检索结果-南通市图书馆

Optical coherence tomography and Doppler optical coherence tomography in the gastrointestinal tract

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2011年第1期17卷 15-20页

作者： Eugen Osiac Adrian Sǎftoiu dan ionut gheonea Ion Mandrila Radu Angelescu Centre for Research in Gastroenterology and Hepatology University of Medicine and Pharmacy200349 CraiovaRomania

Optical coherence tomography(OCT) is a noninvasive,high-resolution,high-potential imaging method that has recently been introduced into medical investigations.A growing number of studies have used this technique in the field of gastroenterology in order to assist classical ***,3D-imaging and Doppler capabilities have been developed in different configurations,which make this type of investigation more *** paper reviews the principles and characteristics of OCT and Doppler-OCT in connection with analyses of the detection of normal and pathological structures,and with the possibility to investigate angiogenesis in the gastrointestinal tract.

关键词： Optical coherence tomography Doppler Gastrointestinal tract Gastrointestinal cancer Angiogenesis

Current strategies for malignant pedunculated colorectal polyps

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2018年第12期10卷 465-475页

作者： Adriana Ciocalteu dan ionut gheonea Adrian Saftoiu Liliana Streba Nicoleta Alice Dragoescu Tiberiu Stefanita Tenea-Cojan Department of Gastroenterology Research Center of Gastro-enterology and HepatologyUniversity of Medicine and Pharmacy of Craiova Department of Oncology University of Medicine and Pharmacy of Craiova Department of Anesthesiology and Intensive Care Emergency County Hospital of CraiovaUni-versity of Medicine and Pharmacy of Craiova Department of General Surgery C.F. Clinical HospitalUniversity of Medicine and Pharmacy of Craiova

Despite significant advances in imaging techniques, the incidence of colorectal cancer has been increasing in recent years, with many cases still being diagnosed in advanced stages. Early detection and accurate staging remain the main factors that lead to a decrease in the cost and invasiveness of the curative techniques, significantly improving the outcome. However, the diagnosis of pedunculated early colorectal malignancy remains a current challenge. Data on the management of pedunculated cancer precursors, apart from data on nonpolypoid lesions, are still limited. An adequate technique for complete resection, which provides the best long-term outcome, is mandatory for curative intent. In this context, a discussion regarding the diagnosis of malignancy of pedunculated polyps, separate from nonpedunculated variants, is necessary. The purpose of this review is to provide a critical review of the most recent literature reporting the different features of malignant pedunculated colorectal polyps, including diagnosis and management strategies.

关键词： Pedunculated colorectal polyps Malignant colorectal polyp Early colorectal cancer Polypoid early colon cancer Advanced adenoma Depth of invasion Colorectal cancer Polypectomy Colorectal surgery Early colorectal carcinoma

Confocal laser endomicroscopy and immunoendoscopy for real-time assessment of vascularization in gastrointestinal malignancies

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2011年第1期17卷 21-27页

作者： dan ionut gheonea Tatiana Crtnǎ Tudorel Ciurea Carmen Popescu Anca Bǎdǎrǎu Adrian Sǎftoiu Research Center of Gastroenterology and Hepatology University of Medicine and Pharmacy CraiovaCraiova 200349Romania Physiology Department University of Medicine and Pharmacy Carol Davila BucharestBucharest 050474Romania Cytology Laboratory Emergency Hospital CraiovaCraiova 200642Romania

Gastrointestinal cancers represent a major cause of morbidity and mortality,with incomplete response to chemotherapy in the advanced stages and poor *** plays a crucial part in tumor growth and metastasis,with most gastrointestinal cancers depending strictly on the development of a new and devoted capillary *** laser endomicroscopy is a new technology which allows in vivo microscopic analysis of the gastrointestinal mucosa and its microvascularization during ongoing endoscopy by using topically or systemically administered contrast *** markers of angiogenesis in association with confocal laser endomicroscopic examination(immunoendoscopy),as a future challenge,will add functional analysis to the morphological aspect of the neoplastic *** review describes previous experience in endomicroscopic examination of the upper and lower digestive tract with emphasis on vascularization,resulting in a broad spectrum of potential clinical applications,and also preclinical research that could be translated to human studies.

