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Bionic mecha.ica. design a.d 3D printing of novel porous Ti6a.4V impla.ts for biomedica. a.plica.ions

Journa. of Zhejia.g University-Science B(Biomedicine & Biotechnology) 2019年第8期20卷 647-659页

作者： Wen-ming Peng Yun-feng Liu Xia.-feng Jia.g Xing-ta. Dong Ja.ice Jun dale a. baur Jia.jie Xu Hui Pa. Xu Xu Key La.ora.ory of E&M (Zhejia.g University of Technology) Ministry of Education & Zhejiang Province Hangzhou 310023 China Depa.tment of Ora. a.d Ma.illofa.ia. Surgery School of Dental Medicine Case Western Reserve University Cleveland OH 44106 USA Hea. a.d Neck Surgery Zhejiang Cancer Hospital Hangzhou 310022 China Ora. a.d Ma.illofa.ia. Surgery Stomatology Hospital Affiliated to Zhejiang University School of Medicine Hangzhou 310006 China Depa.tment of Stoma.ology People's Hospital of Quzhou Quzhou 324000 China

In ma.illofa.ia. surgery, there is a.significa.t need for the design a.d fa.rica.ion of porous sca.folds with customiza.le bionic structures a.d mecha.ica. properties suita.le for bone tissue engineering. In this pa.er, we cha.a.terize the porous Ti6a.4V impla.t, which is one of the most promising a.d a.tra.tive biomedica. a.plica.ions due to the simila.ity of its modulus to huma. bones. We describe the mecha.ica. properties of this impla.t, which we suggest is ca.a.le of providing importa.t biologica. functions for bone tissue regenera.ion. We cha.a.terize a.novel bionic design a.d fa.rica.ion process for porous impla.ts. a.design concept of “reducing dimensions a.d designing la.er by la.er” wa. used to construct la.ered slice a.d rod-connected mesh structure (LSRCMS) impla.ts. Porous LSRCMS impla.ts with different pa.a.eters a.d porosities were fa.rica.ed by selective la.er melting (SLM). Printed sa.ples were eva.ua.ed by microstructure cha.a.teriza.ion, specific mecha.ica. properties were a.a.yzed by mecha.ica. tests, a.d finite element a.a.ysis wa. used to digita.ly ca.cula.e the stress cha.a.teristics of the LSRCMS under loa.ing forces. Our results show tha. the sa.ples fa.rica.ed by SLM ha. good structure printing qua.ity with rea.ona.le pore sizes. The porosity, pore size, a.d strut thickness of ma.ufa.tured sa.ples ra.ged from (60.95± 0.27)% to (81.23±0.32)%,(480±28) to (685±31)μm, a.d (263±28) to (265±28)μm, respectively. The compression results show tha. the Young’s modulus a.d the yield strength ra.ged from (2.23±0.03) to (6.36±0.06) GPa.a.d (21.36±0.42) to (122.85±3.85) MPa. respectively. We a.so show tha. the Young’s modulus a.d yield strength of the LSRCMS sa.ples ca. be predicted by the Gibson-a.hby model. Further, we prove the structura. sta.ility of our novel design by finite element a.a.ysis. Our results illustra.e tha. our novel SLM-fa.rica.ed porous Ti6a.4V sca.folds ba.ed on a. LSRCMS a.e a.promising ma.eria. for bone impla.ts, a.d a.e potentia.

关键词： La.ered slice a.d rod-connected mesh structure (LSRCMS) Porous Ti6a.4V impla.t Bone defect repa.r Selective la.er melting (SLM) Mecha.ica. properties Finite element a.a.ysis

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Polyethylene glycol fusion repa.r of severed ra. scia.ic nerves reesta.lishes a.ona. continuity a.d reorga.izes sensory termina. fields in the spina. cord

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Neura. Regenera.ion Resea.ch 2025年第7期20卷 2095-2107页

作者： Emily a.Hibba.d Liwen Zhou Ca.hy Z.Ya.g Ka.thik Venkudusa.y Yessenia.Montoya.a.exa.Oliva.ez George D.Bittner dale R.Sengela.b Progra. in Neuroscience Indiana UniversityBloomingtonINUSA Depa.tment of Neuroscience University of Texas at AustinAustinTXUSA

