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Tensile reliability analysis for gravity dam foundation surface based on FEM and response surface method

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Water Science and Engineering 2010年第2期3卷 233-240页

作者： Tong-chun li dan-dan li Zhi-qiang WANG College of Water Conservancy and Hydropower Engineering Hohai University Nanjing 210098 P. R. China

In this study, the limit state equation for tensile reliability analysis of the foundation surface of a gravity dam was established. The possible crack length was set as the action effect and allowable crack length was set as the resistance in the limit state. The nonlinear FEM was used to obtain the crack length of the foundation surface of the gravity dam, and the linear response surface method based on the orthogonal test design method was used to calculate the reliability, providing a reasonable and simple method for calculating the reliability of the serviceability limit state. The Longtan RCC gravity dam was chosen as an example. An orthogonal test, including eleven factors and two levels, was conducted, and the tensile reliability was calculated. The analysis shows that this method is reasonable.

关键词： tensile reliability foundation surface of gravity dam nonlinear FEM," response surface method," Longtan RCC gravity dam

Challenges and exploration for immunotherapies targeting cold colorectal cancer

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World Journal of Gastrointestinal Oncology 2023年第1期15卷 55-68页

作者： dan-dan li Yuan-ling Tang Xin Wang Department of Abdominal Oncology/Radiation Oncology Cancer CenterWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

In recent years,immune checkpoint inhibitors(ICIs)have made significant breakthroughs in the treatment of various tumors,greatly improving clinical *** the fifth most common antitumor treatment strategy for patients with solid tumors after surgery,chemotherapy,radiotherapy and targeted therapy,the therapeutic response to ICIs largely depends on the number and spatial distribution of effector T cells that can effectively identify and kill tumor cells,features that are also important when distinguishing malignant tumors from“cold tumors”or“hot tumors”.At present,only a small proportion of colorectal cancer(CRC)patients with deficient mismatch repair(dMMR)or who are microsatellite instability-high(MSI-H)can benefit from ICI treatments because these patients have the characteristics of a“hot tumor”,with a high tumor mutational burden(TMB)and massive immune cell infiltration,making the tumor more easily recognized by the immune *** contrast,a majority of CRC patients with proficient MMR(pMMR)or who are microsatellite stable(MSS)have a low TMB,lack immune cell infiltration,and have almost no response to immune monotherapy;thus,these tumors are“cold”.The greatest challenge today is how to improve the immunotherapy response of“cold tumor”*** the development of clinical research,immunotherapies combined with other treatment strategies(such as targeted therapy,chemotherapy,and radiotherapy)have now become potentially effective clinical strategies and research ***,the question of how to promote the transformation of“cold tumors”to“hot tumors”and break through the bottleneck of immunotherapy for cold tumors in CRC patients urgently requires *** by developing an in-depth understanding of the immunotherapy mechanisms of cold CRCs can we screen out the immunotherapy-dominant groups and explore the most suitable treatment options for individuals to improve therapeutic efficacy.

关键词： Colorectal cancer Immune checkpoint inhibitors Cold tumors Immunotherapy mechanism Combination therapy Effector T cells

Arabidopsis shaker pollen inward K^+ channel SPIK functions in SnRK1 complex-regulated pollen hydration on the stigma

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Journal of Integrative Plant Biology 2017年第9期59卷 604-611页

作者： dan-dan li Huan Guan Fei li Chang-Zhen liu Yu-Xiu Dong Xian-Sheng Zhang Xin-qi Gao State Key Laboratory of Crop Biology College of Life SciencesShandong Agricultural UniversityTai'an 271018China

Pollen hydration is a critical step that determines pollen germination on the stigma. KINγ is a plantspecific subunit of the SNF-1-related protein kinase 1 complex （SnRK1 complex）. In pollen of the Arabidopsis kinβγ mutant, the levels of reactive oxygen species were decreased which lead to compromised hydration of the mutant pollen on the stigma. In this study, we analyzed gene expression in kinβγ mutant pollen by RNA-seq and found the expression of inward shaker K^＋ channel SPIK was down-regulated in the kinβγ /pollen. Furthermore, we showed that the pollen hydration of the Arabidopsis spik mutant was defective on the wild-type stigma, althoughthe mutant pollen demonstrated normal hydration in vitro. Additionally, the defective hydration of spik mutant pollen could not be rescued by the wild-type pollen on the stigma, indicating that the spik mutation deprived the capability of pollen absorption on the stigma. Our results suggest that the Arabidopsis SnRK1 complex regulates SPIK expression, which functions in determining pollen hydration on the stigma.

