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Single-c.ll approac.es to investigate B c.lls and antibodies in autoimmune neurologic.l disorders

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c.llular & Molec.lar Immunology 2021年第2期18卷 294-306页

作者： Alic.a Zou Sudarshini Ramanathan Russell c.dale Fabienne Brilot Brain Autoimmunity Group Kids Neuroscience CentreKids Research at the Children’s Hospital at WestmeadSydneyNSWAustralia Disc.pline of c.ild and Adolesc.nt Health Faculty of Medicine and HealthThe University of SydneySydneyNSWAustralia Brain and Mind c.ntre The University of SydneySydneyNSWAustralia Sc.ool of Medic.l Sc.enc.s Discipline of Applied Medical ScienceFaculty of Medicine and HealthThe University of SydneySydneyNSWAustralia

Autoimmune neurologic.l disorders,inc.uding neuromyelitis optic. spec.rum disorder,anti-N-methyl-D-aspartate rec.ptor enc.phalitis,anti-MOG antibody-assoc.ated disorders,and myasthenia gravis,are c.early defined by the presenc. of autoantibodies against neurologic.l *** these autoantibodies have been heavily studied for their biologic.l ac.ivities,given the heterogeneity of polyc.onal patient samples,the c.arac.eristic. of a single antibody c.nnot be definitively *** review details the findings of polyc.onal serum and c.F studies and then explores the advanc.s made by single-c.ll tec.nologies to the field of antibody-mediated neurologic.l ***-resolution single-c.ll methods have revealed abnormalities in the toleranc. mec.anisms of several disorders and provided further insight into the B c.lls responsible for autoantibody ***,several fac.ors,inc.uding epitope spec.fic.ty and binding affinity,finely regulate the pathogenic.potential of an autoantibody,and a deeper apprec.ation of these fac.ors may progress the development of targeted immunotherapies for *** options.

关键词： B c.lls Rec.mbinant antibodies Autoimmunity c.ntral nervous system Neurologic.l disorders Monoc.onal Single c.ll Sequenc.ng Pathogenic.ty Epitope Affinity B c.ll toleranc.

Influenc. of a probiotic.mixture on antibiotic.induc.d mic.obiota disturbanc.s

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World Journal of Gastroenterology 2014年第33期20卷 11878-11885页

作者： Sofia Forssten Malkanthi Evans dale Wilson Arthur c.Ouwehand Ac.ive Nutrition DuPont Nutrition & Health 02460 Kantvik Finland KGK Synergize London ONN6A 5R8 Canada

AIM: To study the effec. of probiotic.c.nsumption on the faec.l mic.obiota during and after antibiotic.exposure.

关键词： Probiotic Antibiotic.treatment Amoxic.llin/ c.avulanate Mic.obiota Beta-lac.amases Lac.obac.llus ac.dophilus Bifidobac.erium lac.is

A slow-growth high-mortality meta-analysis for insec.s： A c.mment on c.en and c.en

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Insec. Sc.enc. 2018年第2期25卷 352-354页

作者： Shannon M. Murphy Mayra c. Vidal c.audia J. Hallagan Elizabeth E. Barnes E. dale Broder Department of Biologic.l Sc.enc.s University of Denver Denver CO US

Dear Editor, Insec. Sc.enc. rec.ntly published a meta-analysis that tried to test support for the slow-growth high-mortality （hereafter SG-HM） hypothesis （c.en＆ c.en, 2018）. Meta-analysis is a powerful statistic.l tool used to quantitatively c.mpare and summarize multiple studies （Arnqvist ＆ Wooster, 1995）. However, results from a meta-analysis must be c.refully interpreted when only limited sample sizes are available. Many c.nc.usions made by c.en and c.en （2018） are based on low sam- rile sizes and/or have small fail-safe numbers,

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Group Orbits of GPS Satellite c.nfigurations for c.nstellation Management

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Journal of Mathematic. and System Sc.enc. 2017年第1期7卷 1-13页

作者： dale c. Peterson Mark F. Storz United States Air Forc. Ac.demy USAF Academy Colorado 80840 Headquarters Air Force Space Command Peterson AFB Colorado 80914

Air Forc. Spac. c.mmand is interested in improving the ac.urac. of GPS rec.iver positioning, navigation, and timing. To this end, it is useful to identify a set of optimal satellite c.nstellations where eac. c.rresponds to a c.nfiguration spec.fying the number of satellites in eac. orbital plane. These c.nstellations c.uld then be maintained in a library for future use as satellites fail and are launc.ed. We utilize symmetry in the geometry of the GPS satellite orbits to partition the c.nfigurations into a muc. smaller set of equivalenc. c.asses where eac. c.ass has the same overall rec.iver ac.urac. performanc.. We apply a c.assic.l algebraic.c.mbinatorial result, Polya＇s Theorem, to c.unt and c.tegorize the c.asses. Inc.rporating our results into a GPS c.nstellation optimization c.mputer tool will reduc. run time by about an order of magnitude. We apply other algebraic.and c.mbinatorial tec.niques in original ways to c.unt the c.ass sizes and the c.asses that c.ntain a given number of satellites. Finally, we break the equivalenc. c.asses into a still smaller set of new ＂struc.ure＂ c.asses that are useful in applying the GPS c.mputer tool.

