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Effect of Systolic Cardiac Function on Passive Leg Raising for Predicting Fluid Responsiveness： A Prospective Observational Study

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Chinese Medical Journal 2018年第3期131卷 253-261页

作者： Xiang Si dai-yin cao Juan Chen Jian-Feng Wu Zi-Meng Liu Hai-Lin Xu Min-ying Chen Yong-Jun Liu Xiang-Dong Guan Department of SICU The First Affiliated Hospital of Sun Yat-sen University Guangzhou Guangdong 510080 China Department of Critical Care Medicine The Sixth Affiliated Hospital of Sun Yat-sen University Guangzhou Guangdong 510655 China

Background：Passive leg raising （PLR） represents a ＂self-volume expansion （VE）＂ that could predict fluid responsiveness,but the influence of systolic cardiac function on PLR has seldom been *** study aimed to investigate whether systolic cardiac function,estimated by the global ejection fraction （GEF） from transpulmonary-thermodilution,could influence the diagnostic value of ***：This prospective,observational study was carried out in the surgical Intensive Care Unit of the First Affiliated Hospital of Sun Yat-sen University from December 2013 to July ***-eight mechanically ventilated patients considered for VE were prospectively included and divided into a low-GEF （〈20%） and a near-normal-GEF （〉20%） *** each group,baseline hemodynamics,after PLR and after VE （250 ml 5% albumin over 30 min）,were ***-induced hemodynamic changes （PLR-△） were *** responders were defined by a 15% increase of stroke volume （SV） after ***：Twenty-five out of 38 patients were responders in the GEF 〈20% group,compared to 26 out of 40 patients in the GEF 〉20% *** thresholds of PLR-△SV and PLR-△ cardiac output （PLR-△CO） for predicting fluid responsiveness were higher in the GEF 〉20% group than in the GEF 〈20% group （△SV：12% vs.8%;△CO：7% vs.6%）,with increased sensitivity （△SV：92% vs.92%;△CO：81% vs.80%） and specificity （△SV：86% vs.70%;△CO：86% vs.77%）,respectively PLR-△ heart rate could predict fluid responsiveness in the GEF 〉20% group with a threshold value of-5% （sensitivity 65%,specificity 93%） but could not in the GEF 〈20% *** pressure index changes were poor ***：In the critically ill patients on mechanical ventilation,the diagnostic value of PLR for predicting fluid responsiveness depends on cardiac systolic ***,cardiac systolic function must be considered when using *** Registration：Chinese Clinical Trial Register,ChiCTR-OCH-13004027;http：//***/***？proj=5540

关键词： Fluid Responsiveness Passive Leg Raising Systolic Cardiac Function Volume Expansion

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Gut microbiota-astrocyte axis: new insights into age-related cognitive decline

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Neural Regeneration Research 2025年第4期20卷 990-1008页

作者： Lan Zhang Jingge Wei Xilei Liu dai Li Xiaoqi Pang Fanglian Chen Hailong cao Ping Lei Haihe Laboratory of Cell Ecosystem Department of GeriatricsTianjin Medical University General HospitalTianjinChina Tianjin Geriatrics Institute Tianjin Medical University General HospitalTianjinChina Department of Gastroenterology and Hepatology Tianjin Medical University General HospitalNational Key Clinical SpecialtyTianjin Institute of Digestive DiseasesTianjin Key Laboratory of Digestive DiseasesTianjinChina Department of Urology Tianjin Medical University General HospitalTianjinChina Tianjin Neurological Institution Tianjin Medical University General HospitalTianjinChina

With the rapidly aging human population,age-related cognitive decline and dementia are becoming increasingly prevalent *** is considered the main risk factor for cognitive decline and acts through alterations in the composition of the gut microbiota,microbial metabolites,and the functions of *** microbiota–gut–brain axis has been the focus of multiple studies and is closely associated with cognitive *** article provides a comprehensive review of the specific changes that occur in the composition of the gut microbiota and microbial metabolites in older individuals and discusses how the aging of astrocytes and reactive astrocytosis are closely related to age-related cognitive decline and neurodegenerative *** article also summarizes the gut microbiota components that affect astrocyte function,mainly through the vagus nerve,immune responses,circadian rhythms,and microbial ***,this article summarizes the mechanism by which the gut microbiota–astrocyte axis plays a role in Alzheimer’s and Parkinson’s *** findings have revealed the critical role of the microbiota–astrocyte axis in age-related cognitive decline,aiding in a deeper understanding of potential gut microbiome-based adjuvant therapy strategies for this condition.

