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<i>Citrus jabara</i>Extracts Suppress MUC5AC Mucin Production in Human Lung Epithelial Cells

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Advances in Biological Chemistry 2017年第3期7卷 139-150页

作者： Jun Iwashita Naoki Iguchi Akiko Takashima daisuke watanabe Kimihiko Sano Masahiko Ishikuro Keishi Hata Jun Murata Faculty of Bioresource Sciences Akita Prefectural University Akita Japan Sano Inc. Akita Japan IWAKI & CO. Ltd. Tokyo Japan Akita Research Institute of Food & Brewing Akita Japan

In the human airway, the overproduction of MUC5AC mucin is a key feature of allergic asthma, and it induces airway narrowing and obstruction. The production of MUC5AC is regulated by several signals, but the mechanism is not completely understood. We investigated the effect of jabara, a citrus containing abundant flavonoids, on the regulation of MUC5AC production. When NCI-H292 human airway epithelial cells were cultured with jabara extracts, we found that the expression of Periodic acid-schiff stained mucin was suppressed with downregulated MUC5AC production. In human primary airway cells derived from asthmatic patients, MUC5AC production was also suppressed by jabara extracts. The treatment of cells with jabara extracts decreased ERK activation in NCI-H292 and in primary cells. These results show that jabara extracts contain some factors that suppress MUC5AC production and ERK activity and suggest that it will be useful for relieving asthma.

关键词： MUC5AC Mucin Citrus jabara ERK

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日本针灸标准研制现状及其对一些问题的思考

中国针灸 2012年第10期32卷 925-927页

作者：渡边大佑高木健赵雪郭义天津中医药大学针灸学院国家中医药管理局针灸标准化研究中心试点建设单位天津300193

从国家标准、行业标准及企业标准3方面介绍日本针灸标准的研制现状。日本现有一项国家标准,即一次性毫针标准,有9项行业标准和若干企业标准。日本针灸标准化的一些问题是数量偏少,在一些重要领域没有相应的标准,同时由于日本政府的重视... 详细信息

从国家标准、行业标准及企业标准3方面介绍日本针灸标准的研制现状。日本现有一项国家标准,即一次性毫针标准,有9项行业标准和若干企业标准。日本针灸标准化的一些问题是数量偏少,在一些重要领域没有相应的标准,同时由于日本政府的重视度尚不够,来自国家的支持也少,日本针灸标准化刚刚起步,还需要进一步的发展。

关键词：针灸标准日本

Protein-losing enteropathy caused by a jejunal ulcer after an internal hernia in Petersen's space: A case report

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World Journal of Clinical Cases 2022年第1期10卷 323-330页

作者： Tomohiko Yasuda Nobuyuki Sakurazawa Komei Kuge Jun Omori Hiroki Arai daisuke Kakinuma Masanori watanabe Hideyuki Suzuki Katsuhiko Iwakiri Hiroshi Yoshida Department of Gastrointestinal Surgery Nippon Medical School Chiba Hokusoh HospitalChiba 270-1694Japan Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery Nippon Medical SchoolTokyo 113-8603Japan Department of Gastroenterology Nippon Medical SchoolTokyo 113-8603Japan

BACKGROUND The incidence of internal hernias has recently increased in concordance with the popularization of laparoscopic surgery.Of particular concern are internal hernias occurring in Petersen's space,a space that is surgically created after treatment for gastric cancer and obesity.These hernias cause devastating sequelae,such as massive intestinal necrosis,fatal Roux limb necrosis,and superior mesenteric vein thrombus.In addition,protein-losing enteropathy(PLE)is a rare syndrome involving gastrointestinal protein loss,although its relationship with internal Petersen’s hernias remains unknown.CASE SUMMARY A 75-year-old man with a history of laparotomy for early gastric cancer developed Petersen's hernia 1 year and 5 mo after surgery.He was successfully treated by reducing the incarcerated small intestine and closure of Petersen’s defect without resection of the small intestine.Approximately 3 mo after his surgery for Petersen’s hernia,he developed bilateral leg edema and hypoalbuminemia.He was diagnosed with PLE with an alpha-1 antitrypsin clearance of 733 mL/24 h.Double-balloon enteroscopy revealed extensive jejunal ulceration as the etiology,and it facilitated minimum bowel resection.Pathological analysis showed extensive jejunal ulceration and collagen hyperplasia with nonspecific inflammation of all layers without lymphangiectasia,lymphoma,or vascular abnormalities.His postoperative course was unremarkable,and his bilateral leg edema and hypoalbuminemia improved after 1 mo.There was no relapse over the 5-year follow-up period.CONCLUSION PLE and extensive jejunal ulceration may occur after Petersen's hernia.Doubleballoon enteroscopy helps identify and resect these lesions.