关键词： Confocal laser endomicroscopy Immunoendoscopy Fluoresceine Acriflavine Cancer

Contrast-enhanced ultrasonography parameters in neural network diagnosis of liver tumors

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2012年第32期18卷 4427-4434页

作者： Costin Teodor Streba Mihaela Ionescu dan ionut gheonea Larisa Sandulescu Tudorel Ciurea Adrian Saftoiu Cristin Constantin Vere Ion Rogoveanu Research Center of Gastroenterology and Hepatology University of Medicine and Pharmacy of Craiova200349 CraiovaRomania Department of Bioinformatics and Statistics University of Medicine and Pharmacy Craiova200349 CraiovaRomania

AIM:To study the role of time-intensity curve(TIC) analysis parameters in a complex system of neural networks designed to classify liver ***:We prospectively included 112 patients with hepatocellular carcinoma(HCC)(n = 41),hypervascular(n = 20) and hypovascular(n = 12) liver metastases,hepatic hemangiomas(n = 16) or focal fatty changes(n = 23) who underwent contrast-enhanced ultrasonography in the Research Center of Gastroenterology and Hepatology,Craiova,*** recorded full length movies of all contrast uptake phases and post-processed them offline by selecting two areas of interest(one for the tumor and one for the healthy surrounding parenchyma) and consecutive TIC *** difference in maximum intensities,the time to reaching them and the aspect of the late/portal phase,as quantified by the neural network and a ratio between median intensities of the central and peripheral areas were analyzed by a feed forward back propagation multi-layer neural network which was trained to classify data into five distinct classes,corresponding to each type of liver ***:The neural network had 94.45% training accuracy(95% CI:89.31%-97.21%) and 87.12% testing accuracy(95% CI:86.83%-93.17%).The automatic classification process registered 93.2% sensitivity,89.7% specificity,94.42% positive predictive value and 87.57% negative predictive *** artificial neural networks(ANN) incorrectly classified as hemangyomas three HCC cases and two hypervascular metastases,while in turn misclassifying four liver hemangyomas as HCC(one case) and hypervascular metastases(three cases).Comparatively,human interpretation of TICs showed 94.1% sensitivity,90.7% specificity,95.11% positive predictive value and 88.89% negative predictive *** accuracy and specificity of the ANN diagnosis system was similar to that of human interpretation of the TICs(P = 0.225 and P = 0.451,respectively).Hepatocellular carcinoma cases showed contrast uptake during the arterial phase

关键词： Hepatocellular carcinoma Liver tumors Contrast enhanced ultrasound Time-intensity curve Artificial neural network Computer-aided diagnosis system

Real-time sono-elastography in the diagnosis of diffuse liver diseases

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2010年第14期16卷 1720-1726页

作者： dan ionut gheonea Adrian S ǎftoiu Tudorel Ciurea Florin Gorunescu Sevastita Iordache Gabriel Lucian Popescu Smaranda Belciug Marina Gorunescu Larisa Sǎndulescu Research Center of Gastroenterology and Hepatology University of Medicine and Pharmacy Craiova 200349 Romania Department of Biostatistics and Informatics University of Medicine and Pharmacy Craiova 200349 Romania IT Department University of Medicine and Pharmacy Craiova 200349 Romania Faculty of Mathematics of Computer Science University of Craiova Craiova 200585 Romania

AIM: To analyze whether computer-enhanced dynamic analysis of elastography movies is able to better characterize and differentiate between different degrees of liver fibrosis. METHODS: The study design was prospective. A total of 132 consecutive patients with chronic liver diseases and healthy volunteers were examined by transabdominal ultrasound elastography. All examinations were done by two ***: Due to the limitations of the method, we obtained high-quality elastography information in only 73.48% of the patients. The κ-means clustering method was applied to assess the inter-observer diagnosis varia- bility, which showed good variability values in accordance with the experience of ultrasound examination of every observer. Cohen’sκ test indicated a moderate agreement between the study observers (κ = 0.4728). Furthermore, we compared the way the two observers clustered the patients, using the test for comparing two proportions (t value, two-sided test). There was no statistically significant difference between the two physicians, regardless of the patients’ real status. CONCLUSION: Transabdominal real-time elastography is certainly a very useful method in depicting liver hard- ness, although it is incompletely tested in large multicenter studies.

