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Clinical Practice of Evidence-Based PDCA Cycle Management Model in Accelerated Recovery of Lung Cancer Patients

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Journal of Cancer Therapy 2024年第4期15卷 130-140页

作者： Lu Kang Juan Yuan dandan Liu Bo Deng Sun Yat-sen University Cancer Center Guangzhou China

Objective: To explore the nursing effect of evidence-based PDCA cycle management mode in accelerated rehabilitation of patients undergoing thoracoscopic lung cancer radical surgery. Methods: 104 patients who underwent thoracoscopic lung cancer radical surgery in our hospital from June 2022 to February 2023 were randomly divided into control group and intervention group, with 52 cases in each group. The control group implemented evidence-based ERAS clinical pathway management, while the intervention group implemented evidence-based PDCA cycle quality management. The postoperative recovery of the two groups of patients was compared. Results: The postoperative recovery of the intervention group was significantly better than that of the control group. The first time to get out of bed, the first time to eat, the duration of chest drainage tube placement, and the length of hospital stay were significantly shorter than those of the control group. The incidence of postoperative chest complications and hospitalization costs were significantly lower than those of the control group, and patient satisfaction was significantly higher than that of the control group (P Conclusion: Evidence-based PDCA cycle quality management mode can effectively improve the implementation quality of accelerated rehabilitation nursing for patients undergoing thoracoscopic lung cancer radical surgery, and it is worthy of clinical promotion.

关键词： Evidence-Based PDCA Cycle Thoracoscopic Lung Cancer Radical Surgery Accelerated Rehabilitation

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Yangtze Cruise

The World of Chinese 2024年第3期 60-69页

作者： Chu dandan Ana Padilla Fornieles 不详

A four-day,three-night cruise down China’s largest *** my family of six hopped off the subway at Chaotianmen Wharf,we found ourselves on the third floor of a shopping mall,instead of *** is the unique magic of Chongq... 详细信息

关键词： Cruise Yangtze shopping

Application Effect of External Diaphragm Pacemaker Combined with Active Respiratory Circulation Technology in Pulmonary Rehabilitation of Perioperative Lung Cancer Patients

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Journal of Cancer Therapy 2024年第4期15卷 190-200页

作者： Linjuan Zeng Gaoyang Duan dandan Liu Heping Wu Cancer Prevention and Treatment Center Department of Thoracic Surgery Sun Yat-sen University Guangzhou China

Aim: To explore the application effect of external diaphragm pacemaker combined with active respiratory circulation technology in pulmonary rehabilitation of perioperative lung cancer patients. Methods: A total of 98 lung cancer patients admitted to our hospital from April 2020 to November 2021 were selected as the observation objects, and then divided into a control group and an observation group using the random number table method, with 49 cases in each group. The control group received routine admission guidance and active respiratory circulation training, while the observation group was supplemented with external diaphragm pacemaker on the basis of the control group. The intervention effect was evaluated by blood gas indicators, pulmonary function indicators, diaphragm function indicators, sputum comfort degree, and activity tolerance indicators before and after intervention. Results: Before intervention, there were no significant differences in blood gas analysis indicators, pulmonary function indicators, diaphragm function indicators, sputum comfort degree, and activity tolerance indicators between the two groups (P > 0.05). After intervention, the improvement degree of the above indicators in the observation group was higher than that in the control group (P < 0.05). Conclusions: The application of external diaphragm pacemaker combined with active respiratory circulation technology in pulmonary rehabilitation of perioperative lung cancer patients is significant, which can effectively improve the pulmonary function, blood gas function, and diaphragm function of lung cancer patients after surgery, and improve the activities of daily living and quality of life of patients.

关键词： The Extracorporeal Diaphragm Pacemaker Active Breathing and Circulation Training Lung Cancer Diaphragmatic Mobility Pulmonary Function

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CuO/ZnO复合光催化材料研究进展

化工新型材料 2021年第5期49卷 51-55页

作者：唐茂薛娅向丹丹马洋朱晓东成都大学机械工程学院成都610106

ZnO具有光催化活性强、热稳定性高、无毒无污染等优点,是研究最广泛的光催化材料之一。ZnO禁带宽度大,只能吸收紫外光,太阳能利用率低;且其光生电子易与空穴复合,量子效率低。CuO作为一种窄带隙半导体,与ZnO复合形成半导体异质结,不仅... 详细信息

ZnO具有光催化活性强、热稳定性高、无毒无污染等优点,是研究最广泛的光催化材料之一。ZnO禁带宽度大,只能吸收紫外光,太阳能利用率低;且其光生电子易与空穴复合,量子效率低。CuO作为一种窄带隙半导体,与ZnO复合形成半导体异质结,不仅可以提高太阳光利用率,而且能加快载流子转移,提高光催化性能。介绍了CuO/ZnO复合光催化材料的制备方法,综述了国内外CuO/ZnO复合光催化材料的研究进展,并展望了其未来研究方向。

