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High-performance GaSb planar PN junction detector

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Journal of Semiconductors 2024年第9期45卷 48-52页

作者： Yuanzhi Cui Hongyue Hao Shihao Zhang Shuo Wang Jing Zhang Yifan Shan Ruoyu Xie Xiaoyu Wang Chuang Wang Mengchen Liu Dongwei Jiang Yingqiang Xu Guowei Wang Donghai wu Zhichuan Niu Derang Cao College of Physics National Demonstration Center for Experimental Applied Physics EducationQingdao UniversityQingdao 266071China Key Laboratory of Optoelectronic Materials and Devices Chinese Academy of SciencesBeijing 100083China College of Materials Science and Opto-Electronic Technology University of Chinese Academy of SciencesBeijing 100049China

This paper examines GaSb short-wavelength infrared detectors employing planar PN junctions. The fabrication was based on the Zn diffusion process and the diffusion temperature was optimized. Characterization revealed a 50% cut-off wavelength of 1.73 μm, a maximum detectivity of 8.73 × 10^(10) cm·Hz^(1/2)/W, and a minimum dark current density of 1.02 × 10^(-5) A/cm^(2).Additionally, a maximum quantum efficiency of 60.3% was achieved. Subsequent optimization of fabrication enabled the realization of a 320 × 256 focal plane array that exhibited satisfactory imaging results. Remarkably, the GaSb planar detectors demonstrated potential in low-cost short wavelength infrared imaging, without requiring material epitaxy or deposition.

关键词： antimonide short-wave infrared planar junction zinc diffusion

Brain region-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior

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Neural Regeneration Research 2025年第1期20卷 159-173页

作者： Man Han Deyang Zeng Wei Tan Xingxing Chen Shuyuan Bai Qiong wu Yushan Chen Zhen Wei Yufei Mei Yan Zeng Brain Science and Advanced Technology Institute Wuhan University of Science and TechnologyWuhanHubei ProvinceChina Geriatric Hospital Affiliated to wuhan University of Science and Technology WuhanHubei ProvinceChina School of Public Health Wuhan University of Science and TechnologyWuhanHubei ProvinceChina

Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral *** studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and *** how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress *** this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of *** focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B signaling pathway and the ventral tegmental area–nucleus accumbens dopamine *** determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic ***,BDNF might be a biological indicator regulating stress-related processes in various brain regions.

关键词： amygdala chronic mild stress chronic social defeat stress corticolimbic system depression hippocampus medial prefrontal cortex nucleus accumbens social stress models ventral tegmental area

Perilipin-2 mediates ferroptosis in oligodendrocyte progenitor cells and myelin injury after ischemic stroke

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Neural Regeneration Research 2025年第7期20卷 2015-2028页

作者： Jian Yang Jiang wu Xueshun Xie Pengfei Xia Jinxin Lu Jiale Liu Lei Bai Xiang Li Zhengquan Yu Haiying Li Department of Neurosurgery&Brain and Nerve Research Laboratory The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Stroke Research Soochow UniversitySuzhouJiangsu ProvinceChina

Differentiation of oligodendrocyte progenitor cells into mature myelin-forming oligodendrocytes contributes to *** of remyelination due to oligodendrocyte progenitor cell death can result in severe nerve *** is an iron-dependent form of regulated cell death caused by membrane rupture induced by lipid peroxidation,and plays an important role in the pathological process of ischemic ***,there are few studies on oligodendrocyte progenitor cell *** analyzed transcriptome sequencing data from GEO databases and identified a role of ferroptosis in oligodendrocyte progenitor cell death and myelin injury after cerebral *** analysis suggested that perilipin-2(PLIN2)was involved in oligodendrocyte progenitor cell ***2 is a lipid storage protein and a marker of hypoxia-sensitive lipid droplet *** further investigation,we established a mouse model of cerebral ischemia/*** found significant myelin damage after cerebral ischemia,as well as oligodendrocyte progenitor cell death and increased lipid peroxidation levels around the infarct *** ferroptosis inhibitor,ferrostatin-1,rescued oligodendrocyte progenitor cell death and subsequent myelin *** also found increased PLIN2 levels in the peri-infarct area that co-localized with oligodendrocyte progenitor ***2 knockdown rescued demyelination and improved neurological *** findings suggest that targeting PLIN2 to regulate oligodendrocyte progenitor cell ferroptosis may be a potential therapeutic strategy for rescuing myelin damage after cerebral ischemia.