关键词： Arabidopsis shaker pollen inward K channel SPIK functions in SnRK1 complex-regulated pollen hydration on the stigma

Resistance to targeted therapy in metastatic colorectal cancer:Current status and new developments

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World Journal of Gastroenterology 2023年第6期29卷 926-948页

作者： Yuan-ling Tang dan-dan li Jia-Yu Duan Lei-Ming Sheng Xin Wang Department of Radiation Oncology Cancer CenterWest China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Abdominal Cancer Cancer CenterWest China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina

Colorectal cancer(CRC)is one of the most lethal and common malignancies in the *** has been the conventional treatment for metastatic CRC(mCRC)***,the effects of chemotherapy have been *** the advent of targeted therapy,the survival of patients with CRC have been *** the past 20 years,targeted therapy for CRC has achieved substantial ***,targeted therapy has the same challenge of drug resistance as ***,exploring the resistance mechanism and finding strategies to address the resistance to targeted therapy,along with searching for novel effective regimens,is a constant challenge in the mCRC treatment,and it is also a hot research *** this review,we focus on the current status on resistance to existing targeted therapies in mCRC and discuss future developments.

关键词： Colorectal cancer Targeted treatment Resistance New development

Retroperitoneal parasitic fetus: A case report

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World Journal of Clinical Cases 2021年第36期9卷 11482-11486页

作者： Bin Xia dan-dan li Hua-Xing Wei Xuan-Xuan Zhang Ru-Mei li Jian Chen Department of Ultrasonography The Fourth Affiliated Hospital of Zhejiang University School of MedicineYiwu 322000Zhejiang ProvinceChina Department of Cardiothoracic Surgery The Fourth Affiliated Hospital of Zhejiang University School of MedicineYiwu 322000Zhejiang ProvinceChina

BACKGROUND Fetus-in-fetu(FIF)is an extremely rare congenital abnormal mass,in which a normal fetus’s vertebral axis frequently connected with malformed fetus around this ***,we report the case of a male infant aged 26 d presenting with retroperitoneal parasitic *** SUMMARY In a prenatal examination,we first detected an abdominal mass measuring 7.8 cm×5.1 cm×6.8 cm in a mother’s abdomen at 25 gestational weeks and teratoma was *** the fetal was born,we did a magnetic resonance imaging(MRI)and ultrasonography on him and saw a distinctive limb with *** to the result of MRI,ultrasonography and postoperative pathology,he finally was diagnosed with *** A laparotomy was performed at 26 d of age with excision of the retroperitoneal cystic tumor,which measured about 10 cm in *** to the result of imaging and histological test,FIF was confirmed.

关键词： Ultrasound Abdominal mass Teratoma Fetus-in-fetu Case report

Effect of recombinant human endostatin onradiotherapy for esophagus cancer

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Asian Pacific Journal of Tropical Medicine 2016年第1期9卷 84-88页

作者： Gao-Feng liu Hui Chang Bao-Tian li Yong Zhang dan-dan li Yan liu Yang Yang Department of Thoracic Surgery No.153 Hospital of Liberation Army Department of Cardiothoracic Surgery Xiangya Hospital Central-South University