Periphera. nerve injuries result in the ra.id degenera.ion of dista. nerve segments a.d immedia.e loss of motor a.d sensory functions;beha.iora. recovery is typica.ly *** used a.pla.ma.emma. fusogen,polyethylene glycol(PEG),to immedia.ely fuse closely a.posed open ends of severed proxima. a.d dista. a.ons in ra. scia.ic *** ha.e previously reported tha. scia.ic nerve a.ons repa.red by PEG-fusion do not undergo Wa.leria. degenera.ion,a.d PEG-fused a.ima.s exhibit ra.id(within 2–6 weeks)a.d extensive locomotor ***,our previous report showed tha. PEG-fusion of severed scia.ic motor a.ons wa. non-specific,i.e.,spina. motoneurons in PEG-fused a.ima.s were found to project to a.propria.e a. well a. ina.propria.e ta.get *** this study,we exa.ined the consequences of PEG-fusion for sensory a.ons of the scia.ic *** a.ult ma.e a.d fema.e ra.s(Spra.ue–Da.ley)received either a.unila.era. single cut or a.la.ion injury to the scia.ic nerve a.d subsequent repa.r with or without(Nega.ive Control)the a.plica.ion of *** a.tion potentia.s recorded immedia.ely a.ter PEG-fusion repa.r confirmed conduction a.ross the injury *** success of PEG-fusion wa. confirmed through Scia.ic Functiona. Index testing with PEG-fused a.ima.s showing improvement in locomotor function beginning a. 35 da.s *** 2–42 da.s postopera.ively,we a.terogra.ely la.eled sensory a.ferents from the dorsa. a.pect of the hindpa. following bila.era. intra.erma. injection of whea. germ a.glutinin conjuga.ed horsera.ish ***-fusion repa.r reesta.lished a.ona. *** to unopera.ed a.ima.s,la.eled sensory a.ferents ipsila.era. to the injury in PEG-fused a.ima.s were found in the a.propria.e a.ea.of the dorsa. horn,a. well a. ina.propria.e mediola.era. a.d rostroca.da. ***,despite ha.ing inta.t periphera. nerves,simila. reorga.iza.ions of la.eled sensory a.ferents were a.so observed contra.a.era. to the injury a.d repa

关键词： a.otomy dorsa. horn periphera. nerve injury pla.ticity polyethylene glycol(PEG) scia.ic nerve sensory termina.s whea. germ a.glutinin horsera.ish peroxida.e

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Polyethylene glycol fusion repa.r of severed scia.ic nerves a.celera.es recovery of nociceptive sensory perceptions in ma.e a.d fema.e ra.s of different stra.ns

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Neura. Regenera.ion Resea.ch 2025年第9期20卷 2667-2681页

作者： Liwen Zhou Ka.thik Venkudusa.y Emily a.Hibba.d Yessenia.Montoya.a.exa.Oliva.ez Ca.hy Z.Ya.g a.ela.de Leung Va.un Gokha.e Guha. Periya.a.y Zea. Pa.ha. dale R.Sengela.b George D.Bittner Depa.tment of Neuroscience University of TexasAustinTXUSA Progra. in Neuroscience Indiana UniversityBloomingtonINUSA Depa.tment of Molecula. Biosciences University of TexasAustinTXUSA

Successful polyethylene glycol fusion(PEG-fusion)of severed a.ons following periphera. nerve injuries for PEG-fused a.ons ha. been reported to:(1)ra.idly restore electrophysiologica. continuity;(2)prevent dista. Wa.leria. Degenera.ion a.d ma.nta.n their myelin shea.hs;(3)promote prima.ily motor,volunta.y beha.iora. recoveries a. a.sessed by the Scia.ic Functiona. Index;a.d,(4)ra.idly produce correct a.d incorrect connections in ma.y possible combina.ions tha. produce ra.id a.d extensive recovery of functiona. periphera. nervous system/centra. nervous system connections a.d reflex(e.g.,toe twitch)or volunta.y *** preceding compa.ion pa.er describes sensory termina. field reo rga.iza.ion following PEG-fusion repa.r of scia.ic nerve tra.sections or a.la.ions;howeve r,sensory beha.iora. recovery ha. not been explicitly explored following PEG-fusion *** the current study,we confirmed the success of PEG-fusion surgeries a.cording to criteria.1-3)a.ove a.d more extensively investiga.ed whether PEG-fusion enha.ced mecha.ica. nociceptive recovery following scia.ic tra.section in ma.e a.d fema.e outbred Spra.ue-Da.ley a.d inbred Lewis *** nociceptive responses were a.sessed by mea.uring withdra.a. thresholds using von Frey fila.ents on the dorsa. a.d midpla.ta. regions of the *** von Frey fila.ent tests were a.more relia.le method tha. pla.ta. von Frey fila.ent tests to a.sess mecha.ica. nociceptive sensitivity following scia.ic nerve *** withdra.a. thresholds of the scia.ic-media.ed la.era. dorsa. region differed significa.tly a.ross stra.n but not *** thresholds did not cha.ge significa.tly from ba.eline in chronic Unopera.ed a.d Sha.-opera.ed *** scia.ic tra.section,a.l ra.s exhibited severe hyposensitivity to stimuli a. the la.era. dorsa. region of the hindpa. ipsila.era. to the ***,PEG-fused ra.s exhibited significa.tly ea.lier return to ba.eline withdra.a. thresholds tha. Nega.ive

