检索结果-南通市图书馆

Paraneoplastic Leukocytosis and Thrombocytosis as Prognostic Biomarkers in Non-small Cell Lung Cancer

中国肺癌杂志 2016年第11期19卷 725-730页

作者： Prajwal BODDU dana villlines Mebea AKLILU Department of Internal Medicine Advocate Illinois Masonic Medical Center Department of Clinical Research Advocate Illinois Masonic Hospital Hematology/Oncology Advocate Creticos Cancer Center

Background and Objectives: Search for inexpensive laboratory markers have identified associations between blood counts and lung cancer outcomes. In this study, we evaluated the prognostic value of paraneoplastic leukocytosis(p-Leukocytosis) and paraneoplastic thrombocytosis(p-Thrombocytosis) in patients with non-small cell lung cancer(NSCLC). We also studied their relation to the expression of commonly detected molecular markers. Methods: We conducted a retrospective chart review on 571 consecutive NSCLC patients over a 10 year period. Blood counts were recorded at the time of cancer diagnosis. Kaplan-Meier survival curves were used to compare overall survival(OS) between patients with and without p-Leukocytosis(or) p-Thrombocytosis(p-Leuko/Thrombocytosis). Cox regression was used to determine if leukocytosis/thrombocytosis was a predictor of OS in ***: Patients with p-Leukocytosis and p-Thrombocytosis had a significantly poorer survival compared patients with normal blood counts(P<0.001). In a multivariate survival analysis, both continued to correlate even when adjusted for histology, gender, stage and chemotherapy(P<0.01, 0.03 respectively). Stage I and II NSCLC with p-Leuko/Thrombocytosis did not perform poorly compared to stage I/II NSCLC patients without paraneoplasia. Patients with the combined leukothrombocytosis syndrome did not have worse outcomes compared to those with either paraneoplastic syndrome alone. Conclusions: p-Leuko/Thrombocytosis is an accessible laboratory parameter of prognostic value in NSCLC. Evidence of p-Leuko/Thrombocytosis portends poor survival. The role of various cytokines in tumor pathobiology provides a rationale for identifying cytokine factors responsible for the paraneoplasia and administering anti-cytokine therapies alongside traditional chemotherapy in an attempt to improve survival outcomes in these subset of patients.

关键词： Paraneoplastic Leukothrombocytosis Paraneoplastic leukocytosis Paraneoplastic thrombocytosis Lung neoplasms Prognosis Cytokine Epidermal growth factor receptor

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Developing a phenomenological model to simulate single and mixed scale formation during flow in porous media:Coupling a salt precipitation model with an ion transport equation under dynamic conditions

引用

Petroleum Research 2024年第1期9卷 17-36页

作者： Erfan Hosseini dana Mohammad Nazar Negar Hosseini Mohammad Sarmadivaleh Exploration Directorate National Iranian Oil Company(NIOC)TehranIran Institute of Physical Chemistry and Polymer Physics Leibniz Institute of Polymer Research DresdenDresdenGermany Department of Petroleum Engineering Islamic Azad University(IAU)IlamIran WA School of Mines:Minerals Energy and Chemical EngineeringCurtin UniversityPerthWestern AustraliaAustralia

Water flooding and pressure maintenance are recommended to improve oil recovery practices after low recovery of petroleum reservoirs occurs during primary *** crystal formation is a frequent occurrence when using these *** experimental,numerical,and theoretical studies have been done on the mechanisms underlying scaling and permeability reduction in porous media;however,there has not been a satisfactory model *** study developed a phenomenological model to predict formation damage caused by salt *** with existing models,which provide a scaling tendency,the proposed model predicts the profile of scale *** salt precipitation model simulates reactive fluid flow through porous media.A thermodynamic,kinetic,and flow hydrodynamic model was developed and coupled with the ion transport equation to describe the movement of ***,a set of carefully designed dynamic experiments were conducted and the data were compared with the model *** forecasts and experimental data were observed to have an average absolute error(AAE)ranging from 0.68%to 5.94%,which indicates the model's suitability.

