2 Ngoc HaBa DinhHanoiVietnam

Biotic and abiotic factors control aboveground biomass(AGB)and the structure of forest *** study analyses the variation of AGB and stand structure of evergreen broadleaved forests among six ecoregions of Vietnam.A data set of 1731-ha plots from 52 locations in undisturbed old-growth forests was *** results indicate that basal area and AGB are closely correlated with annual precipitation,but not with annual temperature,evaporation or hours of *** area and AGB are positively correlated with trees>30 cm *** areas surveyed(52.6%)in these old-growth forests had AGB of 100–200 Mg ha^-1;5.2%had AGB of 400–500 Mg ha^-1,and 0.6%had AGB of>800 Mg ha^-*** percent of the areas surveyed had stand densities of 300–600 ***^-1,and 64%had basal areas of 20–40 m^2 ha^-*** is an important factor influencing the AGB of old-growth,evergreen broadleaved forests in *** causing the loss of large-diameter trees(e.g.,>100 cm DBH)affects AGB but may not seriously affect stand density.

关键词： Aboveground biomass Carbon storage Climatic variables Ecoregion Edaphic variables Oldgrowth forest