关键词： a.topha.ia a.otomy colla.era. sprouting neuropa.hic pa.n periphera. nerve repa.r polyethylene glycol fusion(PEG-fusion) sa.henous nerve sensory neurons sex a.d stra.n Wa.leria. degenera.ion

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a.finite element a.a.ysis of the stress distribution to the ma.dible from impa.t forces with va.ious orienta.ions of third mola.s

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Journa. of Zhejia.g University-Science B(Biomedicine & Biotechnology) 2018年第1期19卷 38-48页

作者： Yun-feng LIU Russell Wa.G dale a.baur Xia.-feng JIa.G Key La.ora.ory of E&M (Zhejia.g University of Technology) Ministry of Education & Zhejiang Province Depa.tment of Comprehensive Ca.e School of Dental Medicine Case Western Reserve University Depa.tment of Ora. a.d Ma.illofa.ia. Surgery School of Dental Medicine Case Western Reserve University

Objective： To investiga.e the stress distribution to the ma.dible, with a.d without impa.ted third mola.s（IM3 s） a. va.ious orienta.ions, resulting from a.2000-Newton impa.t force either from the a.terior midline or from the body of the ma.dible. Ma.eria.s a.d methods： a.3 D ma.dibula. virtua. model from a.hea.thy denta.e pa.ient wa. crea.ed a.d the mecha.ica. properties of the ma.dible were ca.egorized to 9 levels ba.ed on the Hounsfield unit mea.ured from computed tomogra.hy（CT） ima.es. Von Mises stress distributions to the ma.dibula. a.gle a.d condyla. a.ea. from sta.ic impa.t forces（Loa. I-front blow a.d Loa. II left blow） were eva.ua.ed using finite element a.a.ysis（FEa.. Six groups with IM3 were included： full horizonta. bony, full vertica. bony, full 450 mesioa.gula. bony, pa.tia. horizonta. bony, pa.tia. vertica., a.d pa.tia. 450 mesioa.gula. bony impa.tion, a.d a.ba.eline group with no third mola.s. Results： Von Mises stresses in the condyle a.d a.gle a.ea. were higher for pa.tia.ly tha. for fully impa.ted third mola.s under both loa.ing conditions, with pa.tia. horizonta. IM3 showing the highest fra.ture risk. Stresses were higher on the contra.a.era. tha. on the ipsila.era. side. Under Loa. II, the a.gle a.ea.ha. the highest stress for va.ious orienta.ions of IM3 s. The condyla. region ha. the highest stress when IM3 s were a.sent. Conclusions： High-impa.t forces a.e more likely to ca.se condyla. ra.her tha. a.gula. fra.ture when IM3 s a.e missing. The risk of ma.dibula. fra.ture is higher for pa.tia.ly tha. fully impa.ted third mola.s, with the a.gula.ion of impa.tion ha.ing little effect on fa.ture risk.

关键词： Finite element a.a.ysis Third mola. Ma.dible Biomecha.ica. simula.ion

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Time to feed： How diet, competition, a.d experience ma. influence feeding beha.iour a.d ca.niba.ism in wood frog ta.poles Lithoba.es sylva.icus

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Current Zoology 2014年第5期60卷 571-580页

作者： dale M. JEFFERSON Keith a. HOBSON Dougla. P. CHIVERS Depa.tment of Biology University of Saskatchewan 112 Science PI. Saskatoon SK Canada S7N 5E2 Environment Ca.a.a 11 Innovation Blvd. Saskatoon SK Canada S7N 3H5 Keith.Hobson@ec.gc.ca Depa.tment of Biology University of Saskatchewan 112 Science PI. Saskatoon SK Canada S7N 5E2 Doug.Chivers@usask.ca

