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Does local vaginal estrogen after tension-free transobturator vaginal tape reduce overactive bladder symptoms in postmenopausal women? A prospective randomized, controlled study

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Asian Journal of Urology 2024年第1期11卷 86-92页

作者： Samer Mahmoud Morsy dalia Farouk Sara Hassan Ahmed Yehia Abdelaziz Hussein Aly Hussein Urology Department Kasr Al Ainy HospitalCairo UniversityCairoEgypt Obstetrics and Gynecology Department Kasr Al Ainy HospitalCairo UniversityCairoEgypt

Objective:We aimed to evaluate the efficacy of topical estrogen after transvaginal tension-free vaginal tape-obturator(TVT-O)in the treatment of de novo overactive bladder symptoms that appear after ***:This is a prospective randomized controlled study performed in the Urology and Gynecology Departments,Kasr Al Ainy Hospital,Cairo University,Cairo,*** hundred and ten postmenopausal females presenting during the period between January 2017 and November 2020 with stress urinary incontinence were included in the *** were divided into two groups,105 patients in Group A(treatment group)and 105 patients in Group B(control group).Patients in Group A underwent transvaginal TVT-O followed by local vaginal estrogen treatment for 6 months,while patients in Group B underwent transvaginal TVT-O *** study included any postmenopausal female with urodynamic stress urinary *** patients had to fulfill a 3-day bladder diary,overactive bladder symptoms score,urine analysis,urodynamic study,and post-voiding residual urine measurement by abdominal ultrasound preoperatively and at 3-month and 6-month ***:At 6-month follow-up,daytime frequency was reduced to 8%in Group A(increased to 21%in Group B)with a statistically significant difference between both groups(p=0.009).At 6-month follow-up,nocturia was 8%in Group A(11%in Group B)with no statistically significant difference between both groups(p=0.469).There was a statistically significant difference between both groups as regards to urinary urgency at 6-month follow-up(p=0.024).There was a statistically significant difference in postoperative wound healing events as regards to cure,hyperemia,gapping,and wound infection 1 week after intervention between both groups(p=0.008).No local or systemic side-effects were reported from local estrogen ***:Local vaginal estrogen treatment given to postmenopausal patients after midurethral sling procedures can reduce the symptoms o

关键词： Stressurinary incontinence Estrogen Midurethral sling Overactive bladder symptom

Synthesis, Characterization, Anti-Bacterial and Anti-Fungal Activities of New Quinoxaline 1,4-di-N-Oxide Derivatives

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International Journal of Organic Chemistry 2013年第3期3卷 65-72页

作者： dalia Hussein Soliman Pharmaceutical Chemistry Department Faculty of Pharmacy Al-Azhar University Cairo Egypt

A new series of quinoxaline 1,4-di-N-oxides were synthesized and evaluated for their antibacterial and antifungal activities. The best result was demonstrated by 3-amino-N-(4-methoxyphenyl)-2-quinoxalinecarboxamide 1,4-di-N-oxide 4e, MIC (0.24 μg/ml) against Aspergillus fumigatus, and (0.12 μg/ml) against Streptococcus pneumonia.

关键词： Quinoxaline 1 4-di-N-Oxide Beirut Reaction Benzofuroxanes β-Ketoamide β-Cyanoamide Antibacterial Antifungal

Protective and therapeutic potentials of Dunaliella salina on aging-associated cardiac dysfunction in rats

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Asian Pacific Journal of Tropical Biomedicine 2018年第8期8卷 403-410页

作者： Farouk K.El-Baz Gehad A.Abdel Jaleel dalia O.Saleh Rehab A.Hussein Plant Biochemistry Department National Research Centre (NRC) Pharmacology Department National Research Centre (NRC) Pharmacognosy Department National Research Centre (NRC)