关键词：氧化铜/氧化锌复合材料光催化性能半导体异质结

Meningeal lymphatic vessel crosstalk with central nervous system immune cells in aging and neurodegenerative diseases

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Neural Regeneration Research 2025年第3期20卷 763-778页

作者： Minghuang Gao Xinyue Wang Shijie Su Weicheng Feng Yaona Lai Kongli Huang dandan Cao Qi Wang Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina Institute of Clinical Pharmacology Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina The Sixth Affiliated Hospital Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Meningeal lymphatic vessels form a relationship between the nervous system and periphery, which is relevant in both health and disease. Meningeal lymphatic vessels not only play a key role in the drainage of brain metabolites but also contribute to antigen delivery and immune cell activation. The advent of novel genomic technologies has enabled rapid progress in the characterization of myeloid and lymphoid cells and their interactions with meningeal lymphatic vessels within the central nervous system. In this review, we provide an overview of the multifaceted roles of meningeal lymphatic vessels within the context of the central nervous system immune network, highlighting recent discoveries on the immunological niche provided by meningeal lymphatic vessels. Furthermore, we delve into the mechanisms of crosstalk between meningeal lymphatic vessels and immune cells in the central nervous system under both homeostatic conditions and neurodegenerative diseases, discussing how these interactions shape the pathological outcomes. Regulation of meningeal lymphatic vessel function and structure can influence lymphatic drainage, cerebrospinal fluid-borne immune modulators, and immune cell populations in aging and neurodegenerative disorders, thereby playing a key role in shaping meningeal and brain parenchyma immunity.

关键词： central nervous system meningeal lymphatic vessels immunity myeloid cells lymphatic cells neurodegenerative disease

Development and optimization of object detection technology in pavement engineering: A literature review

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Journal of Road Engineering 2024年第2期4卷 163-188页

作者： Hui Yao Yaning Fan Yanhao Liu dandan Cao Ning Chen Tiancheng Luo Jingyu Yang Xueyi Hu Jie Ji Zhanping You Beijing Key Laboratory of Transportation Engineering Faculty of ArchitectureCivil and Transportation EngineeringBeijing University of TechnologyBeijing 100124China School of Civil and Transportation Engineering Beijing University of Civil Engineering and ArchitectureBeijing 100044China Department of Civil and Environmental Engineering Michigan Technological UniversityHoughtonMI 49931USA

Due to the rapid advancement of the transportation industry and the continual increase in pavement infrastructure,it is difficult to keep up with the huge road maintenance task by relying only on the traditional manual detection *** pavement detection technology with deep learning techniques is available for the research and industry areas by the gradual development of computer vision *** to the different characteristics of pavement distress and the uncertainty of the external environment,this kind of object detection technology for distress classification and location still faces great *** paper discusses the development of object detection technology and analyzes classical convolutional neural network(CNN)*** addition to the one-stage and two-stage object detection frameworks,object detection without anchor frames is introduced,which is divided according to whether the anchor box is used or *** paper also introduces attention mechanisms based on convolutional neural networks and emphasizes the performance of these mechanisms to further enhance the accuracy of object *** network architecture is introduced for mobile and industrial *** stereo cameras and sensors are rapidly developed,a detailed summary of three-dimensional object detection algorithms is also *** reviewing the history of the development of object detection,the scope of this review is not only limited to the area of pavement crack detection but also guidance for researchers in related fields is shared.

关键词： Pavement engineering Object detection Lightweight network Attention mechanism Convolutional neural network

抗对硫磷单链抗体在昆虫细胞中的表达及活性鉴定

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农药学学报 2016年第2期18卷 177-184页

作者：刘蕊项丹丹刘鹏琰梁晓郭逸蓉朱国念浙江大学农药与环境毒理研究所杭州310058 中国热带农业科学院环境与植物保护研究所海口571101

利用Bac-to-Bac杆状病毒表达系统,在Sf9昆虫细胞中表达抗对硫磷单链抗体,并评价该重组抗体sc Fv-4C6的分子识别活性。以分泌能特异性识别对硫磷的单克隆抗体的杂交瘤细胞株4C6为RNA来源,采用RT-PCR方法扩增抗体的重链和轻链可变区基因,... 详细信息

