Crk-associated substrate,vascular smooth muscle and hypertension

作     者：Dale D.TANG 

作者机构：The Center for Cardiovascular SciencesAlbany Medical CollegeNY 12208USA 

出 版 物：《Frontiers of Medicine》 (医学前沿（英文版）)

年 卷 期：2008年第2卷第4期

页      面：323-331页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by a Grant from the National Heart Lung and Blood Institute of USA(No.HL-75388) 

主　　题：Crk-associated substrate protein cytoskeleton muscle contraction cell movement cardiovascular diseases 

摘      要：Hypertension is characterized by vascular smooth muscle constriction and vascular remodeling involving cell migration,hypertrophy and ***-associated substrate(CAS),the first discovered member of the adapter protein CAS family,has been shown to be a critical cellular component that regulates various smooth muscle *** this review,the molecular structure and protein interactions of the CAS family members are *** for the role of CAS in the regu-lation of vascular smooth muscle contractility is *** stimulation induces CAS phosphor-ylation on Tyr-410 in arterial smooth muscle,creating the binding site for the Src homology(SH)2/SH3 protein CrkII,which activates neuronal Wiskott-Aldrich syn-drome protein(N-WASP)-mediated actin assembly and force *** functions of CAS in cell migra-tion,hypertrophy and growth are also *** tyrosine kinase(Abl),c-Src,focal adhesion kinase(FAK),proline-rich tyrosine kinase 2(PYK2),pro-tein tyrosine phosphatase-proline,glutamate,serine and threonine sequence protein(PTP-PEST)and SHP-2 have been documented to coordinate the phosphorylation and dephosphorylation of *** downstream signaling partners of CAS in the context of cell motility,hyper-trophy,survival and growth are also *** new findings establish the important role of CAS in the modulation of vascular smooth muscle ***,the upstream regulators of CAS may be new biologic targets for the development of more effective and specific treatment of cardiovascular diseases such as hypertension.