关键词： age aging Alzheimer’s disease astrocytes cognitive decline dementia gut microbiota gut–brain axis microbial metabolites neuroinflammation Parkinson’s disease

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Optimizing the key parameter to accelerate the recovery of AMOC under a rapid increase of greenhouse gas forcing

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 39-45页

作者： Haolan Ren Fei Zheng Tingwei cao Qiang Wang International Center for Climate and Environment Science(ICCES) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina University of Chinese Academy of Sciences BeijingChina College of Oceanography Hohai UniversityNanjingChina CAS Key Laboratory of Ocean Circulation and Waves Institute of OceanologyChinese Academy of Sciences and Pilot National Laboratory for Marine Science and Technology(Qingdao)QingdaoChina

Atlantic Meridional Overturning Circulation(AMOC)plays a central role in long-term climate variations through its heat and freshwater transports,which can collapse under a rapid increase of greenhouse gas forcing in climate *** studies have suggested that the deviation of model parameters is one of the major factors in inducing inaccurate AMOC *** this work,with a low-resolution earth system model,the authors try to explore whether a reasonable adjustment of the key model parameter can help to re-establish the AMOC after its *** a new optimization strategy,the extra freshwater flux(FWF)parameter is determined to be the dominant one affecting the AMOC’s *** traditional ensemble optimal interpolation(EnOI)data assimilation and new machine learning methods are adopted to optimize the FWF parameter in an abrupt 4×CO_(2) forcing experiment to improve the adaptability of model parameters and accelerate the recovery of *** results show that,under an abrupt 4×CO_(2) forcing in millennial simulations,the AMOC will first collapse and then re-establish by the default FWF parameter ***,during the parameter adjustment process,the saltier and colder sea water over the North Atlantic region are the dominant factors in usefully improving the adaptability of the FWF parameter and accelerating the recovery of AMOC,according to their physical relationship with FWF on the interdecadal timescale.

关键词： Recovery of AMOC 4×CO_(2)forcing Key parameter Parameter estimation Data assimilation Machine learning

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Can patients with mild non-neoplastic lesions diagnosed at baseline screening be safely exempt from surveillance: evidence from multicenter community-based cohorts

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Science China Life Sciences 2025年第1期 263-271页

作者： Siyi He Zhiyi Zhang Guohui Song Zhenhai Wang Chunyun dai Shipeng Yan Kun Jiang Bingbing Song He Li Maomao cao Dianqin Sun Fan Yang Xinxin Yan Shaoli Zhang Yi Teng Qianru Li Changfa Xia Wanqing Chen Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College Department of Gastroenterology Gansu Wuwei Tumor Hospital Cixian Cancer Institute Linzhou Cancer Hospital Center for Disease Control and Prevention of Sheyang County Department of Cancer Prevention and Control Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South University Luoshan Center for Disease Control and Prevention Office for Cancer Control and Research Affiliated Cancer Hospital of Harbin Medical University

Surveillance recommendations for gastric cancer（GC） in current guidelines focused on advanced precancerous lesions and were based on precise diagnosis of severity/extent of baseline lesions. We aimed to develop a less endoscopy-related equipment-dependent risk-stratification tool, and assessed whether mild-precursor-lesion patients can be safely exempt from surveillance. In the multicenter communitybased cohort, 75,051 participants receiving baseline endoscopy were enrolled during 2015–2017 and followed-up until 2021. Cumulative incidence rates（CIRs） of GC for precancerous-conditions were calculated by Kaplan-Meier method and compared by Log-rank tests. Mixedeffects Cox regression models were used to detect potential factors for progression towards GC. A risk score was calculated as counts of selected factors. An independent cohort, including 26,586 participants was used for external validation. During a median follow-up of 6.25 years, CIRs of GC were 0.302%, 0.436%, and 4.756% for normal group, non-neoplastic（atrophic gastritis/intestinal metaplasia） and neoplastic lesions（low-grade/high-grade dysplasia）, respectively(Ptrend<0.001). Four predictors, including male, ≥60 years, smoking, and limited vegetable consumption, were selected for risk-stratification. High-risk patients（≥3 risk factors） with non-neoplastic lesions showed higher GC risks（adjusted HR=7.73, 95%CI: 4.29–13.92）, and their four-year CIR reached the one-year CIR of neoplastic lesions. Further categorizing non-neoplastic lesions by histological grade, both patients with moderate-to-severe lesions（aHR=3.07, 95%CI: 1.67–5.64） and high-risk patients with mild lesions（aHR=7.29, 95%CI: 3.58–14.86） showed higher risks. Consistent trends were observed in validation cohort. High-risk mild-precursor-lesion patients should receive surveillance within 3–5 years after baseline screening. Our study provides evidence on supplementing current guideline recommendations.