利用Bac-to-Bac杆状病毒表达系统,在Sf9昆虫细胞中表达抗对硫磷单链抗体,并评价该重组抗体sc Fv-4C6的分子识别活性。以分泌能特异性识别对硫磷的单克隆抗体的杂交瘤细胞株4C6为RNA来源,采用RT-PCR方法扩增抗体的重链和轻链可变区基因,经重叠延伸PCR方法串联拼接获得单链抗体基因片段(sc Fv-4C6)。构建包含目的片段的重组杆粒Bacmidsc Fv-4C6,转染Sf9细胞表达目的蛋白,采用免疫印迹法(Western blotting)检测表达产物,间接竞争酶联免疫吸附(ic-ELISA)法评价产物的生物活性。结果表明:sc Fv-4C6基因片段拼装正确,成功转染Sf9细胞,并在转染后72 h表达量最高,表达的单链抗体大小为28.3 k D;表达产物能特异性识别对硫磷,IC50值为7.9 ng/m L,对甲基对硫磷和杀螟硫磷分别有12%和1.8%的交叉反应率,与亲本单克隆抗体的识别性能相似。该研究表明,具有生物活性的抗对硫磷单链抗体sc Fv-4C6可在昆虫细胞中成功得到表达。

关键词：对硫磷单链抗体昆虫细胞表达酶联免疫吸附

Advances in intelligent mass spectrometry data processing technology for in vivo analysis of natural medicines

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Chinese Journal of Natural Medicines 2024年第10期22卷 900-913页

作者： CHEN Simian DAI Binxin ZHANG dandan YANG Yuexin ZHANG Hairong ZHANG Junyu LU Di WU Caisheng Fujian Provincial Key Laboratory of Innovative Drug Target Research and State Key Laboratory of Cellular Stress Biology School of Pharmaceutical Sciences Xiamen University Xiamen Key Laboratory for Clinical Efficacy and Evidence-Based Research of Traditional Chinese Medicine Xiamen University

Natural medicines(NMs) are crucial for treating human diseases. Efficiently characterizing their bioactive components in vivo has been a key focus and challenge in NM research. High-performance liquid chromatography-high-resolution mass spectrometry(HPLC-HRMS) systems offer high sensitivity, resolution, and precision for conducting in vivo analysis of NMs. However, due to the complexity of NMs, conventional data acquisition, mining, and processing techniques often fail to meet the practical needs of in vivo NM analysis. Over the past two decades, intelligent spectral data-processing techniques based on various principles and algorithms have been developed and applied for in vivo NM analysis. Consequently, improvements have been achieved in the overall analytical performance by relying on these techniques without the need to change the instrument hardware. These improvements include enhanced instrument analysis sensitivity, expanded compound analysis coverage, intelligent identification, and characterization of nontargeted in vivo compounds, providing powerful technical means for studying the in vivo metabolism of NMs and screening for pharmacologically active components. This review summarizes the research progress on in vivo analysis strategies for NMs using intelligent MS data processing techniques reported over the past two decades. It discusses differences in compound structures, variations among biological samples, and the application of artificial intelligence(AI) neural network algorithms. Additionally, the review offers insights into the potential of in vivo tracking of NMs, including the screening of bioactive components and the identification of pharmacokinetic markers. The aim is to provide a reference for the integration and development of new technologies and strategies for future in vivo analysis of NMs.

关键词： Artificial Intelligence Data-acquisition Data-processing High-performance liquid chromatography–High-resolution mass spectrometry Metabolomics

Elucidating ligand effects in rhodium(Ⅲ)-catalyzed arene-alkene coupling reactions

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Chinese Chemical Letters 2024年第5期35卷 130-134页

作者： Kongchuan Wu dandan Lu Jianbin Lin Ting-Bin Wen Wei Hao Kai Tan Hui-Jun Zhang Department of Chemistry College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Molecular Recognition and FunctionInstitute of ChemistryChinese Academy of Sciences(CAS)Beijing 100190China

Rhodium(Ⅲ)-catalyzed C-H couplings of arenes with alkenes are among the most powerful methods for C-C bond *** these transformations,subtle manipulation of ancillary ligands can lead to dramatic changes in reactivity and ***,detailed mechanistic studies concerning the ligand effects are *** this study,we investigated the origin of ligand-controlled product-selectivity in rhodium(Ⅲ)-catalyzed C-H couplings of arenes with alkenes,using a series of well-defined[CpXRhⅢ]complexes that feature electronically or sterically distinct Cp^(X)(Cp(η^(5)-C_(5)H_(5)),Cp^(CF3)(η^(5)-C_(5)Me_(4)CF_(3))and Cp^(∗)(η^(5)-C_(5)Me_(5)))ligands.A combination of experimental and theoretical investigations showed that(i)rhodium hydride species containing the electron rich Cp^(∗)ligand can undergo reinsertion of the alkene,thereby allowing rhodium-walking,(ii)rhodium hydride species involving the electron-deficient Cp or Cp^(CF3) ligands prefer reductive elimination rather than alkene *** findings offer valuable insights on future rational catalyst design for selective arene-alkene cross coupling reactions.

关键词： Organometallics Transition metal catalysis Arene-alkene coupling β-H elimination Rhodium hydride