Objective: To investigate the possible protective and/or therapeutic potentials of Dunaliella salina(D. salina) biomass, its carotenoid and polar fractions on cardiac dysfunction associated with D-galactose(D-GAL) induced aging in rats. Methods: Aging associated cardiac dysfunction was induced in rats by injection of D-GAL(200 mg/kg; i.p) for 8 weeks. D-GAL injected rats were treated with two regimens; protective regimen where D. salina biomass(250 mg/kg), its carotenoid(250 μg/kg) and polar(250 μg/kg) fractions were given orally for two weeks concurrently with D-GAL injection as well as treatment regimen where the three treatments were given orally for 28 consecutive days after D-GAL injection. Results: D-GAL injection for 8 weeks was accompanied with dramatic electrocardiographic changes as well as profound elevation in serum levels of homocysteine, creatinine kinase isoenzyme and lactate dehydrogenase in addition to the reduction of the cardiac content of glucose trasporter 4. D-GAL also induced reduction in cardiac superoxide dismutase activity and elevation of inducible nitric oxide synthetase and interleukin-6. On the other hand, oral administration of D. salina carotenoid fraction as well as the total biomass significantly attenuated the D-GAL-induced disturbances in the above mentioned parameters where the protective regimen appeared more successful in controlling the manifestations of cardiac dysfunction. The histopathological examination further emphasized the promising results. Besides, the HPLC analysis of the carotenoid fraction of D. salina revealed the presence of 2.31%. salina carotenoid fraction as well as the total biomass amelior β-carotene. Conclusions: Date D-GAL-induced aging associated cardiac dysfunction which is attributed to the potent antioxidant activity of β-carotene.

关键词： Aging Cardiac dysfunction Dunaliella salina Rats

Expression of Mitochondrial Gene Fragments within the Tapetum Induce Male Sterility by Limiting the Biogenesis of the Respiratory Machinery in Transgenic Tobacco

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Journal of Integrative Plant Biology 2012年第2期54卷 115-129页

作者： Felix Shaya Svetlana Gaiduk Ido Keren Sofia Shevtsov Hanita Zemah Eduard Belausov dalia Evenor Moshe Reuveni Oren Ostersetzer-Biran Institute of Plant Sciences Agricultural Research Organization (ARO) Volcani CenterBet Dagan 50250 Israel Department of Plant Sciences The Hebrew University of JerusalemRehovot 76100 Israel Australian Research Council (ARC) Centre of Excellence in Plant Energy Biology The University of Western AustraliaCrawley WA 6009 Australia

Plant mitochondrial genomes （mtDNAs） are large and undergo frequent recombination events. A common phenotype that emerges as a consequence of altered mtDNA structure is cytoplasmic-male sterility （CMS）. The molecular basis for CMS remains unclear, but it seems logical that altered respiration activities would result in reduced pollen production. Analysis of tobacco （Nicotiana tabacum） mtDNAs indicated that CMS-associated loci often contain fragments of known organellar genes. These may assemble with organellar complexes and thereby interfere with normal respiratory functions. Here, we analyzed whether the expression of truncated fragments of mitochondrial genes （i.e. atp4, cox1 and rps3） may induce male sterility by limiting the biogenesis of the respiratory machinery, cDNA fragments corresponding to atp4f, coxlfand rps3f were cloned in-frame to a mitochondrial localization signal and a C-termini HA-tag under a tapetum-specific promoter and introduced to tobacco plants by Agrobacterium-mediated transformation. The constructs were then analyzed for their effect on mitochondrial activity and pollen fertility. Atp4f, Coxlf and Rps3f plants demonstrated male sterility phenotypes, which were tightly correlated with the expression of the recombinant fragments in the floral meristem. Fractionation of native organellar extracts showed that the recombinant ATP4f-HA, COXlf-HA and RPS3f-HA proteins are found in large membrane-associated particles. Analysis of the respiratory activities and protein profiles indicated that organellar complex I was altered in Atp4f, Coxlfand Rps3f plants.

关键词： CMS ORF-fragments Complex-I mitochondria tobacco

MMP-2 Rs24386(C-->T) gene polymorphism and the phenotype of age-related macular degeneration

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International Journal of Ophthalmology(English edition) 2017年第9期10卷 1349-1353页

作者： Rasa Liutkeviciene Vaiva Lesauskaite Giedre Sinkunaite-Marsalkiene Sandrita Simonyte Reda Zemaitiene Loresa Kriauciuniene dalia Zaliuniene Department of Ophthalmology Lithuanian University of Health SciencesMedical AcademyKaunas LT-50161Lithuania Neuroscience Institute Lithuanian University of Health SciencesMedical AcademyKaunas LT-50161Lithuania Intitute of Cardiology Lithuanian University of Health SciencesMedical AcademyKaunas LT-50161Lithuania

