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Nano Research 2022年第2期15卷 1587-1592页

作者： Chengyi Hong Lingling Chen Chenyue Wu dan yang Jia-Yong Dai Zhiyong Huang ren Cai Weihong Tan College of Food and Biological Engineering Fujian Provincial Key Laboratory of Food Microbiology and Enzyme EngineeringJimei UniversityXiamen 361021China Molecular Science and Biomedicine Laboratory State Key Laboratory for Chemo/Bio-Sensing and ChemometricsCollege of Chemistry and Chemical EngineeringCollege of Biology College of Material Science and Engineeringand Collaborative Research Center of Molecular Engineering for TheranosticsHunan UniversityChangsha 410082China RMIT University MelbourneVIC 3000Australia Key Laboratory of Musculoskeletal System Degeneration and Regeneration Translational Research of Zhejiang Province Sir Run Run Shaw HospitalMedical College of Zhejiang UniversityHangzhou 310016China

We report a colorimetric method for glucose detection based on Au nanoparticle-decorated WSe_(2)(Au@WSe_(2))hybrid *** hybrid structures are easily synthesized by simply stirring HAuCl_(4) precursor with WSe_(2) nanosheets in aqueous *** to strong synergistic catalytic effects of Au nanoparticles and WSe_(2) nanosheets,the Au@WSe_(2) hybrid nanostructures exhibit enhanced peroxidase-like activity(about 2-fold higher compared to WSe_(2) nanosheets alone)for 3,3',5,5'-tetramethylbenzidine oxidation by H_(2)O_(2).Based on the highly catalytical property,the colorimetric method for glucose detection is established by coupling glucose oxidase(GOx).The detection limit of glucose is 3.66 ***,the proposed colorimetric method is applicable to glucose detection in serum samples and is promising for applications in biomedical fields.

关键词： Hybrid nanomaterials peroxidase-like activity two-dimensional nanomaterials glucose detection

Dual-Prior Integrated Image Reconstruction for Quanta Image Sensors Using Multi-Agent Consensus Equilibrium

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IEEE/CAA Journal of Automatica Sinica 2023年第6期10卷 1407-1420页

作者： dan Zhang Qiusheng Lian Yueming Su Tengfei ren the School of Information Science and Engineering Yanshan Universityand also with Hebei Key Laboratory of Information Transmission and Signal ProcessingYanshan UniversityQinhuangdao 066004China the School of Information Science and Engineering Yanshan UniversityQinhuangdao 066004China.She is now with the School of InformationBeijing Wuzi UniversityBeijing 101149China

Quanta image sensors(QIS) are a new type of singlephoton imaging device that can oversample the light field to generate binary bit-streams. The reconstruction for QIS refers to the recovery of original scenes from these binary *** reconstruction algorithms for QIS generally depend solely on one instantiated prior and are certainly insufficient for capturing the statistical properties over high-dimensional *** the other hand, deep learning-based methods have shown promising performance, due to their excellent ability to learn feature representations from relevant databases. However, most deep models only focus on exploring local features while generally overlooking long-range similarity. In view of this, a dual-prior integrated reconstruction algorithm for QIS(DPI-QIS) is proposed, which combines a deep prior with a non-local self-similarity one using the multi-agent consensus equilibrium(MACE)framework. In comparison to the approaches that utilize a single prior, DPI-QIS fits the reconstruction model sufficiently by leveraging the respective merits of both priors. An effective yet flexible MACE framework is employed to integrate the physical forward model allying with the two prior-based models to achieve an overall better result. Extensive experiments demonstrate that the proposed algorithm achieves state-of-the-art performance in terms of objective and visual perception at multiple oversampling factors, while having stronger robustness to noise.

关键词： utilize looking similarity

Understanding the intrinsic synergistic mechanism between Pt-O-Ti interface sites and TiO_(2) surface sites of Pt/TiO_(2) catalysts in Fenton-like reaction

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Science China Chemistry 2022年第12期65卷 2596-2603页

作者： Yawen Ma Huibin Ge Siwen Yi Man yang dan Feng Yujing ren Jie Gao Yong Qin Interdisciplinary Research Center of Biology&Catalysis School of Life SciencesNorthwestern Polytechnical UniversityXi’an710072China School of Materials Science and Engineering Xi’an University of TechnologyXi’an710048China Analytical&Testing Center Northwestern Polytechnical UniversityXi’an710072China State Key Laboratory of Coal Conversion Institute of Coal ChemistryChinese Academy of SciencesTaiyuan030001China