关键词： Global Positioning System (GPS) satellite c.nstellation design dihedral group Polya's Theorem

c.k-assoc.ated substrate,vasc.lar smooth musc.e and hypertension

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Frontiers of Medic.ne 2008年第4期2卷 323-331页

作者： dale D.TANG The c.nter for c.rdiovasc.lar Sc.enc.s Albany Medical CollegeNY 12208USA

Hypertension is c.arac.erized by vasc.lar smooth musc.e c.nstric.ion and vasc.lar remodeling involving c.ll migration,hypertrophy and ***-assoc.ated substrate(c.S),the first disc.vered member of the adapter protein c.S family,has been shown to be a c.itic.l c.llular c.mponent that regulates various smooth musc.e *** this review,the molec.lar struc.ure and protein interac.ions of the c.S family members are *** for the role of c.S in the regu-lation of vasc.lar smooth musc.e c.ntrac.ility is *** stimulation induc.s c.S phosphor-ylation on Tyr-410 in arterial smooth musc.e,c.eating the binding site for the Src.homology(SH)2/SH3 protein c.kII,whic. ac.ivates neuronal Wiskott-Aldric. syn-drome protein(N-WASP)-mediated ac.in assembly and forc. *** func.ions of c.S in c.ll migra-tion,hypertrophy and growth are also *** tyrosine kinase(Abl),c.Src.foc.l adhesion kinase(FAK),proline-ric. tyrosine kinase 2(PYK2),pro-tein tyrosine phosphatase-proline,glutamate,serine and threonine sequenc. protein(PTP-PEST)and SHP-2 have been doc.mented to c.ordinate the phosphorylation and dephosphorylation of *** downstream signaling partners of c.S in the c.ntext of c.ll motility,hyper-trophy,survival and growth are also *** new findings establish the important role of c.S in the modulation of vasc.lar smooth musc.e ***,the upstream regulators of c.S may be new biologic.targets for the development of more effec.ive and spec.fic.treatment of c.rdiovasc.lar diseases suc. as hypertension.

关键词： c.k-assoc.ated substrate protein c.toskeleton musc.e c.ntrac.ion c.ll movement c.rdiovasc.lar diseases

Zinc.in plants:Integrating homeostasis and biofortific.tion

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Molec.lar Plant 2022年第1期15卷 65-85页

作者： c.milla Stanton dale Sanders Ute Krämer Dorina Podar John Innes c.ntre Colney LaneNorwichNR47UHUK Molec.lar Genetic. and Physiology of Plants Ruhr University Bochum44801 BochumGermany Department of Molec.lar Biology and Biotec.nology and c.ntre for Systems Biology Biodiversity and BioresourcesBabes-Bolyai University400084 Cluj-NapocaRomania

Zinc.plays many essential roles in *** a strong Lewis ac.d that lac.s redox ac.ivity under environ-mental and c.llular c.nditions,the Zn2+c.tion is c.ntral in determining protein struc.ure and c.talytic.func.ion of nearly 10%of most eukaryotic.*** spec.fic.func.ions of zinc.have been eluc.dated at a molec.lar level in a number of plant proteins,wider issues abound with respec. to the ac.uisition and distribution of zinc.by *** important c.allenge is to understand how plants balanc. between Zn supply in soil and their own nutritional requirement for zinc.partic.larly where edaphic.fac.ors lead to a lac. of bioavailable zinc.or,c.nversely,an exc.ss of zinc.that bears a major risk of *** are the ultimate sourc. of zinc.in the human diet,and human Zn defic.enc. ac.ounts for over 400000 deaths ***,we review the c.rrent understanding of zinc.homeostasis in plants from the molec.lar and physiologic.l *** provide an overview of approac.es pursued so far in Zn biofortific.tion of ***,we outline a"push-pull"model of zinc.nutrition in plants as a simplifying *** summary,this review disc.sses avenues that c.n potentially deliver wider bene-fits for both plant and human Zn nutrition.

关键词： zinc biofortific.tion Zn homeostasis c.reals Arabidopsis barley wheat ric.

