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A nanoagent for concurrent therapy of breast cancer bone metastasis and cancer-induced bone pain through SLC7A11 interruption and photodynamic therapy

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Chinese Chemical Letters 2024年第2期35卷 295-299页

作者： Qi Fu Zhongming Lian Mengya niu Yaru Huang Yanqiu Ai Long He dandan Zhang Cuixia Zheng Jian-Jun Yang Lei Wang dandan Tian Department of Anesthesiology Pain and Perioperative MedicineThe First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450001China School of Pharmaceutical Sciences Zhengzhou UniversityZhengzhou 450001China Translational Medical Center of Huaihe Hospital Henan UniversityKaifeng 475004China Key Laboratory of Advanced Drug Preparation Technologies Ministry of EducationSchool of Pharmaceutical SciencesZhengzhou UniversityZhengzhou 450001China

Bone metastasis,a life-threatening complication of advanced breast cancer,is often accompanied by debilitating pain(cancer-induced bone pain,CIBP)that severely impairs life quality and *** concurrent treatment of bone metastases and CIBP remains a clinical challenge because the therapeutic options are *** this study,we construct a near-infrared light-activated nano-therapeutic system to meet this *** detail,sorafenib(SRF)and photosensitizer(chlorin e6,Ce6)are encapsulated into mesoporous hydroxyapatite nanoparticles(HANPs),which are further functionalized with hyaluronic acid(HA)to obtain HA-SRF/Ce6@HANPs *** designed nanoplatform destroys tumor cells in vitro and in vivo via the synergism of SRF(interrupting the exchange of cystine/glutamate by inhibiting SLC7A11)and photodynamic therapy(PDT,inducing reactive oxygen species generation).The decrease in tumor burden and reduction of extracellular glutamate significantly attenuate CIBP in mice model with developing bone ***,the combination of HA-SRF/Ce6@HANPs and PDT inhibit osteoclasts activation,promote osteoblast differentiation and accelerate bone ***,the nanoagent with good biocompatibility may provide an effective therapy method for the concurrent treatment of breast cancer bone metastasis and CIBP.

关键词： Breast cancer bone metastasis Cancer-induced bone pain Cystine/glutamate antiporter Sorafenib Photodynamic therapy

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玉米螟防治措施

北京农业 2012年第6期 93-93页

作者：王理牛丹丹河南沈丘县农业局

玉米螟,俗称玉米钻心虫,玉米螟是危害玉米较重的常发性害虫,每年都有不同程度的发生,平均减产10%,近年来,随着气候条件的变化,耕作制度的改变,玉米种植密度的加大,肥水务件的提高,玉米螟的危害日益加重,因此做好玉米螟防治工作对提高粮... 详细信息

玉米螟,俗称玉米钻心虫,玉米螟是危害玉米较重的常发性害虫,每年都有不同程度的发生,平均减产10%,近年来,随着气候条件的变化,耕作制度的改变,玉米种植密度的加大,肥水务件的提高,玉米螟的危害日益加重,因此做好玉米螟防治工作对提高粮食生产意义重大。

关键词：玉米螟危害防治措施

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蔗糖为原料同步糖化发酵生产乳酸单体

甘蔗糖业 2021年第4期50卷 77-84页

作者：张桦宇田康明赵继华牛丹丹 MCHUNU Nokuthula Peace 王正祥天津科技大学生物工程学院天津300457 天津科技大学化工与材料学院天津300457 Biotechnology Platform Agricultural Research CouncilPretoria South Africa 0001

为了适应糖品消费结构的改变并平衡蔗糖产业经济结构与组成,本文研究了同步糖化发酵蔗糖生产L-乳酸单体的新工艺技术。以产L-乳酸重组菌JC31L为生产菌株,在5 L发酵罐中,起始工作体积为2.5 L,于37℃、30 g/L蔗糖和10 U/g蔗糖的蔗糖酶下... 详细信息

