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Digital Chinese Medicine 2018年第2期1卷 164-172页

作者： Lin KUANG En-Hui HUANG Qing-Hu HE Shao-Wu CHENG Xiao-dan LIU Hunan University of Chinese Medicine ChangshaHunan 410208China

Objective To explore the effects of Long dan xie Gan formula granule(LDXGFG)on regulation of pro-inflammatory cytokines in female guinea pigs with recurrent genital herpes(herpes simplex virus 2,HSV-2).Methods Levels of pro-inflammatory cytokines in blood of HSV-2-infected guinea pigs,including IL-6,IL-8,IL-10,IL-12,IFN-α,IFN-β,IFN-γ,and TNF-α,were detected by ELISA;corresponding gene expression levels in tissues were detected by real-time *** IL-6,IL-10,IL-12,IFN-α,IFN-γand TNF-αdecreased significantly in both blood and diseased tissues after infection with recurrent genital *** feeding LDXGFG to HSV-2-infected guinea pigs,IL-6,IL-10,IL-12,IFN-α,IFN-γand TNF-αdemonstrated significant increases,similar to the effects of acyclovir(ACV).LDXGFG promoted the expression of pro-inflammatory cytokines in blood and tissue,with a stronger effect than ***,LDXGFG demonstrated broader effects than *** The present results suggest that LDXGFG can serve as an alternative,inexpensive,and long-term treatment for HSV-2 infection.

关键词： Recurrent genital herpes HSV-2 Long dan xie Gan formula granule(LDXGFG) Pro-inflammatory cytokines ACV Guinea pig

Recent Advance in Synaptic Plasticity Modulation Techniques for Neuromorphic Applications

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Nano-Micro Letters 2024年第10期16卷 403-434页

作者： Yilin Sun Huaipeng Wang dan xie School of Integrated Circuits and Electronics Beijing Institute of TechnologyBeijing 100081People's Republic of China School of Integrated Circuits Beijing National Research Center for Information Science and Technology(BNRist)Tsinghua UniversityBeijing 100084People's Republic of China

Manipulating the expression of synaptic plasticity of neuromorphic devices provides fascinating opportunities to develop hardware platforms for artifi-cial ***,great efforts have been devoted to exploring biomimetic mechanisms of plasticity simulation in the last few *** progress in various plasticity modulation techniques has pushed the research of synaptic electronics from static plasticity simulation to dynamic plasticity modulation,improving the accuracy of neuromorphic computing and providing strategies for implementing neuromorphic sensing ***,several fascinating strategies for synap-tic plasticity modulation through chemical techniques,device structure design,and physical signal sensing are *** chemical techniques,the underly-ing mechanisms for the modification of functional materials were clarified and its effect on the expression of synaptic plasticity was also *** on device structure design,the reconfigurable operation of neuromorphic devices was well demonstrated to achieve programmable neuromorphic ***,integrating the sensory units with neuromorphic processing circuits paved a new way to achieve human-like intelligent perception under the modulation of physical signals such as light,strain,and ***,considering that the relevant technology is still in the basic exploration stage,some prospects or development suggestions are put forward to promote the development of neuromorphic devices.

关键词： Plasticity modulation Dynamic plasticity Chemical techniques Programmable operation Neuromorphic sensing

Global interpolating meshless shape function based on generalized moving least-square for structural dynamic analysis

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Applied Mathematics and Mechanics(English Edition) 2016年第9期37卷 1153-1176页

作者： dan xie Kailin JIAN Weibin WEN College of Aerospace Engineering Chongqing University State Key Laboratory of Coal Mine Disaster Dynamics and Control Chongqing University College of Engineering Peking University

A global interpolating meshless shape function based on the generalized moving least-square （GMLS） is formulated by the transformation technique. Both the shape function and its derivatives meet the Kronecker delta function property. With the interpolating GMLS （IGMLS） shape function, an improved element-free Galerkin （EFG） method is proposed for the structural dynamic analysis. Compared with the conven- tional EFG method, the obvious advantage of the proposed method is that the essential boundary conditions including both displacements and derivatives can be imposed by the straightforward way. Meanwhile, it can greatly improve the ill-condition feature of the standard GMLS approximation, and provide good accuracy at low cost. The dynamic analyses of the Euler beam and Kirchhoff plate are performed to demonstrate the feasi- bility and effectiveness of the improved method. The comparison between the numerical results of the conventional method and the improved method shows that the proposed method has better stability, higher accuracy, and less time consumption.