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Unraveling post-growth mechanisms of monolayer CsPbBr3 nanocubes:Laser-enhanced transformations and cathodoluminescence-electron microscopy correlations

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Journal of Energy Chemistry 2025年第1期100卷 146-156页

作者： Mingxing Li Xiaoge Wang Xiaofan cao Zhiqun He Chunjun Liang Mingxing Chen Jing Ju Fangtian You Key Laboratory of Luminescence and Optical Information Ministry of Education Institute of Optoelectronic Technology Beijing Jiaotong University Beijing National Laboratory for Molecular Sciences (BNLMS) College of Chemistry and Molecular Engineering Peking University

Lead-halide perovskite nanoparticles（LHP NPs） are highly promising materials for next-generation displays and solid-state lighting due to their exceptional optical properties. However, their inherent instability presents a significant challenge. Recent advances have demonstrated that optoelectronic devices based on monolayer nanoparticle films exhibit both high luminescence efficiency and long-term *** research demonstrates that mobility limitations and anisotropic alignments in CsPbBr3nanocube monolayer films are key to their stabilization, hindering spontaneous growth through face-to-face fusion and resulting in the formation of connecting necks in a diagonal direction. Introducing laser irradiation confirmed this by significantly accelerating nanocubes growth, increasing mobility, and enhancing local structural ordering, leading to larger and more regularly shaped nanosheets. Fourier transform infrared spectroscopy and energy dispersive spectroscopy line-scan analyses indicated that laser irradiation did not disrupt the ligand structure. Transmission electron microscopy and correlative cathodoluminescence electron microscopy revealed the effects of post-growth and heterogeneous structures, including enhanced luminescence and inhomogeneous intensity in the nanosheets. These findings deepen the understanding of the post-growth mechanism of monolayer nanoparticles and the structure-emission correlation and highlight the unique role of laser irradiation in directing the formation of well-defined and regular nanostructures.

关键词： Post-growth mechanism Heterogeneous structure Single-particle spectroscopy Laser irradiation

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Mitophagy in acute central nervous system injuries:regulatory mechanisms and therapeutic potentials

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Neural Regeneration Research 2025年第9期20卷 2437-2453页

作者： Siyi Xu Junqiu Jia Rui Mao Xiang cao Yun Xu Department of Neurology Nanjing Drum Tower HospitalClinical College of Jiangsu UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalChinese Academy of Medical Science&Peking Union Medical CollegeNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing UniversityNanjingJiangsu ProvinceChina Nanjing Neurology Medical Center NanjingJiangsu ProvinceChina

Acute central nervous system injuries,including ischemic stro ke,intracerebral hemorrhage,subarachnoid hemorrhage,traumatic brain injury,and spinal co rd injury,are a major global health *** optimal therapies and improving the long-term neurological functions of patients with acute central nervous system injuries are urgent *** are susceptible to damage after acute central nervous system injury,and this leads to the release of toxic levels of reactive oxygen species,which induce cell ***,a selective form of autophagy,is crucial in eliminating redundant or damaged mitochondria during these *** evidence has highlighted the significant role of mitophagy in acute central nervous system *** this review,we provide a comprehensive overview of the process,classification,and related mechanisms of *** also highlight the recent developments in research into the role of mitophagy in various acute central nervous system injuries and drug therapies that regulate *** the final section of this review,we emphasize the potential for treating these disorders by focusing on mitophagy and suggest future research paths in this area.

关键词： autophagy intracerebral hemorrhage ischemic stroke mitochondria mitochondrial biogenesis mitochondrial quality control mitophagy spinal cord injury subarachnoid hemorrhage traumatic brain injury

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Investigation on tunneling in optoelectronic devices with consideration of subwaves

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Science China(Physics,Mechanics & Astronomy) 2011年第3期54卷 388-392页

作者： WANG XianPing yin Cheng SANG MingHuang dai ManYuan cao ZhuangQi Department of Physics Jiangxi Normal University Nanchang 330027 China Department of Physics the State Key Laboratory on Fiber Optic Local Area Communication Networks and Advanced Optical Communication Systems Shanghai Jiao Tong University Shanghai 200240 China

Since novel optoelectronic devices based on the peculiar behaviors of the tunneling probability, e.g., resonant tunneling devices (RTD) and band-pass filter, are steadily proposed, the analytic transfer matrix (ATM) method is extended to study these devices. For several examples, we explore the effect of the scattered subwaves on tunneling; it is shown that the resonant or band-pass structures in tunneling probability are determined by the phase shift results from the scattered subwaves.