Identifying the active site of oxide-supported metal catalysts and revealing the intrinsic synergistic mechanism between metal and oxide support remain a large ***,we report the identification and separation of the Pt-O-Ti interface and TiO_(2) surface in Pt-TiO_(2)-based catalysts by depositing different thickness of TiO_(2) shell with∼0.4-nm micropores onto the surface of Pt/TiO_(2) catalyst through atomic layer deposition(ALD).In the oxidation of 3,3′,5,5′-tetramethylbenzidine(TMB)by hydrogen peroxide(H_(2)O_(2))process,the TiO_(2) microporous shells can prevent the contact between TMB and embedded Pt clusters,but not delay the diffusion of H_(2)O_(2).The heterolysis of H_(2)O_(2) to ·OH occurs on the Pt-O-Ti interface,and the generated•OH migrates to the TiO_(2) surface to supplement the surface lattice oxygen,which sequentially oxidizes TMB to *** the synergistic effect between Pt-O-Ti interface active sties and TiO_(2) surface active sites can significantly improve the catalytic *** study provides a guide for the understanding of the intrinsic synergistic mechanism between the metal and oxide support in the metal-oxide catalysts.

关键词： Intrinsic synergistic mechanism Pt-O-Ti interface site TiO_(2)surface site Fenton-like reaction metal-oxide catalyst

Dysfunction of autophagy as the pathological mechanism of motor neuron disease based on a patient-specific disease model

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Neuroscience Bulletin 2015年第4期31卷 445-451页

作者： dan-Jing yang Liang Zhu Jie ren Rong-Jie Ma Hongwen Zhu Jun Xu Advanced Institute of Translational Medicine Tongji University East Hospital Tongji University School of Medicine Tianjin Hospital Tianjin Academy of Integrative Medicine

Autophagy is the main catabolic pathway in cells for the degradation of impaired proteins and organelles. Accumulating evidence supports the hypothesis that dysfunction of autophagy, leading to an imbalance of proteostasis and the accumulation of toxic proteins in neurons, is a central player in the pathogenesis of neurodegenerative diseases such as Alzheimer＇s disease, Parkinson＇s disease, and amyotrophic lateral sclerosis （ALS）. The clinical pathology of ALS is complex and many genes associated with autophagy and RNA processing are mutated in patients with the familial form. But a causal relationship between autophagic dysfunction and ALS has not been fully established. More importantly, studies on the pathological mechanism of ALS are mainly based on animal models that may not precisely recapitulate the disease itself in human beings. The development of human iPSC techniques allows us to address these issues directly in human cell models that may profoundly influence drug discovery for ALS.

关键词： motor neuron disease iPSC autophagy amyotrophic lateral sclerosis spinal muscular atrophy

Network pharmacology and molecular docking identify mechanisms of medicinal plant-derived 1,2,3,4,6-penta-O-galloyl-beta-D-glucose treating gastric cancer

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BIOCELL 2023年第5期47卷 977-989页

作者： MAN ren YUAN yang dan LI NANNAN ZHAO YUPING WANG YONGNING ZHOU The First Clinical Medical College Lanzhou UniversityLanzhou730000China Gansu Key Laboratory of Gastroenterology Lanzhou UniversityLanzhou730000China Department of Geriatrics Gerontology The First Hospital of Lanzhou UniversityLanzhou730000China Office of National Drug Clinical Trial Institutions The First Hospital of Lanzhou UniversityLanzhou730000China School of Pharmacy Lanzhou UniversityLanzhou730000China Department of Gastroenterology The First Hospital of Lanzhou UniversityLanzhou730000China

Background:1,2,3,4,6-penta-O-galloyl-beta-D-glucose(PGG)is a natural polyphenolic compound derived from multiple medicinal plants with favorable anticancer ***:In this study,the mechanisms of PGG against gastric cancer were explored through network pharmacology and molecular ***,the targets of PGG were searched in the Herbal Ingredients’Targets(HIT),Similarity Ensemble Approach(SEA),and Super-PRED *** potential targets related to gastric cancer were predicted from the Human Gene Database(GeneCards)and DisGeNET *** intersecting targets of PGG and gastric cancer were obtained by Venn diagram and then subjected to protein-protein interaction analysis to screen hub *** and pathway enrichment of hub targets were analyzed through Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway *** differential expression and survival analysis of hub targets in gastric cancer were performed based on The Cancer Genome Atlas ***,the affinity of PGG with hub targets was visualized by molecular ***:Three hub targets were screened,including mitogen-activated protein kinase 14(MAPK14),BCL2 like 1(BCL2L1),and vascular endothelial growth factor A(VEGFA).MAPK14 had a higher expression,while BCL2L1 and VEGFA had lower expression in gastric cancer than in normal *** analysis indicated enrichment of these hub targets in MAPK,neurotrophin,programmed death-ligand 1(PD-L1)checkpoint,phosphatidylinositol 3-kinases/protein kinase B(PI3K-Akt),Ras,and hypoxia-inducible factor-1(HIF-1)signaling ***:Therefore,network pharmacology and molecular docking analyses revealed that PGG exerts a therapeutic efficacy on gastric cancer by multiple targets(MAPK14,BCL2L1,and VEGFA)and pathways(MAPK,PD-L1 checkpoint,PI3K-Akt,Ras,and HIF-1 pathways).