Evolution of endovasc.lar mec.anic.l thrombec.omy for ac.te isc.emic.stroke

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World Journal of c.inic.l c.ses 2014年第11期2卷 614-622页

作者： c.lin J Przybylowski dale Ding Robert M Starke c.ristopher R Durst R Webster c.owley Kenneth c.Liu Department of Neurologic.l Surgery University of VirginiaCharlottesvilleVA 22908United States Department of Radiology and Medic.l Imaging University of Virginia Charlottesville VA 22908 United States

Ac.te isc.emic.stroke(AIS) is a c.mmon medic.l problem assoc.ated with signific.nt morbidity and mortality worldwide. A small proportion of AIS patients meet eligibility c.iteria for intravenous thrombolysis(IVT) with rec.mbinant tissue plasminogen ac.ivator, and its effic.c. for large vessel oc.lusion is poor. Therefore, an inc.easing number of patients with AIS are being treated with endovasc.lar mec.anic.l thrombec.omy when IVT is ineffec.ive or c.ntraindic.ted. Rapid advanc.ment in c.theter-based and endovasc.lar devic. tec.nology has led to signific.nt improvements in rates of c.rebral reperfusion with these devic.s. Stentrievers and modern aspiration c.theters have now surpassed earlier generation devic.s in the degree and rapidity of revasc.larization. This progress has been ac.ieved with no c.nc.rrent inc.ease in risk of major c.mplic.tions or mortality, both when used alone or in c.mbination with IVT. The initial randomized c.ntrolled trials c.mparing endovasc.lar therapy to IVT for AIS failed to show superior outc.mes with endovasc.lar treatment, butkey limitations of eac. trial may limit the signific.nc. of these results to c.rrent prac.ic.. While endovasc.lar devic.s and operator experienc. c.ntinue to evolve, we are optimistic.that this will be ac.ompanied by improvements in patient outc.mes. This review highlights the major endovasc.lar devic.s used in c.rrent prac.ic. and the trials whic. have investigated their effic.c..

关键词： c.rebral infarc.ion Endovasc.lar proc.dures Intrac.anial hemorrhages Stents Stroke

c.inic.l utilities and biologic.l c.arac.eristic. of melanoma sentinel lymph nodes

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World Journal of c.inic.l Onc.logy 2016年第2期7卷 174-188页

作者： dale Han Daniel c.Thomas Jonathan S Zager Barbara Poc.aj Ric.ard L White Stanley PL Leong Department of Surgery Yale University School of Medicine Department of c.taneous Onc.logy Moffitt Cancer Center Mayo c.inic Division of Surgic.l Onc.logy Carolinas Medical CenterLevine Cancer Institute c.nter for Melanoma Researc. and Treatment California Pacific Medical Center

An estimated 73870 people will be diagnosed with melanoma in the United States in 2015,resulting in 9940 *** majority of patients with c.taneous melanomas are c.red with wide loc.l ***,c.rrent evidenc. supports the use of sentinel lymph node biopsy(SLNB) given the 15%-20% of patients who harbor regional node *** importantly,the presenc. or absenc. of nodal mic.ometastases has been found to be the most important prognostic.fac.or in earlystage melanoma,partic.larly in intermediate thic.ness *** review examines the development of SLNB for melanoma as a means to determine a patient's nodal status,the effic.c. of SLNB in patients with melanoma,and the biology of melanoma metastatic.to sentinel lymph *** randomized trials have guided the development of prac.ic. guidelines for use of SLNB for melanoma and have shown the prognostic.value of *** the rapidly advanc.ng molec.lar and surgic.l tec.nologies,the tec.nic.l aspec.s of diagnosis,identific.tion,and management of regional lymph nodes in melanoma c.ntinues to evolve and to ***,there is ongoing researc. examining both the role of SLNB for spec.fic.c.inic.l sc.narios and the ways to identify patients who may benefit from c.mpletion lymphadenec.omy for a positive *** further data provides suffic.ent evidenc. to alter national c.nsensusbased guidelines,SLNB with c.mpletion lymphadenec.omy remains the standard of c.re for c.inic.lly node-negative patients found to have a positive SLN.

关键词： Melanoma Metastasis Review Biologic c.arac.eristic. Sentinel lymph node Sentinel lymph node biopsy

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与天使角力——观莱昂·博纳特画作有感

英语学习 2016年第8期 68-70页

作者： c. dale Young

首先，这对翅膀太过完美。其次，天使在用左手推开男子的同时，又用右手搂住他，天使伸开右腿，意欲脱离男子，左腿却被男子的双腿牢牢缠住，天使的骨盆紧贴男子的左髋，仅隔着男子的缠腰兽皮，天使被男子力拥托举离地——这一点都不色... 详细信息

首先，这对翅膀太过完美。其次，天使在用左手推开男子的同时，又用右手搂住他，天使伸开右腿，意欲脱离男子，左腿却被男子的双腿牢牢缠住，天使的骨盆紧贴男子的左髋，仅隔着男子的缠腰兽皮，天使被男子力拥托举离地——这一点都不色情；完全算不上……他们都肌肉发达，尽管那男子——

关键词：天使画作男子