为了适应糖品消费结构的改变并平衡蔗糖产业经济结构与组成,本文研究了同步糖化发酵蔗糖生产L-乳酸单体的新工艺技术。以产L-乳酸重组菌JC31L为生产菌株,在5 L发酵罐中,起始工作体积为2.5 L,于37℃、30 g/L蔗糖和10 U/g蔗糖的蔗糖酶下好氧培养菌体,进入乳酸单体发酵生产阶段,分4次等量补加210.5mL60%蔗糖溶液和1500U蔗糖酶下进行L-乳酸发酵。发酵结束时,发酵液中L-乳酸浓度达到140 g/L,L-乳酸平均合成速率为5.38 g/(L·h),L-乳酸的光学纯度达到99.9%,厌氧产酸阶段的糖酸转化率达到98%。本文所建工艺技术,可以经进一步放大工艺,应用于规模化生物转化蔗糖为乳酸单体。

关键词：蔗糖 L-乳酸同步糖化发酵蔗糖酶

Surface hydrophobic modification enhanced catalytic performance of electrochemical nitrogen reduction reaction

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Nano Research 2022年第5期15卷 3886-3893页

作者： Lijuan niu Ziwen Liu Guohua Liu Mengxuan Li Xupeng Zong dandan Wang Li An Dan Qu Xiaoming Sun Xiayan Wang Zaicheng Sun Beijing Key Laboratory for Green Catalysis and Separation Center of Excellence for Environmental Safety and Biological EffectsFaculty of Environment and LifeBeijing University of TechnologyBeijing 100124China State Key Laboratory of Chemical Resource Engineering College of Energy Beijing Advanced Innovation Center for Soft Matter Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China Key Laboratory of Functional Materials Physics and Chemistry of the Ministry of Education Jilin Normal UniversityChangchun 130103China

Electrocatalytic nitrogen reduction reaction(NRR)is a sustainable approach for NH_(3)production with low energy ***,competing hydrogen reduction reaction(HER)in aqueous solution results in low NH_(3)production and Faraday efficiency(FE).Here,MoS_(2)nanostructures with a hydrophobic surface are synthesized by alkyl thiols *** and hydrophobic surface facilitates an efficient three-phase contact of N_(2),H_(2)O,and ***,localized concentrated N_(2)molecules can overcome the mass transfer limitation of N2 and depress the HER due to lowering the proton *** the active-sites decrease with the increase of the alkyl chain since the thiol may cover the active site,the optimized electrocatalyst achieves NH_(3)yield of 12.86×10^(-11)mol·cm^(-2)·s^(-1)at-0.25 V and 22.23%FE,which are 4.3 and 24 times higher than those of MoS2-CP electrocatalyst,*** increased catalytic performance is attributed to the high N_(2)adsorption and depressed HER.

关键词： nitrogen reduction reaction MoS_(2)electrocatalyst hydrophobic modification density functional theory calculations

Role of oxygen vacancy in rare-earth-free LiCa_(3)Mg(VO_(4))_(3) phosphor: Enhancing photoluminescence by heat-treatment in oxygen flow

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Journal of Materials Science & Technology 2021年第20期79卷 123-132页

作者： Yixuan Lv Yijun Zhang Le Shi Jian-Wen Shi Jun Li Zhihui Li Xin Ji dandan Ma Yonghong Cheng Chunming niu State Key Laboratory of Electrical Insulation and Power Equipment Center of Nanomaterials for Renewable EnergySchool of Electrical EngineeringXi’an Jiaotong UniversityXi’an710049China Key Laboratory of Electronic Ceramics and Devices of Ministry of Education Department of Electronics and InformationXi’an Jiaotong UniversityXi’an710049China

As a kind of white light emitting diode(w-LED)with many advantages,rare-earth-free vanadate phosphor has attracted more and more *** oxygen vacancies and other surface defects in vanadate oxide have obvious effects on its structure and *** order to reveal the specific effects,we heat-treat the original LiCa_(3)Mg(VO_(4))_(3)(LCMV)in an oxygen flow with different time to decrease oxygen vacancies,and find that the lattice distortion of[VO_(4)]tetrahedron caused by oxygen vacancy is effectively ***,the crystallinity of the treated samples increases,the surface defects decreases,and the fluorescence intensity *** variation of photoluminescence quantum yield(PLQY)with oxygen treatment time is as follows:the enhancement effect firstly reaches the strongest(69.34%)within one hour,then begins to decline after two hours,and finally reaches the platform after three hours and remains basically *** reason for the enhancement of PLQY is the decrease of oxygen vacancy after one-hour treatment,and the reason for the decrease of PLQY after a further increased treatment time is that the absorption of oxygen and water in air caused by excessive surface defects introduced by oxygen treatment.