关键词： 1,2,3,4,6-penta-O-galloyl-beta-D-glucose Gastric cancer Network pharmacology Molecular docking MAPK14 BCL2L1 VEGFA

A new method for concentration analysis of bacterial endotoxins in perfluorocarbon

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Frontiers of Materials Science 2014年第4期8卷 399-402页

作者： dan-dan CHEN Xiao-Ming FENG Chun-ren WANG Qing-Quan HUANG Zhao-Peng yang Qing-Yuan MENG National Institutes for Food and Druq Control Beijing 100050 China School of Materials Science and Engineering Tsinghua University Beijing 100084 China

This communication demonstrates the feasibility of the gel-clot method for the analysis of bacterial endotoxins in water extracts of perfluorocarbon which is a water insoluble liquid medical device. Perfluorocarbon （10 mL） was shaken with 10 mL water for 15 min at 2000 r/min and the endotoxin present was extracted to the aqueous phase without interference inhibition/enhancement of the product and the recovery of endotoxin added to perfluorocarbon was determined, A validation study confirmed that endotoxins presented in perfluorocarbon pass over into the aqueous phase at concentrations of 20, 10 and 5EU/mL with recoveries from 86.8% to 96.8%. Therefore, the gel-clot test is suitable for detecting bacterial endotoxins in perfluorocarbon which is a water insoluble medical device.

关键词： perfluorocarbon bacterial endotoxin endotoxin recovery

Numerical studies on supersonic spray combustion in high-temperature shear flows in a scramjet combustor

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Chinese Journal of Aeronautics 2018年第9期31卷 1870-1879页

作者： Zhaoxin ren Bing WANG Longxi ZHENG dan ZHAO School of Power and Energy Northwestern Polytechnical University Xi'an 710072 China School of Aerospace Engineering Tsinghua University Beijing 100084 China Department of Mechanical Engineering College of Engineering University of Canterbury Private Bag 4800 Christchureh 8140New Zealand

Numerical simulation is applied to detail the combustion characteristics of n-decane sprays in highly compressible vortices formed in a supersonic mixing layer. The multi-phase reacting flow is modeled, in which the shear flow is solved Eulerianly by means of direct numerical simulation, and the motions of individual sub-grid point-mass fuel droplets are tracked *** combustion behaviors are studied under different ambient pressures. Results indicate that ignition kernels are formed at high-strain vortex braids, where the scalar dissipation rates are *** flame kernels are then strongly strained, associated with the rotation of the shearing vortex, and propagate to envelop the local vortex. It is observed that the flammable mixtures entrained in the vortex are burned from the edge to the core of the vortex until the reactants are completely consumed. As the ambient pressure increases, the high-temperature region expands so that the behaviors of spray flames are strongly changed. An overall analysis of the combustion field indicates that the time-averaged temperature increases, and the fluctuating pressure decreases, resulting in a more stable spray combustion under higher pressures, primarily due to the acceleration of the chemical reaction.

关键词： Combustion Flame kernel Mixing layer Numerical simulation Shearing vortex Spray flame Supersonic flow

Insights into the effect of substrate adsorption behavior over hemelike Fe_(1)/AC single-atom catalyst

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Nano Research 2022年第7期15卷 5970-5976页

作者： Jianglin Duan Yanan Zhou Yujing ren dan Feng Jinlong Shang Huibin Ge Jie Gao Jinlong yang Yong Qin Interdisciplinary Research Center of Biology&Catalysis School of Life SciencesNorthwestern Polytechnical UniversityXi’an 710072China Hefei National Laboratory for Physical Sciences at the Microscale University of Science and Technology of ChinaHefei 230026China Analytical&Testing Center Northwestern Polytechnical UniversityXi’an 710072China State Key Laboratory of Coal Conversion Institute of Coal ChemistryChinese Academy of SciencesTaiyuan 030001China

Unraveling the substrate adsorption structure–performance relationship is pivotal for heterogeneous carbon supported metal single-atom catalysts(M_(1)/C SACs).However,due to the complexity of the functional groups on carbon material surface,it is still a great ***,inspired by structure of enzymes,we used activated carbon(AC),which has adjustable surface oxygen functional groups(OFGs),supported atomically dispersed Fe-N_(4) sites as heme-like *** based on a combination of scanning transmission electron microscopy(STEM),X-ray photoelectron spectroscopy(XPS),X-ray absorption spectroscopy(XAS),Mössbauer spectroscopy,Fourier transform infrared(FT-IR)characterizations,kinetics experiments and density functional theory(DFT)calculations,we revealed the effect of substrate adsorption behavior on AC support surface,that is,with the increase of carboxyl group in OFGs,the adsorbed 3,3',5,5'-tetramethylbenzidine(TMB)molecular increased,and consequently the substrate enriched on AC *** carboxyl group as well as Fe-N_(4) active sites synergistically realized high-efficiency peroxidase-like activity,just like the *** work suggests that simultaneously constructing metal single-atom active sites and specific functional groups on carbon support surface may open an avenue for engineering metal-support synergistic catalysis in M_(1)/C SACs,which can further improve catalytic performance.