AIM：To examine the MMP-2（-1306 C/T）gene polymorphism and the phenotype characterized by soft and hard drusen of early age-related macular degeneration（AMD）and geographic atrophy of late AMD ***：The study enrolled 850 investigations（290AMD patients with soft and hard drusen,34 with geographic atrophy and a random sample of the population n=526）.Early AMD was classified according to the International Classification and Grading *** geographic atrophy diagnosis the Age-Related Eye Disease Study classification was *** potential association with single nucleotide polymorphisms on MMP-2 Rs243865 was evaluated for all patients,adjusted for age and *** genotyping test of MMP-2 Rs243865（C--〉T）was conducted using the real-time polymerase chain reaction ***：MMP-2（-1306 C/T）C/C genotype was more frequently detected in AMD patients with hard drusen than the soft drusen or control group（66.43%vs 53.74%,vs54.94%,P=0.047）.Logistic regression analysis showed that the MMP-2（-1306）C/C genotype increased the likelihood to develop hard drusen in AMD patients（OR=1.7,95%CI：1.06-2.74;P=0.028）.No association between MMP-2（-1306C/T）gene polymorphism in patients with atrophic AMD and control group was found（54.94%,37.64%,7.41%vs50%,38.24%,11.76%;P=0.6）.CONCLUSION：The MMP-2 Rs24386（C--〉T）polymorphism is found to be associated with the development of hard drusen in patients with AMD.

关键词： age-related macular degeneration phenotype matrix metalloproteinases gene polymorphism

Early and aggressive presentation of wild-type transthyretin amyloid cardiomyopathy:A case report

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World Journal of Cardiology 2022年第12期14卷 657-664页

作者： Ilham Boda Hassan Farhoud Tarun dalia Amandeep Goyal Zubair Shah Andrija Vidic Department of Internal Medicine University of Kansas Medical CenterKansas CityKS 66160United States School of Medicine University of Kansas Medical CenterKansas CityKS 66160United States Department of Cardiovascular Medicine University of Kansas Medical CenterKansas CityKS 66160United States

BACKGROUND Wild-type transthyretin amyloidosis(ATTRwt)is the most common form of transthyretin amyloid cardiomyopathy,occurring mostly over age of 60 years(mean age of 80 years).Mean survival without treatment is 3.6 years,making early detection *** report an unusual case of a 58-year-old patient with ATTRwt cardiomyopathy requiring heart *** SUMMARY A 58-year-old male presented with progressive fatigue,shortness of breath,weight gain,leg swelling,orthopnoea,and paroxysmal nocturnal dyspnoea for several *** ten months before this clinical presentation,the patient had first received a diagnosis of heart failure with reduced ejection fraction(EF)of 15% to 20%.The patient was started on appropriate guidelinedirected medical therapy with only mild improvement in his *** further investigation,echocardiogram,technetium pyrophosphate scan(Tc PYP),and cardiac magnetic resonance imaging(cMRI)suggested a diagnosis of amyloidosis,and ATTRwt was subsequently confirmed with native heart tissue biopsy,congo red staining,liquid chromatography-tandem mass spectrometry,and genetic *** patient was successfully treated with heart transplantation and is doing well *** Wild-type ATTR amyloidosis should be kept on differentials in all patients(even less than 60 years old)with non-ischemic cardiomyopathy,especially in the setting of increased ventricular wall thickness and other classic echocardiogram,cMRI,and Tc PYP *** diagnosis and management can be consequential in improving patient outcomes.

关键词： Wild-type Transthyretin Amyloidosis Young Heart failure Heart transplant Case report

Burden of pediatric influenza A virus infection post swine-flu H1N1pandemic in Egypt

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Asian Pacific Journal of Tropical Medicine 2013年第9期6卷 693-698页

作者： Adel Khattab Malak Shaheen Terez Kamel Amel El Faramay Safaa Abd El Rahman dalia Nabil Mohamed Gouda Influenza Advisory Board Egyptian Ministry of Health Chest Department Faculty of MedicineAin Shams University Pediatrics Department Faculty of MedicineAin Shams University Medical Microbiology and Immunology Department Faculty of MedicineAin Shams University

Objectne:To screen children with influenza like illness or with symptoms of acute respiratory tract infections for influenza A virus infection-post swine flu pandemic era-using rapid influenza diagnostic ***:During two year,(2010&2011),1200 children with influenza like illness or acute respiratory tract infections(according to World Health Organization criteria)were *** ages ranged from 2-60 *** aspirates specimens were collected from all children for rapid influenza A diagnostic ***:Influenza A virus rapid test was positive in 47.5%of the children;the majority(89.6%)were presented with lower respiratory tract *** rate and temperature were significantly higher among positive rapid influenza test ***:Influenza A virus infection is still a major cause of respiratory tract infections in Egyptian *** should be considered in all cases with cough and febrile episodes and influenza like symptoms even post swine flu pandemic.