关键词： bioinformatics bulk RNA sequencing ferroptosis ischemic stroke myelin injury oligodendrocyte progenitor cell perilipin-2 single-cell RNA sequencing

Study on the Mechanism of Glutamine Promoting the Synthesis of Colonic Mucin and Maintaining the Stability of Intestinal Microbiota in Septic Mice

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Food Science and Human Wellness 2024年

作者： Yanyan Pan Gang Yang Dan wu Yan Wei Shijun Fan Lin Xia Qian Chen Qianying Huang Yongling Lu Xi Peng Clinical Medical Research Center， Southwest Hospital， Third Military Medical University (Army Medical University) Burn Department， Ningbo No.2 Hospital nstitute of Burn Research， State Key Laboratory of Trauma and Chemical Poisoning， Southwest Hospital， Third Military Medical University (Army Medical University)

Colonic mucus and gut microbiota closely linked through mutual regulatory effect. While their alterations during sepsis and whether glutamine can maintain the colonic mucus barrier and gut microbiota stability are unclear. Cecal ligation and puncture-induced sepsis in mice was utilized to observe changes in colonic mucus， gut microbiota， and their interaction with glutamine intervention. Our findings indicated that glutamine mitigated sepsis-induced intestinal damage and restores colonic mucus barrier function by augmenting mucin synthesis. Further analysis revealed that goblet cells were under oxidative stress after sepsis， resulting in anterior gradient-2 (AGR2)， the key mucin-modifying enzyme， being dissynthesized， and inhibiting mucin2 (MUC2) maturation. glutamine could ameliorates this situation by promoting the key enzyme glucose-6-phosphate dehydrogenase (G6PD) glycosylation in the pentose phosphate pathway， increasing the reduced nicotinamide adenine dinucleotide phosphate (NADPH) synthesis， reducing endoplasmic reticulum stress， and accelerating AGR2 synthesis and MUC2 maturation. Additionally， glutamine aided in maintaining gut microbiota stability during sepsis， up-regulating mucin-associated bacteria such as Akkermansia and Alistipes. These bacteria， intimately linked to mucin synthesis and degradation， may impact intestinal mucus stability. In conclusion， glutamine can maintain goblet cell redox balance， promotes AGR2 synthesis and MUC2 maturation， shields the mucus barrier， and potentially maintains gut microbiota stability by regulating the interaction between bacteria and mucus， thus alleviating sepsis-induced intestinal damage.

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Identification of SSR markers linked to the abscission of cotton boll traits and mining germplasm in Cotton

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Journal of Cotton Research 2024年第2期7卷 177-187页

作者： SHUI Guangling LIN Hairong MA Xiaomei ZHU Bo HAN Peng AINI Nurimanguli GUO Chunping wu Yuanlong PAN Zhenyuan YOU Chunyuan SONG Guoli NIE Xinhui Key Laboratory of Oasis Ecology Agricultural of Xinjiang Bingtuan Agricultural CollegeShihezi UniversityShiheziXinjiang 832003China Cotton Institute Xinjiang Academy of Agriculture and Reclamation ScienceShiheziXinjiang 832000China Agricultural Science Research Institute of the 5th Division of Xinjiang Production and Construction Corps ShuangheXinjiang 833408China Modern Agricultural College Kashi UniversityKashiXinjiang 844000China National Key Laboratory of Crop Genetic Improvement College of Plant Sciences&TechnologyHuazhong Agricultural UniversityWuhanHubei 430070China National Key Laboratory of Cotton Bio‑Breeding and Integrated Utilization Institute of Cotton ResearchChinese Academy of Agricultural SciencesAnyangHenan 455000China