关键词： Phosphor Oxygen vacancy Surface defect Rare-earth-free White light emitting diode

Premature aging of skeletal stem/progenitor cells rather than osteoblasts causes bone loss with decreased mechanosensation

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Bone Research 2023年第3期11卷 560-573页

作者： Ruici Yang dandan Cao Jinlong Suo Lingli Zhang Chunyang Mo Miaomiao Wang Ningning niu Rui Yue Weiguo Zou State Key Laboratory of Cell Biology Shanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China Shenzhen Institute of Synthetic Biology Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Institute for Regenerative Medicine Shanghai East HospitalShanghai Key Laboratory of Signaling and Disease ResearchFrontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China Institute of Microsurgery on Extremities and Department of Orthopedic SurgeryShanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200233China

A distinct population of skeletal stem/progenitor cells(SSPCs)has been identified that is indispensable for the maintenance and remodeling of the adult ***,the cell types that are responsible for age-related bone loss and the characteristic changes in these cells during aging remain to be ***,we established models of premature aging by conditional depletion of Zmpste24(Z24)in mice and found that Prx1-dependent Z24 deletion,but not Osx-dependent Z24 deletion,caused significant bone ***,Acan-associated Z24 depletion caused only trabecular bone ***-cell RNA sequencing(sc RNA-seq)revealed that two populations of SSPCs,one that differentiates into trabecular bone cells and another that differentiates into cortical bone cells,were significantly decreased in Prx1-Cre;Z24^(f/f)*** premature SSPC populations exhibited apoptotic signaling pathway activation and decreased *** exercise reversed the effects of Z24depletion on cellular apoptosis,extracellular matrix expression and bone *** study identified two populations of SSPCs that are responsible for premature aging-related bone *** impairment of mechanosensation in Z24-deficient SSPCs provides new insight into how physical exercise can be used to prevent bone aging.

关键词： sensation progenitor mec

Dehydrozaluzanin C,a novel type of anti-bacterial agent which targets transporting proteins,Opp and OpuC

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Genes & Diseases 2022年第4期9卷 830-832页

作者： Xiangyang Qin Jinmei Xu dandan Yin Fan Feng Xianfei Zeng Bing niu Xingbin Hu Department of Chemistry School of PharmacyFourth Military Medical UniversityXi'anShaanxi 710032PR China Department of Transfusion Medicine Xijing HospitalFourth Military Medical UniversityXi'anShaanxi 710032PR China Department of Hematology Tangdu HospitalFourth Military Medical UniversityXi'anShaanxi 710038PR China Division of Digestive Surgery Xijing Hospital of Digestive DiseasesFourth Military Medical UniversityXianShaanxi 710032PR China School of Medicine Northwest UniversityXi'anShaanxi 710069PR China Xi'an Area Medical Laboratory Center Xi'anShaanxi 710000PR China School of Life Sciences Shanghai UniversityShanghai 200444PR China

To the Editor:The evolution and widespread distribution of antibiotic-resistant elements in bacterial pathogens is eroding our ability to control infections with existing *** aureus(***)and Methicillin-resistant ***(MRSA)have acquired alarming broad-spectrum antibiotic resistance resulting in hospital-and community-associated infections,which has been responsible for significant morbidities and deaths worldwide.1 It is estimated that the number of deaths caused by antibiotic resistance may exceed 10 million per year by 2050.