关键词： structural dynamics meshless method element-free Galerkin (EFG)method generalized moving least-square (GMLS)

Variational quantum algorithms for scanning the complex spectrum of non-Hermitian systems

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Frontiers of physics 2024年第4期19卷 275-285页

作者： Xu-dan xie Zheng-Yuan Xue dan-Bo Zhang Key Laboratory of Atomic and Subatomic Structure and Quantum Control(Ministry of Education) Guangdong Basic Research Center of Excellence for Structure and Fundamental Interactions of Matterand School of PhysicsSouth China Normal UniversityGuangzhou 510006China Guangdong Provincial Key Laboratory of Quantum Engineering and Quantum Materials Guangdong–Hong Kong Joint Laboratory of Quantum Matterand Frontier Research Institute for PhysicsSouth China Normal UniversityGuangzhou 510006China

Solving non-Hermitian quantum many-body systems on a quantum computer by minimizing the variational energy is challenging as the energy can be ***,we propose a variational quantum algorithm for solving the non-Hermitian Hamiltonian by minimizing a type of energy variance,where zero variance can naturally determine the eigenvalues and the associated left and right ***,the energy is set as a parameter in the cost function and can be tuned to scan the whole spectrum efficiently by using a two-step optimization *** numerical simulations,we demonstrate the algorithm for preparing the left and right eigenstates,verifying the biorthogonal relations,as well as evaluating the *** also investigate the impact of quantum noise on our algorithm and show that its performance can be largely improved using error mitigation ***,our work suggests an avenue for solving non-Hermitian quantum many-body systems with variational quantum algorithms on near-term noisy quantum computers.

关键词： quantum algorithm non-Hermitian physics quantum manybody systems

Living Copolymerization of EOVE and MOVE:Fast Flow Synthesis and Thermal Responsive Behavior

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Chinese Journal of Polymer Science 2022年第10期40卷 1193-1200,I0008页

作者： Yu-Hang He dan xie Yang-Cheng Lu State Key Laboratory of Chemical Engineering Department of Chemical EngineeringTsinghua UniversityBejing 100084China

Random and block copolymers of 2-methoxyethyl vinyl ether(MOVE)and 2-ethoxyethyl vinyl ether(EOVE)were synthesized within 180 s via IBVE-HCl/SnCl_(4) initiating system in the presence of THF in a microflow *** polymers can be produced continuously and efficiently with extremely narrow molecular weight distributions(M_(w)/M_(n)=1.09-1.18)even at the existence of pendant oxyethylene units Polymerization rate can be accelerated by reducing THF to very low concentration([THF]=50 mmol/L),reaching conversions over 60%and 70%in 60 s for EOVE and MOVE,*** copolymers poly(MOVE_(100x)-r-EOVE(_(100)(1-x)))(x=0.25,0.5,0.75)experienced very sensitive phase separation process,of which phase separation temperature(T_(ps))can be adjusted between 20 and 70℃by controlling monomer *** the other hand,thermally induced phase separation of diblock copolymers poly(MOVE_(100)-b-EOVE_(100))was not so sensitive as its random copolymer *** bigger difference between phase separation temperatures of heating and cooling process(ΔT_(ps))was found for diblock copolymer.

关键词： Living cationic polymerization Stimuli-responsive Microflow system

Discovery of Radiolaria from the Zongzhuo Formation in Tianba,Kangmar,Tibet and its Age Implication

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Acta Geologica Sinica(English Edition) 2009年第5期83卷 853-859页

作者： LI Guobiao xie dan WAN Xiaoqiao HAN Hongdou CHEN Puli China University of Geosciences Beijing 100083 China

There is a group of variegated marine deposits, including the red beds widespread in the area of Tianba, Kangmar, southern Tibet, which previous works have contributed to Cretaceous Zongzhuo Formation by lithologic associations only, but with poor fossil evidence. Due to the absence of age dating fossils, the red bed age is obscure. Abundant Cretaceous radiolaria were discovered from the Zongzhuo Formation in the present study. In spite of the poor general preservation of some radiolarian specimens as recrystallized quartz infillings, 58 species from 46 genera of radiolaria, extracted from chert and silicous limestone of the Zongzhuo Formation in Kangmar, were identified on the basis of their shape and ornamentation. Based on the radiolaria, the age of the Zongzhuo Formation of this area has been referred to as Late Cretaceous. The new radiolarian data from the Zongzhuo Formation of Tianba area provide a local basis to correlate these deposits with other regions of the Tethyan Himalaya.

关键词： red bed radiolaria late Cretaceous Zongzhuo Formation Kangmar

Effectiveness of entomopathogenic fungal strains against poplar/willow weevil(Cryptorhynchus lapathi L.)larvae

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Journal of Forestry Research 2022年第5期33卷 1691-1702页

作者： Fang Niu Ya Xing Niya Jia Kai Ding dan xie Huanwen Chen Defu Chi Key Laboratory for Sustainable Forest Ecosyst Management of Ministry of Education College of ForestryNortheast Forestry UniversityHarbin 150040HeilongjiangPeople’s Republic of China