关键词： Elastography Ultrasonography Liver steato- sis Viral hepatitis Liver cirrhosis

Could there be an interplay between periodontal changes and pancreatic malignancies?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2023年第3期11卷 545-555页

作者： Bogdan Silviu Ungureanu Dorin Nicolae Gheorghe Flavia Mirela Nicolae Sandu Ramboiu Petru Adrian Radu Valeriu MarinȘurlin Victor dan Eugen Strambu dan ionut gheonea Alexandra Roman PetraȘurlin Department of Gastroenterology University of Medicine and Pharmacy of CraiovaCraiova 200349Romania Department of Periodontology Research Center of Periodontal-Systemic ImplicationsUniversity of Medicine and Pharmacy of CraiovaCraiova 200349Romania Department 1st of Surgery University of Medicine and Pharmacy of CraiovaCraiova 200349Romania Department of General Surgery “Carol Davila”University of Medicine and PharmacyBucharest 020021Romania Department of Periodontology "Iuliu Hațieganu"University of Medicine and PharmacyCluj-Napoca 400012Romania

The term"periodontal disease"refers to a group of chronic inflammatory illnesses caused by specific microorganisms from subgingival biofilm,that affect the toothsupporting *** research has also shown that periodontal infection plays a role in aggravating systemic disease states at distal sites,reinforcing the significance of the oral cavity for general ***,it has been suggested that gastroenterological malignancies may be promoted by hematogenous,enteral or lymphatic translocation of *** the past 25 years,the global burden of pancreatic cancer(PC)has more than doubled,making it one of the major causes of cancer-related *** has been linked to at least 50%increased risk of PC and it could be considered a risk factor for this malignancy.A recent study performed on 59000 African American women with a follow up of 21 years showed that participants who had poor dental health had higher chances of *** findings,according to researchers,might be related to the inflammation that some oral bacteria *** the mortality of PC,periodontitis considerably raises the chance of dying from *** alterations in the gut,oral cavity and pancreatic tissues of PC patients occur when compared to healthy flora,demonstrating a link between PC and *** may also contribute to PC development,although the underlying pathway is not yet *** function of the microbiome in PC risk has drawn more focus over the last *** risk of PC has been linked to the oral microbiome,specifically increased levels of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans and decreased relative abundance of Leptotrichia and Fusobacteria,suggesting that it may have an impact on the inflammatory condition by expanding,altering,and regulating the commensal *** who received periodontal treatment had significantly decreased incidence rate ratios for *** analyzing patterns in

关键词： Periodontal disease Pancreatic cancer Microbiome Periodontitis Periopathogens Periodontal medicine

Autophagy in colorectal cancer:An important switch from physiology to pathology

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2015年第11期7卷 271-284页

作者： Florin Burada Elena Raluca Nicoli Marius Eugen Ciurea daniel Constantin Uscatu Mihai Ioana dan ionut gheonea Research Center of Gastroenterology and Hepatology University of Medicine and Pharmacy of Craiova Department of Pharmacology University of Oxford Human Genomics Laboratory University of Medicine and Pharmacy of Craiova

Colorectal cancer(CRC) remains a leading cause of cancer death in both men and women *** the factors and mechanisms that are involved in the multifactorial etiology of CRC,autophagy is an important transformational switch that occurs when a cell shifts from normal to *** recent years,multiple hypotheses have been considered regarding the autophagy mechanisms that are involved in *** currently accepted hypothesis is that autophagy has dual and contradictory roles in carcinogenesis,but the precise mechanisms leading to autophagy in cancer are not yet fully defined and seem to be context *** is a surveillance mechanism used by normal cells that protects them from the transformation to malignancy by removing damaged organelles and aggregated proteins and by reducing reactive oxygen species,mitochondrial abnormalities and DNA ***,autophagy also supports tumor formation by promoting access to nutrients that are critical to the metabolism and growth of tumor cells and by inhibiting cellular death and increasing drug *** studies in CRC have focused on several molecules,mainly microtubule-associated protein 1 light chain 3,beclin 1,and autophagy related 5,with conflicting *** effects were observed for some agents that modulate autophagy in CRC either alone or,more often,in combination with other *** extensive studies are needed in the future to clarify the roles of autophagy-related genes and modulators in colorectal carcinogenesis,and to develop potential beneficial agents for the prognosis and treatment of CRC.