关键词： Improved oil recovery Water flooding Formation damage Scaling tendency Salt precipitation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Developing three-dimensional groundwater flow modeling for the Erbil Basin using Groundwater Modeling System (GMS)

引用

Journal of Groundwater Science and Engineering 2024年第2期12卷 178-189页

作者： Jwan Sabah Mustafa dana Khider Mawlood Department of Civil College of EngineeringUniversity of SalahaddinErbil 00044Iraq Vice President in University of Kurdistan-Hawler(UKH) ErbilIraq

This study presents the development of a comprehensive three-dimensional groundwater flow model for the Erbil Basin utilizing the Groundwater Modeling System(GMS).The Erbil Basin,situated in the Kurdistan Region of Iraq,is a vital water resource area facing increasing water demands and environ-mental *** three-dimensional nature of the groundwater flow system is crucial for accurately understanding and managing water resources in the *** modeling process involved data collection,geological and hydrogeological characterization,conceptual model development,and numerical simulation using GMS software MODFLOW 2000 *** parameters such as hydraulic conductivity,recharge rates,and boundary conditions were integrated into the model to represent the complex hydrogeo-logical conditions of the *** calibration was performed by comparing simulated groundwater levels with observed data from monitoring wells across the basin,using the automatic calibration method of automated Parameter Estimation(PEST).Pilot points were applied to adjust the hydraulic conductivity in the model area *** analysis was conducted to assess the influence of key parameters on model predictions and to identify areas of *** developed three-dimensional groundwater flow model provides valuable insights into the dynamics of groundwater flow,recharge-discharge mechanisms,and potential impacts of future scenarios such as climate change and water resource management *** serves as a useful tool for decision-makers,water resource managers,and researchers to evaluate differ-ent management scenarios and formulate sustainable groundwater management policies for the Erbil *** conclusion,this study demonstrates the effectiveness of using GMS for developing three-dimensional groundwater flow models in complex hydrogeological settings like the Erbil Basin,contributing to improved understanding and management of groundwater resources in the

关键词： Aquifer System Erbil Basin Groundwater Management GMS MODFLOW

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Existing and emerging biomarkers in hepatocellular carcinoma:relevance in staging,determination of minimal residual disease,and monitoring treatment response:a narrative review

引用

Hepatobiliary Surgery and Nutrition 2024年第1期13卷 39-55页

作者： dana A.Dominguez Paul Wong Laleh G.Melstrom Department of Surgical Oncology City of Hope National Medical CenterDuarteCAUSA University of California San FranciscoSan FranciscoCAUSA

Background and Objective:With the development of novel active systemic therapies,the landscape of hepatocellular carcinoma(HCC)management is rapidly ***,HCC lacks sensitive and specific biomarkers to predict prognosis,monitor for minimal residual disease after locoregional therapy,and predict treatment *** this review,we aim to summarize the best supporting evidence for refining existing,and development of novel biomarkers for staging,prognosis,determination of minimal residual disease and monitoring treatment response in HCC,focusing on those with evidence in clinical ***:PubMed and Embase databases were searched using the keywords;hepatocellular carcinoma,biomarker,minimal residual disease,surveillance,prognosis,staging,alpha-fetoprotein(AFP),liquid biopsy,treatment response,adjuvant,*** clinical studies were *** Content and Findings:AFP remains the major workhorse as the most widely used biomarker in HCC,however,its lack of wide applicability due to the high proportion of patients with HCC who are AFP negative,limits its value throughout all stages of HCC *** work has been done to combine AFP with other clinical and serologic factors to increase its accuracy and utility as a ***,it is likely that other more novel biomarkers such as those obtained through liquid biopsy will provide the prognostic power necessary for applications such as detecting recurrence and predicting treatment *** biopsy provides not only a wealth of potential biomarkers including circulating tumor cells and cell-free RNA/DNA,but also the ability to examine the mutational characteristics of the tumor with next generation *** early evidence supports the potential impact of many new biomarkers,validation in large clinical trials is ***:This review highlights the paucity of sensitive and specific,widely applicable biomarkers,throughout all phases of management of

