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Neuroscience edited by dale Purves ... [et al.]. 2nd ed.

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Polyethylene glycol fusion repair of severed rat sciatic nerves reestablishes axonal continuity and reorganizes sensory terminal fields in the spinal cord

2001年

作者： edited by dale Purves ... [et al.].

来源：畅想之星图书光盘版（南... 评论

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Neural Regeneration Research 2025年第7期20卷 2095-2107页

作者： Emily A.Hibbard Liwen Zhou Cathy Z.Yang Karthik Venkudusamy Yessenia Montoya Alexa Olivarez George D.Bittner dale R.Sengelaub Program in Neuroscience Indiana UniversityBloomingtonINUSA Department of Neuroscience University of Texas at AustinAustinTXUSA

Peripheral nerve injuries result in the rapid degeneration of distal nerve segments and immediate loss of motor and sensory functions;behavioral recovery is typically *** used a plasmalemmal fusogen,polyethylene glycol(PEG),to immediately fuse closely apposed open ends of severed proximal and distal axons in rat sciatic *** have previously reported that sciatic nerve axons repaired by PEG-fusion do not undergo Wallerian degeneration,and PEG-fused animals exhibit rapid(within 2–6 weeks)and extensive locomotor ***,our previous report showed that PEG-fusion of severed sciatic motor axons was non-specific,i.e.,spinal motoneurons in PEG-fused animals were found to project to appropriate as well as inappropriate target *** this study,we examined the consequences of PEG-fusion for sensory axons of the sciatic *** adult male and female rats(Sprague–Dawley)received either a unilateral single cut or ablation injury to the sciatic nerve and subsequent repair with or without(Negative Control)the application of *** action potentials recorded immediately after PEG-fusion repair confirmed conduction across the injury *** success of PEG-fusion was confirmed through Sciatic Functional Index testing with PEG-fused animals showing improvement in locomotor function beginning at 35 days *** 2–42 days postoperatively,we anterogradely labeled sensory afferents from the dorsal aspect of the hindpaw following bilateral intradermal injection of wheat germ agglutinin conjugated horseradish ***-fusion repair reestablished axonal *** to unoperated animals,labeled sensory afferents ipsilateral to the injury in PEG-fused animals were found in the appropriate area of the dorsal horn,as well as inappropriate mediolateral and rostrocaudal ***,despite having intact peripheral nerves,similar reorganizations of labeled sensory afferents were also observed contralateral to the injury and repa

关键词： axotomy dorsal horn peripheral nerve injury plasticity polyethylene glycol(PEG) sciatic nerve sensory terminals wheat germ agglutinin horseradish peroxidase

Polyethylene glycol fusion repair of severed sciatic nerves accelerates recovery of nociceptive sensory perceptions in male and female rats of different strains

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Neural Regeneration Research 2025年第9期20卷 2667-2681页

作者： Liwen Zhou Karthik Venkudusamy Emily A.Hibbard Yessenia Montoya Alexa Olivarez Cathy Z.Yang Adelaide Leung Varun Gokhale Guhan Periyasamy Zeal Pathak dale R.Sengelaub George D.Bittner Department of Neuroscience University of TexasAustinTXUSA Program in Neuroscience Indiana UniversityBloomingtonINUSA Department of Molecular Biosciences University of TexasAustinTXUSA

Successful polyethylene glycol fusion(PEG-fusion)of severed axons following peripheral nerve injuries for PEG-fused axons has been reported to:(1)rapidly restore electrophysiological continuity;(2)prevent distal Wallerian Degeneration and maintain their myelin sheaths;(3)promote primarily motor,voluntary behavioral recoveries as assessed by the Sciatic Functional Index;and,(4)rapidly produce correct and incorrect connections in many possible combinations that produce rapid and extensive recovery of functional peripheral nervous system/central nervous system connections and reflex(e.g.,toe twitch)or voluntary *** preceding companion paper describes sensory terminal field reo rganization following PEG-fusion repair of sciatic nerve transections or ablations;howeve r,sensory behavioral recovery has not been explicitly explored following PEG-fusion *** the current study,we confirmed the success of PEG-fusion surgeries according to criteria(1-3)above and more extensively investigated whether PEG-fusion enhanced mechanical nociceptive recovery following sciatic transection in male and female outbred Sprague-Dawley and inbred Lewis *** nociceptive responses were assessed by measuring withdrawal thresholds using von Frey filaments on the dorsal and midplantar regions of the *** von Frey filament tests were a more reliable method than plantar von Frey filament tests to assess mechanical nociceptive sensitivity following sciatic nerve *** withdrawal thresholds of the sciatic-mediated lateral dorsal region differed significantly across strain but not *** thresholds did not change significantly from baseline in chronic Unoperated and Sham-operated *** sciatic transection,all rats exhibited severe hyposensitivity to stimuli at the lateral dorsal region of the hindpaw ipsilateral to the ***,PEG-fused rats exhibited significantly earlier return to baseline withdrawal thresholds than Negative

关键词： autophagia axotomy collateral sprouting neuropathic pain peripheral nerve repair polyethylene glycol fusion(PEG-fusion) saphenous nerve sensory neurons sex and strain Wallerian degeneration

Monitoring the 2008 cold surge and frozen disasters snowstorm in South China based on regional ATOVS data assimilation

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Science China Earth Sciences 2010年第8期53卷 1216-1228页

