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TRAF7 negatively regulates the RLR signaling pathway by facilitating the K48-linked ubiquitination of TBK1

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Virologica Sinica 2023年第3期38卷 419-428页

作者： Jing-Ping Huang Ya-Xian Yang Tian Chen dan-dan wang Jing Li Liang-Guo Xu College of Life Science Jiangxi Normal UniversityNanchang330022China

TANK-binding kinase 1(TBK1)is a nodal protein involved in multiple signal transduction *** RNA virus-mediated innate immunity,TBK1 is recruited to the prion-like platform formed by MAVS and subsequently activates the transcription factors IRF3/7 and NF-κB to produce type I interferon(IFN)and proinflammatory cytokines for the signaling *** this study,TRAF7 was identified as a negative regulator of innate immune ***7 interacts with TBK1 and promotes K48-linked polyubiquitination and degradation of TBK1 through its RING domain,impairing the activation of IRF3 and the production of IFN-β.In addition,we found that the conserved cysteine residues at position 131 of TRAF7 are necessary for its function toward *** of TRAF7 could facilitate the activation of IRF3 and increase the transcript levels of downstream antiviral *** data suggest that TRAF7 negatively regulates innate antiviral immunity by promoting the K48-linked ubiquitination of TBK1.

关键词： TANK-Binding kinase 1(TBK1) Type I interferon TRAF7 Ubiquitination Innate immunity

Reconstructing the temporal evolution of the speed of light in a flat FRW Universe

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Research in Astronomy and Astrophysics 2019年第10期19卷 138-144页

作者： dan-dan wang Han-Yu Zhang Jing-Lan Zheng Yu-Ting wang Gong-Bo Zhao National Astronomical Observatories Chinese Academy of Sciences Beijing 100101 China University of Chinese Academy of Sciences Beijing 100049 China Department of Physics Kansas State University116 Cardwell HallManhattanKS 66506USA School of Astronomy and Space Science University of Chinese Academy of Sciences Beijing 100049 China Institute of Cosmology and Gravitation University of Portsmouth Portsmouth POl 3FX UK

We present a novel method to reconstruct the temporal evolution of the speed of light c(z) in a flat Friedmann-Robertson-Walker(FRW) Universe using astronomical observations. After validating our pipeline with mock datasets, we apply our method to the latest baryon acoustic oscillations(BAO) and supernovae observations, and reconstruct c(z) in the redshift range of z ∈[0, 1.5]. We find no evidence of a varying speed of light, although we see some interesting features of △c(z), the fractional difference between c(z) and c0(the speed of light in the International System of Units), e.g.,△c(z) 0 at 0.2≤z≤0.5 and 0.8≤z≤1.3, respectively, although the significance of these features is currently far below statistical importance.

关键词： cosmology-dark energy-large scale structure

Study on the Interferation of the Concentration of Free Calcium in Peripheral Human Lymphocyte by Low Dose Penicillin, Using Fura-2 as Fluorescent Probe

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Chinese Chemical Letters 2006年第5期17卷 665-666页

作者： Hai Yan wang dan dan wang Chun Gui ZHAO Ye Hong ZHOU Shao Min SHUANG Chuan DONG School of Chemistry and Chemical Engineering Shanxi University Taiyuan 030006 Medical College of Datong University Datong 037000

The effect of penicillin on the human peripheral lymphocytes was studied by steady fluorescent technique and ratiometric fluorescence dye, Fura-2, The change of the free calcium concentration in cytosol was examined under different conditions. A characterization of Fura-2-Ca interaction in an isotonic saline solution showed that Ca^2＋ formed a 1：1 Fura-2-Ca complex with the apparent dissociation constant 1.81×10^-7 mol/L. The mechanism, by which penicillin induced the decrease of [Ca^2＋]i , was discussed in detail. The low dose of penicillin might modify the lymphocytes＇ immunology response by interfering the increase in the intracellular free calcium concentration.

关键词： Penicillin lymphocytes Fura-2 Ca^2+ ouabain.

Study on the effects of cefotaxime on intracellular Ca^(2+) in human peripheral lymphocytes by fluoremetry

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Chinese Chemical Letters 2007年第4期18卷 424-426页

作者： dan dan wang Hai Yan wang Ye Hong Zhou Chun Gui Zhao Chuan Dong Shao Min Shuang School of Chemistry and Chemical Engineering Shanxi University Taiyuan 030006 China Medical College of Shanxi Datong University Datong 037000 China

Characteristic of Fura-2-Ca^2＋ interaction was studied based on the fluorescence technique. The apparent dissociation constants （Kd） of the Fura-2-Ca^2＋ complex were determined at different temperature. The effect of cefotaxime （CEFA） on intracellular Ca^2＋ concentration （[Ca^2＋]i） was discussed by using a ratiometric fluorescence dye Fura-2 as a probe. The basal [Ca^2＋]i in resting human peripheral lymphocytes was 100 4- 7 nmol/L but after treatment with cefotaxime, the changes of [Ca^2＋]i were observed in different conditions. In the concentration range of 1-30 μmol/L of cefotaxime [Ca^2＋]i increased, as a result of releasing intracellular Ca^2＋ stores. Higher concentration of cefotaxime （50-500 μmol/L） stimulated to decrease of [Ca^2＋]i.