关键词： Hepatocellular carcinoma(HCC) biomarker liquid biopsy alpha-fetoprotein(AFP)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Free-standing microscale photonic lantern spatial mode(De-)multiplexer fabricated using 3D nanoprinting

引用

Light(Science & Applications) 2024年第6期13卷 1170-1185页

作者： Yoav dana Yehudit Garcia Aleksei Kukin Lauren Dallachiesa Sterenn Guerrier Nicolas K.Fontaine Dan M.Marom Institute of Applied Physics Hebrew University of JerusalemJerusalemIsrael Nokia Bell Labs 600 Mountain AveNew ProvidenceNJ07974USA

Photonic lantern(PL)spatial multiplexers show great promise for a range of applications,such as future high-capacity mode division multiplexing(MDM)optical communication networks and free-space optical *** enable efficient conversion between multiple single-mode(SM)sources and a multimode(MM)waveguide of the same *** multiplexers operate by facilitating adiabatic transitions between the SM arrayed space and the single MM ***,current fabrication methods are forcing the size of these devices to multi-millimeters,making integration with micro-scale photonic systems quite *** advent of 3D micro and nano printing techniques enables the fabrication of freestanding photonic structures with a high refractive index contrast(photopolymer-air).In this work we present the design,fabrication,and characterization of a 6-mode mixing,375µm long PL that enables the conversion between six single-mode inputs and a single six-mode *** PL was designed using a genetic algorithm based inverse design approach and fabricated directly on a 7-core fiber using a commercial two-photon polymerization-based 3D printer and a *** the waveguides exhibit high index contrast,low insertion loss(−2.6 dB),polarization dependent(−0.2 dB)and mode dependent loss(−4.4 dB)were measured.

关键词： mode enable printing

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cardiac differentiation is modulated by anti-apoptotic signals in murine embryonic stem cells

引用

World Journal of Stem Cells 2024年第5期16卷 551-559页

作者： Amani Yehya Joseph Azar Mohamad Al-Fares Helene Boeuf Wassim Abou-Kheir dana Zeineddine Ola Hadadeh Department of Anatomy Cell Biology and Physiological SciencesAmerican University of BeirutBeirut 1107-2020Lebanon Inserm BiotisU1026University BordeauxBordeaux F-33000France Rammal Rammal Lab Physio-Toxicity Environmental TeamFaculty of SciencesLebanese UniversityNabatieh 0000Lebanon

BACKGROUND Embryonic stem cells(ESCs)serve as a crucial ex vivo model,representing epiblast cells derived from the inner cell mass of blastocyst-stage *** exhibit a unique combination of self-renewal potency,unlimited proliferation,and *** latter is evident by the ability of the isolated cells to differ-entiate spontaneously into multiple cell lineages,representing the three primary embryonic germ *** regulatory networks guide ESCs,directing their self-renewal and lineage-specific ***,or programmed cell death,emerges as a key event involved in sculpting and forming various organs and structures ensuring proper embryonic ***-ever,the molecular mechanisms underlying the dynamic interplay between diffe-rentiation and apoptosis remain poorly *** To investigate the regulatory impact of apoptosis on the early differentiation of ESCs into cardiac cells,using mouse ESC(mESC)models-mESC-B-cell lym-phoma 2(BCL-2),mESC-PIM-2,and mESC-metallothionein-1(MET-1)-which overexpress the anti-apoptotic genes Bcl-2,Pim-2,and Met-1,*** mESC-T2(wild-type),mESC-BCL-2,mESC-PIM-2,and mESC-MET-1 have been used to assess the effect of potentiated apoptotic signals on cardiac *** hanging drop method was adopted to generate embryoid bodies(EBs)and induce terminal differentiation of *** size of the generated EBs was measured in each condition compared to the wild *** the functional level,the percentage of cardiac differentiation was measured by calculating the number of beating cardiomyocytes in the manipulated mESCs compared to the *** the molecular level,quantitative reverse transcription-polymerase chain reaction was used to assess the mRNA expression of three cardiac markers:Troponin T,GATA4,and ***,troponin T protein expression was evaluated through immunofluorescence and western blot *** Our findings showed that the upregulation of Bcl-