Background Cotton is an economically important *** is crucial to find an effective method to improve cotton yield,and one approach is to decrease the abscission of cotton bolls and ***,the lack of knowledge of the genetic and molecular mechanisms underlying cotton boll abscission traits has hindered genetic *** Pearson’s correlation analysis revealed a significant positive correlation between boll abscission rates 1(AR1)and boll abscission rates 2(AR2).A genome-wide association study was conducted on 145 loci that exhibited high polymorphism and were uniformly distributed across 26 chromosomes(pair).The study revealed 18,46,and 62 markers that were significantly associated with boll abscission,fiber quality,and yield traits(P<0.05),explaining 1.75%–7.13%,1.16%–9.58%,and 1.40%–5.44%of the phenotypic variation,***,the marker MON_SHIN-1584b was associated with the cotton boll abscission trait,whereas MON_CGR5732a was associated with cotton boll abscission and fiber quality *** of the marker loci identified in this study had been previously *** on phenotypic effects,six typical cultivars with elite alleles related to cotton boll abscission,fiber quality,and yield traits were *** cultivars hold great promise for widespread utilization in breeding *** These results lay the foundation for understanding the molecular regulatory mechanism of cotton boll abscission and provide data for the future improvement of cotton breeding.

关键词： SSR Genome wide association studies Abscission Favorable alleles Cotton Genetic improvement

Versatile chiroptical induction/manipulation through specific solvation of ion pairs by alcohols

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Science China Chemistry 2024年

作者： Chunhong Liu Xin Chen Yanling Shen Ting Zhao Dayang Zhou Kun Li Jiecheng Ji Wanhua wu Xuemei Pu Cheng Yang Key Laboratory of Green Chemistry & Technology of Ministry of Education Sichuan University Comprehensive Analysis Center ISIR Osaka University

While extensive research has explored manipulating supramolecular chirality through internal and external factors, the specific solvation effect remains uncharted territory. This study synthesized ortho-functionalized pillar[5]arene（P[5]） derivatives Mn and Dn via thiol-Michael addition, characterizing them through spectroscopic and X-ray single-crystal analyses. Mn and Dn interacted with chiral amines, yielding significant circular dichroism（CD） responses. Intriguingly, the chiral induction exhibited pronounced specific solvation effects, where achiral alcohols either enhanced, attenuated, or reversed CD signals. Testing over40 alcohols revealed correlations between the specific solvation effects and alcohol polarity and acidity. Molecular dynamics simulations unveiled that the alcohol interacted distinctly through hydrogen bonding, with one ion pair bonding up to four alcohol molecules. The Rp-and Sp-preference of the P[5] core could be altered by the number of bonded alcohols. This work uncovers the critical role of alcohol-specific solvation in ion pair-involved chiral assembly, pertinent for asymmetric ion-pairing catalysis and the use of alcohol additives in organic solvents.

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Brillouin Klein space and half-turn space in three-dimensional acoustic crystals

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Science Bulletin 2024年第13期69卷 2050-2058页

作者： Zhenxiao Zhu Linyun Yang Jien wu Yan Meng Xiang Xi Bei Yan Jingming Chen Jiuyang Lu Xueqin Huang Weiyin Deng Ce Shang Perry Ping Shum Yihao Yang Hongsheng Chen Kexin Xiang Gui-Geng Liu Zhengyou Liu Zhen Gao State Key Laboratory of Optical Fiber and Cable Manufacture Technology Department of Electronic and Electrical EngineeringSouthern University of Science and TechnologyShenzhen 518055China School of Physics and Optoelectronics South China University of TechnologyGuangzhou 510640China Key Laboratory of Artificial Micro-and Nanostructures of Ministry of Education and School of Physics and Technology Wuhan UniversityWuhan 430072China King Abdullah University of Science and Technology(KAUST) Physical Science and Engineering Division(PSE)Thuwal 23955-6900Saudi Arabia Interdisciplinary Center for Quantum Information State Key Laboratory of Modern Optical InstrumentationZJU-Hangzhou Global Science and Technology Innovation CenterCollege of Information Science and Electronic EngineeringZJU-UIUC InstituteZhejiang UniversityHangzhou 310027China Division of Physics and Applied Physics School of Physical and Mathematical SciencesNanyang Technological UniversitySingapore 637371Singapore Institute for Advanced Studies Wuhan UniversityWuhan 430072China

