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Meningeal lymphatic vessel crosstalk with central nervous system immune cells in aging and neurodegenerative diseases

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Neural Regeneration Research 2025年第3期20卷 763-778页

作者： Minghuang Gao Xinyue Wang Shijie Su Weicheng Feng Yaona Lai Kongli Huang dandan cao Qi Wang Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina Institute of Clinical Pharmacology Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina The Sixth Affiliated Hospital Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Meningeal lymphatic vessels form a relationship between the nervous system and periphery, which is relevant in both health and disease. Meningeal lymphatic vessels not only play a key role in the drainage of brain metabolites but also contribute to antigen delivery and immune cell activation. The advent of novel genomic technologies has enabled rapid progress in the characterization of myeloid and lymphoid cells and their interactions with meningeal lymphatic vessels within the central nervous system. In this review, we provide an overview of the multifaceted roles of meningeal lymphatic vessels within the context of the central nervous system immune network, highlighting recent discoveries on the immunological niche provided by meningeal lymphatic vessels. Furthermore, we delve into the mechanisms of crosstalk between meningeal lymphatic vessels and immune cells in the central nervous system under both homeostatic conditions and neurodegenerative diseases, discussing how these interactions shape the pathological outcomes. Regulation of meningeal lymphatic vessel function and structure can influence lymphatic drainage, cerebrospinal fluid-borne immune modulators, and immune cell populations in aging and neurodegenerative disorders, thereby playing a key role in shaping meningeal and brain parenchyma immunity.

关键词： central nervous system meningeal lymphatic vessels immunity myeloid cells lymphatic cells neurodegenerative disease

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Development and optimization of object detection technology in pavement engineering: A literature review

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Journal of Road Engineering 2024年第2期4卷 163-188页

作者： Hui Yao Yaning Fan Yanhao Liu dandan cao Ning Chen Tiancheng Luo Jingyu Yang Xueyi Hu Jie Ji Zhanping You Beijing Key Laboratory of Transportation Engineering Faculty of ArchitectureCivil and Transportation EngineeringBeijing University of TechnologyBeijing 100124China School of Civil and Transportation Engineering Beijing University of Civil Engineering and ArchitectureBeijing 100044China Department of Civil and Environmental Engineering Michigan Technological UniversityHoughtonMI 49931USA

Due to the rapid advancement of the transportation industry and the continual increase in pavement infrastructure,it is difficult to keep up with the huge road maintenance task by relying only on the traditional manual detection *** pavement detection technology with deep learning techniques is available for the research and industry areas by the gradual development of computer vision *** to the different characteristics of pavement distress and the uncertainty of the external environment,this kind of object detection technology for distress classification and location still faces great *** paper discusses the development of object detection technology and analyzes classical convolutional neural network(CNN)*** addition to the one-stage and two-stage object detection frameworks,object detection without anchor frames is introduced,which is divided according to whether the anchor box is used or *** paper also introduces attention mechanisms based on convolutional neural networks and emphasizes the performance of these mechanisms to further enhance the accuracy of object *** network architecture is introduced for mobile and industrial *** stereo cameras and sensors are rapidly developed,a detailed summary of three-dimensional object detection algorithms is also *** reviewing the history of the development of object detection,the scope of this review is not only limited to the area of pavement crack detection but also guidance for researchers in related fields is shared.

关键词： Pavement engineering Object detection Lightweight network Attention mechanism Convolutional neural network

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Stromal cell decidualization and embryo implantation: a vulnerable step leading to successful pregnancy

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Reproductive and Developmental Medicine 2024年第2期8卷 101-110页

作者： Luhan Jiang Sudini R.Fernando Suranga P.Kodithuwakku dandan cao William S.B.Yeung Kai-Fai Lee Department of Obstetrics and Gynaecology School of Clinical MedicineLKS Faculty of MedicineThe University of Hong KongHong Kong SAR 999077China Department of Animal Science Faculty of Animal Science&Export AgricultureUva Wellassa UniversityBadulla 50000Sri Lanka Department of Animal Science Faculty of AgricultureUniversity of PeradeniyaPeradeniya 20400Sri Lanka Shenzhen Key Laboratory of Fertility Regulation.The University of Hong Kong-Shenzhen Hospital Shenzhen 518053China

Endometrial stromal cell decidualization is a crucial step in endometrial remodeling during *** is controlled by orchestrated ovarian hormones,followed by the activation of various downstream signaling *** evidence has shown multiple functions of decidualized endometrial stromal cells during embryo implantation,including tissue remodeling,antioxidative stress,angiogenesis,and immune *** distinct secretomes of decidualized stromal cells also reveal their intensive interactions with epithelial,endothelial,and immune ***,aberrant decidualization leads to pregnancy failures,such as recurrent pregnancy loss and repeated implantation *** review aimed to provide an overview of the molecular mechanisms underlying the divergent functions of decidualized endometrial stromal cells and their potential clinical ***,the use of single-cell RNA sequencing data further enhances our understanding of these biological *** review discusses decidualization-related signaling pathways that serve as potential therapeutic targets for treating implantation failure in in vitro fertilization and provides novel approaches to investigate the underlying causes of female infertility.

