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Pericytes protect rats and mice from sepsis-induced injuries by maintaining vascular reactivity and barrier function:implication of miRNAs and microvesicles

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Military Medical Research 2024年第1期11卷 1-18页

作者： Zi-Sen Zhang Yi-Yan Liu Shuang-Shuang He dai-qin bao Hong-Chen Wang Jie Zhang Xiao-Yong Peng Jia-Tao Zang Yu Zhu Yue Wu qing-Hui Li Tao Li Liang-Ming Liu State Key Laboratory of Trauma Burns and Combined InjuryDepartment of Shock and TransfusionResearch Institute of SurgeryDaping HospitalArmy Medical UniversityChongqing 400042China

Background Vascular hyporeactivity and leakage are key pathophysiologic features that produce multi-organ damage upon *** hypothesized that pericytes,a group of pluripotent cells that maintain vascular integrity and tension,are protective against sepsis via regulating vascular reactivity and *** We conducted a series of in vivo experiments using wild-type(WT),platelet-derived growth factor receptor-β(PDGFR-β)-Cre+mT/mG transgenic mice and Tie2-Cre+Cx43^(flox/flox)mice to examine the relative contribution of pericytes in sepsis,either induced by cecal ligation and puncture(CLP)or lipopolysaccharide(LPS)*** a separate set of experiments with Sprague-Dawley(SD)rats,pericytes were depleted using CP-673451,a selective PDGFR-βinhibitor,at a dosage of 40 mg/(kg·d)for 7 consecutive *** pericytes,vascular endothelial cells(VECs)and vascular smooth muscle cells(VSMCs)were used for mechanistic *** effects of pericytes and pericyte-derived microvesicles(PCMVs)and candidate miRNAs on vascular reactivity and barrier function were also *** CLP and LPS induced severe injury/loss of pericytes,vascular hyporeactivity and leakage(P<0.05).Transplantation with exogenous pericytes protected vascular reactivity and barrier function via microvessel colonization(P<0.05).Cx43 knockout in either pericytes or VECs reduced pericyte colonization in microvessels(P<0.05).Additionally,PCMVs transferred miR-145 and miR-132 to VSMCs and VECs,respectively,exerting a protective effect on vascular reactivity and barrier function after sepsis(P<0.05).miR-145 primarily improved the contractile response of VSMCs by activating the sphingosine kinase 2(Sphk2)/sphingosine-1-phosphate receptor(S1PR)1/phosphorylation of myosin light chain 20 pathway,whereas miR-132 effectively improved the barrier function of VECs by activating the Sphk2/S1PR2/zonula occludens-1 and vascular endothelial-cadherin *** Pericytes are protective a

关键词： Pericyte Vascular reactivity Vascular permeability Cx43 Microvesicle

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传播学视域中的地方文化外译——以赣鄱文化外译为例

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佳木斯职业学院学报 2018年第2期34卷 374-374,376页

作者：黄娟戴宝琴南昌理工学院外国语学院江西南昌330044

当今,世界进入全球化进程,各个国家都极其重视对外宣传。赣鄱文化——中国文化的优秀分支,也有着走出去的急切需求。本文以传播学相关理论为研究视域,将传播学理论和外宣翻译研究相结合,指出赣鄱文化外译的必要性、赣鄱文化中急需外译... 详细信息

当今,世界进入全球化进程,各个国家都极其重视对外宣传。赣鄱文化——中国文化的优秀分支,也有着走出去的急切需求。本文以传播学相关理论为研究视域,将传播学理论和外宣翻译研究相结合,指出赣鄱文化外译的必要性、赣鄱文化中急需外译的内容及赣鄱文化外译策略的主要影响因素及相应策略,以更好的回应我国对外传播工作以及国家形象建构的迫切需求。

关键词：传播学赣鄱文化文化外译翻译策略

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MCM-41-HY介-微孔复合分子筛的水热合成及应用

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石油学报（石油加工） 2009年第6期25卷 835-840页

作者：常玉红戴宝琴王东青孙发民田然中国石油大庆化工研究中心黑龙江大庆163714 中国石油大学重质油国家重点实验室北京102249

以微孔HY浆液为母液,合成出了一种介-微孔复合分子筛MCM-41-HY。采用XRD、NH3-TPD、N2吸附-脱附等手段对复合材料进行了表征,并考察了其水热稳定性。以大庆VGO和CGO混合油为原料,采用200mL固定床加氢装置和一段串联加氢裂化工艺,考察了... 详细信息