关键词： agent resistance deaths

迭代重建技术结合不同噪声指数对不同体型肺标本图像质量和剂量的影响

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医学影像学杂志 2020年第7期30卷 1296-1299页

作者：牛丹丹杨晨晓翟艳慧王君鑫张颖颖李莹贾守强山东省济南市人民医院影像科山东济南271100

目的评估迭代重建技术结合不同噪声指数对不同体型肺标本图像质量和辐射剂量的影响。方法肺标本周围用不同体积的生理盐水模拟不同体型。应用GE Revolution CT,扫描条件为管电压120Kvp,自动毫安秒技术,前置0ASIR-V、40%ASIR-V。噪声指数... 详细信息

目的评估迭代重建技术结合不同噪声指数对不同体型肺标本图像质量和辐射剂量的影响。方法肺标本周围用不同体积的生理盐水模拟不同体型。应用GE Revolution CT,扫描条件为管电压120Kvp,自动毫安秒技术,前置0ASIR-V、40%ASIR-V。噪声指数(NI)预设8、10、12。每种NI水平下,根据不同体型将肺标本分成三组,A组(胖肺组)、B组(痩肺组)、C组(正常肺)。扫描后记录并比较每种NI下,每组图像的平均噪声(分别记录上、中、下肺野层面生理盐水的SD,计算平均值)和有效辐射剂量(ED)。采用方差分析和LSD-t统计学方法分析其差异。由两名有经验的影像科医师采用双盲法对每组图像质量进行主观评分,评价标准为4分细支气管显示清楚,噪声小;3分细支气管可显示,边缘毛糙;2分细支气管显示模糊,噪声较大;1分细支气管不能分辨,噪声很大。3分以上为可诊断。结果40%ASIR-V条件下,NI=8,三组图像的SD分别为8.30±0.79、6.57±3.07、7.90±1.32,无统计学差异(P=0.565)。对三种噪声指数水平下的图像质量进行主观评分,两名医师一致性为中等(K=0.727>0.4)。三组图像的主观评分分别为4、4、4,没有差异。三组的ED分别为1.52mSv、0.46mSv、0.58mSv,体型不同,辐射剂量不同,与A组相比,B组、C组的辐射剂量分别降低了69.74%、61.84%。NI=10及NI=12水平下,图像质量及辐射剂量结果与NI=8水平下类似。结论在同一噪声指数下,不同体型的图像质量没有差异,但辐射剂量可根据体型不同有变化,部分人可适当降低辐射剂量。

关键词：肺标本体层摄影术,X线计算机辐射剂量体型噪声指数

China's wetland change (1990-2000) determined by remote sensing

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Science China Earth Sciences 2010年第7期53卷 1036-1042页

作者： Peng Gong ZhenGuo niu Xiao Cheng KuiYi Zhao DeMin Zhou JianHong Guo Lu Liang XiaoFeng Wang dandan Li HuaBing Huang et al. 1. State Key Laboratory of Remote Sensing Science jointly sponsored by Institute of Remote Sensing Applications Chinese Academy of Sciences and Beijing Normal University Beijing 100101 China2. Institute of Northeast Geographical and Agricultural Ecology Research Chinese Academy of Sciences Changchun 130012 China3. Institute of Geographical Science and Resources Research Chinese Academy of Sciences Beijing 100101 China4. Beijing Yushi Lantu Information Technology Ltd. Beijing 100096 China

Two wetland maps for the entire China have been produced based on Landsat data acquired around 1990 and 2000. Wetlands in China have been divided into 3 broad categories with 15 sub-categories except rice fields. In 1990, the total wetland area in China was 355208 km2 whereas in 2000 it dropped to 304849 km2 with a net loss of 50360 km2. During an approximate 10-year period, inland wetland reduced from 318326 to 257922 km2, coastal wetland dropped from 14335 to 12015 km2, while artificial wetland increased from 22546 to 34911 km2. The greatest natural wetland loss occurred in Heilongjiang, Inner Mon- golia, and Jilin with a total loss of over 57000 km2 of wetland. In western China, over 13000 km2 of wetlands were newly formed in Xinjiang, Tibet, and Qinghai. About 12000 km2 of artificial wetlands were also added for fish farm and reservoir constructions. The newly formed wetlands in western China were caused primarily by climate warming over that region whereas the newly created artificial wetlands were caused by economic developments. China’s wetland loss is caused mainly by human activities.

关键词： wetland mapping natural wetland loss artificial wetland increase