Confocal laser endomicroscopy and immunoendoscopy for real-time assessment of vascularization in gastrointestinal malignancies

作     者：Dan Ionut Gheonea Tatiana Crtnǎ Tudorel Ciurea Carmen Popescu Anca Bǎdǎrǎu Adrian Sǎftoiu 

作者机构：Research Center of Gastroenterology and HepatologyUniversity of Medicine and Pharmacy CraiovaCraiova 200349Romania Physiology DepartmentUniversity of Medicine and Pharmacy Carol Davila BucharestBucharest 050474Romania Cytology LaboratoryEmergency Hospital CraiovaCraiova 200642Romania 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2011年第17卷第1期

页      面：21-27页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by Research Grant,No.239/2007,entitled OCTEUS,financed by the CNCSIS Romania by the Sectoral Operational Programme Human Resources Development (SOP HRD),financed from the European Social Fund by the RomanianGovernment under the contract number POSDRU/89/1.5/S/64109 

主　　题：Confocal laser endomicroscopy Immunoendoscopy Fluoresceine Acriflavine Cancer 

摘      要：Gastrointestinal cancers represent a major cause of morbidity and mortality,with incomplete response to chemotherapy in the advanced stages and poor *** plays a crucial part in tumor growth and metastasis,with most gastrointestinal cancers depending strictly on the development of a new and devoted capillary *** laser endomicroscopy is a new technology which allows in vivo microscopic analysis of the gastrointestinal mucosa and its microvascularization during ongoing endoscopy by using topically or systemically administered contrast *** markers of angiogenesis in association with confocal laser endomicroscopic examination(immunoendoscopy),as a future challenge,will add functional analysis to the morphological aspect of the neoplastic *** review describes previous experience in endomicroscopic examination of the upper and lower digestive tract with emphasis on vascularization,resulting in a broad spectrum of potential clinical applications,and also preclinical research that could be translated to human studies.