关键词： Influenza A virus Burden Children Influenza like illness Egypt

Rare case of chronic Q fever myocarditis in end stage heart failure patient:A case report

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World Journal of Cardiology 2022年第9期14卷 508-513页

作者： Amandeep Goyal Tarun dalia Poonam Bhyan Hassan Farhoud Zubair Shah Andrija Vidic Department of Cardiovascular Medicine University of Kansas Medical CenterKansas CityKS 66160United States Department of Internal Medicine Cape Fear Valley HospitalFayettevilleNC 28304United States School of Medicine University of Kansas Medical CenterKansas CityKS 66160United States

BACKGROUND Q fever myocarditis is a rare disease manifestation of Q fever infection caused by Coxiella *** is associated with significant morbidity and mortality if left *** studies have reported myocarditis in patients with acute Q *** present the first case of chronic myocarditis in an end-stage heart failure patient with chronic Q fever *** SUMMARY A 69-year-old male was admitted with dyspnea on exertion,hypotension and bilateral lower extremity edema for a few *** has a past medical history of ischemic cardiomyopathy with left ventricular ejection fraction of 25%,implantable cardioverter defibrillator in place,bioprosthetic aortic valve and mitral valve *** continued to have shortness of breath despite diuresis along with low grade *** infectious work up came back *** further questioning,the patient was found to have close contact with farm animals and the recurrent fevers prompted the work-up for Q fever.Q fever serologies and cardiac positron emission tomography confirmed the diagnosis of chronic Q fever *** was then successfully treated with doxycycline and hydroxychloroquine for 18 *** Chronic Q fever myocarditis,if left untreated,carries a poor *** should be kept in differentials,especially in patients with recurrent fevers and contact with farm animals.

关键词： Chronic Q fever Myocarditis Coxiella burnetii Heart failure Farm animals Case report

Ovarian hyperstimulation syndrome following the use of GnRH agonist trigger of final oocyte maturation and freeze-all strategy: A case report and review of the literature

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Asian pacific Journal of Reproduction 2022年第6期11卷 292-298页

作者： dalia Khalife Suleiman Ghunaim Lina El Taha Omar Odeh Natasha Habr Johnny Awwad Department of Obstetrics and Gynecology Division of Reproductive Endocrinology and InfertilityHaifa Idriss-ART UnitAmerican University of BeirutBeirutLebanon School of Medicine The University of JordanAmmanJordan Division of Plastic and Reconstructive Surgery American University of Beirut Medical CenterBeirutLebanon

Rationale:The current literature has a surprising controversy regarding the use of low-dose human chorionic gonadotropin(hCG)for luteal support as an explanation for the development of ovarian hyperstimulation syndrome,and this is because of the gap in the listing of the predisposing factors that put women at an increased risk of ovarian hyperstimulation *** concerns:A case of 25-year-old woman presented with abdominal pain,distention,dyspnea,and nausea with a 6.5 kg increase in weight from *** examination showed bilaterally enlarged multicystic ovaries after gonadotropin-releasing hormone(GnRH)agonist triggering and cycle segmentation with no hCG rescue ***:Moderate/severe ovarian hyperstimulation ***:The woman was admitted to the hospital for medical management of moderate/severe ovarian hyperstimulation syndrome,and pain management was advanced to patient-controlled anesthesia with the start of low molecular weight *** day 2,albumin therapy followed by a furosemide chase was started due to an increase in abdominal *** day 1,Cabergoline was maintained,and on day 2 the GnRH antagonist Cetrorelix was ***:The woman’s clinical condition improved,and a clinical pregnancy was eventually achieved during the first cryo-warmed blastocyst ***:Ovarian hyperstimulation syndrome can still happen even after the use of GnRH agonist and avoidance of hCG *** of in vitro fertilization with complete avoidance of hCG for luteal support remains the best approach.

关键词： Ovarian hyperstimulation syndrome Gonadotropin releasing hormone agonist In vitro fertilization Human chorionic gonadotropin support Ovulation induction Reproductive endocrinology