关键词： Mouse embryonic stem cells Self-renewal Apoptosis Cardiac differentiation B-cell lymphoma 2 PIM-2 Metallothionein-1

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

An electropenetrography waveform library for the probing and ingestion behaviors of Culex tarsalis on human hands

引用

Insect Science 2024年第4期31卷 1165-1186页

作者： Anastasia M.W.Cooper Samuel B.Jameson Victoria Pickens Cameron Osborne Elaine A.Backus Kristopher Silver dana N.Mitzel Department of Entomology Kansas State UniversityManhattanKansasUSA Department of Tropical Medicine Tulane University School of Public Health and Tropical MedicineNew OrleansLos AngelesUSA USDA Agricultural Research Service San Joaquin Valley Agricultural Sciences CenterParlierCaliforniaUSA National Bio and Agro-Defense Facility USDA Agricultural Research ServiceManhattanKansasUSA

Culex tarsalis Coquillett(Diptera:Culicidae)mosquitoes are capable of vectoring numerous pathogens affecting public and animal ***,the probing behaviors of mosquitoes are poorly understood because they occur in opaque ***(EPG)has the potential to elucidate these behaviors by recording the electrical signals generated during *** used an AC–DC EPG with variable input resistors(Ri levels)to construct a waveform library for *** feeding on human *** events associated with mosquito probing were used to characterize waveforms at four Ri levels and with two electrical current *** optimal settings for EPG recordings of *** probing on human hands was an Ri level of 10^(7)Ohms using an applied signal of 150 millivolts alternating *** for *** included those previously observed and associated with probing behaviors in Aedes aegypti L.(Diptera:Culicidae):waveform families J(surface salivation),K(stylet penetration through the skin),L(types 1 and 2,search for a blood vessel/ingestion site),M(types 1 and 2,ingestion),N(type 1,an unknown behavior which may be a resting and digestion phase),and W(withdrawal).However,we also observed variations in the waveforms not described in ***,which we named types L3,M3,M4,and *** investigation enhances our understanding of mosquito probing *** also provides a new tool for the automated calculation of peak *** work will facilitate future pathogen acquisition and transmission studies and help identify new pest and disease management targets.

关键词： AC-DC blood feeders electrical penetration graph EPG human hands mosquitoes waveform library

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Association of initial assessment variables and mortality in severe pediatric traumatic brain injury

引用

World Journal of Pediatric Surgery 2024年第2期7卷 125-133页

作者： Katherine C Bergus Kelli N Patterson Lindsey Asti Josh Bricker Tariku J Beyene Lauren N Schulz dana M Schwartz Rajan K Thakkar Eric A Sribnick Pediatric Surgery Nationwide Children's HospitalColumbusOhioUSA CenterforSurgical Outcomes Research Nationwide Children's HospitalColumbusOhioUSA Neurologic Surgery The Ohio State UniversityColumbusOhioUSA Neurologic Surgery Nationwide Children's HospitalColumbusOhioUSA