关键词： quantum tunneling WKB approximation the ATM method subwaves

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Video-Driven 2D Character Animation

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Chinese Journal of Electronics 2021年第6期30卷 1038-1048页

作者： yin Qinran cao Weiqun School of Information Science and Technology Beijing Forestry University Engineering Research Center for Forestry-oriented Intelligent Information Processing of National Forestry and Grassland Administration

Video-driven animation has always been a hot and challenging topic in the field of computer animation. We propose a method of mapping a sequence of human skeletal keypoints in a video onto a two-dimensional character to generate 2 D character animation. For a given two-dimensional character picture, we extract the motion of real human in video data, driving the character deformation. We analyze common two-dimensional human body movements, classify the basic posture of the human body, realize the recognition of skeleton posture based on back propagation network, capture human body motion by automatically tracking the position of the human skeleton keypoints coordinates in the video and redirect the motion data to a 2 D character. Compared with the traditional method, our work is less affected by video data illumination and background complexity. We calibrate human body motion in videos to a 2 D character according to the skeleton topology to avoid motion distortion caused by the difference in skeleton size and ratio. The experimental results show that the proposed algorithm can generate the motion of two-dimensional characters based on the motion of human characters in video data. The animation is natural and smooth, and the algorithm has strong robustness.

关键词： two-dimensional character picture motion distortion skeleton size video data illumination human characters video signal processing computer animation character deformation basic posture two-dimensional human body movements background complexity hot topic motion data video-driven animation computational geometry human skeleton keypoints skeleton topology skeleton posture human skeletal keypoints video-driven 2D character animation capture human body motion

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Diagnosis of CO2 dynamics and fluxes in global coastal oceans

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National Science Review 2020年第4期7卷 786-797页

作者： Zhimian cao Wei Yang Yangyang Zhao Xianghui Guo Zhiqiang yin Chuanjun Du Huade Zhao Minhan dai State Key Laboratory of Marine Environmental Science and College of Ocean and Earth Sciences Xiamen University

Global coastal oceans as a whole represent an important carbon sink but, due to high spatial–temporal variability, a mechanistic conceptualization of the coastal carbon cycle is still under development, hindering the modelling and inclusion of coastal carbon in Earth System Models. Although temperature is considered an important control of sea surface p CO2, we show that the latitudinal distribution of global coastal surface p CO2does not match that of temperature, and its inter-seasonal changes are substantially regulated by non-thermal factors such as water mass mixing and net primary production. These processes operate in both ocean-dominated and river-dominated margins, with carbon and nutrients sourced from the open ocean and land, respectively. These can be conceptualized by a semi-analytical framework that assesses the consumption of dissolved inorganic carbon relative to nutrients, to determine how a coastal system is a CO2source or sink. The framework also finds utility in accounting for additional nutrients in organic forms and testing hypotheses such as using Redfield stoichiometry, and is therefore an essential step toward comprehensively understanding and modelling the role of the coastal ocean in the global carbon cycle.

关键词： CO2 dynamics and fluxes coastal ocean ocean-dominated margin river-dominated ocean margin carbon cycle

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Depth and Residual Images Based Rendering

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Chinese Journal of Electronics 2016年第1期25卷 131-138页

作者： DENG Xiangdong cao Xun dai Qionghai Academy of Broadcasting Planning School of Electronic Science and Engineering Nanjing University Department of Automation Tsinghua University Tsinghua National Laboratory for Information Science and Technology (TNList)

This paper proposes a novel representation method which is called Depth and residual images based representation(DRIBR) for virtual image rendering in 3D video. The proposed DRIBR is composed of three parts:a single view image from one particular viewpoint, its corresponding depth map as well as a residual image. The residual image is pre-calculated from the combination of the above two components plus an image taken from the other viewpoint. The proposed DRIBR achieves low data redundancy, and resolves the occlusion problem which is one of the most annoying artifacts during the rendering of virtual image in traditional Depth image based rendering(DIBR). This paper addresses details of DRIBR and virtual image rendering algorithms based on the proposed format. We test the DRIBR on various stereo datasets and the experimental results demonstrate that our method can achieve better performance on both subjective and objective quality assessment.

关键词： Depth map Residual image Depth image based representation(DIBR) Occlusion Multi-view video(MVV)

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