关键词： Fura-2 Lymphocytes Cefotaxime [Ca^2+]i

Fabrication and properties of silver-based composites reinforced with carbon-coated Ti_(3)AlC_(2)

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International Journal of Minerals,Metallurgy and Materials 2021年第11期28卷 1836-1843页

作者： Yong-fa Zhu Wu-bian Tian dan-dan wang Heng Zhang Jian-xiang Ding Pei-gen Zhang Zheng-ming Sun Jiangsu Key Laboratory of Advanced Metallic Materials School of Materials Science and EngineeringSoutheast UniversityNanjing 211189China Key Laboratory of Metallurgical Emission Reduction&Resources Recycling Ministry of EducationSchool of Materials Science and EngineeringAnhui University of TechnologyMa’anshan 243002China

Ti_(3)AlC_(2)-reinforced Ag-based composites,which are used as sliding current collectors,electrical contacts,and electrode materials,exhibit remarkable ***,the interfacial reactions between Ag and Ti_(3)AlC_(2) significantly degrade the electrical and thermal properties of these *** diminish these interfacial reactions,we fabricated carbon-coated Ti_(3)AlC_(2) particles(C@Ti_(3)AlC_(2))as reinforcement and prepared Ag–10wt%C@Ti_(3)AlC_(2) composites with carbon-layer thicknesses ranging from 50–200 *** with the uncoated Ag–Ti_(3)AlC_(2) composite,Ag–C@Ti_(3)AlC_(2) was found to have a better distribution of Ti_(3)AlC_(2) *** increases in the carbon-layer thickness,the Vickers hardness value and relative density of Ag–C@Ti_(3)AlC_(2) gradually *** a carbon-layer thickness of 150 nm,we obtained the lowest resistivity of Ag–C@Ti_(3)AlC_(2) of 29.4135.5×10^(−9)Ω·m,which is half that of Ag–Ti_(3)AlC_(2)(66.7×10^(−9)Ω·m).The thermal conductivity of Ag–C@Ti_(3)AlC_(2) reached a maximum value of 135.5 W·m^(−1)·K^(−1) with a 200-nm carbon coating(~1.8 times that of Ag–Ti_(3)AlC_(2)).These results indicate that the carbon-coating method is a feasible strategy for improving the performance of Ag–C@Ti_(3)AlC_(2) composites.

关键词： silver-based composite titanium aluminum carbide carbon coating interfacial reaction properties

Determination of triazine herbicide residues in water samples by on-line sweeping concentration in micellar electrokinetic chromatography

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Chinese Chemical Letters 2008年第12期19卷 1487-1490页

作者： Shuai Hua Zhang Yuan Yuan Yang dan dan Han Chun wang Xin Zhou Xiao Huan Zang Zhi wang Key Laboratory of Bioinorganic Chemistry College of Sciences Agricultural University of Hebei Baoding 071001 China

A new method for the determination of atrazine, simazine and prometryn in water samples by on-line sweeping concentration technique in micellar electrokinetic chromatography （MEKC） was developed. Various parameters affecting sample enrichment and separation efficiency were systematically studied. Compared with the conventional MEKC method, up to 60-200-fold improvement in concentration sensitivity was achieved in terms of peak height by using this sweeping injection technique. The compound strychnine was used as the internal standard for the improvement of the experimental reproducibility. The limits of detection （S/ N = 3：1） for atrazine, simazine and prometryn were 9, 10 and 0.5 ng mL-1, respectively. This method has been successfully applied to the analysis of atrazine, simazine and prometryn in lake, steam and ground water.