以微孔HY浆液为母液,合成出了一种介-微孔复合分子筛MCM-41-HY。采用XRD、NH3-TPD、N2吸附-脱附等手段对复合材料进行了表征,并考察了其水热稳定性。以大庆VGO和CGO混合油为原料,采用200mL固定床加氢装置和一段串联加氢裂化工艺,考察了复合分子筛的催化性能。结果表明,复合分子筛MCM-41-HY同时具有中孔分子筛MCM-41和微孔HY型分子筛的特点,与纯MCM-41分子筛相比,其酸强度明显增强,并且水热稳定性提高。在控制原料中>350℃馏分油转化率为75%的条件下,加氢裂化生成油C5+液收为98.51%,最大量柴油馏分的收率为69.09%,中油(馏分138～370℃)选择性80.5%,能满足工业装置最大量生产柴油的需要。

关键词：复合分子筛加氢裂化催化性能中油选择性

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基于学习策略研究开展“以学生为中心”的英语词汇教学

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海外英语 2012年第3X期 31-33页

作者：黄娟戴宝琴南昌理工学院外语系江西南昌330044

词汇在英语学习和教学中非常重要,它是学习英语的基础,但许多学生反映词汇难记,今天背明天忘,导致对英语缺乏信心。在词汇教学课堂上,大多数教师以自身为主向学生灌输词汇知识,没有调动学生自身的主动性和积极性,导致词汇教学的沉闷和... 详细信息

词汇在英语学习和教学中非常重要,它是学习英语的基础,但许多学生反映词汇难记,今天背明天忘,导致对英语缺乏信心。在词汇教学课堂上,大多数教师以自身为主向学生灌输词汇知识,没有调动学生自身的主动性和积极性,导致词汇教学的沉闷和低效率。笔者通过探索学习策略,根据研究者对学生学习策略的调查研究及对学生词汇学习的观察,发现学生在词汇学习上存在的问题,并在此基础上提出教师应调整学生学习策略,开展以学生为中心的词汇教学,从而减少词汇教学的盲目性,提高学生学习词汇的积极性和效率,进一步提高学生的英语成绩。

关键词：学习策略调查研究以学生为中心词汇教学

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浅谈运用小组合作学习以锻炼学生口语

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井冈山医专学报 2007年第1期14卷 74-75页

作者：戴宝琴熊丽琼南昌理工学院外语系江西南昌330013

根据教学实践,本文提出在英语听力课中运用小组合作学习的方法,以提高学生的英语口语,真正做到听、说不分家。

关键词：课堂小组合作学习口语

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DZD-1柴油加氢精制催化剂的性能及工业应用

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化工科技市场 2005年第12期28卷 4-7页

作者：张庆武刘文勇张铁珍戴宝琴暴希忠中国石油大庆石化公司研究院大庆163714 中国石油大庆石化分公司化工一厂大庆163714

研制出以改性的国产γ-Al2O3为载体,以钨镍为活性组分的DZD-1柴油加氢精制催化剂,并通过了活性稳定性试验。以大庆石化公司炼油厂催化柴油和焦化柴油的混合油为原料,在氢分压8.0MPa、体积空速2.5h-1～2.7h-1、氢油比340:1～360:1、反应... 详细信息

研制出以改性的国产γ-Al2O3为载体,以钨镍为活性组分的DZD-1柴油加氢精制催化剂,并通过了活性稳定性试验。以大庆石化公司炼油厂催化柴油和焦化柴油的混合油为原料,在氢分压8.0MPa、体积空速2.5h-1～2.7h-1、氢油比340:1～360:1、反应器床层平均温度327～380℃的工艺条件下,可生产出硫含量小于50μg·g-1的柴油。

关键词：柴油二次加工柴油加氢精制催化剂

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A method of line spectrum extraction based on target radiated spectrum feature and its post-processing

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Journal of Systems Engineering and Electronics 2021年第6期32卷 1381-1393页

作者： dai Wenshu ZHENG Enming bao Kaikai Key Laboratory of Instrumentation Science&Dynamic Measurement North University of ChinaTaiyuan 030006China Institute of Acoustics Chinese Academy of SciencesBeijing 100190China Northern Institute of Automatic Control Technology Taiyuan 030051China

To improve the ability of detecting underwater targets under strong wideband interference environment,an efficient method of line spectrum extraction is proposed,which fully utilizes the feature of the target spectrum that the high intense and stable line spectrum is superimposed on the wide continuous *** method modifies the traditional beam forming algorithm by calculating and fusing the beam forming results at multi-frequency band and multi-azimuth interval,showing an excellent way to extract the line spectrum when the interference and the target are not in the same azimuth interval *** efficiency of the estimated azimuth variance and corresponding power of the line spectrum band depends on the line spectra ratio(LSR)of the line *** change laws of the output signal to noise ratio(SNR)with the LSR,the input SNR,the integration time and the filtering bandwidth of different algorithms bring the selection principle of the critical *** the basis,the detection gain of wideband energy integration and the narrowband line spectrum algorithm are theoretically *** simulation detection gain demonstrates a good match with the theoretical *** application conditions of all methods are verified by the receiver operating characteristic(ROC)curve and experimental data from Qiandao *** fact,combining the two methods for target detection reduces the missed detection *** proposed post-processing method in2-dimension with the Kalman filter in the time dimension and the background equalization algorithm in the azimuth dimension makes use of the strong correlation between adjacent frames,could further remove background fluctuation and improve the display effect.