The poplar and willow weevil,Crypto rhynchus lapathi L.,a major universally destructive wood-boring insect has become one of the important quarantine pests that is extremely destructive to forestry development and needs to be *** fungi(EPF) are considered safe and friendly for humans and the environment and play important roles in controlling insect pest *** this study,the screening of entomopathogenic fungi for control of *** is reported through the evaluation of virulence of four fungal Beauveria bassiana(CFCC81428,CFCC83116,CFCC83486,CFCC87297)strains,one ***(CFCC83487) strain and one Metarhizium anisopliae(CFCC88953) *** virulence of the different strains was appraised by correct mortality rate,cumulative mortality rate,median lethal concentration(LC_(50)) and median lethal time(LT_(50)).*** strains CFCC81428 and CFCC83116 were the most virulent among the six strains with a mortality up to 100%,and the LT_(50) were 2.7 and 3.1 *** conidia concentrations of three strains(CFCC81428,CFCC83116 and CFCC87298) that caused high virulence was screened for *** effect on controlling *** larvae were also determined under field condition by brushing conidia suspensions on *** larvae infested in a poplar *** cumulative rate in the field was lower than those obtained from the laboratory,but the order of the virulence of different strains did not *** in all three strains occurred at their highest concentration(1.0 × 10^(8) conidia mL^(-1)).Under field conditions,the CFCC81428 strain was the most effective,causing mortalities of 80.3% and 75.2%in two plots in Beipiao and Lindian counties,respectively,followed by CFCC83116(69.1%,66.6%) and CFCC87298(60.7%,59.3%).Based on our results,the *** strain CFCC81428 has the potential as a biological insecticide to control *** larvae.

关键词： Entomopathogenic fungi Pathogenicity Biocontrol control Beauveria bassiana Cryptorhynchus lapathi

Recent progress in single crystal perovskite X-ray detectors

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Science China(Information Sciences) 2024年第3期67卷 5-19页

作者： Xiao LIU Jun REN Yu-Ang CHEN Xiangshun GENG dan xie Tian-Ling REN School of Integrated Circuits Tsinghua University Beijing National Research Center for Information Science and Technology (BNRist)

Perovskites have attracted extensive attention as radiation detection material due to their long carrier diffusion length and lifetime, high absorption coefficient, and flexible manufacturing process. Compared with polycrystalline structures, single crystal perovskites improve the performance of optoelectronic devices due to their low defect state density, better photoelectric characteristics, and chemical ***, we review the recent progress of single crystal perovskite X-ray detectors. First, we briefly introduced the basic concepts, detection mechanisms, figure of merits of perovskite X-ray detectors, and the preparation methods of single crystal perovskites. Then, we summarized the significant advancements in single crystal perovskite X-ray detectors in recent times. Finally, we discussed the critical challenges and some practicable solutions for developing high-performance X-ray detectors.

关键词： single crystal perovskites carrier transport radiation detection X-ray detectors X-ray imaging

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NADPH homeostasis in cancer:functions,mechanisms and therapeutic implications

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Signal Transduction and Targeted Therapy 2020年第1期5卷 518-529页

作者： Huai-Qiang Ju Jin-Fei Lin Tian Tian dan xie Rui-Hua Xu State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterSun Yat-sen University510060 GuangzhouChina Research Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer Chinese Academy of Medical Sciences510060 GuangzhouChina

Nicotinamide adenine dinucleotide phosphate(NADPH)is an essential electron donor in all organisms,and provides the reducing power for anabolic reactions and redox *** homeostasis is regulated by varied signaling pathways and several metabolic enzymes that undergo adaptive alteration in cancer *** metabolic reprogramming of NADPH renders cancer cells both highly dependent on this metabolic network for antioxidant capacity and more susceptible to oxidative *** the unique NADPH homeostasis of cancer cells might be an effective strategy to eliminate these *** this review,we summarize the current existing literatures on NADPH homeostasis,including its biological functions,regulatory mechanisms and the corresponding therapeutic interventions in human cancers,providing insights into therapeutic implications of targeting NADPH metabolism and the associated mechanism for cancer therapy.

关键词： homeostasis therapeutic metabolism

Enhanced thermoelectric performance of CoSbS_(0.85)Se_(0.15) by point defect

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Rare Metals 2018年第4期37卷 326-332页

作者： Shan-Shan Zhang Ding-Feng Yang Nusrat Shaheen Xing-Chen Shen dan-dan xie Yan-Ci Yan Xu Lu Xiao-Yuan Zhou Department of Applied Physics Chongqing University Institute of Microstructure and Properties of Advanced Materials Beijing University of Technology

In this study, we report the effect of Zn doping on the thermoelectric properties of CO1-xZnxSbS0.85Se0.15 solid solutions （x = 0, 0.02, 0.05, 0.08）. The results show the dimensionless figure of merit （zT） increases from 0.17 to 0.34 at 875 K for Co0.95Zn0.05SbS0.85Se0.15 sample, due to the noticeable decrease in the lattice thermal conductivity by introducing point defect, which is further confirmed by an analysis based on the Debye-Callaway- Klemens model. Meanwhile, the thermoelectric power factor is maintained at high temperatures. This work highlights the important role of point defect in improving the thermoelectric performance of CoSbS-based compounds.

关键词： CoSbS Point defect Thermal conductivity Thermoelectric performance