关键词： Internal hernia Ulcer Protein-losing enteropathy Double-balloon enteroscopy Ischemia-reperfusion injury Case report

澳大利亚、韩国、日本和美国针灸标准概况（英文）

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World Journal of Acupuncture-Moxibustion 2017年第4期27卷 20-26页

作者：杨馥铭杨毅渡边大佑金光郭义赵雪郭永明陈泽林林慧敏高旸天津中医药大学小雀斋汉方针灸治疗院天津中医药大学第一教学医院

目的:通过比较针灸标准的不同侧重点,总结不同地区针灸行业管理的模式和方法,为制定适合不同地区针灸标准的机构和区域提供参考。方法:将使用针灸的地区按运用针灸的原因划分,选择检索国家为澳大利亚、韩国、日本和美国,检索语言限定为... 详细信息

目的:通过比较针灸标准的不同侧重点,总结不同地区针灸行业管理的模式和方法,为制定适合不同地区针灸标准的机构和区域提供参考。方法:将使用针灸的地区按运用针灸的原因划分,选择检索国家为澳大利亚、韩国、日本和美国,检索语言限定为英文、韩文和日文,检索上述4个国家的国家标准网,针刺协会/学会官网。将针刺立法情况视为该国针刺标准的一部分纳入研究。结果:日本技术标准比重最大,韩国基础标准比重最大,美国和澳大利亚管理标准占比重最大。结论:日本和韩国受文化和历史影响,建立的针灸标准体系以技术和基础为重心,而美国和澳大利亚颁布的针刺标准体系以管理为重心。

关键词：针灸标准立法澳大利亚韩国日本美国

Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome-wide association and whole genome sequencing analyses

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Cancer Communications 2024年第2期44卷 287-293页

作者： Kouya Shiraishi Atsushi Takahashi Yukihide Momozawa Yataro Daigo Syuzo Kaneko Takahisa Kawaguchi Hideo Kunitoh Shingo Matsumoto Hidehito Horinouchi Akiteru Goto Takayuki Honda Kimihiro Shimizu Masahiro Torasawa daisuke Takayanagi Motonobu Saito Akira Saito Yuichiro Ohe Shun-ichi watanabe Koichi Goto Masahiro Tsuboi Katsuya Tsuchihara Sadaaki Takata Tomomi Aoi Atsushi Takano Masashi Kobayashi Yohei Miyagi Kazumi Tanaka Hiroyuki Suzuki Daichi Maeda Takumi Yamaura Maiko Matsuda Yoko Shimada Takaaki Mizuno Hiromi Sakamoto Teruhiko Yoshida Yasushi Goto Tatsuya Yoshida Taiki Yamaji Makoto Sonobe Shinichi Toyooka Kazue Yoneda Katsuhiro Masago Fumihiro Tanaka Megumi Hara Nobuo Fuse Satoshi S.Nishizuka Noriko Motoi Norie Sawada Yuichiro Nishida Kazuki Kumada Kenji Takeuchi Kozo Tanno Yasushi Yatabe Kuniko Sunami Tomoyuki Hishida Yasunari Miyazaki Hidemi Ito Mitsuhiro Amemiya Hirohiko Totsuka Haruhiko Nakayama Tomoyuki Yokose Kazuyoshi Ishigaki Toshiteru Nagashima Yoichi Ohtaki Kazuhiro Imai Ken Takasawa Yoshihiro Minamiya Kazuma Kobayashi Kenichi Okubo Kenji Wakai Atsushi Shimizu Masayuki Yamamoto Motoki Iwasaki Koichi Matsuda Johji Inazawa Yuichi Shiraishi Hiroyoshi Nishikawa Yoshinori Murakami Michiaki Kubo Fumihiko Matsuda Yoichiro Kamatani Ryuji Hamamoto Keitaro Matsuo Takashi Kohno Division of Genome Biology National Cancer Center Research InstituteTokyoJapan Department of Clinical Genomics National Cancer Center Research InstituteTokyoJapan Laboratory for Statistical Analysis Center for Integrative Medical SciencesRIKENYokohamaJapan Department of Genomic Medicine Research InstituteNational Cerebral and Cardiovascular CenterOsakaJapan Laboratory for Genotyping Development Center for Integrative Medical SciencesRIKENYokohamaJapan Center for Antibody and Vaccine Therapy Research HospitalInstitute of Medical ScienceThe University of TokyoTokyoJapan Department of Medical Oncology and Cancer Center and Center for Advanced Medicine against CancerShiga University of Medical ScienceOtsuJapan Division of Medical AI Research and Development National Cancer Center Research InstituteTokyoJapan Center for Genomic Medicine Graduate School of MedicineKyoto UniversityKyotoJapan Department of Medical Oncology Japanese Red Cross Medical CenterTokyoJapan Department of Thoracic Oncology National Cancer Center Hospital EastJapan Department of Thoracic Oncology National Cancer Center HospitalTokyoJapan Department of Cellular and Organ Pathology Graduate School of MedicineAkita UniversityAkitaJapan Department of Respiratory Medicine Tokyo Medical and Dental UniversityBunkyo-kuTokyoJapan Division of General Thoracic Surgery Department of SurgeryShinshu University School of MedicineMatsumotoNaganoJapan Department of General Surgical Science Division of General Thoracic SurgeryGunma University Graduate School of MedicineIntegrative Center of General SurgeryGunma University HospitalGunmaJapan Department of Gastrointestinal Tract Surgery Fukushima Medical University School of MedicineFukushimaJapan StaGen Co. LtdTokyoJapan Division of Thoracic Surgery National Cancer Center HospitalTokyoJapan Department of Thoracic Surgery National Cancer Center Hospital EastChibaJapan Division of Translational Informatics Exploratory Oncology Research and Clinical Trial Center(EPOC