关键词： single-atom catalysts heme-like carboxyl group substrate adsorption behavior peroxidase-like activity

Effects of sepsis and its treatment measures on intestinal flora structure in critical care patients

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World Journal of Gastroenterology 2021年第19期27卷 2376-2393页

作者： Xiao-Juan yang dan Liu Hong-Yan ren Xiao-Ya Zhang Jun Zhang Xiao-Jun yang Department of Critical Care Medicine General Hospital of Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Department of Critical Care Medicine Taihe HospitalHubei University of MedicineShiyan 442000Hubei ProvinceChina Shanghai Mobio Biomedical Technology Co. Shanghai 201318China

BACKGROUND Sepsis is a common disease in intensive care units,with high morbidity and *** microecology plays a vital part in the development and progression of this disease,possibly because sepsis and its treatment cause specific changes in the composition of the intestinal *** To investigate the characteristics of intestinal flora disturbance in sepsis patients treated with *** In this prospective comparative study,we enrolled ten patients with sepsis(sepsis group),hospitalized in the Department of Critical Care Medicine of the General Hospital,Ningxia Medical University,China(a class IIIa general hospital)from February 2017 to June 2017;ten patients without sepsis hospitalized in the same period(non-sepsis group)and ten healthy individuals(control group)were also *** samples collected from the three groups were subjected to 16S rRNA gene sequencing and the intestinal flora diversity,structure,and composition were ***,the dynamics of the intestinal flora diversity,structure,and composition in sepsis patients were investigated via 16S rRNA gene sequencing of samples collected 0 d,3 d,and 7 d after admittance to the intensive care *** between the serum levels of procalcitonin,endotoxin,diamine oxidase,and D-lactic acid and the intestinal flora composition of sepsis patients were also *** Compared with the healthy control group,sepsis and non-sepsis patients showed reduced intestinal floraα-diversity and a distinct flora structure,with Firmicutes as the dominant phylum,and significantly decreased proportions of Bacteroidetes,as well as Prevotella and Lachnospira,among other *** note,the proportion of Enterococcus was significantly increased in the intestinal tract of sepsis ***,theα-diversity in the sepsis group decreased gradually,from days 1 to 7 of ***,pairwise comparisons showed that both the diversity and structure of the int

关键词： Sepsis Intestinal flora 16S rRNA gene sequencing Dynamic changes Intestinal barrier index Procalcitonin

Melting and floating processes of inorganic materials in molten steel:Visualization physical simulation and mathematical modelling

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China Foundry 2023年第2期20卷 89-98页

作者： Jin-hu Lai Sheng Yu yang-jian Xu dan-qing Jiang San-san Shuai Jiang Wang Zhong-ming ren State Key Laboratory of Advanced Special Steel School of Materials Science and EngineeringShanghai UniversityShanghai 200444China Shaoxing Institute of Technology Shanghai UniversityShaoxing 312000ZhejiangChina

It has been demonstrated that heat absorption method by using the inorganic material rod to cool the molten steel can significantly reduce the macrosegregation level of the large steel ***,owing to the opacity of the molten steel,the physical mechanism of the heat absorption method is not *** this work,a transparent hydraulic physical model with water and paraffin wax was built to simulate the melting and floating processes of inorganic materials in the molten steel.A mathematical simulation was also carried out to analyze the connection between the actual ingot and the physical *** show that it is feasible to simulate the molten steel and inorganic materials with water and paraffin *** the help of the physical model,the process of the melting of paraffin wax and its floating to the surface of water were clearly observed,during which the temperature of water at some characteristic positions in the mold was *** visualization findings demonstrate that the melting and floating processes of paraffin wax can help to bring the heat from the center of the mold to the top surface more quickly,which reduces the superheat and significantly accelerates the cooling rate of *** experimental results show that for the water with a certain superheat,the use of a larger mass of paraffin wax can accelerate the cooling of the water,but there is a risk of incomplete melting of the paraffin wax.A higher superheat of water will lead to a quicker melting rate for a given mass of paraffin wax,while a lower superheat leads to the incomplete melting of paraffin wax as well.

关键词： water and paraffin wax heat absorption method physical simulation superheat large steel ingot