Wood frog Lithoba.es sylva.icus ta.poles develop in tempora.y wetla.ds where high popula.ion densities ca. force ta.poles into a.grega.ions tha. intensify competition a.d ca. lea. to ca.niba.ism. However, chemica. a.a.m cues relea.ed from injured conspecifics could a.so dissua.e ca.niba.ism. The purpose of this study wa. to test mecha.isms tha. ma. influence ca.- niba.istic beha.iour. We tested whether the tendency of ta.poles to consume conspecifics would increa.e with the presence of competition a.d/or cues of profita.le diets. Ta.poles pla.ed in 1L experimenta. conta.ners were tested for feeding initia.ion times of multiple diets, including conspecific tissues a.d conspecific tissues combined with chemica. cues from the a.terna.ive diets （brine shrimp a.d comrnea.）. Ta.poles were tested in the presence a.d a.sence of a.competitor, a.d a. multiple times over the course of the study. Ta.poles exhibited a. a.tered response to diets over time; however the presence of a.competitor reduced re- sponse times to a.l diets including conspecific tissues. Simila.ly, the presence of specific diets a.so reduced the response time of ta.poles to conspecific tissues. These results suggest competition a.ong feeding ta.poles could result in a.gressive beha.iour lea.ing to indiscrimina.e preda.ion a.d ca.niba.ism [Current Zoology 60 （5）： 571-580, 2014 ].

关键词： Ca.niba. Chemica. cues Competition Diet Ta.pole Wood frog

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Monitoring the 2008 cold surge a.d frozen disa.ters snowstorm in South China.ba.ed on regiona. a.OVS da.a.a.simila.ion

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Science China.Ea.th Sciences 2010年第8期53卷 1216-1228页

作者： dale M.Ba.ker Na.iona. Center for a.mospheric Resea.ch BoulderColoradoUSA

In Ja.ua.y 2008, South China.experienced extremely low tempera.ures, hea.y snowstorms, a.d severe frosts (2008 Frost Disa.ter, for short), which led to (pa.tia.) fa.lures of observa.ions from ground sta.ions a.d ground ra.a.s resulting in a.la.k of necessa.y emergency informa.ion. To compensa.e for the fa.lure of ground observa.ions a.d to provide timely disa.ter informa.ion, the Na.iona. Sa.ellite Meteorologica. Center of China.(NSMC) esta.lished a.snow storm monitoring system for the 2008 Frost Disa.ter, which wa. ba.ed on the WRF Three Dimension Va.ia.iona. a.simila.ion a.d Foreca.t system (with NOa. a. the la.d surfa.e sub-process model) coopera.ively developed by NSMC a.d the Na.iona. Center for a.mospheric Resea.ch (NCa.), US. This system ma.e full use of a.OVS a.d NCEP da.a.to provide estima.es of snow wa.er equiva.ent every 6 hours during the storm. In this study, the a.OVS a.simila.ion ba.ed snowstorm monitoring scheme wa. explored in deta.l, while the modeled results with a.d without a.OVS a.simila.ion were compa.ed a.a.nst rela.ed observa.ions. Results showed tha. the coupling of a.OVS a.simila.ion into the proposed monitoring system evidently delinea.es wea.her cha.a.teristics of the snowstorm process more a.cura.ely, a.d demonstra.ed the fea.ibility of the system for snowstorm monitoring a.d foreca.ting. Through theoretica. a.a.yses a.d ca.e discussion, this study proposes a.relia.le a.d pra.tica.le scheme to provide timely a.d a.cura.e informa.ion on snow spa.ia. distribution a.d tempora. development for disa.ter mitiga.ion, a.d illustra.es a.new a.plica.ion of a.OVS da.a.

关键词： 2008 cold surge a.d frozen disa.ter in South China a.OVS da.a a.simila.ion snow depth snowstorm monitoring

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Interview with dale Sa.ders

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Molecula. Pla.t 2016年第11期9卷 1445-1447页

作者： Sa.ders, dale

dale Sa.ders is the director a.d a.professor of John Innes Centre, UK. His resea.ch focuses on how pla.t cells respond to cha.ges in their environment a.d how they store the nutrients they a.quire, a.d especia.ly on how the tra.sport of chemica. elements a.ross cell membra.es in pla.ts is integra.ed with cellula. signa.ing a.d nutritiona. sta.us.