作者： dale M.Barker National Center for Atmospheric Research BoulderColoradoUSA

In January 2008, South China experienced extremely low temperatures, heavy snowstorms, and severe frosts (2008 Frost Disaster, for short), which led to (partial) failures of observations from ground stations and ground radars resulting in a lack of necessary emergency information. To compensate for the failure of ground observations and to provide timely disaster information, the National Satellite Meteorological Center of China (NSMC) established a snow storm monitoring system for the 2008 Frost Disaster, which was based on the WRF Three Dimension Variational Assimilation and Forecast system (with NOAH as the land surface sub-process model) cooperatively developed by NSMC and the National Center for Atmospheric Research (NCAR), US. This system made full use of ATOVS and NCEP data to provide estimates of snow water equivalent every 6 hours during the storm. In this study, the ATOVS assimilation based snowstorm monitoring scheme was explored in detail, while the modeled results with and without ATOVS assimilation were compared against related observations. Results showed that the coupling of ATOVS assimilation into the proposed monitoring system evidently delineates weather characteristics of the snowstorm process more accurately, and demonstrated the feasibility of the system for snowstorm monitoring and forecasting. Through theoretical analyses and case discussion, this study proposes a reliable and practicable scheme to provide timely and accurate information on snow spatial distribution and temporal development for disaster mitigation, and illustrates a new application of ATOVS data.

关键词： 2008 cold surge and frozen disaster in South China ATOVS data assimilation snow depth snowstorm monitoring

Health systems perspectives - infectious diseases of poverty

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Infectious Diseases of Poverty 2012年第1期1卷 107-109页

作者： dale Huntington Asia Pacific Observatory on Health Systems and Policies WHO/WPROManilaPhilippines

The right to health as a fundamental human right is enshrined in the World Health Organization’s charter and has been reaffirmed in international agreements spanning *** new journal reminds us of the essential characteristic of poverty as a violent abuse of human *** context of poverty–its social,political and economic dimensions–remain in the reader’s mind as evidence is provided on technical solutions to managing the infectious diseases that afflict poor populations *** a health systems framework to a discussion on infectious diseases of poverty emerges from the papers in this journal’s first *** of the articles discuss treatments,indicating the importance of pharmaceuticals for neglected *** strategies to reach impoverished populations also figure within this first round of *** programs that provide diagnostics and treatment for infectious diseases to hard-to-reach rural and urban communities are needed clearly needed,and some good examples are discussed *** editions will explore other health system components,broadening the evidence base to increase understanding of effective and sustainable interventions to reduce the burden of infectious disease among the *** editors are to be congratulated on the release of this inaugural issue of the journal Infectious Diseases of *** look forward to reading subsequent editions.

关键词： journal poverty neglected

Focus on Health: 6th ed.

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Purines:From Diagnostic Biomarkers to Therapeutic Agents in Brain Injury

2003年

作者： Hahn dale B.

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Neuroscience Bulletin 2020年第11期36卷 1315-1326页

作者： Bruno G.Frenguelli Nicholas dale School of Life Sciences The University WarwickCoventry CV47ALUK

The purines constitute a family of inter-related compounds that serve a broad range of important intracellular and extracellular biological *** particular,adenosine triphosphate(ATP)and its metabolite and precursor,adenosine,regulate a wide variety of cellular and systems-level physiological processes extending from ATP acting as the cellular energy currency,to the adenosine arising from the depletion of cellular ATP and responding to reduce energy demand and hence to preserve ATP during times of metabolic *** inter-relationship provides opportunities for both the diagnosis of energy depletion during conditions such as stroke,and the replenishment of ATP after such *** this review we address these opportunities and the broad potential of purines as diagnostics and restorative agents.

关键词： Purines Adenosine ATP Biomarker Stroke Cerebral ischemia Traumatic brain injury Adenine D-ribose

Exercise promotes recovery after motoneuron injury via hormonal mechanisms

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Neural Regeneration Research 2020年第8期15卷 1373-1376页

作者： Cory Chew dale R.Sengelaub Psychological and Brain Sciences Indiana University

Injuries to spinal motoneurons manifest in a variety of forms,including damage to peripheral axons,neurodegenerative disease,or direct insult *** injuries produce a variety of negative structural and functional changes in both the directly affected and neighboring *** is a relatively simple behavioral intervention that has been demonstrated to protect against,and accelerate recovery from,these negative *** this article,we describe how exercise is neuroprotective for motoneurons,accelerating axon regeneration following axotomy and attenuating dendritic atrophy following the death of neighboring *** both of these injury models,the positive effects of exercise have been found to be dependent on gonadal hormone *** we describe a model in which exercise,hormones,and brain-derived neurotrophic factor might all interact to produce neuroprotective effects on motoneuron structure following neural injury.

关键词： axon regeneration axotomy dendritic morphology exercise hormones neuroprotection neurotrophins

The Amur tiger in Northeast Asia:Conservation and ecology of an endangered subspecies

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Integrative Zoology 2015年第4期10卷 311-314页

作者： dale G.MIQUELLE Wildlife Conservation Society Bronx New YorkUSA

When I first traveled to Russia to begin a radiotelemetry project on Amur tigers,I was operating on the false assumption that we would be“the first”to study and begin to understand the ecology of this northernmost subspecies of *** ignorance was,as it turned out,primarily a language barrier,as nearly all work that had been conducted on this subspecies existed in either Russian or Chinese languages.

关键词： Conservation endangered Northeast