关键词： towed linear array sonar target radiated noise spectrum line spectra level ratio(LSR) receiver operating characteristic(ROC)curve post-processing

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Spatial Distribution of Integrated Impact Index of Mega-event——A Case Study of Expo '99 Kunming

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Chinese Geographical Science 2008年第3期18卷 214-223页

作者： dai Guangquan bao Jigang School of Economics and Commerce South China University of Technology Guangzhou 510006 China Center for Tourism Planning ＆ Research SUN Yat-Sen University Guangzhou 510275 China

Taking the affinity between events and media as a conceptualization base, a total of 1032 related news re-ports of Expo '99 Kunming, gathered from the internet data bank of China INFOBANK from 1992 to 2003, are used as data sources. After classifying them with a communication research method-the content analysis, a data bank for SPSS is set up, and a mathematic model called the Integrated Impact Index of Expo '99 Kunming is constituted. With the model, the spatial distribution of the total integrated impacts of Expo '99 Kunming on the regions or cities with different regional scales is analysed quantitatively. The conclusions are: 1) the Expo '99 Kunming made obvious integrated impacts on the regions or cities of every scale, especially in the venue city and the region-Kunming City and Yunnan Province; 2) it had corresponding impacts on other provinces; 3) the spatial distribution of Integrated Impact Index had a disaggregation with both plane extension and spotted decentralization; and 4) there was a distance decay law in all three scales of regions (Kunming City, Yunnan Province and the whole China), which incarnated the spatial extension law of the integrated impact of a special mega-event.

关键词： Expo '99 Kunming Integrated Impact Index mega-event Yunnan Province

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Clinical analysis of solid-pseudopapillary tumor of the pancreas:report of 15 cases

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Hepatobiliary & Pancreatic Diseases International 2008年第2期7卷 196-200页

作者： Chen, Shao-qin Zou, Sheng-Quan dai, Qi-bao Li, Hong Huazhong Univ Sci & Technol Tongji Hosp Tongji Med Coll Dept Gen Surg Wuhan 430030 Peoples R China

BACKGROUND: Solid-pseudopapillary tumor of the pancreas (SPTP) is an uncommon and enigmatic pancreatic neoplasm that occurs mainly in young women. Although more and more cases have been reported in recent years, misdiagnosis and incorrect treatment still frequently take place. This study was designed to stimulate consideration of this tumor. METHODS: We retrospectively reviewed the experience of diagnosis and treatment of 15 patients with SPTP and compared them with 516 patients with pancreatic cancer from January 1997 to March 2007. RESULTS: Most of the SPTP cases were asymptomatic except for one palpable mass. Almost all SPTPs demonstrated a solid structure with hypo- or isoattenuation, cystic structure with hypo-attenuation on precontrast CT scan, and enhancement of solid portions on post-contrast CT scan. By contrast, most cases of pancreatic carcinoma had multiple symptoms and abnormal blood results. The tumors showed hypo-attenuation on both precontrast and post-contrast CT scan, and only a few showed iso-attenuation on post-contrast CT scan. All cases of SPTP in our group were cured by surgical resection, while only 16.86% of patients with pancreatic carcinoma could undergo a radical resection. CONCLUSIONS: Clinical features and CT scans were helpful to differentiate SPTP from pancreatic carcinoma. Radical surgical resection was the most effective and safe method for the treatment of SPTP.

关键词： pancreatic neoplasm solid-pseudopapillary tumor diagnosis treatment

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A semi-implicit three-step method based on SUPG finite element formulation for flow in lid driven cavities with different geometries

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2011年第1期12卷 33-45页

作者： Cheng HUAN dai ZHOU Yan bao School of Naval Architecture Ocean and Civil Engineering Shanghai Jiao Tong University Shanghai 200240 China

A numerical algorithm using a bilinear or linear finite element and semi-implicit three-step method is presented for the analysis of incompressible viscous fluid problems. The streamline upwind/Petrov-Galerkin (SUPG) stabilization scheme is used for the formulation of the Navier-Stokes equations. For the spatial discretization, the convection term is treated explicitly, while the viscous term is treated implicitly, and for the temporal discretization, a three-step method is employed. The present method is applied to simulate the lid driven cavity problems with different geometries at low and high Reynolds numbers. The results compared with other numerical experiments are found to be feasible and satisfactory.

关键词： Semi-implicit three-step method Streamline upwind/Petrov-Galerkin (SUPG) finite element method (FEM) Unsteady incompressible flows Lid driven cavity problem

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