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De novo combined lamivudine and adefovir dipivoxil therapy vs entecavir monotherapy for hepatitis B virus-related decompensated cirrhosis

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World Journal of Gastroenterology 2013年第37期19卷 6278-6283页

作者： Jiang-Shan Lian Lin-Yan Zeng Jian-Yang Chen Hong-Yu Jia Yi-Min Zhang dai-rong xiang Liang Yu Jian-Hua Hu Ying-Feng Lu Ling Zheng Lan-Juan Li Yi-Da Yang State Key Laboratory for Diagnosis and Treatment of Infectious Diseases the FirstAffiliated HospitalZhejiang University School of Medicine

AIM:To compare efficacy of combined lamivudine(LAM)and adefovir dipivoxil(ADV)therapy with that of entecavir(ETV)monotherapy for hepatitis B virus(HBV)-related decompensated liver ***:A total of 120 na ve patients with HBVrelated decompensated cirrhosis participated in this *** patients were treated with combined LAM and ADV therapy(LAM+ADV group),while the other60 were treated with ETV monotherapy(ETV group)for two *** for liver and kidney function,alpha-fetoprotein,HBV serum markers,HBV DNA load,prothrombin time(PT),and ultrasonography or computed tomography scan of the liver were performed every1 to 3 *** measure ANOVA and theχ2test were performed to compare the efficacy,side effects,and the cumulative survival rates at 48 and 96 ***:Forty-five patients in each group were observed for 96 *** significant differences in HBV DNA negative rates and alanine aminotransferase(ALT)normalization rates at weeks 48(χ2=2.12 and 2.88)and96(χ2=3.21 and 3.24)between the two groups were *** B e antigen seroconversion rate in the LAM+ADV group at week 96 was significantly higher in the ETV group(43.5%vs 36.4%,χ2=4.09,P<0.05).Viral breakthrough occurred in 2 cases(4.4%)by week 48 and in 3 cases(6.7%)by week 96 in the LAM+ADV group,and no viral mutation was *** the ETV group,viral breakthrough occurred in 1 case(2.2%)at the end of week *** increase in albumin(F=18.9 and 17.3),decrease in total bilirubin and in ALT(F=16.5,17.1 and 23.7,24.8),reduced PT(F=22.7 and 24.5),and improved Child-Turcotte-Pugh and the model for end-stage liver disease scores(F=18.5,17.8,and 24.2,23.8)were observed in both *** cumulative rates of mortality and liver transplantation were 16.7%(10/60)and 18.3%(11/60)in the LAM+ADV and ETV groups,***:Both LAM+ADV combination therapy and ETV monotherapy can effectively inhibit HBV replication,improve liver function,and decrease mortality.

关键词： Chronic hepatitis B Decompensated liver cirrhosis Lamivudine Adefovir dipivoxil Combination therapy Entecavir

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Hepatitis B surface antigen levels during natural history of chronic hepatitis B: A Chinese perspective study

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World Journal of Gastroenterology 2014年第27期20卷 9178-9184页

作者： Lin-Yan Zeng Jiang-Shan Lian Jian-Yang Chen Hong-Yu Jia Yi-Min Zhang dai-rong xiang Liang Yu Jian-Hua Hu Ying-Feng Lu Lin Zheng Lan-Juan Li Yi-Da Yang State Key Laboratory for Diagnosis and Treatment of Infectious Diseases the First Affiliated Hospital of Zhejiang University School of Medicine

AIM: To determine the baseline hepatitis B surface antigen (HBsAg) levels during the different phases of chronic hepatitis B (CHB) patients in China.

关键词： Hepatitis B surface antigen quantification Chronic hepatitis B Natural history Perspective

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浅议中小物流企业联合体—物流超市

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物流技术 2012年第2期31卷 172-173,212页

作者：代湘荣武汉交通职业学院湖北武汉430065

近年来,受国际金融危机不断蔓延和加深的影响,我国物流市场开始萎缩,多达数万家的中小物流企业经营尤其困难,物流业到了一个需要整合的时期。物流超市新型经营模式为中小物流商提供了一个协助竞争,抱团取暖共渡危机的机会,结合实例对物... 详细信息

近年来,受国际金融危机不断蔓延和加深的影响,我国物流市场开始萎缩,多达数万家的中小物流企业经营尤其困难,物流业到了一个需要整合的时期。物流超市新型经营模式为中小物流商提供了一个协助竞争,抱团取暖共渡危机的机会,结合实例对物流超市运作进行了探讨。

关键词：物流中小企业 IR合体物流超市

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Early kidney injury during long-term adefovir dipivoxil therapy for chronic hepatitis B

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World Journal of Gastroenterology 2015年第12期21卷 3657-3662页

作者： Hong-Yu Jia Feng Ding Jian-Yang Chen Jiang-Shan Lian Yi-Min Zhang Lin-Yan Zeng dai-rong xiang Liang Yu Jian-Hua Hu Guo-Dong Yu Huan Cai Ying-Feng Lu Lin Zheng Lan-Juan Li Yi-Da Yang Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases State Key Laboratory for Diagnosis and Treatment of Infectious Disease First Affiliated Hospital of Zhejiang University School of Medicine