The Bloch band theory and Brillouin zone(BZ)that characterize wave-like behaviors in periodic mediums are two cornerstones of contemporary physics,ranging from condensed matter to topological *** theoretical breakthrough revealed that,under the projective symmetry algebra enforced by artificial gauge fields,the usual two-dimensional(2D)BZ(orientable Brillouin two-torus)can be fundamentally modified to a non-orientable Brillouin Klein bottle with radically distinct manifold ***,the physical consequence of artificial gauge fields on the more general three-dimensional(3D)BZ(orientable Brillouin three-torus)was so far ***,we theoretically discovered and experimentally observed that the fundamental domain and topology of the usual 3D BZ can be reduced to a non-orientable Brillouin Klein space or an orientable Brillouin half-turn space in a 3D acoustic crystal with artificial gauge *** experimentally identify peculiar 3D momentum-space non-symmorphic screw rotation and glide reflection symmetries in the measured band ***,we experimentally demonstrate a novel stacked weak Klein bottle insulator featuring a nonzero Z2 topological invariant and self-collimated topological surface states at two opposite surfaces related by a nonlocal twist,radically distinct from all previous 3D topological *** discovery not only fundamentally modifies the fundamental domain and topology of 3D BZ,but also opens the door towards a wealth of previously overlooked momentum-space multidimensional manifold topologies and novel gaugesymmetry-enriched topological physics and robust acoustic wave manipulations beyond the existing paradigms.

关键词： Momentum-space non-symmorphic symmetry Brillouin Klein space and half-turn space Acoustic Klein bottle insulator Self-collimated topological surface states

丙型病毒性肝炎供者器官在实体器官移植中的应用现状与展望

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器官移植 2024年第3期15卷 390-397页

作者：秦旨文张武浙江中医药大学杭州310000 树兰(杭州)医院肝胆胰外科

丙型病毒性肝炎供者器官作为一种边缘性器官已经被应用于实体器官移植中,在有效缓解器官短缺现况的同时,也面临着一些挑战,如丙型肝炎病毒(HCV)传播。但随着直接抗病毒药物的出现和应用,丙型病毒性肝炎的治愈逐渐成为现实,这也为丙型病... 详细信息

丙型病毒性肝炎供者器官作为一种边缘性器官已经被应用于实体器官移植中,在有效缓解器官短缺现况的同时,也面临着一些挑战,如丙型肝炎病毒(HCV)传播。但随着直接抗病毒药物的出现和应用,丙型病毒性肝炎的治愈逐渐成为现实,这也为丙型病毒性肝炎患者成为器官移植供者奠定了基础。目前,在抗病毒药物的辅助治疗下,丙型病毒性肝炎供者实体器官移植取得了一定的疗效。因此,本文总结丙型病毒性肝炎供者肾脏、心脏、肺脏及肝脏等移植的研究现状,就丙型病毒性肝炎供者在实体器官移植中的应用情况及抗病毒药物辅助治疗的安全有效性做一综述,探究丙型病毒性肝炎供者在实体器官移植中可行性,以期为扩大器官移植供体池提供参考,减少终末期疾病患者器官移植的等待时间。

关键词：丙型病毒性肝炎丙型肝炎病毒边缘供者实体器官移植直接抗病毒药物持续病毒学应答病毒血症供者短缺

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胰腺癌伴肝脏寡转移外科治疗的再认识

中华消化外科杂志 2024年第5期23卷 667-675页

作者：吴鹏飞何进南京医科大学第一附属医院(江苏省人民医院)胰腺中心南京210029 美国约翰霍普金斯大学医学院肝胆胰外科巴尔的摩21287

胰腺癌恶性程度高,预后差。以外科手术为基础的综合治疗可最大程度改善胰腺癌患者的预后。但胰腺癌患者确诊时常已合并远处转移,其中以肝转移为主。大多数情况下,初诊时即转移的胰腺癌患者已失去手术机会,其标准治疗为姑息性化疗,治疗... 详细信息

胰腺癌恶性程度高,预后差。以外科手术为基础的综合治疗可最大程度改善胰腺癌患者的预后。但胰腺癌患者确诊时常已合并远处转移,其中以肝转移为主。大多数情况下,初诊时即转移的胰腺癌患者已失去手术机会,其标准治疗为姑息性化疗,治疗效果欠佳。近年来,随着多药联合化疗方案的实施,部分胰腺癌伴肝脏寡转移患者已通过转化手术治疗获得了生存时间的延长。然而,目前临床医师对胰腺癌伴肝脏寡转移的疾病认知仍不充分,导致其对此类患者所需的治疗方案仍不明确。笔者评述胰腺癌伴肝脏寡转移的定义,总结手术治疗的安全性和肿瘤学疗效,并从生物学可切除性角度探讨并提出具有可行性的转化手术治疗策略。

关键词：胰腺肿瘤肝转移寡转移疾病生物可切除性转化手术预后