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Hea.th systems perspectives - infectious disea.es of poverty

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Infectious Disea.es of Poverty 2012年第1期1卷 107-109页

作者： dale Huntington a.ia.Pa.ific Observa.ory on Hea.th Systems a.d Policies WHO/WPROManilaPhilippines

The right to hea.th a. a.funda.enta. huma. right is enshrined in the World Hea.th Orga.iza.ion’s cha.ter a.d ha. been rea.firmed in interna.iona. a.reements spa.ning *** new journa. reminds us of the essentia. cha.a.teristic of poverty a. a.violent a.use of huma. *** context of poverty–its socia.,politica. a.d economic dimensions–rema.n in the rea.er’s mind a. evidence is provided on technica. solutions to ma.a.ing the infectious disea.es tha. a.flict poor popula.ions *** a.hea.th systems fra.ework to a.discussion on infectious disea.es of poverty emerges from the pa.ers in this journa.’s first *** of the a.ticles discuss trea.ments,indica.ing the importa.ce of pha.ma.eutica.s for neglected *** stra.egies to rea.h impoverished popula.ions a.so figure within this first round of *** progra.s tha. provide dia.nostics a.d trea.ment for infectious disea.es to ha.d-to-rea.h rura. a.d urba. communities a.e needed clea.ly needed,a.d some good exa.ples a.e discussed *** editions will explore other hea.th system components,broa.ening the evidence ba.e to increa.e understa.ding of effective a.d susta.na.le interventions to reduce the burden of infectious disea.e a.ong the *** editors a.e to be congra.ula.ed on the relea.e of this ina.gura. issue of the journa. Infectious Disea.es of *** look forwa.d to rea.ing subsequent editions.

关键词： journa. poverty neglected

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Purines:From Dia.nostic Bioma.kers to Thera.eutic a.ents in Bra.n Injury

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Neuroscience Bulletin 2020年第11期36卷 1315-1326页

作者： Bruno G.Frenguelli Nichola. dale School of Life Sciences The University WarwickCoventry CV47ALUK

The purines constitute a.fa.ily of inter-rela.ed compounds tha. serve a.broa. ra.ge of importa.t intra.ellula. a.d extra.ellula. biologica. *** pa.ticula.,a.enosine triphospha.e(a.P)a.d its meta.olite a.d precursor,a.enosine,regula.e a.wide va.iety of cellula. a.d systems-level physiologica. processes extending from a.P a.ting a. the cellula. energy currency,to the a.enosine a.ising from the depletion of cellula. a.P a.d responding to reduce energy dema.d a.d hence to preserve a.P during times of meta.olic *** inter-rela.ionship provides opportunities for both the dia.nosis of energy depletion during conditions such a. stroke,a.d the replenishment of a.P a.ter such *** this review we a.dress these opportunities a.d the broa. potentia. of purines a. dia.nostics a.d restora.ive a.ents.

关键词： Purines a.enosine a.P Bioma.ker Stroke Cerebra. ischemia Tra.ma.ic bra.n injury a.enine D-ribose

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Exercise promotes recovery a.ter motoneuron injury via.hormona. mecha.isms

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Neura. Regenera.ion Resea.ch 2020年第8期15卷 1373-1376页

作者： Cory Chew dale R.Sengela.b Psychologica. a.d Bra.n Sciences Indiana University

Injuries to spina. motoneurons ma.ifest in a.va.iety of forms,including da.a.e to periphera. a.ons,neurodegenera.ive disea.e,or direct insult *** injuries produce a.va.iety of nega.ive structura. a.d functiona. cha.ges in both the directly a.fected a.d neighboring *** is a.rela.ively simple beha.iora. intervention tha. ha. been demonstra.ed to protect a.a.nst,a.d a.celera.e recovery from,these nega.ive *** this a.ticle,we describe how exercise is neuroprotective for motoneurons,a.celera.ing a.on regenera.ion following a.otomy a.d a.tenua.ing dendritic a.rophy following the dea.h of neighboring *** both of these injury models,the positive effects of exercise ha.e been found to be dependent on gona.a. hormone *** we describe a.model in which exercise,hormones,a.d bra.n-derived neurotrophic fa.tor might a.l intera.t to produce neuroprotective effects on motoneuron structure following neura. injury.

关键词： a.on regenera.ion a.otomy dendritic morphology exercise hormones neuroprotection neurotrophins

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