关键词： Endometrial stromal cell Decidualization Embryo implantation Recurrent pregnancy loss Repeated implantation failure

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数字劳动者主体性危机的形成及其化解

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理论探讨 2024年第4期 144-151页

作者：曾祥炎曹丹丹湖南科技大学马克思主义学院湖南湘潭411201 湖南科技大学大数据与智能决策研究中心湖南湘潭411201

在数字技术与数字资本主义生产关系结合下,数字劳动者陷入了主体性危机:一方面,数字资本利用数字技术将个人化的情感表达和认同归属推向了一个高峰,使个人不断走向极其自由、自主与灵活的创造实践;另一方面,数字资本在数字技术的掩护下... 详细信息

在数字技术与数字资本主义生产关系结合下,数字劳动者陷入了主体性危机:一方面,数字资本利用数字技术将个人化的情感表达和认同归属推向了一个高峰,使个人不断走向极其自由、自主与灵活的创造实践;另一方面,数字资本在数字技术的掩护下对劳动者进行隐匿性剥削与算法规训,实现了对数字劳动者的人身控制和奴役。其结果是,数字资本裹挟数字技术成为一种压迫与剥削数字劳动者的力量,并最终导致了数字劳动者主体性危机的发生。在数字资本主义劳资关系重构的背景下,我们必须站在马克思主义立场,从解放数字生产力和推动数字劳动者自由发展的角度出发,通过设置引导数字资本健康发展的“红绿灯”、突出数字技术的工具性本质、唤醒数字劳动者主体意识和推动数字劳动成果共建共享等方面,全面解蔽数字资本逻辑,推动人的本质全面复归。

关键词：马克思异化劳动数字劳动者数字资本数字技术

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变化环境下河南省水资源情势与驱动力分析

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人民黄河 2024年第8期46卷 71-75,81页

作者：张修宇曹丹丹陈卓赵济泽华北水利水电大学河南郑州450046

为了解河南省水资源利用现状及趋势,为水资源管理部门提供参考,以应对变化环境下未来水资源供需所面临的挑战,基于河南省1999—2022年有关气象水文资料及水资源统计资料,采用统计分析、Mann-Kendall趋势检验及BP神经网络方法,对河南省... 详细信息

为了解河南省水资源利用现状及趋势,为水资源管理部门提供参考,以应对变化环境下未来水资源供需所面临的挑战,基于河南省1999—2022年有关气象水文资料及水资源统计资料,采用统计分析、Mann-Kendall趋势检验及BP神经网络方法,对河南省水资源演变情势及其驱动力进行分析研究。结果表明:河南省降水量及水资源总量年际变化较大,整体不太稳定且丰枯水年交替频繁,供用水量呈现增长趋势但增速有所放缓;全省降水量、地下水资源量及水资源总量呈现不显著的减少趋势,地表水量及耗水量呈现不显著的增加趋势,供用水量呈现显著的增加趋势;降水量、年平均气温及下垫面的变化都是影响河南省水资源总量变化的重要因素。

关键词：水资源情势驱动力 Mann-Kendall趋势检验 BP神经网络河南省

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人民胜利渠灌区水资源安全综合评价

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人民黄河 2024年第7期46卷 56-59页

作者：张修宇宓金鹏李颖博曹丹丹华北水利水电大学河南郑州450046

基于灌区水资源安全理论,构建水量、用水效率、生态3个准则层,选取水资源总量、每公顷农田灌溉水量、万元工业增加值用水量、生态用水量占比等10个指标,并依据人民胜利渠灌区2015—2020年社会、自然、经济和水资源等相关数据及统计资料... 详细信息

基于灌区水资源安全理论,构建水量、用水效率、生态3个准则层,选取水资源总量、每公顷农田灌溉水量、万元工业增加值用水量、生态用水量占比等10个指标,并依据人民胜利渠灌区2015—2020年社会、自然、经济和水资源等相关数据及统计资料,采用熵权法-层次分析法评价模型,对人民胜利渠灌区水资源安全进行综合评价。结果表明:2015年、2016年和2020年人民胜利渠灌区水资源处于基本安全状态,2018年和2019年处于安全状态,2017年处于不安全状态。通过深入辨识分析影响人民胜利渠灌区水资源安全的各项指标,发现提升水资源利用效率、推广节水灌溉技术以及实现水资源供需均衡,是确保人民胜利渠灌区水资源安全的关键。

关键词：水资源安全指标体系熵权法-层次分析法人民胜利渠灌区

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Speciation of organomercury compounds by capillary electrophoresis with pre-column derivatization and on-line stacking

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Chinese Chemical Letters 2019年第3期30卷 650-652页

作者： dandan cao Yongguang Yin Bin He State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences University of Chinese Academy of Sciences

Simultaneous separation and detection of three organomercury species, namely methylmercury(MeHg),ethylmercury(EtHg), and phenylmercury(PhHg), was performed by using capillary electrophoresis(CE)with UV detection. Pre-column derivatization with thiosalicylic acid and on-line salt-induced stacking significantly improved the detection performance. Buffer pH, ion strength, and additive were optimized for CE separation, concentration of NaCl in sample solution and injection time were optimized for on-line stacking. The limits of detection were 76.9,83.0 and 76.4 μg/L for PhHg, EtHg and MeHg, respectively. The developed method was validated by certified reference material and liquid chromatography-atomic fluorescence spectroscopy, which suggests this method could be useful in the speciation of organomercury compounds in biological samples.