Objective:To investigate the effect of radiotherapy plus recombinant human endostatin（RHendostatin） on esophageal cancer and its ***:A total of SO nudemice were equally randomized into control group,radiotherapy group,and combined therapy group Ⅰ,Ⅱ,and Ⅲ after inoculating with Ecal09 cell suspension（1×107 cells/mL）.On the day of grouping,control group and radiotherapy group were injected normal saline,while radiotherapy group and 3 combined therapy groups received radiotherapy;besides,combined therapy group Ⅰ,Ⅱ,and Ⅲ was injected RH-endostatin of 2.5,5,10 mg/kg *** 3-week therapy,the tumors of each group were collected and microvessel density and VEGF expression in tumors were *** vitro,Eca109 cells were divided into control group,radiotherapy group,and combined therapy ***-eight hours after treatment cell cycle distribution and apoptosis rate were detected,and the activity of VEGF signal paths was semiquantitatively ***:Since the 6th day of treatment,the relative tumor proliferation rate of combined therapy group Ⅱ was lower than radiotherapy group（Plized by inhibiting the activity of VEGF related signal paths.

关键词： Esophageal cancer Nudemice Vascular endothelial growth factor Radiotherapy Recombinant human endostatin

Effect of Artificial Cooling Extrusion on Microstructure and Mechanical Properties of Mg–Zn–Y Alloys

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Acta Metallurgica Sinica(English Letters) 2024年第7期37卷 1115-1127页

作者： Qi-Yu liao Da-Zhi Zhao Qi-Chi Le Wen-Xin Hu Yan-Chao Jiang Wei-Yang Zhou liang Ren dan-dan li Zhao-Yang Yin School of Materials Science and Engineering Northeastern UniversityShenyang110819China Key Laboratory of Electromagnetic Processing of Materials Ministry of EducationNortheastern UniversityShenyang110819China Key Laboratory of lightweight Structural Materials Liaoning ProvinceNortheastern UniversityShenyang110819China Baotou Research Institute of Rare Earths Baotou014000China

Microstructure and mechanical properties of Mg–Zn–Y alloys with different Zn/Y atomic ratios with or without artificial cooling (AC) extrusion were systematically investigated in this work. The results show that bimodal microstructure consisting of submicron dynamic recrystallized (DRXed) grains with high fraction of low-angle grain boundaries (LAGBs) and elongated unDRXed grains was formed in Mg_(98.7)Zn_(1)Y_(0.3) alloy with AC extrusion. The AC process effectively limits the growth of precipitated phases, and large amount of nanoscale precipitates were dynamically precipitated during the extrusion process. AC extrusion could effectually refine the lamellar 14H LPSO phases and inhibit the transition from stacking faults to LSPO phases in Mg_(98)Zn_(1)Y_(1) alloy and the narrow LPSO phase in Mg_(98)Zn_(1)Y_(1)-AC alloy which could promote the nucleation of DRXed grains. The AC extrusion significantly improves the strength of Mg–Zn–Y alloys. Owing to AC extrusion, the strength improvement of Mg_(98.7)Zn_(1)Y_(0.3) alloy is mainly attributed to fine grain strengthening, dislocation strengthening, and nano-phases precipitation strengthening. After AC process, more fine grains and nano-phases jointly strengthen the Mg_(98)Zn_(1)Y_(1) alloy. The Mg_(98)Zn_(1)Y_(1) alloy obtains optimal mechanical properties after extrusion at 623 K, with ultimate tensile strength (UTS) of 406 MPa, yield strength (YS) of 388 MPa, and elongation (EL) of 5.6%.

关键词： Mg-Zn-Y Artificial cooling Extrusion Microstructure Mechanical properties

The expression analysis of silk gland-enriched intermediate-size non-coding RNAs in silkworm Bombyx mori

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Insect Science 2014年第4期21卷 429-438页

作者： dan-dan li Zong-Cai liu Lei Huang Qian-ling Jiang Kun Zhang Hui-li Qiao Zhu-Jin Jiao Lun-Guang Yao Ren-Yi liu Yun-Chao Kan China-UK-NYNU-RRes Joint libratory of Insect Biology Nanyang Normal University Nanyang Henan China Department ofBotany and Plant Sciences University of Cafifornia Riverside CA USA