关键词： Triazine herbicides On-line concentration MEKC Sweeping Water samples

Salidroside attenuates oxygen and glucose deprivation-induced neuronal injury by inhibiting ferroptosis

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Asian Pacific Journal of Tropical Biomedicine 2023年第2期13卷 70-79页

作者： Ying-Zhi Li Ai-Ping Wu dan-dan wang Pan-Pan Yang Bin Sheng Department of Rehabilitation Medicine Zhejiang HospitalHangzhou 310007ZhejiangChina Department of Emergency Medicine Zhejiang Provincial People’s HospitalHangzhou 310014ZhejiangChina

Objective: To evaluate the effect of salidroside on oxygen and glucose deprivation(OGD)-treated NT2 cells and its underlying mechanisms of ***: Retinoic acid was used to induce the differentiation of NT2 cells into neurons. The effects of salidroside on survival, apoptosis, inflammatory response, and oxidative stress of neurons undergoing OGD were evaluated. Using precursor cells as controls, the effect of salidroside on the differentiation progression of OGDtreated cells was evaluated. In addition, the effect of erastin, a ferroptosis inducer, on NT2 cells was examined to investigate the underlying mechanisms of neuroprotective action of ***: Salidroside alleviated the effects of OGD on neuronal survival, apoptosis, inflammation, and oxidative stress, and promoted NT2 cell differentiation. Moreover, salidroside prevented ferroptosis of OGD-treated cells, which was abolished following erastin treatment, indicating that ferroptosis mediated the regulatory pathway of ***: Salidroside attenuates OGD-induced neuronal injury by inhibiting ferroptosis and promotes neuronal differentiation.

关键词： Salidroside Rhodiola rosea Ferroptosis Oxygen and glucose deprivation Neuronal differentiation Ischemic stroke

Hemophagocytic lymphohistiocytosis with jaundice as first manifestation:A case report

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World Journal of Clinical Cases 2023年第34期11卷 8212-8218页

作者： dan-dan wang Sheng Wu Bing-Bing Kong Lin-Lin Song Department of Emergency Medicine Beijing Tsinghua Changgung HospitalMedical CenterTsinghua UniversityBeijing 102218China

BACKGROUND Hemophagocytic lymphohistiocytosis(HLH)is a rare but life-threatening *** is an immune-mediated disease that has a wide range of causes,elicits a hyperinflammatory response,and results in multiple organ *** presentations vary,and in some cases,jaundice occurs as the first *** SUMMARY We report the case of a 71-year-old female patient who presented with *** was admitted to our hospital because of the occurrence of“jaundice for half a month”,and upon examination,obstructive jaundice with choledocholithiasis and gallstones was *** and choledocholithotomy were ***,the jaundice did not improve after *** found splenomegaly,cytopenia,hypertriglyceridemia,hypofibrinogenemia,and elevated *** marrow biopsy revealed ***,cardiac arrest occurred when she returned 3 wk after the *** considered that HLH was triggered by septic *** patient’s condition deteriorated rapidly,with multiple organ dysfunction and severe gastrointestinal *** therapy and symptomatic treatment failed to save her *** Jaundice rarely presents as the first symptom in HLH *** HLH in this case was triggered by septic shock with jaundice as the first *** should try hard to reduce missed diagnoses and misdiagnoses.

关键词： Hemophagocytic lymphohistiocytosis Jaundice Common bile duct stones Bile duct obstruction Septic shock Case report

Challenges and Opportunities in Preserving Key Structural Features of 3D-Printed Metal/Covalent Organic Framework

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Nano-Micro Letters 2024年第8期16卷 362-381页

作者： Ximeng Liu dan Zhao John wang Department of Materials Science and Engineering National University of SingaporeSingapore 117574Singapore Department of Chemical and Biomolecular Engineering National University of SingaporeSingapore 117585Singapore National University of Singapore(Chongqing)Research Institute Chongqing 401123People’s Republic of China

Metal-organic framework(MOF)and covalent organic framework(COF)are a huge group of advanced porous materials exhibiting attractive and tunable microstructural features,such as large surface area,tunable pore size,and functional surfaces,which have significant values in various application *** emerging 3D printing technology further provides MOF and COFs(M/COFs)with higher designability of their macrostructure and demonstrates large achievements in their performance by shaping them into advanced 3D ***,the currently available 3D printing M/COFs strategy faces a major challenge of severe destruction of M/COFs’microstructural features,both during and after 3D *** is envisioned that preserving the microstructure of M/COFs in the 3D-printed monolith will bring a great improvement to the related *** this overview,the 3D-printed M/COFs are categorized into M/COF-mixed monoliths and M/COF-covered *** differences in the properties,applications,and current research states are *** up-to-date advancements in paste/scaffold composition and printing/covering methods to preserve the superior M/COF microstructure during 3D printing are further discussed for the two types of 3D-printed M/*** the analysis of the current states of 3D-printed M/COFs,the expected future research direction to achieve a highly preserved microstructure in the 3D monolith is proposed.

关键词： Metal-organic frameworks Covalent organic frameworks 3D printing Microstructure Monolith