Dear editor,Lung carcinoma is responsible for the highest fatal-ity rate among cancer-related deaths globally,with lung adenocarcinoma(LADC)emerging as the prevailing sub-type.

关键词： adenocarcinoma lung Lung

Screening of agonistic activities against four nuclear receptors in wastewater treatment plants in Japan using a yeast two-hybrid assay

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Journal of Environmental Sciences 2011年第1期23卷 125-132页

作者： daisuke Inoue Koki Nakama Kazuko Sawada Taro watanabe Hisae Matsui Kazunari Sei Tsuyoshi Nakanishi Michihiko Ike Division of Sustainable Energy and Environmental Engineering Osaka University2-1 YamadaokaSuitaOsaka 565-0871Japan Laboratory of Hygienic Chemistry and Molecular Toxicology Gifu Pharmaceutical University5-6-1 Mitahora-higashiGifu 502-8585Japan

To assess the potential endocrine disruptive effects through multiple nuclear receptors （NRs）, especially non-steroidal NRs, in municipal wastewater, we examined the agonistic activities on four NRs （estrogen receptor α, thyroid hormone receptor α, retinoic acid receptor ct and retinoid X receptor α） of untreated and treated wastewater from municipal wastewater treatment plants （WWTPs） in Japan using a yeast two-hybrid assay. Investigation of the influent and effluent of seven WWTPs revealed that agonistic activities against steroidal and non-steroidal NRs were always detected in the influents and partially remained in the effluents. Further investigation of four WWTPs employing conventional activated sludge, pseudo-anoxic-oxic, anoxic-oxic and anaerobic-anoxic-oxic processes revealed that the ability to reduce the agonistic activity against each of the four NRs varies depending on the treatment process. These results indicated that municipal wastewater in Japan commonly contains endocrine disrupting chemicals that exert agonistic activities on steroidal and non-steroidal NRs, and that some of these chemicals are released into the natural aquatic environment. Although the results obtained in yeast assays suggested that measured levels of non-steroidal NR agonists in the effluent of WWTPs were not likely to cause any biological effect, further study is required to assess their possible risks in detail.