AIM: To evaluate urine β2-microglobulin(β2-M), retinol-binding protein(RBP) excretion, and renal impairment with adefovir dipivoxil(ADV) for chronic hepatitis B. METHODS: We enrolled 165 patients with chronic hepatitis B infection who were treated with ADV monotherapy(n = 90) or ADV plus lamivudine combination therapy(n = 75). An additional 165 chronic hepatitis B patients treated with entecavir were recruited as controls. We detected serum creatinine, urine β2-M, and RBP levels, and estimated the glomerular filtration rate(e GFR) at the initiation of antiviral therapy and every 6 mo for a period of five years. RESULTS: Urine β2-M abnormalities were observed in patients during the first(n = 3), second(n = 7), third(n = 11), fourth(n = 16), and fifth(n = 21) year of ADV treatment. Urinary RBP abnormalities were observed in patients during the first(n = 2), second(n = 8), third(n = 12), fourth(n = 15), and fifth(n = 22) year of ADV treatment. e GFR decreased 20%-30% from baseline in 20 patients, 30%-50% in 12 patients, and > 50% in 3 patients during the five years of treatment. Further analysis indicated that decreases in e GFR of ≥ 30% relative to the baseline level correlated significantly with urine RBP and β2-M abnormalities. In contrast, both serum creatinine and e GFR remained stable in patients treated with entecavir, and only one of these patients developed a urine β2-M abnormality, and two developed urine RBP abnormalities during the five years of treatment. CONCLUSION: Urine RBP and β2-M are biomarkers of renal injury during long-term ADV treatment for chronic hepatitis B, and indicate when treatment should be switched to entecavir.

关键词： Adefovir dipivoxil Entecavir Retinol binding prote

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柠檬醛胁迫环境下黄曲霉线粒体的畸变

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微生物学报 2006年第6期46卷 1011-1013页

作者：罗曼蒋立科戴向荣暨南大学生物医学工程研究所广州510632 安徽农业大学生命科学学院合肥230036

通过对黄曲霉细胞受柠檬醛损伤后线粒体形态畸变的透射电镜观察,发现柠檬醛所产生胁迫环境影响线粒体DNA复制系统,产生增生变异的巨型线粒体而与之应答。丙二醛法测定黄曲霉细胞内自由基,结果表明药物进入细胞后还通过诱发自由基使线粒... 详细信息

通过对黄曲霉细胞受柠檬醛损伤后线粒体形态畸变的透射电镜观察,发现柠檬醛所产生胁迫环境影响线粒体DNA复制系统,产生增生变异的巨型线粒体而与之应答。丙二醛法测定黄曲霉细胞内自由基,结果表明药物进入细胞后还通过诱发自由基使线粒体损伤,致使氧化还原系统及细胞能量代谢途径受到影响。

关键词：柠檬醛黄曲霉线粒体畸变

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梁板式与筏板式底板经济比较

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山西建筑 2014年第14期40卷 29-31页

作者：戴向荣广东中山建设监理咨询有限公司广东中山528400

对梁板式与筏板式底板的特点进行了介绍,并通过工程实例,分析比较了梁板式底板结构与筏板式底板结构的经济性,分析结果显示:筏板式底板比梁板式底板经济。

关键词：梁板式筏板式经济性特点

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肉桂醛抑制黄曲霉机理初探

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食品科学 2008年第1期29卷 36-40页

作者：戴向荣蒋立科罗曼安徽农业大学生命科学学院安徽合肥230036 暨南大学生命科学技术学院生物医学工程系广东广州510632

肉桂油为新发现的天然抗菌防腐香精油,其有效成分为肉桂醛。本研究采用肉桂醛抑制黄曲霉生长过程,并通过测定不同抑制方式下孢子提取液光密度、丙二醛值的变化,初步揭示该醛抑菌防腐的生物化学机理,为其在食品上的抗菌防腐应用提供科学... 详细信息

肉桂油为新发现的天然抗菌防腐香精油,其有效成分为肉桂醛。本研究采用肉桂醛抑制黄曲霉生长过程,并通过测定不同抑制方式下孢子提取液光密度、丙二醛值的变化,初步揭示该醛抑菌防腐的生物化学机理,为其在食品上的抗菌防腐应用提供科学依据。结果发现肉桂醛的不同浓度、抑制方式毒化黄曲霉细胞孢子提取液的OD260nm、OD280nm值都增大,丙二醛(MDA)值也均上升,表明肉桂醛能通过损伤黄曲霉细胞质膜而进入细胞,使胞内大分子空间结构改变并且有序的新陈代谢被破坏,导致抑制黄曲霉的生长。

关键词：肉桂醛黄曲霉 OD 丙二醛

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Complete response of gallbladder cancer treated with gemcitabine and cisplatin chemotherapy combined with durvalumab:A case report and review of literature

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 226-232页

作者： Kai Chen Xu Feng Yuan Shi Xin-Lin Li Zheng-rong Shi xiang Lan Department of Hepatobiliary Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Gallbladder cancer(GBC)is the most common and aggressive subtype of biliary tract cancer(BTC)and has a poor prognosis.A newly developed regimen of gemcitabine,cisplatin,and durvalumab shows promise for the treatment of advanced ***,the efficacy of this treatment for GBC remains *** SUMMARY In this report,we present a case in which the triple-drug regimen exhibited marked effectiveness in treating locally advanced GBC,thus leading to a long-term survival benefit.A 68-year-old man was diagnosed with locally advanced GBC,which rendered him ineligible for curative *** three cycles of therapy,a partial response was *** one year of combined therapy,a clinical complete response was successfully *** maintenance therapy with durvalumab monotherapy resulted in a disease-free survival of 9 months for the *** patient experienced tolerable toxicities of reversible grade 2 nausea and *** adverse events were observed in the patient throughout the entirety of the *** The combination of gemcitabine and cisplatin chemotherapy with durvalumab was proven to be an effective treatment approach for advanced GBC,with manageable adverse *** research is warranted to substantiate the effectiveness of the combined regimen in the context of GBC.

关键词： Gallbladder cancer Chemotherapy Immunotherapy Durvalumab Complete response Case report

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