Background Predictive scales have been used to prognosticate long-term outcomes of traumatic brain injury(TBI),but gaps remain in predicting mortality using initial trauma resuscitation *** sought to evaluate the association of clinical variables collected during the initial resuscitation of intubated pediatric severe patients with TBI with in-hospital *** Intubated pediatric trauma patients<18 years with severe TBI(Glasgow coma scale(GCS)score≤8)from January 2011 to December 2020 were *** between initial trauma resuscitation variables(temperature,pulse,mean arterial blood pressure,GCS score,hemoglobin,international normalized ratio(INR),platelet count,oxygen saturation,end tidal carbon dioxide,blood glucose and pupillary response)and mortality were evaluated with multivariable logistic *** Among 314 patients,median age was 5.5 years(interquartile range(IQR):2.2-12.8),GCS score was 3(IQR:3-6),Head Abbreviated Injury Score(hAIS)was 4(IQR:3-5),and most had a severe(25-49)Injury Severity Score(ISS)(48.7%,153/314).Overall mortality was 26.8%.GCS score,hAIS,ISS,INR,platelet count,and blood glucose were associated with in-hospital mortality(all p<0.05).As age and GCS score increased,the odds of mortality *** 1-point increase in GCS score was associated with a 35%decrease in odds of *** hAIS,INR,and blood glucose increased,the odds of mortality *** each 1.0 unit increase in INR,the odds of mortality increased by 1427%.Conclusions Pediatric patients with severe TBI are at substantial risk for in-hospital *** are needed to examine whether earlier interventions targeting specific parameters of INR and blood glucose impact mortality.

关键词： mortality pediatric traumatic

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

纤维弯曲对其集合体过滤特性影响的稳态数值分析

引用

纺织学报 2024年第7期45卷 31-39页

作者：刘倩倩尤健明王琰孙成磊 JIRI Militky dana Kremenakova JAKUB Wiener 祝国成浙江理工大学纺织科学与工程学院(国际丝绸学院) 浙江杭州310018 浙江朝晖过滤技术股份有限公司浙江嘉兴314511 浙江理工大学浙江-捷克先进纤维材料联合实验室浙江杭州310018 利贝雷茨理工大学纺织工程学院捷克利贝雷茨46117 浙江省现代纺织技术创新中心(鉴湖实验室) 浙江绍兴312000

为探究纤维过滤介质中纤维曲率对其内部速度分布、压力损失、过滤效率的影响,通过Digimat建模软件建立曲率K分别为0、2、4、6,固体体积分数为8%,在三维空间中随机分散排列的纤维过滤介质模型,结合计算流体力学方法,基于拉格朗日离散模型... 详细信息

为探究纤维过滤介质中纤维曲率对其内部速度分布、压力损失、过滤效率的影响,通过Digimat建模软件建立曲率K分别为0、2、4、6,固体体积分数为8%,在三维空间中随机分散排列的纤维过滤介质模型,结合计算流体力学方法,基于拉格朗日离散模型和Laminar流场,利用雷诺相似准则,设置入口速度分别为0.05、0.142、0.5、1、2 m/s,平均颗粒粒径为0.25、0.5、1、1.5、2.5、4、5 mm,对微米纤维模型内部气-固两相流动情况进行数值模拟。结果表明:随着纤维曲率K由0增大至6,在入口速度为0.5 m/s时,纤维曲率对速度场分布的影响不明显,速度场的分布呈无规律性;纤维曲率对模型内部压力损失有显著影响,随着纤维曲率的提高,纤维模型内部压力损失呈线性增大;纤维过滤介质的过滤效率随纤维模型曲率的增大而提高,在入口速度为1 m/s、模型曲率K为6时,对平均粒径为5 mm的颗粒过滤效率接近90%,明显高于相同粒径下K为0时的过滤效率。

关键词：计算流体力学纤维曲率压力损失数值模拟过滤效率

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

高考英语写作：开好头，结好尾

引用

新世纪智能 2024年第Z8期 28-36页

作者： dana

一、应用文写作高考英语应用文常分为开头、正文和结尾三个部分。文章开头和结尾的表达是否准确到位、安排是否得体，在整篇文章中具有举足轻重的作用，直接影响到整篇文章的质量。信件的开头近几年高考应用文大多是写书信，其重点是根...

一、应用文写作高考英语应用文常分为开头、正文和结尾三个部分。文章开头和结尾的表达是否准确到位、安排是否得体，在整篇文章中具有举足轻重的作用，直接影响到整篇文章的质量。信件的开头近几年高考应用文大多是写书信，其重点是根据提纲要求，用礼貌的语气传递准确、周全的信息，同时体现一种真实感。信件的开头可以从问候语、自我介绍、写作背景、写作目的等方面展开。

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：