关键词： Colorectal cancer Autophagy Gene Protein Carcinoge

Tumor neoangiogenesis detection by confocal laser endomicroscopy and anti-CD105 antibody:Pilot study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2015年第11期7卷 361-368页

作者： Adriana Ciocalteu Adrian Saftoiu daniel Pirici Claudia-Valentina Georgescu Tatiana Cartana dan ionut gheonea Lucian Gheorghe Gruionu Cosmin Gabriel Cristea Gabriel Gruionu Research Center of Gastroenterology and Hepatology University of Medicine and Pharmacy of Craiova Department of Research Methodology University of Medicine and Pharmacy of Craiova Department of Pathology Emergency County Hospital Department of Mechanical Engi-neering University of Craiova Edwin Steele Laboratory of Tumor Biology Department of Radiation OncologyMassachusetts General HospitalHarvard Medical School

AIM: To evaluate neoangiogenesis in patients with colon cancer by two fluorescently labeled antibodies on fresh biopsy samples imaged with confocal laser endomicroscopy(CLE).METHODS: CLE is an imaging technique for gastrointestinal endoscopy providing in vivo microscopy at subcellular *** important question in validating tumor angiogenesis is what proportion of the tumor vascular network is represented by preexisting parent tissue vessels and newly formed ***105(endoglin) represents a proliferation-associated endothelial cell adhesion *** contrast to panendothelial markers,such as CD31,CD105 is preferentially expressed in activated endothelial cells that participate in ***,we evaluated CD105 and CD31 expression from samples of ten patients with primary rectal adenocarcinoma,using a dedicated endomicroscopy system.A imaging software was used to obtain the Z projection of the confocal serial images from each biopsy sample previously combined into *** density and vessel diameters were measured within two 50 μm x 475 μm rectangular regions of interest centered in the middle of each image in the horizontal and vertical *** results were averaged over all the patients and were expressed as the mean ± ***: The use of an anti-CD105 antibody was found to be suitable for the detection of blood vessels in colon *** anti-CD31 antibodies stained blood vessels in both normal and pathologic colon equally,CD105 expression was observed primarily in malignant lesions,with little or no expression in the vessels of the normal mucosa(244.21 ± 130.7 vessels/mm3 in only four patients).The average diameter of antiCD105 stained vessels was 10.97 ± 0.6 μm in tumor tissue,and the vessel density was 2787.40 ± 134.8 vessels/*** using the anti-CD31 antibody,the average diameter of vessels in the normal colon tissue was 7.67 ± 0.5 μm and the vessel density was 3191.60 ± 387.8 vessels/mm3,while in the tumors w

关键词： Rectal cancer Neoangiogenesis Confocal laser endomicroscopy Panendothelial markers Anti-CD105 antibody

Advances in endoscopic ultrasound imaging of colorectaldiseases

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2016年第5期22卷 1756-1766页

作者： Elena Tatiana Cârțână dan Ionuțgheonea Adrian Săftoiu Department of Gastroenterology Research Center of Gastroenterology and Hepatology CraiovaUniversity of Medicine and Pharmacy of Craiova200638 CraiovaRomania Department of Endoscopy Gastrointestinal UnitCopenhagen University Hospital HerlevHerlev Ringvej2730 HerlevDenmark

The development of endoscopic ultrasound(EUS) has had a significant impact for patients with digestive diseases, enabling enhanced diagnostic and therapeutic procedures, with most of the available evidence focusing on upper gastrointestinal(GI) and pancreaticobiliary diseases. For the lower GI tract the main application of EUS has been in staging rectal cancer, as a complementary technique to other cross-sectional imaging methods. EUS can provide highly accurate indepth assessments of tumour infiltration, performing best in the diagnosis of early rectal tumours. In the light of recent developments other EUS applications for colorectal diseases have been also envisaged and are currently under investigation, including beyond-rectum tumour staging by means of the newly developed forward-viewing radial array echoendoscope. Due to its high resolution, EUS might be also regarded as an ideal method for the evaluation of subepithelial lesions. Their differential diagnosis is possible by imaging the originating wall layer and the associated echostructure, and cytological and histological confirmation can be obtained through EUS-guided fine needle aspiration or trucut biopsy. However, reports on the use of EUS in colorectal subepithelial lesions are currently limited. EUS allows detailed examination of perirectal and perianal complications in Crohn's disease and, as a safe and less expensive investigation, can be used to monitor therapeutic response of fistulae, which seems to improve outcomes and reduce the need for additional surgery. Furthermore, EUS image enhancement techniques, such as the use of contrast agents or elastography, have recently been evaluated for colorectal indications as well. Possible applications of contrast enhancement include the assessment of tumour angiogenesis in colorectal cancer, the monitoring of disease activity in inflammatory bowel disease based on quantification of bowel wall vascularization, and differentiating between benign and malignant

关键词： Endoscopic ultrasound Contrast-enhancedendoscopic ultrasound Elastography Colorectal cancer Inflammatory bowel disease Colorectal submucosaltumours Endoscopic ultrasound-guided therapy