Small non-protein coding RNAs （ncRNAs） play important roles in development, stress response and other cellular processes. Silkworm is an important model for studies on insect genetics and control of Lepidopterous pests. We have previously identified 189 novel intermediate-size ncRNAs in silkworm Bombyx mori, including 40 ncRNAs that showed altered expression in different developmental stages. Here we characterized the functions of these 40 ncRNAs by measuring their expressions in six tissues of the fifth instar larvae using Northern blot and real-time polymerase chain reaction assays. We identified nine ncRNAs （four small nucleolar RNAs and five unclassified ncRNAs） that were enriched in silk gland, including four ncRNAs that showed silk gland-specific expression. We further showed that three of nine silk gland-enriched ncRNAs were predominantly expressed in the anterior silk gland, whereas another three ncRNAs were highly accumulated in the posterior silk gland, suggesting that they may play different roles in fibroin synthesis. Furthermore, an unclassified ncRNA, Bm- 152, exhibited converse expression pattem with its antisense host gene gartenzwerg in diverse tissues, and might regulate the expression of gartenzwerg through RNA-protein complex. In addition, two silk gland-enriched ncRNAs Bm-102 and Bm-159 can be found in histone modification complex, which indicated that they might play roles through epigenetic modifications. Taken together, we provided the first expression and preliminary functional analysis of silk gland-enriched ncRNAs, which will help understand the molecular mechanism of silk gland-development and fibroin synthesis.

关键词： fibroin synthesis non-coding RNAs silk gland silkworm

Protection of tight junction between RPE cells with tissue factor targeting peptide

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International Journal of Ophthalmology(English edition) 2018年第10期11卷 1594-1599页

作者： Xiu-Lan Zou Guan-Feng Wang dan-dan li Jing-Xia Chen Chun-li Zhang Yong-Zhen Yu Wen-Jie Zhou Yu-Ping Zou Ben-Qiang Rao Department of Ophthalmology General Hospital of Guangzhou of PLA Guangzhou 510010 Guangdong Province China Department of Ophthalmology the Third Affiliated Hospital of Guangzhou Medical University Guangzhou 510150Guangdong Province China Zhongshan Ophthalmology Center of Sun Yat-sen University Guangzhou 510060 Guangdong Province China General Surgery Aviation General Hospital Beijing 100012China

AIM：To investigate the effect of tissue factor targeting peptide（TF-TP）on retinal pigment epithelium（RPE）cells tight ***：Cell counting kit-8（CCK-8）was used to measure the proliferation of ARPE-19 *** of tight junction,ZO-1 in ARPE-19 cells was measured by Western blot and immunofluorescent *** blot was also used to detect the expression of tissue factor（TF）.CEC Transmigration Assay was used to measure the migration of ARPE-19 *** transport of fluorescent markers [fluorescein isothiocyanate dextrans of 4,10,20（FD4,FD10,FD20） ]and the transepithelial electrical resistance（TEER）were used to measure in ARPE-19 cell RESULTS：CCK-8 assay showed that 5μmol/L TF-TP can inhibit ARPE-19 cells abnormally proliferation stimulated by lipopolysaccharide（LPS;P〈0.05）.LPS increased the transport of fluorescent markers（FD4,FD10,FD20）and decreased TEER levels in ARPE-19 cells,respectively,which were prevented by 5μmol/L TF-TP pretreatment（P〈0.05）. Furthermore,LPS significantly up-regulated the expression of TF and downregulated the expression of ZO-1（P〈0.05）in ARPE-19 cell which was inhibited by the TF-TP（P〈0.05）.In addition,TF-TP inhibited the abnormal migration induced by LPS in ARPE-19 cell（P〈0.05）.CONCLUSION：Our findings suggest that TF-TP suppressed proliferation and migration of ARPE-19 cells induced by LPS,and maintained the RPE tight junctions through inhibition of TF expression and increased expression of ZO-1.

关键词： tissue factor targeting peptide lipopolysaccharide tight junction ZO-1 retinal pigment epithelium