关键词： agonistic activity endocrine disrupting chemicals non-steroidal nuclear receptor wastewater treatment plants

Corticotropin-releasing factor secretion from dendritic cells stimulated by commensal bacteria

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World Journal of Gastroenterology 2011年第35期17卷 4017-4022页

作者： Mariko Hojo Toshifumi Ohkusa Harumi Tomeoku Shigeo Koido daisuke Asaoka Akihito Nagahara Sumio watanabe Department of Gastroenterology Juntendo University School of MedicineTokyo 113-8421Japan Department of Gastroenterology and Hepatology The Jikei University Kashiwa HospitalChiba 277-8567Japan

AIM:To study the production and secretion of corticotropin-releasing factor (CRF) by dendritic cells and the influence of commensal bacteria.METHODS:JAWSⅡ cells (ATCC CRL-11904),a mouse dendritic cell line,were seeded into 24-well culture plates and grown for 3 d.Commensal bacterial strains of Clostridium clostrodiiforme (JCM1291),Bacteroides vulgatus (B.vulgatus) (JCM5856),Escherichia coli (JCM1649),or Fusobacterium varium (F.varium) (ATCC8501) were added to the cells except for the control well,and incubated for 2 h.After incubation,we performed enzyme-linked immunosorbent assay for the cultured medium and reverse transcription polymerase chain reaction for the dendritic cells,and compared these values with controls.RESULTS:The level of CRF secretion by control dendritic cells was 40.4±6.2 pg/mL.The CRF levels for cells incubated with F.varium and B.vulgatus were significantly higher than that of the control (P<0.0001).CRF mRNA was present in the control sample without bacteria,and CRF mRNA levels in all samples treated with bacteria were above that of the control sample.F.varium caused the greatest increase in CRF mRNA expression.CONCLUSION:Our results suggest that dendritic cells produce CRF,a process augmented by commensal bacteria.

关键词：促肾上腺皮质激素释放因子树突状细胞共生细菌细胞分泌慢性肾功能衰竭逆转录聚合酶链反应酶联免疫吸附试验 mRNA水平

Side-wall effect of runner casing on performance of Darrieus-type hydro turbine with inlet nozzle for extra-low head utilization

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Science China(Technological Sciences) 2010年第1期53卷 93-99页

作者： Kai SHIMOKAWA Akinori FURUKAWA Kusuo OKUMA daisuke MATSUSHITA Satoshi watanabe Graduate School of Engineering Kyushu UniversityMotooka 744Nishi-kuFukuoka819-0395Japan Department of Mechanical Engineering Kyushu UniversityMotooka 744Nishi-kuFukuoka819-0395Japan

A ducted Darrieus-type turbine has been proposed for hydropower utilization of extra-low head less than 2 m.Though the hydro turbine system,in general,might consist of an intake,runner casing section and a draft tube for higher efficiency operation,it was clarified in previous experiment that there was no need of the side-walls of runner casing section and a draft-tube for keeping the efficiency high in the case of duct with an inlet nozzle.This would yield a simplification of the structure of the turbine system.In order to reconfirm this result for large-sized turbine with 560 mm×300 mm duct,instead of small-sized one with 400 mm×200 mm duct,the side-wall effect on turbine performance was experimentally investigated for three-or four-bladed runner.In the present paper,the experimental results are shown with considering flow behaviors in the runner section.

关键词： hydro turbine Darrieus-type runner duct side-wall effect turbine performance

Studies on numerical site calibration over complex terrain for wind turbines

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Science China(Technological Sciences) 2010年第1期53卷 8-12页

作者： daisuke MATSUSHITA Hikaru MATSUMIYA Yoshinori HARA Satoshi watanabe Akinori FURUKAWA Department of Mechanical Engineering Science Kyushu University Hikaruwind Lab 5234 Seijo Setagaya-kuTokyoJapan

The estimation of wind turbine performance over complex terrain is very difficult because of the document of standard IEC61400-12 is adapted for flat or slightly complex topography.And the cost of constructing a meteorological mast is higher with scaling wind turbine up.We have proposed a numerical site calibration(NSC) technique in order to estimate the inflow velocity at the position of wind turbine by using CFD tool to calculate the flow field around the site.The present paper shows the problems for the procedure of NSC in which a commercial nonlinear CFD tool and the improvement method are used to gain a more accurate result.It is clarified that the wind turbine performance which is estimated by using the wind speed on the meteorological mast has a good result for annual energy production.

关键词： wind turbine site calibration complex terrain wind turbine performance