关键词： Capillary electrophoresis Mercury speciation Derivatization On-line stacking

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外周静脉波形分析的临床应用进展

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中国医药导报 2024年第7期21卷 53-56页

作者：曹丹丹王金荣河北医科大学附属哈励逊国际和平医院重症医学科河北衡水053000

本文目的是综述外周静脉压(PVP)波形的生理学特点、获取方法及临床应用进展。PVP与中心静脉压高度相关和一致,是一种有潜力的替代指标。经上肢浅静脉留置导管,连接压力传感器进行外周静脉波形分析(PIVA),或腕关节掌侧皮肤表面放置专门... 详细信息

本文目的是综述外周静脉压(PVP)波形的生理学特点、获取方法及临床应用进展。PVP与中心静脉压高度相关和一致,是一种有潜力的替代指标。经上肢浅静脉留置导管,连接压力传感器进行外周静脉波形分析(PIVA),或腕关节掌侧皮肤表面放置专门的压电传感器,进行非侵入性静脉波形分析(NIVA),均可早期识别低血容量状态,包括出血和脱水。对于心力衰竭患者,PIVA/NIVA可准确评估容量过负荷,甚至预测短期恶化风险。PVP主要缺陷是波幅低、信号弱,需要进一步改进以提高临床应用能力。

关键词：周围静脉压波形分析中心静脉压血流动力学

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Minimal residual disease in solid tumors:an overview

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Frontiers of Medicine 2023年第4期17卷 649-674页

作者： Yarui Ma Jingbo Gan Yinlei Bai dandan cao Yuchen Jiao State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Genetron Health(Beijing)Co.Ltd. Beijing 102206China

Minimal residual disease(MRD)is termed as the small numbers of remnant tumor cells in a subset of patients with *** biopsy is increasingly used for the detection of MRD,illustrating the potential of MRD detection to provide more accurate management for cancer *** new techniques and algorithms have enhanced the performance of MRD detection,the approach is becoming more widely and routinely used to predict the prognosis and monitor the relapse of cancer *** fact,MRD detection has been shown to achieve better performance than imaging *** this basis,rigorous investigation of MRD detection as an integral method for guiding clinical treatment has made important *** review summarizes the development of MRD biomarkers,techniques,and strategies for the detection of cancer,and emphasizes the application of MRD detection in solid tumors,particularly for the guidance of clinical treatment.

关键词： MRD solid tumor CTC ctDNA

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The thermal transformation mechanism of chlorinated paraffins:An experimental and density functional theory study

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Journal of Environmental Sciences 2019年第1期31卷 378-387页

作者： Shanzhi Xin Wei Gao dandan cao Kun Lv Yaquan Liu Chunyan Zhao Yawei Wang Guibin Jiang State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Hubei Key Laboratory of Industrial Fume and Dust Pollution Control Jianghan University University of Chinese Academy of Sciences Environment Research Institute Shandong University School of Pharmacy Lanzhou University Institute of Environment and Health Jianghan University

The increasing production and usage of chlorinated paraffins(CPs) correspondently increase the amount of CPs that experience thermal processes. Our previous study revealed that a significant amount of medium-chain chlorinated paraffins(MCCPs), short-chain chlorinated paraffins(SCCPs) as well as aromatic and chlorinated polycyclic aromatic hydrocarbons(Cl-PAHs) were formed synergistically during the thermal decomposition of CP-52(a class of CP products).However, the transformation mechanisms of CP-52 to these compounds are still not very *** article presents a mechanistic analysis on the decomposition of CP-52 experimentally and theoretically. It was found that CP-52 initially undergoes dehydrochlorination and carbon chain cleavage and it transformed into chlorinated and unsaturated hydrocarbons. Cyclization and aromatization were the most accessible pathways at low temperatures(200–400°C), both of which produce mostly aromatic hydrocarbons. As the temperature exceeds 400°C, the hydrocarbons could decompose into small molecules, and the subsequent radical-induced reactions become the predominant pathways, leading to the formation of Cl-PAHs. The decomposition of CP-52 was investigated by using density functional theory and calculations demonstrating the feasibility and rationality of PCB and PCN formation from chlorobenzene. The results improve the understanding of the transformation processes from CP-52 to SCCPs and Cl-PAHs as well as provide data for reducing their emissions during thermal-related processes.

关键词： Decomposition mechanism Chlorinated paraffins Chlorinated aromatic hydrocarbons Density functional theory (DFT)

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